Ligand: AME

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 4IWDA
DFGin BLBminus 1 50.0% 3Q6UA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR MET MET_HUMAN 4IWDA P08581 1048 1348 1390.0 AME:50001,1JC:61401 Allosteric,Type1 Inactive DFGin 6.5426 14.3013 ABAminus -108.09, -32.72 -101.39, 130.91 -125.93, 29.16 298.42, 93.31 -62.5, -20.72 in-in in 7.5425 Saltbr-in 2.682 HRD-in -68.72, -51.93 72.01, -13.84 in-in-none SNCiin in-none ActLoopNT-in 2.8644 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -44.03 APE9-dihe-in -64.62, 131.07 APE8-dihe-in -85.04, 84.89 APE8-rot-na 35.71 APE67-dihe-in -69.34, -7.33 -42.52, -52.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.704 APE9-dist-in 6.1062 None PTR1234,PTR1235 PTR1234,PTR1235 XRAY 1.99 0.207 0.257 A 306.0 297.0 4 32 28 4 [[1078, 1339]] 1.0 4iwd TYR_MET_HUMAN TYR 6.7e-92 313.9 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3Q6UA P08581 1048 1348 1390.0 AME:50001 Allosteric Inactive DFGin 5.2997 15.1715 BLBminus -141.8, -165.83 43.31, 48.52 -52.58, 142.95 318.65, 93.03 -67.63, 999.0 in-out in 8.567 Saltbr-out 5.7537 HRD-in -70.18, -46.51 72.44, -16.24 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -18.53 APE8-dihe-in -77.28, 65.76 APE8-rot-na 29.07 APE67-dihe-in -73.85, -1.6 -47.31, -44.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8978 None None None XRAY 1.6 0.185 0.214 A 308.0 281.0 20 32 12 20 [[1078, 1339]] 1.0 3q6u TYR_MET_HUMAN TYR 6.8e-92 313.9 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor

Ligand: AME

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 4IWDA
DFGin BLBminus 1 50.0% 3Q6UA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR MET MET_HUMAN 4IWDA P08581 1048 1348 1390.0 AME:50001,1JC:61401 Allosteric,Type1 Inactive DFGin 6.5426 14.3013 ABAminus -108.09, -32.72 -101.39, 130.91 -125.93, 29.16 298.42, 93.31 -62.5, -20.72 in-in in 7.5425 Saltbr-in 2.682 HRD-in -68.72, -51.93 72.01, -13.84 in-in-none SNCiin in-none ActLoopNT-in 2.8644 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -44.03 APE9-dihe-in -64.62, 131.07 APE8-dihe-in -85.04, 84.89 APE8-rot-na 35.71 APE67-dihe-in -69.34, -7.33 -42.52, -52.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.704 APE9-dist-in 6.1062 None PTR1234,PTR1235 PTR1234,PTR1235 XRAY 1.99 0.207 0.257 A 306.0 297.0 4 32 28 4 [[1078, 1339]] 1.0 4iwd Homo sapiens TYR_MET_HUMAN TYR 6.7e-92 313.9 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3Q6UA P08581 1048 1348 1390.0 AME:50001 Allosteric Inactive DFGin 5.2997 15.1715 BLBminus -141.8, -165.83 43.31, 48.52 -52.58, 142.95 318.65, 93.03 -67.63, 999.0 in-out in 8.567 Saltbr-out 5.7537 HRD-in -70.18, -46.51 72.44, -16.24 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -18.53 APE8-dihe-in -77.28, 65.76 APE8-rot-na 29.07 APE67-dihe-in -73.85, -1.6 -47.31, -44.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8978 None None None XRAY 1.6 0.185 0.214 A 308.0 281.0 20 32 12 20 [[1078, 1339]] 1.0 3q6u Homo sapiens TYR_MET_HUMAN TYR 6.8e-92 313.9 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor

Ligand: AME

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name