Ligand: P30 (Quizartinib)

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 100.0% 4XUFB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR FLT3 FLT3_HUMAN 4XUFA P36888 600 947 993.0 P30:1001 Type2 Inactive DFGout 16.0329 10.199 BBAminus -143.0, -176.09 -145.89, 109.83 -79.74, 65.35 291.29, 82.28 -88.07, 125.53 in-in in 7.6772 Saltbr-in 3.1306 HRD-out -82.56, 115.59 -72.64, -20.56 in-out-in SNCioi out-in ActLoopNT-out 16.5483 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.53, 147.84 APE9-dihe-in -146.85, 149.22 APE8-dihe-in -75.18, 95.57 APE8-rot-na 28.09 APE67-dihe-in -79.56, 0.39 -65.83, -40.86 APE12-dist-na 17.0014 APE11-dist-na 12.6753 APE10-dist-na 12.5 APE9-dist-in 7.1567 None None None XRAY 3.2 0.299 0.32 A 297.0 270.0 27 30 30 0 [[610, 945]] 1.0 4xuf TYR_FLT3_HUMAN TYR 5.8e-103 349.6 1.0 259.0 259.0 828 829 830 832 834 644 661 665 808 810 809 811.0 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
TYR FLT3 FLT3_HUMAN 4XUFB P36888 600 946 993.0 P30:1001 Type2 Inactive DFGout 15.6204 10.1033 BBAminus -144.31, -175.77 -146.27, 108.35 -80.93, 70.68 293.11, 82.52 -83.4, -47.41 in-in in 7.8934 Saltbr-in 2.6077 HRD-out -84.03, 114.48 -73.98, -19.45 in-out-in SNCioi out-in ActLoopNT-out 16.5393 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.34, 144.93 APE9-dihe-in -152.45, 148.59 APE8-dihe-in -76.73, 96.39 APE8-rot-na 28.9 APE67-dihe-in -79.15, 1.24 -66.13, -41.05 APE12-dist-na 17.7249 APE11-dist-na 13.5149 APE10-dist-na 12.373 APE9-dist-in 7.5793 None None None XRAY 3.2 0.299 0.32 B 297.0 274.0 22 30 30 0 [[610, 945]] 1.0 4xuf TYR_FLT3_HUMAN TYR 5.8e-103 349.6 1.0 259.0 259.0 828 829 830 832 834 644 661 665 808 810 809 811.0 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
TYR FLT3 FLT3_HUMAN 4RT7A P36888 599 950 993.0 P30:1001 Type2 Inactive DFGout 16.2803 10.6907 BBAminus -148.52, -175.77 -147.58, 109.4 -60.96, -39.74 289.53, 78.87 49.01, -101.54 in-in in 7.6415 Saltbr-in 2.9875 HRD-out -100.49, 123.78 -88.21, -0.63 in-out-in SNCioi out-in ActLoopNT-out 16.567 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.24, 104.7 APE9-dihe-in -116.44, 148.12 APE8-dihe-in -77.95, 71.82 APE8-rot-na 30.09 APE67-dihe-in -65.85, -17.18 -55.85, -43.14 APE12-dist-na 17.729 APE11-dist-na 14.0524 APE10-dist-na 12.022 APE9-dist-in 7.4427 None None None XRAY 3.1 0.224 0.268 A 415.0 274.0 78 30 30 0 [[610, 945]] 1.0 4rt7 TYR_FLT3_HUMAN TYR 7.6e-102 346.1 1.0 259.0 259.0 828 829 830 832 834 644 661 665 808 810 809 811.0 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3

Ligand: P30 (Quizartinib)

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 100.0% 4XUFB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR FLT3 FLT3_HUMAN 4XUFA P36888 600 947 993.0 P30:1001 Type2 Inactive DFGout 16.0329 10.199 BBAminus -143.0, -176.09 -145.89, 109.83 -79.74, 65.35 291.29, 82.28 -88.07, 125.53 in-in in 7.6772 Saltbr-in 3.1306 HRD-out -82.56, 115.59 -72.64, -20.56 in-out-in SNCioi out-in ActLoopNT-out 16.5483 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.53, 147.84 APE9-dihe-in -146.85, 149.22 APE8-dihe-in -75.18, 95.57 APE8-rot-na 28.09 APE67-dihe-in -79.56, 0.39 -65.83, -40.86 APE12-dist-na 17.0014 APE11-dist-na 12.6753 APE10-dist-na 12.5 APE9-dist-in 7.1567 None None None XRAY 3.2 0.299 0.32 A 297.0 270.0 27 30 30 0 [[610, 945]] 1.0 4xuf Homo sapiens TYR_FLT3_HUMAN TYR 5.8e-103 349.6 1.0 259.0 259.0 828 829 830 832 834 644 661 665 808 810 809 811.0 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
TYR FLT3 FLT3_HUMAN 4XUFB P36888 600 946 993.0 P30:1001 Type2 Inactive DFGout 15.6204 10.1033 BBAminus -144.31, -175.77 -146.27, 108.35 -80.93, 70.68 293.11, 82.52 -83.4, -47.41 in-in in 7.8934 Saltbr-in 2.6077 HRD-out -84.03, 114.48 -73.98, -19.45 in-out-in SNCioi out-in ActLoopNT-out 16.5393 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.34, 144.93 APE9-dihe-in -152.45, 148.59 APE8-dihe-in -76.73, 96.39 APE8-rot-na 28.9 APE67-dihe-in -79.15, 1.24 -66.13, -41.05 APE12-dist-na 17.7249 APE11-dist-na 13.5149 APE10-dist-na 12.373 APE9-dist-in 7.5793 None None None XRAY 3.2 0.299 0.32 B 297.0 274.0 22 30 30 0 [[610, 945]] 1.0 4xuf Homo sapiens TYR_FLT3_HUMAN TYR 5.8e-103 349.6 1.0 259.0 259.0 828 829 830 832 834 644 661 665 808 810 809 811.0 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
TYR FLT3 FLT3_HUMAN 4RT7A P36888 599 950 993.0 P30:1001 Type2 Inactive DFGout 16.2803 10.6907 BBAminus -148.52, -175.77 -147.58, 109.4 -60.96, -39.74 289.53, 78.87 49.01, -101.54 in-in in 7.6415 Saltbr-in 2.9875 HRD-out -100.49, 123.78 -88.21, -0.63 in-out-in SNCioi out-in ActLoopNT-out 16.567 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.24, 104.7 APE9-dihe-in -116.44, 148.12 APE8-dihe-in -77.95, 71.82 APE8-rot-na 30.09 APE67-dihe-in -65.85, -17.18 -55.85, -43.14 APE12-dist-na 17.729 APE11-dist-na 14.0524 APE10-dist-na 12.022 APE9-dist-in 7.4427 None None None XRAY 3.1 0.224 0.268 A 415.0 274.0 78 30 30 0 [[610, 945]] 1.0 4rt7 Homo sapiens TYR_FLT3_HUMAN TYR 7.6e-102 346.1 1.0 259.0 259.0 828 829 830 832 834 644 661 665 808 810 809 811.0 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3

Ligand: P30 (Quizartinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name