Ligand: LWJ (Zoligratinib)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 1 50.0% 5B7VA
DFGin BLBplus 1 50.0% 5B7VB
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR FGFR1 FGFR1_HUMAN 5B7VA P11362 464 763 822.0 LWJ:801 Type1.5_Back Inactive DFGin 5.579 13.122 BLAplus -124.02, 164.1 56.03, 35.18 -83.98, -18.11 54.48, 82.39 -93.9, 14.98 in-in in 7.675 Saltbr-in 3.025 HRD-in -66.75, -56.97 82.51, -19.31 in-out-out SNCioo out-out ActLoopNT-out 8.581 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.75, 145.14 APE9-dihe-in -88.05, 111.6 APE8-dihe-out -54.86, -24.86 APE8-rot-na 336.86 APE67-dihe-in -69.24, -8.96 -56.43, -23.01 APE12-dist-na 20.966 APE11-dist-na 21.63 APE10-dist-na 19.658 APE9-dist-out 12.019 L457V,C488A,C584S None None XRAY 2.15 0.224 0.256 A 310 282 18 0 0 3 [[478, 756]] 1.0 5b7v TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5B7VB P11362 462 762 822.0 LWJ:801 Type1.5_Back Inactive DFGin 5.677 12.94 BLBplus -116.05, 161.84 53.01, 39.08 -76.06, 133.86 41.64, 92.29 65.64, 39.87 in-in in 7.617 Saltbr-in 3.029 HRD-in -64.13, -51.82 87.54, -28.51 in-out-out SNCioo out-out ActLoopNT-out 9.441 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -94.62, 144.39 APE9-dihe-in -82.91, 115.57 APE8-dihe-out -50.0, -27.69 APE8-rot-na 330.02 APE67-dihe-in -70.22, -11.34 -61.05, -21.38 APE12-dist-na 999.0 APE11-dist-na 19.998 APE10-dist-na 18.243 APE9-dist-out 11.702 L457V,C488A,C584S None None XRAY 2.15 0.224 0.256 B 310 277 24 0 0 6 [[478, 756]] 1.0 5b7v TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1

Ligand: LWJ (Zoligratinib)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 1 50.0% 5B7VA
DFGin BLBplus 1 50.0% 5B7VB
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR FGFR1 FGFR1_HUMAN 5B7VA P11362 464 763 822.0 LWJ:801 Type1.5_Back Inactive DFGin 5.579 13.122 BLAplus -124.02, 164.1 56.03, 35.18 -83.98, -18.11 54.48, 82.39 -93.9, 14.98 in-in in 7.675 Saltbr-in 3.025 HRD-in -66.75, -56.97 82.51, -19.31 in-out-out SNCioo out-out ActLoopNT-out 8.581 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.75, 145.14 APE9-dihe-in -88.05, 111.6 APE8-dihe-out -54.86, -24.86 APE8-rot-na 336.86 APE67-dihe-in -69.24, -8.96 -56.43, -23.01 APE12-dist-na 20.966 APE11-dist-na 21.63 APE10-dist-na 19.658 APE9-dist-out 12.019 L457V,C488A,C584S None None XRAY 2.15 0.224 0.256 A 310 282 18 0 0 3 [[478, 756]] 1.0 5b7v Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5B7VB P11362 462 762 822.0 LWJ:801 Type1.5_Back Inactive DFGin 5.677 12.94 BLBplus -116.05, 161.84 53.01, 39.08 -76.06, 133.86 41.64, 92.29 65.64, 39.87 in-in in 7.617 Saltbr-in 3.029 HRD-in -64.13, -51.82 87.54, -28.51 in-out-out SNCioo out-out ActLoopNT-out 9.441 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -94.62, 144.39 APE9-dihe-in -82.91, 115.57 APE8-dihe-out -50.0, -27.69 APE8-rot-na 330.02 APE67-dihe-in -70.22, -11.34 -61.05, -21.38 APE12-dist-na 999.0 APE11-dist-na 19.998 APE10-dist-na 18.243 APE9-dist-out 11.702 L457V,C488A,C584S None None XRAY 2.15 0.224 0.256 B 310 277 24 0 0 6 [[478, 756]] 1.0 5b7v Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1

Ligand: LWJ (Zoligratinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name