Ligand: FRZ

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 1TVOA
DFGin BLAminus 1 50.0% 5V62A
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC MAPK1 MK01_HUMAN 1TVOA 2.5 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii FRZ Type1 8 - 357 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 5V62A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FRZ, AKS Type1, Type1 10 - 360 0 TPO185,PTR187 None Mitogen-activated protein kinase 1

Ligand: FRZ

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 1TVOA
DFGin BLAminus 1 50.0% 5V62A
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC MAPK1 MK01_HUMAN 1TVOA 2.5 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii FRZ Type1 8 - 357 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 5V62A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FRZ, AKS Type1, Type1 10 - 360 0 TPO185,PTR187 None Mitogen-activated protein kinase 1 Homo sapiens

Ligand: FRZ

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
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Hover over column headers for tooltip help

Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism