Ligand: RNF

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 8BUNB
DFGin BLAminus 1 33.3% 8BUNE
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUNB Q9NYV4 715 1041 1490.0 RNF:61101 Type1 Inactive DFGin 7.0092 15.2967 ABAminus -131.36, -49.43 -89.83, 91.44 -92.44, 32.63 287.3, 77.5 -75.27, -18.22 in-in in 7.7476 Saltbr-in 3.2793 HRD-in -75.67, -53.71 75.4, -0.11 in-in-in SNCiii in-in ActLoopNT-in 2.9232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -39.12 APE9-dihe-na -104.98, 151.97 APE8-dihe-in -58.93, 142.91 APE8-rot-in 279.94 APE67-dihe-in -65.42, -33.6 -55.06, -35.14 APE12-dist-in 13.3877 APE11-dist-in 11.6951 APE10-dist-in 7.099 APE9-dist-in 3.6569 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNH Q9NYV4 715 1043 1490.0 RNF:61101 Type1 Inactive DFGin 7.0453 15.2864 ABAminus -125.24, -50.09 -100.69, 94.75 -92.24, 30.97 286.18, 71.82 -75.42, -18.26 in-in in 7.8338 Saltbr-in 3.3735 HRD-in -77.6, -54.36 73.0, -1.25 in-in-in SNCiii in-in ActLoopNT-in 2.74 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.56, -41.65 APE9-dihe-na -95.79, 153.05 APE8-dihe-in -58.87, 144.43 APE8-rot-in 305.25 APE67-dihe-in -65.98, -31.29 -55.83, -37.71 APE12-dist-in 13.7752 APE11-dist-in 11.9719 APE10-dist-in 6.9568 APE9-dist-in 3.4785 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNE Q9NYV4 715 1039 1490.0 RNF:61101 Type1 Inactive DFGin 7.2173 15.3129 BLAminus -143.55, -179.06 50.55, 77.42 -92.12, 34.85 285.27, 76.47 -72.26, -18.51 in-in in 7.8237 Saltbr-in 3.0461 HRD-in -77.13, -53.65 75.0, -0.22 in-in-out SNCiio in-out ActLoopNT-in 2.9239 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.31, -34.23 APE9-dihe-na -92.08, 151.91 APE8-dihe-in -57.84, 145.99 APE8-rot-out 175.35 APE67-dihe-in -65.98, -29.37 -55.72, -38.5 APE12-dist-in 13.1801 APE11-dist-in 12.6112 APE10-dist-in 7.008 APE9-dist-in 3.4323 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: RNF

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 8BUNB
DFGin BLAminus 1 33.3% 8BUNE
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUNB Q9NYV4 715 1041 1490.0 RNF:61101 Type1 Inactive DFGin 7.0092 15.2967 ABAminus -131.36, -49.43 -89.83, 91.44 -92.44, 32.63 287.3, 77.5 -75.27, -18.22 in-in in 7.7476 Saltbr-in 3.2793 HRD-in -75.67, -53.71 75.4, -0.11 in-in-in SNCiii in-in ActLoopNT-in 2.9232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -39.12 APE9-dihe-na -104.98, 151.97 APE8-dihe-in -58.93, 142.91 APE8-rot-in 279.94 APE67-dihe-in -65.42, -33.6 -55.06, -35.14 APE12-dist-in 13.3877 APE11-dist-in 11.6951 APE10-dist-in 7.099 APE9-dist-in 3.6569 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNH Q9NYV4 715 1043 1490.0 RNF:61101 Type1 Inactive DFGin 7.0453 15.2864 ABAminus -125.24, -50.09 -100.69, 94.75 -92.24, 30.97 286.18, 71.82 -75.42, -18.26 in-in in 7.8338 Saltbr-in 3.3735 HRD-in -77.6, -54.36 73.0, -1.25 in-in-in SNCiii in-in ActLoopNT-in 2.74 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.56, -41.65 APE9-dihe-na -95.79, 153.05 APE8-dihe-in -58.87, 144.43 APE8-rot-in 305.25 APE67-dihe-in -65.98, -31.29 -55.83, -37.71 APE12-dist-in 13.7752 APE11-dist-in 11.9719 APE10-dist-in 6.9568 APE9-dist-in 3.4785 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNE Q9NYV4 715 1039 1490.0 RNF:61101 Type1 Inactive DFGin 7.2173 15.3129 BLAminus -143.55, -179.06 50.55, 77.42 -92.12, 34.85 285.27, 76.47 -72.26, -18.51 in-in in 7.8237 Saltbr-in 3.0461 HRD-in -77.13, -53.65 75.0, -0.22 in-in-out SNCiio in-out ActLoopNT-in 2.9239 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.31, -34.23 APE9-dihe-na -92.08, 151.91 APE8-dihe-in -57.84, 145.99 APE8-rot-out 175.35 APE67-dihe-in -65.98, -29.37 -55.72, -38.5 APE12-dist-in 13.1801 APE11-dist-in 12.6112 APE10-dist-in 7.008 APE9-dist-in 3.4323 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: RNF

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name