Ligand: RC8

Total number of chains: 5
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 3DDPA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC CDK12 CDK12_HUMAN 6TD3B 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 6TD3E 3.46 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 6TD3H 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK2 CDK2_HUMAN 3DDPA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RC8 Type1 1 - 297 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3DDPC 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RC8 Type1 1 - 298 0 TPO160 None Cyclin-dependent kinase 2

Ligand: RC8

Total number of chains: 5
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 3DDPA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CDK12 CDK12_HUMAN 6TD3B 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 6TD3E 3.46 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 6TD3H 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3DDPA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RC8 Type1 1 - 297 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 3DDPC 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RC8 Type1 1 - 298 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens

Ligand: RC8

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Advanced page
Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism