Ligand: F82

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 100.0% 6GQOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR KDR VGFR2_HUMAN 6GQOA P35968 811 1168 1356.0 F82:61201 Type2 Inactive DFGout 15.5097 9.872 BBAminus -137.41, -174.48 -148.75, 103.09 -62.92, -33.23 281.85, 85.18 53.53, -124.22 in-in in 7.6522 Saltbr-in 2.8423 HRD-in -77.93, -60.11 81.09, -6.45 in-out-in SNCioi out-in ActLoopNT-out 16.4783 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.71, 109.7 APE9-dihe-in -116.16, 147.79 APE8-dihe-in -80.04, 70.94 APE8-rot-na 31.31 APE67-dihe-in -64.81, -13.7 -51.33, -43.39 APE12-dist-na 16.3984 APE11-dist-na 13.2123 APE10-dist-na 11.0908 APE9-dist-in 7.9513 None None None XRAY 1.87 0.174 0.207 A 322.0 307.0 0 30 30 0 [[834, 1162]] 1.0 6gqo TYR_KDR_HUMAN TYR 4.4e-100 340.2 1.0 260.0 260.0 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028.0 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KIT KIT_HUMAN 6GQJA P10721 567 931 976.0 F82:1001 Type2 Inactive DFGout 15.4314 9.7995 BBAminus -136.14, -170.08 -155.16, 100.15 -61.78, -34.41 278.51, 89.29 45.55, -110.63 in-in in 7.7093 Saltbr-in 2.7848 HRD-in -67.68, -49.72 75.47, -12.89 in-out-in SNCioi out-in ActLoopNT-out 16.2628 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.47, 103.38 APE9-dihe-in -113.89, 148.07 APE8-dihe-in -82.1, 66.48 APE8-rot-na 35.26 APE67-dihe-in -63.13, -15.01 -49.56, -44.22 APE12-dist-na 16.275 APE11-dist-na 13.067 APE10-dist-na 11.3622 APE9-dist-in 7.977 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.33 0.183 0.217 A 327.0 298.0 6 30 30 0 [[589, 926]] 1.0 6gqj TYR_KIT_HUMAN TYR 2.3e-104 354.3 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 6GQJB P10721 572 931 976.0 F82:1001 Type2 Inactive DFGout 15.57 9.8887 BBAminus -134.09, -172.42 -152.78, 100.31 -60.59, -34.13 279.05, 88.45 48.2, -115.16 in-in in 7.6735 Saltbr-in 2.7744 HRD-in -74.21, -50.69 79.42, -13.47 in-out-in SNCioi out-in ActLoopNT-out 16.2406 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.62, 102.98 APE9-dihe-in -113.69, 149.0 APE8-dihe-in -85.17, 67.73 APE8-rot-na 33.45 APE67-dihe-in -61.65, -16.27 -50.45, -44.13 APE12-dist-na 16.6432 APE11-dist-na 13.355 APE10-dist-na 11.5071 APE9-dist-in 7.985 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.33 0.183 0.217 B 327.0 292.0 7 30 30 0 [[589, 926]] 1.0 6gqj TYR_KIT_HUMAN TYR 2.3e-104 354.3 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit

Ligand: F82

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 100.0% 6GQOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR KDR VGFR2_HUMAN 6GQOA P35968 811 1168 1356.0 F82:61201 Type2 Inactive DFGout 15.5097 9.872 BBAminus -137.41, -174.48 -148.75, 103.09 -62.92, -33.23 281.85, 85.18 53.53, -124.22 in-in in 7.6522 Saltbr-in 2.8423 HRD-in -77.93, -60.11 81.09, -6.45 in-out-in SNCioi out-in ActLoopNT-out 16.4783 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.71, 109.7 APE9-dihe-in -116.16, 147.79 APE8-dihe-in -80.04, 70.94 APE8-rot-na 31.31 APE67-dihe-in -64.81, -13.7 -51.33, -43.39 APE12-dist-na 16.3984 APE11-dist-na 13.2123 APE10-dist-na 11.0908 APE9-dist-in 7.9513 None None None XRAY 1.87 0.174 0.207 A 322.0 307.0 0 30 30 0 [[834, 1162]] 1.0 6gqo Homo sapiens TYR_KDR_HUMAN TYR 4.4e-100 340.2 1.0 260.0 260.0 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028.0 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KIT KIT_HUMAN 6GQJA P10721 567 931 976.0 F82:1001 Type2 Inactive DFGout 15.4314 9.7995 BBAminus -136.14, -170.08 -155.16, 100.15 -61.78, -34.41 278.51, 89.29 45.55, -110.63 in-in in 7.7093 Saltbr-in 2.7848 HRD-in -67.68, -49.72 75.47, -12.89 in-out-in SNCioi out-in ActLoopNT-out 16.2628 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.47, 103.38 APE9-dihe-in -113.89, 148.07 APE8-dihe-in -82.1, 66.48 APE8-rot-na 35.26 APE67-dihe-in -63.13, -15.01 -49.56, -44.22 APE12-dist-na 16.275 APE11-dist-na 13.067 APE10-dist-na 11.3622 APE9-dist-in 7.977 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.33 0.183 0.217 A 327.0 298.0 6 30 30 0 [[589, 926]] 1.0 6gqj Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 6GQJB P10721 572 931 976.0 F82:1001 Type2 Inactive DFGout 15.57 9.8887 BBAminus -134.09, -172.42 -152.78, 100.31 -60.59, -34.13 279.05, 88.45 48.2, -115.16 in-in in 7.6735 Saltbr-in 2.7744 HRD-in -74.21, -50.69 79.42, -13.47 in-out-in SNCioi out-in ActLoopNT-out 16.2406 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.62, 102.98 APE9-dihe-in -113.69, 149.0 APE8-dihe-in -85.17, 67.73 APE8-rot-na 33.45 APE67-dihe-in -61.65, -16.27 -50.45, -44.13 APE12-dist-na 16.6432 APE11-dist-na 13.355 APE10-dist-na 11.5071 APE9-dist-in 7.985 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.33 0.183 0.217 B 327.0 292.0 7 30 30 0 [[589, 926]] 1.0 6gqj Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit

Ligand: F82

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name