Ligand: RRC (Seliciclib)

Total number of chains: 8
Active chains: 2
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 50.0% 1UNLA
DFGin ABAminus 1 12.5% 8BU9H
DFGin BLBminus 1 12.5% 8FP0A
DFGin BLBtrans 1 12.5% 2A4LA
DFGin None 1 12.5% 8BU9B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BU9H Q9NYV4 715 1038 1490.0 RRC:61101 Type1 Inactive DFGin 6.8966 15.0279 ABAminus -130.72, -61.46 -86.64, 101.77 -100.72, 17.49 288.44, 80.02 -65.69, -13.23 in-in in 8.1483 Saltbr-in 3.5944 HRD-in -73.34, -52.41 71.89, 3.55 in-in-out SNCiio in-out ActLoopNT-in 2.7833 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.4, -56.59 APE9-dihe-na -80.8, 152.68 APE8-dihe-in -61.03, 143.88 APE8-rot-out 47.91 APE67-dihe-in -59.68, -32.23 -55.45, -41.09 APE12-dist-in 13.7228 APE11-dist-in 11.9439 APE10-dist-in 7.0071 APE9-dist-in 3.5232 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU9E Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.9943 15.2956 BLAminus -144.01, 174.3 58.02, 76.59 -92.29, 23.22 284.15, 79.53 -66.56, -16.01 in-in in 7.9265 Saltbr-in 2.9785 HRD-in -72.29, -52.87 75.22, 4.09 in-in-out SNCiio in-out ActLoopNT-in 2.9527 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -79.11, -41.8 APE9-dihe-na -74.19, 150.88 APE8-dihe-in -62.82, 143.67 APE8-rot-out 166.93 APE67-dihe-in -61.65, -28.3 -55.31, -42.74 APE12-dist-in 13.0026 APE11-dist-in 12.7132 APE10-dist-in 6.8922 APE9-dist-in 3.4751 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU9B Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.8954 15.5504 None -126.5, -98.68 -52.95, 118.93 -112.03, 20.69 280.85, 78.53 -65.13, -14.55 in-in in 8.0334 Saltbr-in 3.4619 HRD-in -71.08, -52.06 74.5, 2.49 in-in-out SNCiio in-out ActLoopNT-in 3.0383 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.03, -51.01 APE9-dihe-na -76.4, 148.49 APE8-dihe-in -61.77, 145.89 APE8-rot-out 190.86 APE67-dihe-in -62.1, -33.32 -50.51, -38.53 APE12-dist-in 13.2624 APE11-dist-in 11.7849 APE10-dist-in 6.4997 APE9-dist-in 3.5775 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK2 CDK2_HUMAN 3DDQA P24941 1 298 298.0 RRC:60299 Type1 Active DFGin 6.8795 15.378 BLAminus -132.75, 169.79 57.41, 82.03 -94.85, 22.97 280.61, 68.74 -62.61, -27.68 in-in in 8.7174 Saltbr-in 2.6315 HRD-in -76.69, -57.1 75.95, 10.79 in-in-in SNCiii in-in ActLoopNT-in 2.8915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 66.92, 123.95 APE9-dihe-na 76.33, 127.94 APE8-dihe-in -56.03, 136.54 APE8-rot-in 295.57 APE67-dihe-in -61.4, -22.16 -47.57, -46.39 APE12-dist-in 13.2992 APE11-dist-in 9.21 APE10-dist-in 7.3861 APE9-dist-in 3.2138 None TPO160 TPO160 XRAY 1.8 0.196 0.229 A 299.0 296.0 2 28 28 0 [[4, 286]] 1.0 3ddq CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3DDQC P24941 1 297 298.0 RRC:60299 Type1 Inactive DFGin 6.6826 15.2371 BLAminus -135.03, 174.73 51.22, 81.22 -92.28, 22.06 280.24, 71.12 -61.17, -31.8 in-in in 8.8023 Saltbr-in 2.6292 HRD-in -78.79, -55.27 70.81, 11.54 in-in-out SNCiio in-out ActLoopNT-in 2.9141 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.5, 150.72 APE9-dihe-na 67.57, 123.07 APE8-dihe-in -58.23, 146.27 APE8-rot-out 184.04 APE67-dihe-in -63.49, -21.74 -43.48, -49.11 APE12-dist-in 12.7649 APE11-dist-in 9.9876 APE10-dist-in 6.8634 APE9-dist-in 3.2438 None TPO160 TPO160 XRAY 1.8 0.196 0.229 C 299.0 266.0 31 28 28 0 [[4, 286]] 1.0 3ddq CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 8FP0A P24941 2 298 298.0 RRC:303,7TW:304 Type1,Type3 Inactive DFGin 9.3912 14.9477 BLBminus -136.63, 174.45 61.03, 42.96 -56.03, 146.23 280.88, 71.31 -87.4, 49.07 out-out out 16.0019 Saltbr-out 16.4922 HRD-in -87.02, -54.08 75.17, -13.79 out-out-out SNCooo out-out ActLoopNT-out 9.5944 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 140.67 APE9-dihe-na -85.45, 141.48 APE8-dihe-in -84.73, 120.79 APE8-rot-in 296.72 APE67-dihe-in -62.27, -23.72 -95.92, -2.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.3227 APE9-dist-out 10.9674 None None None XRAY 1.6 0.213 0.24 A 298.0 274.0 23 28 17 11 [[4, 286]] 1.0 8fp0 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2A4LA P24941 1 298 298.0 RRC:300 Type1 Inactive DFGin 10.578 18.4111 BLBtrans -113.59, 145.45 72.4, 28.76 -70.81, 127.39 225.24, 108.51 92.04, -16.08 out-out out 14.8046 Saltbr-out 16.6523 HRD-in -77.2, -70.83 76.49, 13.56 out-out-out SNCooo out-out ActLoopNT-out 5.7061 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -65.63, 118.77 APE9-dihe-na -67.51, 125.09 APE8-dihe-in -56.92, 143.85 APE8-rot-out 190.58 APE67-dihe-in -61.81, -25.37 -102.66, -1.04 APE12-dist-out 20.0529 APE11-dist-out 17.3595 APE10-dist-out 19.1896 APE9-dist-out 10.4647 None None None XRAY 2.4 0.173 0.27 A 298.0 286.0 12 28 28 0 [[4, 286]] 1.0 2a4l CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK5 CDK5_HUMAN 1UNLA Q00535 1 292 292.0 RRC:1293 Type1 Active DFGin 6.8293 15.2016 BLAminus -128.33, 173.21 66.87, 81.02 -97.91, 23.56 283.17, 72.64 -73.67, -20.59 in-in in 8.3091 Saltbr-in 2.8471 HRD-in -82.56, -50.74 69.72, 10.97 in-in-in SNCiii in-in ActLoopNT-in 2.9193 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.08, 156.73 APE9-dihe-na 71.89, 126.73 APE8-dihe-in -48.26, 136.09 APE8-rot-in 296.72 APE67-dihe-in -59.67, -21.67 -44.15, -47.77 APE12-dist-in 13.5586 APE11-dist-in 10.7803 APE10-dist-in 7.1047 APE9-dist-in 3.2635 D144N None None XRAY 2.2 0.216 0.219 A 292.0 292.0 0 28 28 0 [[4, 286]] 1.0 1unl CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5

Ligand: RRC (Seliciclib)

Total number of chains: 8
Active chains: 2
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 50.0% 1UNLA
DFGin ABAminus 1 12.5% 8BU9H
DFGin BLBminus 1 12.5% 8FP0A
DFGin BLBtrans 1 12.5% 2A4LA
DFGin None 1 12.5% 8BU9B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BU9H Q9NYV4 715 1038 1490.0 RRC:61101 Type1 Inactive DFGin 6.8966 15.0279 ABAminus -130.72, -61.46 -86.64, 101.77 -100.72, 17.49 288.44, 80.02 -65.69, -13.23 in-in in 8.1483 Saltbr-in 3.5944 HRD-in -73.34, -52.41 71.89, 3.55 in-in-out SNCiio in-out ActLoopNT-in 2.7833 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.4, -56.59 APE9-dihe-na -80.8, 152.68 APE8-dihe-in -61.03, 143.88 APE8-rot-out 47.91 APE67-dihe-in -59.68, -32.23 -55.45, -41.09 APE12-dist-in 13.7228 APE11-dist-in 11.9439 APE10-dist-in 7.0071 APE9-dist-in 3.5232 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU9E Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.9943 15.2956 BLAminus -144.01, 174.3 58.02, 76.59 -92.29, 23.22 284.15, 79.53 -66.56, -16.01 in-in in 7.9265 Saltbr-in 2.9785 HRD-in -72.29, -52.87 75.22, 4.09 in-in-out SNCiio in-out ActLoopNT-in 2.9527 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -79.11, -41.8 APE9-dihe-na -74.19, 150.88 APE8-dihe-in -62.82, 143.67 APE8-rot-out 166.93 APE67-dihe-in -61.65, -28.3 -55.31, -42.74 APE12-dist-in 13.0026 APE11-dist-in 12.7132 APE10-dist-in 6.8922 APE9-dist-in 3.4751 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU9B Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.8954 15.5504 None -126.5, -98.68 -52.95, 118.93 -112.03, 20.69 280.85, 78.53 -65.13, -14.55 in-in in 8.0334 Saltbr-in 3.4619 HRD-in -71.08, -52.06 74.5, 2.49 in-in-out SNCiio in-out ActLoopNT-in 3.0383 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.03, -51.01 APE9-dihe-na -76.4, 148.49 APE8-dihe-in -61.77, 145.89 APE8-rot-out 190.86 APE67-dihe-in -62.1, -33.32 -50.51, -38.53 APE12-dist-in 13.2624 APE11-dist-in 11.7849 APE10-dist-in 6.4997 APE9-dist-in 3.5775 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK2 CDK2_HUMAN 3DDQA P24941 1 298 298.0 RRC:60299 Type1 Active DFGin 6.8795 15.378 BLAminus -132.75, 169.79 57.41, 82.03 -94.85, 22.97 280.61, 68.74 -62.61, -27.68 in-in in 8.7174 Saltbr-in 2.6315 HRD-in -76.69, -57.1 75.95, 10.79 in-in-in SNCiii in-in ActLoopNT-in 2.8915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 66.92, 123.95 APE9-dihe-na 76.33, 127.94 APE8-dihe-in -56.03, 136.54 APE8-rot-in 295.57 APE67-dihe-in -61.4, -22.16 -47.57, -46.39 APE12-dist-in 13.2992 APE11-dist-in 9.21 APE10-dist-in 7.3861 APE9-dist-in 3.2138 None TPO160 TPO160 XRAY 1.8 0.196 0.229 A 299.0 296.0 2 28 28 0 [[4, 286]] 1.0 3ddq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3DDQC P24941 1 297 298.0 RRC:60299 Type1 Inactive DFGin 6.6826 15.2371 BLAminus -135.03, 174.73 51.22, 81.22 -92.28, 22.06 280.24, 71.12 -61.17, -31.8 in-in in 8.8023 Saltbr-in 2.6292 HRD-in -78.79, -55.27 70.81, 11.54 in-in-out SNCiio in-out ActLoopNT-in 2.9141 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.5, 150.72 APE9-dihe-na 67.57, 123.07 APE8-dihe-in -58.23, 146.27 APE8-rot-out 184.04 APE67-dihe-in -63.49, -21.74 -43.48, -49.11 APE12-dist-in 12.7649 APE11-dist-in 9.9876 APE10-dist-in 6.8634 APE9-dist-in 3.2438 None TPO160 TPO160 XRAY 1.8 0.196 0.229 C 299.0 266.0 31 28 28 0 [[4, 286]] 1.0 3ddq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 8FP0A P24941 2 298 298.0 RRC:303,7TW:304 Type1,Type3 Inactive DFGin 9.3912 14.9477 BLBminus -136.63, 174.45 61.03, 42.96 -56.03, 146.23 280.88, 71.31 -87.4, 49.07 out-out out 16.0019 Saltbr-out 16.4922 HRD-in -87.02, -54.08 75.17, -13.79 out-out-out SNCooo out-out ActLoopNT-out 9.5944 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 140.67 APE9-dihe-na -85.45, 141.48 APE8-dihe-in -84.73, 120.79 APE8-rot-in 296.72 APE67-dihe-in -62.27, -23.72 -95.92, -2.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.3227 APE9-dist-out 10.9674 None None None XRAY 1.6 0.213 0.24 A 298.0 274.0 23 28 17 11 [[4, 286]] 1.0 8fp0 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2A4LA P24941 1 298 298.0 RRC:300 Type1 Inactive DFGin 10.578 18.4111 BLBtrans -113.59, 145.45 72.4, 28.76 -70.81, 127.39 225.24, 108.51 92.04, -16.08 out-out out 14.8046 Saltbr-out 16.6523 HRD-in -77.2, -70.83 76.49, 13.56 out-out-out SNCooo out-out ActLoopNT-out 5.7061 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -65.63, 118.77 APE9-dihe-na -67.51, 125.09 APE8-dihe-in -56.92, 143.85 APE8-rot-out 190.58 APE67-dihe-in -61.81, -25.37 -102.66, -1.04 APE12-dist-out 20.0529 APE11-dist-out 17.3595 APE10-dist-out 19.1896 APE9-dist-out 10.4647 None None None XRAY 2.4 0.173 0.27 A 298.0 286.0 12 28 28 0 [[4, 286]] 1.0 2a4l Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK5 CDK5_HUMAN 1UNLA Q00535 1 292 292.0 RRC:1293 Type1 Active DFGin 6.8293 15.2016 BLAminus -128.33, 173.21 66.87, 81.02 -97.91, 23.56 283.17, 72.64 -73.67, -20.59 in-in in 8.3091 Saltbr-in 2.8471 HRD-in -82.56, -50.74 69.72, 10.97 in-in-in SNCiii in-in ActLoopNT-in 2.9193 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.08, 156.73 APE9-dihe-na 71.89, 126.73 APE8-dihe-in -48.26, 136.09 APE8-rot-in 296.72 APE67-dihe-in -59.67, -21.67 -44.15, -47.77 APE12-dist-in 13.5586 APE11-dist-in 10.7803 APE10-dist-in 7.1047 APE9-dist-in 3.2635 D144N None None XRAY 2.2 0.216 0.219 A 292.0 292.0 0 28 28 0 [[4, 286]] 1.0 1unl Homo sapiens CMGC_CDK5_HUMAN CMGC 8e-83 284.6 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 5

Ligand: RRC (Seliciclib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name