Ligand: O35

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 100.0% 6XVJA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR KDR VGFR2_HUMAN 6XVJA P35968 813 1167 1356.0 O35:1201 Type2 Inactive DFGout 15.797 9.86 BBAminus -132.46, -168.17 -160.35, 90.75 -54.1, -41.9 283.85, 84.23 55.21, -117.78 in-in in 7.713 Saltbr-in 2.862 HRD-in -84.82, -59.51 82.99, -12.32 in-out-in SNCioi out-in ActLoopNT-out 16.682 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.56, 109.17 APE9-dihe-in -116.73, 149.21 APE8-dihe-in -78.94, 66.26 APE8-rot-na 30.73 APE67-dihe-in -62.92, -14.21 -46.08, -45.25 APE12-dist-na 17.103 APE11-dist-na 13.504 APE10-dist-na 11.345 APE9-dist-in 7.992 E990V None None XRAY 1.78 0.18 0.215 A 322 305 0 0 0 0 [[834, 1162]] 1.0 6xvj TYR_KDR_HUMAN TYR 4.4e-100 340.2 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KIT KIT_HUMAN 6XV9A P10721 566 931 976.0 O35:61001 Type2 Inactive DFGout 15.543 9.748 BBAminus -131.58, -169.39 -156.72, 93.49 -62.05, -42.03 282.46, 88.43 48.41, -104.01 in-in in 7.689 Saltbr-in 2.832 HRD-in -69.28, -49.38 72.93, -5.84 in-out-in SNCioi out-in ActLoopNT-out 16.311 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.37, 97.09 APE9-dihe-in -112.0, 148.71 APE8-dihe-in -81.81, 67.27 APE8-rot-na 29.88 APE67-dihe-in -63.86, -9.66 -46.65, -44.91 APE12-dist-na 16.579 APE11-dist-na 13.135 APE10-dist-na 10.916 APE9-dist-in 7.629 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 3.38 0.197 0.247 A 328 288 0 0 0 0 [[589, 926]] 1.0 6xv9 TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 6XV9B P10721 572 931 976.0 O35:61001 Type2 Inactive DFGout 15.678 9.77 BBAminus -131.94, -171.98 -157.03, 93.9 -61.83, -41.64 282.16, 88.18 48.65, -104.6 in-in in 7.733 Saltbr-in 2.854 HRD-in -68.86, -49.09 75.5, -9.43 in-out-in SNCioi out-in ActLoopNT-out 16.206 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.51, 98.6 APE9-dihe-in -113.58, 149.31 APE8-dihe-in -82.14, 67.2 APE8-rot-na 30.55 APE67-dihe-in -64.65, -9.32 -46.19, -45.23 APE12-dist-na 16.763 APE11-dist-na 13.334 APE10-dist-na 11.149 APE9-dist-in 7.755 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 3.38 0.197 0.247 B 328 282 0 0 0 0 [[589, 926]] 1.0 6xv9 TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit

Ligand: O35

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 100.0% 6XVJA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR KDR VGFR2_HUMAN 6XVJA P35968 813 1167 1356.0 O35:1201 Type2 Inactive DFGout 15.797 9.86 BBAminus -132.46, -168.17 -160.35, 90.75 -54.1, -41.9 283.85, 84.23 55.21, -117.78 in-in in 7.713 Saltbr-in 2.862 HRD-in -84.82, -59.51 82.99, -12.32 in-out-in SNCioi out-in ActLoopNT-out 16.682 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.56, 109.17 APE9-dihe-in -116.73, 149.21 APE8-dihe-in -78.94, 66.26 APE8-rot-na 30.73 APE67-dihe-in -62.92, -14.21 -46.08, -45.25 APE12-dist-na 17.103 APE11-dist-na 13.504 APE10-dist-na 11.345 APE9-dist-in 7.992 E990V None None XRAY 1.78 0.18 0.215 A 322 305 0 0 0 0 [[834, 1162]] 1.0 6xvj Homo sapiens TYR_KDR_HUMAN TYR 4.4e-100 340.2 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KIT KIT_HUMAN 6XV9A P10721 566 931 976.0 O35:61001 Type2 Inactive DFGout 15.543 9.748 BBAminus -131.58, -169.39 -156.72, 93.49 -62.05, -42.03 282.46, 88.43 48.41, -104.01 in-in in 7.689 Saltbr-in 2.832 HRD-in -69.28, -49.38 72.93, -5.84 in-out-in SNCioi out-in ActLoopNT-out 16.311 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.37, 97.09 APE9-dihe-in -112.0, 148.71 APE8-dihe-in -81.81, 67.27 APE8-rot-na 29.88 APE67-dihe-in -63.86, -9.66 -46.65, -44.91 APE12-dist-na 16.579 APE11-dist-na 13.135 APE10-dist-na 10.916 APE9-dist-in 7.629 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 3.38 0.197 0.247 A 328 288 0 0 0 0 [[589, 926]] 1.0 6xv9 Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 6XV9B P10721 572 931 976.0 O35:61001 Type2 Inactive DFGout 15.678 9.77 BBAminus -131.94, -171.98 -157.03, 93.9 -61.83, -41.64 282.16, 88.18 48.65, -104.6 in-in in 7.733 Saltbr-in 2.854 HRD-in -68.86, -49.09 75.5, -9.43 in-out-in SNCioi out-in ActLoopNT-out 16.206 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.51, 98.6 APE9-dihe-in -113.58, 149.31 APE8-dihe-in -82.14, 67.2 APE8-rot-na 30.55 APE67-dihe-in -64.65, -9.32 -46.19, -45.23 APE12-dist-na 16.763 APE11-dist-na 13.334 APE10-dist-na 11.149 APE9-dist-in 7.755 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 3.38 0.197 0.247 B 328 282 0 0 0 0 [[589, 926]] 1.0 6xv9 Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit

Ligand: O35

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name