Ligand: RSU

Total number of chains: 3
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 33.3% 8BULH
DFGin BLAminus 1 33.3% 8BULE
DFGin None 1 33.3% 8BULB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BULH Q9NYV4 715 1034 1490.0 RSU:1101 Type1 Inactive DFGin 7.0023 15.3341 ABAminus -135.61, -41.73 -99.52, 91.67 -88.52, 15.79 285.0, 79.41 -60.56, -30.48 in-in in 7.861 Saltbr-in 2.9464 HRD-in -71.18, -53.58 72.73, 2.44 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.32, -27.33 APE9-dihe-na -113.19, 154.32 APE8-dihe-in -60.54, 141.61 APE8-rot-in 300.72 APE67-dihe-in -58.89, -38.82 -52.85, -42.63 APE12-dist-in 13.5001 APE11-dist-in 11.612 APE10-dist-in 7.1824 APE9-dist-in 3.8181 None TPO893 TPO893 XRAY 3.4 0.179 0.215 H 344.0 320.0 0 29 29 0 [[727, 1020]] 1.0 8bul CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BULE Q9NYV4 715 1038 1490.0 RSU:1101 Type1 Active DFGin 7.2685 15.5744 BLAminus -142.23, 173.11 51.26, 74.93 -90.42, 13.84 281.63, 81.18 -57.04, -28.57 in-in in 8.0731 Saltbr-in 3.0676 HRD-in -70.66, -53.79 75.17, 4.92 in-in-in SNCiii in-in ActLoopNT-in 2.9194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.18, -18.48 APE9-dihe-na -95.24, 149.84 APE8-dihe-in -59.92, 143.14 APE8-rot-in 301.12 APE67-dihe-in -61.61, -35.96 -53.3, -43.95 APE12-dist-in 12.7273 APE11-dist-in 12.5302 APE10-dist-in 6.6866 APE9-dist-in 3.3853 None TPO893 TPO893 XRAY 3.4 0.179 0.215 E 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bul CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BULB Q9NYV4 715 1039 1490.0 RSU:1101 Type1 Inactive DFGin 7.0478 15.5723 None -134.15, -61.62 -82.15, 93.36 -91.03, 19.31 284.15, 82.25 -57.36, -30.14 in-in in 7.9382 Saltbr-in 2.9293 HRD-in -70.64, -53.34 75.97, 4.36 in-in-in SNCiii in-in ActLoopNT-in 3.1167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.1, -23.33 APE9-dihe-na -106.91, 152.49 APE8-dihe-in -59.59, 141.04 APE8-rot-in 301.22 APE67-dihe-in -61.09, -37.16 -52.97, -42.84 APE12-dist-in 13.2976 APE11-dist-in 11.6069 APE10-dist-in 6.723 APE9-dist-in 3.6083 None TPO893 TPO893 XRAY 3.4 0.179 0.215 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bul CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: RSU

Total number of chains: 3
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 33.3% 8BULH
DFGin BLAminus 1 33.3% 8BULE
DFGin None 1 33.3% 8BULB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BULH Q9NYV4 715 1034 1490.0 RSU:1101 Type1 Inactive DFGin 7.0023 15.3341 ABAminus -135.61, -41.73 -99.52, 91.67 -88.52, 15.79 285.0, 79.41 -60.56, -30.48 in-in in 7.861 Saltbr-in 2.9464 HRD-in -71.18, -53.58 72.73, 2.44 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.32, -27.33 APE9-dihe-na -113.19, 154.32 APE8-dihe-in -60.54, 141.61 APE8-rot-in 300.72 APE67-dihe-in -58.89, -38.82 -52.85, -42.63 APE12-dist-in 13.5001 APE11-dist-in 11.612 APE10-dist-in 7.1824 APE9-dist-in 3.8181 None TPO893 TPO893 XRAY 3.4 0.179 0.215 H 344.0 320.0 0 29 29 0 [[727, 1020]] 1.0 8bul Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BULE Q9NYV4 715 1038 1490.0 RSU:1101 Type1 Active DFGin 7.2685 15.5744 BLAminus -142.23, 173.11 51.26, 74.93 -90.42, 13.84 281.63, 81.18 -57.04, -28.57 in-in in 8.0731 Saltbr-in 3.0676 HRD-in -70.66, -53.79 75.17, 4.92 in-in-in SNCiii in-in ActLoopNT-in 2.9194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.18, -18.48 APE9-dihe-na -95.24, 149.84 APE8-dihe-in -59.92, 143.14 APE8-rot-in 301.12 APE67-dihe-in -61.61, -35.96 -53.3, -43.95 APE12-dist-in 12.7273 APE11-dist-in 12.5302 APE10-dist-in 6.6866 APE9-dist-in 3.3853 None TPO893 TPO893 XRAY 3.4 0.179 0.215 E 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bul Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BULB Q9NYV4 715 1039 1490.0 RSU:1101 Type1 Inactive DFGin 7.0478 15.5723 None -134.15, -61.62 -82.15, 93.36 -91.03, 19.31 284.15, 82.25 -57.36, -30.14 in-in in 7.9382 Saltbr-in 2.9293 HRD-in -70.64, -53.34 75.97, 4.36 in-in-in SNCiii in-in ActLoopNT-in 3.1167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.1, -23.33 APE9-dihe-na -106.91, 152.49 APE8-dihe-in -59.59, 141.04 APE8-rot-in 301.22 APE67-dihe-in -61.09, -37.16 -52.97, -42.84 APE12-dist-in 13.2976 APE11-dist-in 11.6069 APE10-dist-in 6.723 APE9-dist-in 3.6083 None TPO893 TPO893 XRAY 3.4 0.179 0.215 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bul Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: RSU

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name