KinCore

Ligand: F88

Total number of chains: 3

Active chains: 0

Total number of genes: 2

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGout	BBAminus	3	100.0%	6GQPA

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	KDR	VGFR2_HUMAN	6GQPA	P35968	821	1168	1356.0	F88:61201	Type2	Inactive	DFGout	16.041	9.828	BBAminus	-137.29, -179.39	-147.6, 105.82	-66.11, -30.27	279.44, 81.63	58.93, -133.79	in-in	in	7.784	Saltbr-in	3.16	HRD-in	-72.29, -59.65	82.33, -13.78	in-out-out	SNCioo	out-out	ActLoopNT-out	16.787	ActLoopCT-out	TYR	APEdihe_iiiai	APEdist_aaao	APE10-dihe-in	-109.31, 108.64	APE9-dihe-in	-119.08, 147.18	APE8-dihe-in	-76.82, 68.93	APE8-rot-na	29.84	APE67-dihe-in	-64.0, -17.44	-48.7, -44.35	APE12-dist-na	16.28	APE11-dist-na	13.029	APE10-dist-na	10.463	APE9-dist-out	8.02	None	None	None	XRAY	2.09	0.201	0.234	A	322	298	0	0	0	0	[[834, 1162]]	1.0	6gqp	TYR_KDR_HUMAN	TYR	4.4e-100	340.2	1	260	260	1045	1046	1047	1049	1051	868	885	889	1025	1027	1026	1028	1087	1075	1070	1069	1068	1067	1066	1065	1064	917	Vascular endothelial growth factor receptor 2
TYR	KIT	KIT_HUMAN	6GQKA	P10721	567	931	976.0	F88:61001	Type2	Inactive	DFGout	16.265	10.54	BBAminus	-138.36, -179.35	-150.62, 102.51	-62.45, -32.35	276.39, 87.37	49.32, -117.03	in-in	in	7.663	Saltbr-in	3.188	HRD-in	-73.61, -52.81	79.41, -11.37	in-out-out	SNCioo	out-out	ActLoopNT-out	16.465	ActLoopCT-out	TYR	APEdihe_iiiai	APEdist_aaao	APE10-dihe-in	-119.95, 100.35	APE9-dihe-in	-115.33, 151.26	APE8-dihe-in	-84.45, 66.8	APE8-rot-na	34.27	APE67-dihe-in	-66.19, -12.65	-48.04, -43.77	APE12-dist-na	16.94	APE11-dist-na	13.676	APE10-dist-na	11.702	APE9-dist-out	8.021	I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D	None	None	XRAY	2.31	0.188	0.22	A	328	282	0	0	0	0	[[589, 926]]	1.0	6gqk	TYR_KIT_HUMAN	TYR	2.4e-104	354.2	1	261	261	809	810	811	813	815	623	640	644	789	791	790	792	851	839	834	833	832	831	830	829	828	671	Mast/stem cell growth factor receptor Kit
TYR	KIT	KIT_HUMAN	6GQKB	P10721	572	931	976.0	F88:61001	Type2	Inactive	DFGout	16.311	10.572	BBAminus	-138.21, -178.47	-152.96, 103.82	-61.94, -32.56	277.07, 85.37	50.17, -117.95	in-in	in	7.649	Saltbr-in	3.206	HRD-in	-72.76, -53.71	79.41, -11.08	in-out-out	SNCioo	out-out	ActLoopNT-out	16.384	ActLoopCT-out	TYR	APEdihe_iiiai	APEdist_aaao	APE10-dihe-in	-116.06, 104.54	APE9-dihe-in	-119.72, 151.19	APE8-dihe-in	-85.12, 66.24	APE8-rot-na	33.44	APE67-dihe-in	-66.35, -13.84	-47.54, -43.83	APE12-dist-na	17.282	APE11-dist-na	13.998	APE10-dist-na	11.892	APE9-dist-out	8.091	I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D	None	None	XRAY	2.31	0.188	0.22	B	328	277	0	0	0	0	[[589, 926]]	1.0	6gqk	TYR_KIT_HUMAN	TYR	2.4e-104	354.2	1	261	261	809	810	811	813	815	623	640	644	789	791	790	792	851	839	834	833	832	831	830	829	828	671	Mast/stem cell growth factor receptor Kit

Ligand: F88

Total number of chains: 3

Active chains: 0

Total number of genes: 2

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGout	BBAminus	3	100.0%	6GQPA

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	KDR	VGFR2_HUMAN	6GQPA	P35968	821	1168	1356.0	F88:61201	Type2	Inactive	DFGout	16.041	9.828	BBAminus	-137.29, -179.39	-147.6, 105.82	-66.11, -30.27	279.44, 81.63	58.93, -133.79	in-in	in	7.784	Saltbr-in	3.16	HRD-in	-72.29, -59.65	82.33, -13.78	in-out-out	SNCioo	out-out	ActLoopNT-out	16.787	ActLoopCT-out	TYR	APEdihe_iiiai	APEdist_aaao	APE10-dihe-in	-109.31, 108.64	APE9-dihe-in	-119.08, 147.18	APE8-dihe-in	-76.82, 68.93	APE8-rot-na	29.84	APE67-dihe-in	-64.0, -17.44	-48.7, -44.35	APE12-dist-na	16.28	APE11-dist-na	13.029	APE10-dist-na	10.463	APE9-dist-out	8.02	None	None	None	XRAY	2.09	0.201	0.234	A	322	298	0	0	0	0	[[834, 1162]]	1.0	6gqp	Homo sapiens	TYR_KDR_HUMAN	TYR	4.4e-100	340.2	1	260	260	1045	1046	1047	1049	1051	868	885	889	1025	1027	1026	1028	1087	1075	1070	1069	1068	1067	1066	1065	1064	917	Vascular endothelial growth factor receptor 2
TYR	KIT	KIT_HUMAN	6GQKA	P10721	567	931	976.0	F88:61001	Type2	Inactive	DFGout	16.265	10.54	BBAminus	-138.36, -179.35	-150.62, 102.51	-62.45, -32.35	276.39, 87.37	49.32, -117.03	in-in	in	7.663	Saltbr-in	3.188	HRD-in	-73.61, -52.81	79.41, -11.37	in-out-out	SNCioo	out-out	ActLoopNT-out	16.465	ActLoopCT-out	TYR	APEdihe_iiiai	APEdist_aaao	APE10-dihe-in	-119.95, 100.35	APE9-dihe-in	-115.33, 151.26	APE8-dihe-in	-84.45, 66.8	APE8-rot-na	34.27	APE67-dihe-in	-66.19, -12.65	-48.04, -43.77	APE12-dist-na	16.94	APE11-dist-na	13.676	APE10-dist-na	11.702	APE9-dist-out	8.021	I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D	None	None	XRAY	2.31	0.188	0.22	A	328	282	0	0	0	0	[[589, 926]]	1.0	6gqk	Homo sapiens	TYR_KIT_HUMAN	TYR	2.4e-104	354.2	1	261	261	809	810	811	813	815	623	640	644	789	791	790	792	851	839	834	833	832	831	830	829	828	671	Mast/stem cell growth factor receptor Kit
TYR	KIT	KIT_HUMAN	6GQKB	P10721	572	931	976.0	F88:61001	Type2	Inactive	DFGout	16.311	10.572	BBAminus	-138.21, -178.47	-152.96, 103.82	-61.94, -32.56	277.07, 85.37	50.17, -117.95	in-in	in	7.649	Saltbr-in	3.206	HRD-in	-72.76, -53.71	79.41, -11.08	in-out-out	SNCioo	out-out	ActLoopNT-out	16.384	ActLoopCT-out	TYR	APEdihe_iiiai	APEdist_aaao	APE10-dihe-in	-116.06, 104.54	APE9-dihe-in	-119.72, 151.19	APE8-dihe-in	-85.12, 66.24	APE8-rot-na	33.44	APE67-dihe-in	-66.35, -13.84	-47.54, -43.83	APE12-dist-na	17.282	APE11-dist-na	13.998	APE10-dist-na	11.892	APE9-dist-out	8.091	I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D	None	None	XRAY	2.31	0.188	0.22	B	328	277	0	0	0	0	[[589, 926]]	1.0	6gqk	Homo sapiens	TYR_KIT_HUMAN	TYR	2.4e-104	354.2	1	261	261	809	810	811	813	815	623	640	644	789	791	790	792	851	839	834	833	832	831	830	829	828	671	Mast/stem cell growth factor receptor Kit

Ligand: F88

Total number of chains: 0

Active chains: 0

Total number of genes: 0

Spatial label	Dihedral label	Number of Chains	Percent	Representative

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name