Ligand: FC8

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 6GU4A
None None 1 50.0% 6GUKA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC CDK1 CDK1_HUMAN 6GU4A 2.73 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio FC8 Type1 1 - 289 0 None None Cyclin-dependent kinase 1
CMGC CDK2 CDK2_HUMAN 6GUKA 1.3 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno FC8 Type1 1 - 298 0 None None Cyclin-dependent kinase 2

Ligand: FC8

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 6GU4A
None None 1 50.0% 6GUKA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CDK1 CDK1_HUMAN 6GU4A 2.73 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio FC8 Type1 1 - 289 0 None None Cyclin-dependent kinase 1 Homo sapiens
CMGC CDK2 CDK2_HUMAN 6GUKA 1.3 Inactive None‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno FC8 Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens

Ligand: FC8

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism