Ligand: RVU

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 33.3% 8BUEH
DFGin BLAminus 1 33.3% 8BUEE
DFGin None 1 33.3% 8BUEB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUEH Q9NYV4 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.9533 15.5282 ABAminus -135.4, -31.77 -104.88, 88.01 -89.97, 37.83 286.95, 75.03 -83.73, -24.85 in-in in 8.0945 Saltbr-in 3.0534 HRD-in -72.11, -58.45 75.28, 1.16 in-in-in SNCiii in-in ActLoopNT-in 2.9141 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.38, -30.92 APE9-dihe-na -101.17, 153.28 APE8-dihe-in -59.63, 146.59 APE8-rot-in 309.03 APE67-dihe-in -63.21, -32.83 -55.37, -40.46 APE12-dist-in 13.5206 APE11-dist-in 11.6573 APE10-dist-in 6.9037 APE9-dist-in 3.3499 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bue CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUEE Q9NYV4 715 1039 1490.0 RVU:61101 Type1 Inactive DFGin 7.242 15.4962 BLAminus -141.72, -174.7 47.09, 73.46 -90.8, 38.01 284.87, 78.5 -78.36, -22.84 in-in in 7.9834 Saltbr-in 3.3242 HRD-in -72.61, -56.11 78.07, 3.62 in-in-out SNCiio in-out ActLoopNT-in 2.8628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -101.94, -25.35 APE9-dihe-na -96.92, 153.79 APE8-dihe-in -59.83, 147.51 APE8-rot-out 172.74 APE67-dihe-in -64.75, -28.9 -55.27, -41.29 APE12-dist-in 12.9803 APE11-dist-in 12.541 APE10-dist-in 7.0055 APE9-dist-in 3.3709 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bue CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUEB Q9NYV4 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.8762 15.6 None -134.01, -59.19 -81.95, 94.22 -92.57, 38.59 286.02, 76.0 -80.72, -24.77 in-in in 7.932 Saltbr-in 2.9874 HRD-in -72.56, -56.91 77.87, 2.52 in-in-out SNCiio in-out ActLoopNT-in 2.9042 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.91, -27.24 APE9-dihe-na -111.61, 155.18 APE8-dihe-in -59.11, 144.49 APE8-rot-out 174.63 APE67-dihe-in -64.14, -33.78 -56.66, -36.69 APE12-dist-in 13.2286 APE11-dist-in 11.5753 APE10-dist-in 6.8399 APE9-dist-in 3.7328 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bue CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: RVU

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 33.3% 8BUEH
DFGin BLAminus 1 33.3% 8BUEE
DFGin None 1 33.3% 8BUEB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUEH Q9NYV4 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.9533 15.5282 ABAminus -135.4, -31.77 -104.88, 88.01 -89.97, 37.83 286.95, 75.03 -83.73, -24.85 in-in in 8.0945 Saltbr-in 3.0534 HRD-in -72.11, -58.45 75.28, 1.16 in-in-in SNCiii in-in ActLoopNT-in 2.9141 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.38, -30.92 APE9-dihe-na -101.17, 153.28 APE8-dihe-in -59.63, 146.59 APE8-rot-in 309.03 APE67-dihe-in -63.21, -32.83 -55.37, -40.46 APE12-dist-in 13.5206 APE11-dist-in 11.6573 APE10-dist-in 6.9037 APE9-dist-in 3.3499 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bue Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUEE Q9NYV4 715 1039 1490.0 RVU:61101 Type1 Inactive DFGin 7.242 15.4962 BLAminus -141.72, -174.7 47.09, 73.46 -90.8, 38.01 284.87, 78.5 -78.36, -22.84 in-in in 7.9834 Saltbr-in 3.3242 HRD-in -72.61, -56.11 78.07, 3.62 in-in-out SNCiio in-out ActLoopNT-in 2.8628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -101.94, -25.35 APE9-dihe-na -96.92, 153.79 APE8-dihe-in -59.83, 147.51 APE8-rot-out 172.74 APE67-dihe-in -64.75, -28.9 -55.27, -41.29 APE12-dist-in 12.9803 APE11-dist-in 12.541 APE10-dist-in 7.0055 APE9-dist-in 3.3709 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bue Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUEB Q9NYV4 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.8762 15.6 None -134.01, -59.19 -81.95, 94.22 -92.57, 38.59 286.02, 76.0 -80.72, -24.77 in-in in 7.932 Saltbr-in 2.9874 HRD-in -72.56, -56.91 77.87, 2.52 in-in-out SNCiio in-out ActLoopNT-in 2.9042 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.91, -27.24 APE9-dihe-na -111.61, 155.18 APE8-dihe-in -59.11, 144.49 APE8-rot-out 174.63 APE67-dihe-in -64.14, -33.78 -56.66, -36.69 APE12-dist-in 13.2286 APE11-dist-in 11.5753 APE10-dist-in 6.8399 APE9-dist-in 3.7328 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bue Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: RVU

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name