Ligand: DJK

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 2J5FA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 2J5FA P00533 696 1020 1210.0 DJK:3021 Type1 None DFGin 5.657 14.384 BLAminus -144.79, -170.55 64.0, 79.04 -97.73, 24.0 296.97, 99.2 -43.96, -47.9 in-in in 8.267 Saltbr-in 2.813 HRD-in -61.54, -44.58 69.15, -3.0 in-in-none SNCiin in-none ActLoopNT-in 2.636 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 173.56 APE9-dihe-in -112.83, 120.26 APE8-dihe-in -93.5, 101.2 APE8-rot-na 33.0 APE67-dihe-in -64.88, -16.77 -72.19, -43.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.227 APE9-dist-in 7.146 None None None XRAY 3.0 0.194 0.246 A 327 309 8 0 0 8 [[712, 970]] 1.0 2j5f TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4LQMA P00533 697 1019 1210.0 DJK:1101 Type1 Active DFGin 5.979 14.54 BLAminus -148.3, -172.91 62.11, 72.19 -94.6, 21.41 296.71, 99.46 -60.17, -37.69 in-in in 8.219 Saltbr-in 2.831 HRD-in -68.88, -49.63 72.39, 3.25 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.81, 131.0 APE9-dihe-in -102.62, 141.96 APE8-dihe-in -82.36, 88.32 APE8-rot-na 26.08 APE67-dihe-in -70.52, -7.71 -65.57, -41.89 APE12-dist-na 999.0 APE11-dist-na 11.501 APE10-dist-na 12.101 APE9-dist-in 7.518 L858R None None XRAY 2.5 0.187 0.228 A 331 305 10 0 0 7 [[712, 970]] 1.0 4lqm TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: DJK

Total number of chains: 6
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 50.0% 2J5FA
DFGin None 1 16.7% 2HWPA
DFGinter None 1 16.7% 3LOKB
None None 1 16.7% 2HWPB
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 3LOKA P00523 257 533 533.0 DJK:1345 Type1 Inactive DFGin 6.972 15.19 BLAminus -142.27, -178.52 61.56, 59.71 -73.15, 15.81 291.17, 75.02 7.94, -78.53 out-none out 12.568 Saltbr-none 999.0 HRD-in -84.72, -53.13 84.0, -29.45 none-in-none SNCnin in-none ActLoopNT-in 2.971 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -21.86 APE8-rot-na 353.04 APE67-dihe-in -78.27, -23.24 -85.98, 1.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338M,S345C None None XRAY 2.48 0.225 0.286 A 286 248 29 0 0 14 [[267, 518]] 1.0 3lok Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 2HWPA P00523 256 533 533.0 DJK:1345 Type1 Inactive DFGin 4.945 11.491 None -149.7, 174.68 63.8, 24.74 24.42, 999.0 327.73, 96.53 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -76.7, -56.82 88.65, -21.99 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.02 APE8-dihe-in -78.72, 120.33 APE8-rot-na 32.38 APE67-dihe-in -69.35, -32.46 -64.49, -21.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.591 S345C None None XRAY 2.48 0.228 0.276 A 286 245 33 0 0 18 [[267, 518]] 1.0 2hwp Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3LOKB P00523 258 533 533.0 DJK:1345 Type1 Inactive DFGinter 8.998 7.343 None -159.95, 165.79 -130.83, 138.21 -129.88, -38.43 343.22, 92.96 171.11, -62.33 none-none none 999.0 Saltbr-none 999.0 HRD-in -82.23, -48.63 85.47, -21.61 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -14.67 APE8-rot-na 348.92 APE67-dihe-in -76.3, -19.85 -81.25, -4.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338M,S345C None None XRAY 2.48 0.225 0.286 B 286 242 34 0 0 17 [[267, 518]] 1.0 3lok Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 2HWPB P00523 258 533 533.0 DJK:1345 Type1 Inactive None 999.0 999.0 None -117.43, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -86.38, -51.49 81.58, -23.56 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 37.35 APE8-dihe-in -83.23, 97.91 APE8-rot-na 31.48 APE67-dihe-in -57.85, -20.33 -55.14, -44.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.709 S345C None None XRAY 2.48 0.228 0.276 B 286 239 37 0 0 20 [[267, 518]] 1.0 2hwp Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR EGFR EGFR_HUMAN 2J5FA P00533 696 1020 1210.0 DJK:3021 Type1 None DFGin 5.657 14.384 BLAminus -144.79, -170.55 64.0, 79.04 -97.73, 24.0 296.97, 99.2 -43.96, -47.9 in-in in 8.267 Saltbr-in 2.813 HRD-in -61.54, -44.58 69.15, -3.0 in-in-none SNCiin in-none ActLoopNT-in 2.636 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 173.56 APE9-dihe-in -112.83, 120.26 APE8-dihe-in -93.5, 101.2 APE8-rot-na 33.0 APE67-dihe-in -64.88, -16.77 -72.19, -43.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.227 APE9-dist-in 7.146 None None None XRAY 3.0 0.194 0.246 A 327 309 8 0 0 8 [[712, 970]] 1.0 2j5f Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4LQMA P00533 697 1019 1210.0 DJK:1101 Type1 Active DFGin 5.979 14.54 BLAminus -148.3, -172.91 62.11, 72.19 -94.6, 21.41 296.71, 99.46 -60.17, -37.69 in-in in 8.219 Saltbr-in 2.831 HRD-in -68.88, -49.63 72.39, 3.25 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.81, 131.0 APE9-dihe-in -102.62, 141.96 APE8-dihe-in -82.36, 88.32 APE8-rot-na 26.08 APE67-dihe-in -70.52, -7.71 -65.57, -41.89 APE12-dist-na 999.0 APE11-dist-na 11.501 APE10-dist-na 12.101 APE9-dist-in 7.518 L858R None None XRAY 2.5 0.187 0.228 A 331 305 10 0 0 7 [[712, 970]] 1.0 4lqm Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: DJK

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 25.0% 3LOKA
DFGin None 1 25.0% 2HWPA
DFGinter None 1 25.0% 3LOKB
None None 1 25.0% 2HWPB
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 3LOKA P00523 257 533 533.0 DJK:1345 Type1 Inactive DFGin 6.972 15.19 BLAminus -142.27, -178.52 61.56, 59.71 -73.15, 15.81 291.17, 75.02 7.94, -78.53 out-none out 12.568 Saltbr-none 999.0 HRD-in -84.72, -53.13 84.0, -29.45 none-in-none SNCnin in-none ActLoopNT-in 2.971 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -21.86 APE8-rot-na 353.04 APE67-dihe-in -78.27, -23.24 -85.98, 1.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338M,S345C None None XRAY 2.48 0.225 0.286 A 286 248 29 0 0 14 [[267, 518]] 1.0 3lok Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 2HWPA P00523 256 533 533.0 DJK:1345 Type1 Inactive DFGin 4.945 11.491 None -149.7, 174.68 63.8, 24.74 24.42, 999.0 327.73, 96.53 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -76.7, -56.82 88.65, -21.99 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.02 APE8-dihe-in -78.72, 120.33 APE8-rot-na 32.38 APE67-dihe-in -69.35, -32.46 -64.49, -21.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.591 S345C None None XRAY 2.48 0.228 0.276 A 286 245 33 0 0 18 [[267, 518]] 1.0 2hwp Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3LOKB P00523 258 533 533.0 DJK:1345 Type1 Inactive DFGinter 8.998 7.343 None -159.95, 165.79 -130.83, 138.21 -129.88, -38.43 343.22, 92.96 171.11, -62.33 none-none none 999.0 Saltbr-none 999.0 HRD-in -82.23, -48.63 85.47, -21.61 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -14.67 APE8-rot-na 348.92 APE67-dihe-in -76.3, -19.85 -81.25, -4.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T338M,S345C None None XRAY 2.48 0.225 0.286 B 286 242 34 0 0 17 [[267, 518]] 1.0 3lok Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 2HWPB P00523 258 533 533.0 DJK:1345 Type1 Inactive None 999.0 999.0 None -117.43, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -86.38, -51.49 81.58, -23.56 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 37.35 APE8-dihe-in -83.23, 97.91 APE8-rot-na 31.48 APE67-dihe-in -57.85, -20.33 -55.14, -44.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.709 S345C None None XRAY 2.48 0.228 0.276 B 286 239 37 0 0 20 [[267, 518]] 1.0 2hwp Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src