Ligand: IYC (Elzovantinib)

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 1 100.0% 8K78A
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR MET MET_HUMAN 8K78A P08581 1048 1345 1390.0 IYC:1401 Type1 Inactive DFGin 5.279 14.37 BLBplus -137.76, -160.13 53.31, 44.71 -142.62, 155.7 79.32, 100.58 65.31, -134.82 out-none out 14.651 Saltbr-none 999.0 HRD-in -77.86, -46.68 52.66, 21.65 none-out-in SNCnoi out-in ActLoopNT-out 10.631 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.34, 117.5 APE9-dihe-in -112.83, 117.81 APE8-dihe-in -78.38, 91.22 APE8-rot-na 27.2 APE67-dihe-in -75.41, 8.19 -65.34, -41.41 APE12-dist-na 17.854 APE11-dist-na 16.52 APE10-dist-na 14.534 APE9-dist-in 6.426 None None None XRAY 2.67 0.244 0.29 A 309 298 0 0 0 0 [[1078, 1339]] 1.0 8k78 TYR_MET_HUMAN TYR 6.9e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor

Ligand: IYC (Elzovantinib)

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 33.3% 8K79A
DFGin BLBplus 1 33.3% 8K78A
DFGin None 1 33.3% 8K79B
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 8K79A P00523 257 533 533.0 IYC:601 Type1 None DFGin 6.882 14.713 BLAminus -150.89, -165.01 59.04, 67.27 -91.46, 24.31 295.38, 96.65 -65.31, -11.66 in-none in 8.016 Saltbr-none 999.0 HRD-in -89.72, -40.35 71.22, -10.35 none-in-none SNCnin in-none ActLoopNT-in 3.268 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 153.26 APE8-dihe-in -71.83, 78.54 APE8-rot-na 326.03 APE67-dihe-in -67.46, -12.7 -49.33, -43.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.665 None None None XRAY 2.8 0.248 0.277 A 286 264 13 0 0 11 [[267, 518]] 1.0 8k79 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 8K79B P00523 269 533 533.0 IYC:601 Type1 Inactive DFGin 6.275 13.616 None -142.02, -165.55 59.65, 45.03 -69.39, 999.0 318.36, 96.34 999.0, 999.0 in-none in 8.243 Saltbr-none 999.0 HRD-in -103.64, -40.14 66.81, -6.75 none-out-none SNCnon out-none ActLoopNT-out 5.807 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.54 APE8-dihe-in -62.36, 104.78 APE8-rot-na 18.14 APE67-dihe-in -67.37, -19.95 -65.33, -31.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.136 None None None XRAY 2.8 0.248 0.277 B 286 244 23 0 0 16 [[267, 518]] 1.0 8k79 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR MET MET_HUMAN 8K78A P08581 1048 1345 1390.0 IYC:1401 Type1 Inactive DFGin 5.279 14.37 BLBplus -137.76, -160.13 53.31, 44.71 -142.62, 155.7 79.32, 100.58 65.31, -134.82 out-none out 14.651 Saltbr-none 999.0 HRD-in -77.86, -46.68 52.66, 21.65 none-out-in SNCnoi out-in ActLoopNT-out 10.631 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.34, 117.5 APE9-dihe-in -112.83, 117.81 APE8-dihe-in -78.38, 91.22 APE8-rot-na 27.2 APE67-dihe-in -75.41, 8.19 -65.34, -41.41 APE12-dist-na 17.854 APE11-dist-na 16.52 APE10-dist-na 14.534 APE9-dist-in 6.426 None None None XRAY 2.67 0.244 0.29 A 309 298 0 0 0 0 [[1078, 1339]] 1.0 8k78 Homo sapiens TYR_MET_HUMAN TYR 6.9e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor

Ligand: IYC (Elzovantinib)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 8K79A
DFGin None 1 50.0% 8K79B
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 8K79A P00523 257 533 533.0 IYC:601 Type1 None DFGin 6.882 14.713 BLAminus -150.89, -165.01 59.04, 67.27 -91.46, 24.31 295.38, 96.65 -65.31, -11.66 in-none in 8.016 Saltbr-none 999.0 HRD-in -89.72, -40.35 71.22, -10.35 none-in-none SNCnin in-none ActLoopNT-in 3.268 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 153.26 APE8-dihe-in -71.83, 78.54 APE8-rot-na 326.03 APE67-dihe-in -67.46, -12.7 -49.33, -43.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.665 None None None XRAY 2.8 0.248 0.277 A 286 264 13 0 0 11 [[267, 518]] 1.0 8k79 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 8K79B P00523 269 533 533.0 IYC:601 Type1 Inactive DFGin 6.275 13.616 None -142.02, -165.55 59.65, 45.03 -69.39, 999.0 318.36, 96.34 999.0, 999.0 in-none in 8.243 Saltbr-none 999.0 HRD-in -103.64, -40.14 66.81, -6.75 none-out-none SNCnon out-none ActLoopNT-out 5.807 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.54 APE8-dihe-in -62.36, 104.78 APE8-rot-na 18.14 APE67-dihe-in -67.37, -19.95 -65.33, -31.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.136 None None None XRAY 2.8 0.248 0.277 B 286 244 23 0 0 16 [[267, 518]] 1.0 8k79 Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src