Ligand: 7XR

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBtrans 2 66.7% 5X2CB
DFGin BLAminus 1 33.3% 5X27A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 5X27A P00533 697 1020 1210.0 7XR:1101 Type1 None DFGin 6.089 14.567 BLAminus -142.52, -171.15 59.08, 68.89 -91.56, 16.87 296.22, 103.35 -59.61, -40.88 in-in in 8.4764 Saltbr-in 3.407 HRD-in -67.74, -41.55 62.13, 9.32 in-in-none SNCiin in-none ActLoopNT-in 2.7947 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.75 APE8-dihe-in -94.41, 99.92 APE8-rot-na 33.71 APE67-dihe-in -62.5, -41.39 -64.95, -42.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1561 L858R None None XRAY 2.952 0.205 0.238 A 327.0 302.0 9 30 21 9 [[712, 970]] 1.0 5x27 TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2CA P00533 700 1015 1210.0 7XR:1104 Type1 Inactive DFGin 5.5213 16.2441 BLBtrans -119.2, -173.9 68.01, 13.0 -61.53, 135.68 163.01, 80.32 88.29, -8.64 out-out out 13.7363 Saltbr-out 12.8437 HRD-in -81.15, -54.79 82.63, -11.78 out-out-out SNCooo out-out ActLoopNT-out 6.5753 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 8.3 APE9-dihe-in -61.54, 131.22 APE8-dihe-in -85.76, 71.43 APE8-rot-na 36.24 APE67-dihe-in -67.14, -14.04 -60.63, -39.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.5467 APE9-dist-out 8.3251 T790M,V948R None None XRAY 2.05 0.175 0.202 A 331.0 304.0 12 30 18 12 [[712, 970]] 1.0 5x2c TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2CB P00533 701 1014 1210.0 7XR:1108 Type1 Inactive DFGin 5.6141 16.5332 BLBtrans -123.4, -172.44 64.48, 17.44 -63.31, 135.2 170.91, 82.18 86.12, -10.39 out-out out 13.9353 Saltbr-out 13.4015 HRD-in -68.72, -52.33 82.34, -14.55 out-out-out SNCooo out-out ActLoopNT-out 6.813 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -134.03 APE9-dihe-in -64.14, 138.31 APE8-dihe-in -88.3, 72.92 APE8-rot-na 37.78 APE67-dihe-in -73.91, -8.47 -60.44, -40.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.5516 APE9-dist-out 8.5693 T790M,V948R None None XRAY 2.05 0.175 0.202 B 331.0 303.0 11 30 19 11 [[712, 970]] 1.0 5x2c TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 7XR

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBtrans 2 66.7% 5X2CB
DFGin BLAminus 1 33.3% 5X27A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 5X27A P00533 697 1020 1210.0 7XR:1101 Type1 None DFGin 6.089 14.567 BLAminus -142.52, -171.15 59.08, 68.89 -91.56, 16.87 296.22, 103.35 -59.61, -40.88 in-in in 8.4764 Saltbr-in 3.407 HRD-in -67.74, -41.55 62.13, 9.32 in-in-none SNCiin in-none ActLoopNT-in 2.7947 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.75 APE8-dihe-in -94.41, 99.92 APE8-rot-na 33.71 APE67-dihe-in -62.5, -41.39 -64.95, -42.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1561 L858R None None XRAY 2.952 0.205 0.238 A 327.0 302.0 9 30 21 9 [[712, 970]] 1.0 5x27 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2CA P00533 700 1015 1210.0 7XR:1104 Type1 Inactive DFGin 5.5213 16.2441 BLBtrans -119.2, -173.9 68.01, 13.0 -61.53, 135.68 163.01, 80.32 88.29, -8.64 out-out out 13.7363 Saltbr-out 12.8437 HRD-in -81.15, -54.79 82.63, -11.78 out-out-out SNCooo out-out ActLoopNT-out 6.5753 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 8.3 APE9-dihe-in -61.54, 131.22 APE8-dihe-in -85.76, 71.43 APE8-rot-na 36.24 APE67-dihe-in -67.14, -14.04 -60.63, -39.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.5467 APE9-dist-out 8.3251 T790M,V948R None None XRAY 2.05 0.175 0.202 A 331.0 304.0 12 30 18 12 [[712, 970]] 1.0 5x2c Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2CB P00533 701 1014 1210.0 7XR:1108 Type1 Inactive DFGin 5.6141 16.5332 BLBtrans -123.4, -172.44 64.48, 17.44 -63.31, 135.2 170.91, 82.18 86.12, -10.39 out-out out 13.9353 Saltbr-out 13.4015 HRD-in -68.72, -52.33 82.34, -14.55 out-out-out SNCooo out-out ActLoopNT-out 6.813 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -134.03 APE9-dihe-in -64.14, 138.31 APE8-dihe-in -88.3, 72.92 APE8-rot-na 37.78 APE67-dihe-in -73.91, -8.47 -60.44, -40.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.5516 APE9-dist-out 8.5693 T790M,V948R None None XRAY 2.05 0.175 0.202 B 331.0 303.0 11 30 19 11 [[712, 970]] 1.0 5x2c Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 7XR

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name