Ligand: JBI

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 3TTJA
DFGin BLAminus 1 50.0% 9QXNAAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK10 MK10_HUMAN 3TTJA P53779 46 400 464.0 JBI:465 Type1 Inactive DFGin 4.4129 14.2584 ABAminus -95.22, -16.81 -130.98, 179.24 -123.69, 12.32 296.9, 84.63 77.36, -154.84 out-out out 10.6067 Saltbr-out 5.6138 HRD-in -85.5, -56.18 74.17, -9.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 115.72 APE8-dihe-in -84.17, 122.25 APE8-rot-out 96.39 APE67-dihe-in -58.1, -21.32 -106.9, -2.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6626 None None None XRAY 2.1 0.206 0.272 A 464.0 333.0 9 27 18 9 [[64, 359]] 1.0 3ttj CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
TYR EGFR EGFR_HUMAN 9QXNAAA P00533 696 1019 1210.0 A1JBI:61107 Type1.5_Back Active DFGin 6.1739 14.2861 BLAminus -130.22, -177.04 61.75, 91.16 -101.11, 22.36 284.94, 80.33 -60.14, -31.4 in-in in 8.3673 Saltbr-in 2.9532 HRD-in -68.76, -48.96 69.89, 3.72 in-in-in SNCiii in-in ActLoopNT-in 2.7908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.32, 133.52 APE9-dihe-in -138.05, 143.6 APE8-dihe-in -59.33, 99.88 APE8-rot-na 336.87 APE67-dihe-in -75.29, -7.57 -63.05, -36.41 APE12-dist-na 12.5336 APE11-dist-na 9.376 APE10-dist-na 10.2709 APE9-dist-in 6.1221 None None None XRAY 2.142 0.158 0.21 AAA 346.0 322.0 2 30 30 0 [[712, 970]] 1.0 9qxn TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: JBI

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 3TTJA
DFGin BLAminus 1 50.0% 9QXNAAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK10 MK10_HUMAN 3TTJA P53779 46 400 464.0 JBI:465 Type1 Inactive DFGin 4.4129 14.2584 ABAminus -95.22, -16.81 -130.98, 179.24 -123.69, 12.32 296.9, 84.63 77.36, -154.84 out-out out 10.6067 Saltbr-out 5.6138 HRD-in -85.5, -56.18 74.17, -9.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 115.72 APE8-dihe-in -84.17, 122.25 APE8-rot-out 96.39 APE67-dihe-in -58.1, -21.32 -106.9, -2.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6626 None None None XRAY 2.1 0.206 0.272 A 464.0 333.0 9 27 18 9 [[64, 359]] 1.0 3ttj Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
TYR EGFR EGFR_HUMAN 9QXNAAA P00533 696 1019 1210.0 A1JBI:61107 Type1.5_Back Active DFGin 6.1739 14.2861 BLAminus -130.22, -177.04 61.75, 91.16 -101.11, 22.36 284.94, 80.33 -60.14, -31.4 in-in in 8.3673 Saltbr-in 2.9532 HRD-in -68.76, -48.96 69.89, 3.72 in-in-in SNCiii in-in ActLoopNT-in 2.7908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.32, 133.52 APE9-dihe-in -138.05, 143.6 APE8-dihe-in -59.33, 99.88 APE8-rot-na 336.87 APE67-dihe-in -75.29, -7.57 -63.05, -36.41 APE12-dist-na 12.5336 APE11-dist-na 9.376 APE10-dist-na 10.2709 APE9-dist-in 6.1221 None None None XRAY 2.142 0.158 0.21 AAA 346.0 322.0 2 30 30 0 [[712, 970]] 1.0 9qxn Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: JBI

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name