Ligand: F88

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 100.0% 6GQPA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR KDR VGFR2_HUMAN 6GQPA P35968 821 1168 1356.0 F88:61201 Type2 Inactive DFGout 16.0412 9.8283 BBAminus -137.29, -179.39 -147.6, 105.82 -66.11, -30.27 279.44, 81.63 58.93, -133.79 in-in in 7.7844 Saltbr-in 3.1604 HRD-in -72.29, -59.65 82.33, -13.78 in-out-out SNCioo out-out ActLoopNT-out 16.7865 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -109.31, 108.64 APE9-dihe-in -119.08, 147.18 APE8-dihe-in -76.82, 68.93 APE8-rot-na 29.84 APE67-dihe-in -64.0, -17.44 -48.7, -44.35 APE12-dist-na 16.2799 APE11-dist-na 13.0288 APE10-dist-na 10.463 APE9-dist-out 8.0203 None None None XRAY 2.09 0.201 0.234 A 322.0 298.0 0 30 30 0 [[834, 1162]] 1.0 6gqp TYR_KDR_HUMAN TYR 4.4e-100 340.2 1.0 260.0 260.0 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028.0 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KIT KIT_HUMAN 6GQKA P10721 567 931 976.0 F88:61001 Type2 Inactive DFGout 16.2645 10.5403 BBAminus -138.36, -179.35 -150.62, 102.51 -62.45, -32.35 276.39, 87.37 49.32, -117.03 in-in in 7.6631 Saltbr-in 3.1883 HRD-in -73.61, -52.81 79.41, -11.37 in-out-out SNCioo out-out ActLoopNT-out 16.465 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -119.95, 100.35 APE9-dihe-in -115.33, 151.26 APE8-dihe-in -84.45, 66.8 APE8-rot-na 34.27 APE67-dihe-in -66.19, -12.65 -48.04, -43.77 APE12-dist-na 16.9399 APE11-dist-na 13.6764 APE10-dist-na 11.7019 APE9-dist-out 8.0209 I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.31 0.188 0.22 A 328.0 282.0 0 30 30 0 [[589, 926]] 1.0 6gqk TYR_KIT_HUMAN TYR 2.4e-104 354.2 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 6GQKB P10721 572 931 976.0 F88:61001 Type2 Inactive DFGout 16.3113 10.5717 BBAminus -138.21, -178.47 -152.96, 103.82 -61.94, -32.56 277.07, 85.37 50.17, -117.95 in-in in 7.6491 Saltbr-in 3.2057 HRD-in -72.76, -53.71 79.41, -11.08 in-out-out SNCioo out-out ActLoopNT-out 16.3837 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -116.06, 104.54 APE9-dihe-in -119.72, 151.19 APE8-dihe-in -85.12, 66.24 APE8-rot-na 33.44 APE67-dihe-in -66.35, -13.84 -47.54, -43.83 APE12-dist-na 17.2818 APE11-dist-na 13.9978 APE10-dist-na 11.8919 APE9-dist-out 8.0905 I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.31 0.188 0.22 B 328.0 277.0 0 30 30 0 [[589, 926]] 1.0 6gqk TYR_KIT_HUMAN TYR 2.4e-104 354.2 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit

Ligand: F88

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 100.0% 6GQPA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR KDR VGFR2_HUMAN 6GQPA P35968 821 1168 1356.0 F88:61201 Type2 Inactive DFGout 16.0412 9.8283 BBAminus -137.29, -179.39 -147.6, 105.82 -66.11, -30.27 279.44, 81.63 58.93, -133.79 in-in in 7.7844 Saltbr-in 3.1604 HRD-in -72.29, -59.65 82.33, -13.78 in-out-out SNCioo out-out ActLoopNT-out 16.7865 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -109.31, 108.64 APE9-dihe-in -119.08, 147.18 APE8-dihe-in -76.82, 68.93 APE8-rot-na 29.84 APE67-dihe-in -64.0, -17.44 -48.7, -44.35 APE12-dist-na 16.2799 APE11-dist-na 13.0288 APE10-dist-na 10.463 APE9-dist-out 8.0203 None None None XRAY 2.09 0.201 0.234 A 322.0 298.0 0 30 30 0 [[834, 1162]] 1.0 6gqp Homo sapiens TYR_KDR_HUMAN TYR 4.4e-100 340.2 1.0 260.0 260.0 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028.0 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KIT KIT_HUMAN 6GQKA P10721 567 931 976.0 F88:61001 Type2 Inactive DFGout 16.2645 10.5403 BBAminus -138.36, -179.35 -150.62, 102.51 -62.45, -32.35 276.39, 87.37 49.32, -117.03 in-in in 7.6631 Saltbr-in 3.1883 HRD-in -73.61, -52.81 79.41, -11.37 in-out-out SNCioo out-out ActLoopNT-out 16.465 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -119.95, 100.35 APE9-dihe-in -115.33, 151.26 APE8-dihe-in -84.45, 66.8 APE8-rot-na 34.27 APE67-dihe-in -66.19, -12.65 -48.04, -43.77 APE12-dist-na 16.9399 APE11-dist-na 13.6764 APE10-dist-na 11.7019 APE9-dist-out 8.0209 I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.31 0.188 0.22 A 328.0 282.0 0 30 30 0 [[589, 926]] 1.0 6gqk Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 6GQKB P10721 572 931 976.0 F88:61001 Type2 Inactive DFGout 16.3113 10.5717 BBAminus -138.21, -178.47 -152.96, 103.82 -61.94, -32.56 277.07, 85.37 50.17, -117.95 in-in in 7.6491 Saltbr-in 3.2057 HRD-in -72.76, -53.71 79.41, -11.08 in-out-out SNCioo out-out ActLoopNT-out 16.3837 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -116.06, 104.54 APE9-dihe-in -119.72, 151.19 APE8-dihe-in -85.12, 66.24 APE8-rot-na 33.44 APE67-dihe-in -66.35, -13.84 -47.54, -43.83 APE12-dist-na 17.2818 APE11-dist-na 13.9978 APE10-dist-na 11.8919 APE9-dist-out 8.0905 I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.31 0.188 0.22 B 328.0 277.0 0 30 30 0 [[589, 926]] 1.0 6gqk Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit

Ligand: F88

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name