Ligand: 7KC

Total number of chains: 4
Active chains: 2
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4KS7A
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK MELK MELK_HUMAN 5MAGA Q14680 3 335 651.0 7KC:401 Type1 Inactive DFGin 6.692 14.987 BLAminus -126.92, 174.57 68.63, 74.58 -97.26, 21.55 288.43, 79.18 -64.62, -40.12 in-in in 9.052 Saltbr-in 2.829 HRD-in -73.74, -51.64 77.77, -11.12 in-in-out SNCiio in-out ActLoopNT-in 3.007 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.12 APE8-rot-out 175.02 APE67-dihe-in -58.72, -25.6 -61.09, -40.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.35 0.196 0.252 A 347 314 19 0 0 14 [[11, 263]] 1.0 5mag CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
STE PAK1 PAK1_HUMAN 4O0RA Q13153 249 541 545.0 7KC:601 Type1 Inactive DFGin 5.707 15.451 BLAminus -136.26, -173.63 66.36, 84.44 -105.38, 22.75 287.98, 73.0 -66.77, -24.67 out-out out 10.536 Saltbr-out 3.843 HRD-in -68.62, -53.92 75.41, -4.06 out-in-in SNCoii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.02, 160.09 APE9-dihe-na 121.29, -167.42 APE8-dihe-in -109.32, 127.14 APE8-rot-in 311.22 APE67-dihe-in -60.58, -24.43 -38.72, -62.41 APE12-dist-in 9.2 APE11-dist-in 11.87 APE10-dist-in 5.901 APE9-dist-in 3.361 None None None XRAY 2.4 0.208 0.242 A 300 293 0 0 0 0 [[270, 521]] 1.0 4o0r STE_PAK1_HUMAN STE 3.4e-94 320.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 2X4ZA O96013 299 590 591.0 7KC:1593 Type1 Active DFGin 7.175 15.683 BLAminus -132.06, -173.98 55.27, 65.86 -89.03, 22.48 286.31, 71.15 -56.55, -18.72 out-in out 10.093 Saltbr-in 3.353 HRD-in -64.34, -55.81 75.26, 4.96 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.15, 164.59 APE9-dihe-na 116.46, -153.03 APE8-dihe-in -123.41, 117.02 APE8-rot-in 305.72 APE67-dihe-in -61.08, -22.54 -22.19, -62.41 APE12-dist-in 8.425 APE11-dist-in 11.116 APE10-dist-in 5.211 APE9-dist-in 3.362 P296G,Q297S,R298H,V299M SEP474 SEP474 XRAY 2.1 0.2 0.262 A 296 292 0 0 0 0 [[321, 572]] 1.0 2x4z STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK6 PAK6_HUMAN 4KS7A Q9NQU5 386 672 681.0 7KC:702 Type1 Active DFGin 6.399 14.07 BLAminus -131.53, -164.02 58.87, 58.03 -84.12, 9.46 299.86, 106.48 -62.0, -36.31 in-in in 6.648 Saltbr-in 2.782 HRD-in -71.32, -50.61 76.7, -3.92 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.42, 131.66 APE9-dihe-na 146.46, -164.78 APE8-dihe-in -110.2, 122.65 APE8-rot-in 303.96 APE67-dihe-in -64.79, -19.68 -38.25, -57.9 APE12-dist-in 9.528 APE11-dist-in 11.564 APE10-dist-in 5.907 APE9-dist-in 3.344 None SEP560 SEP560 XRAY 1.4 0.195 0.217 A 292 287 0 0 0 0 [[407, 658]] 1.0 4ks7 STE_PAK6_HUMAN STE 2.4e-91 311.6 4 257 254 543 544 545 547 549 436 452 456 523 525 524 526 583 571 566 565 564 563 562 561 560 482 Serine/threonine-protein kinase PAK 6

Ligand: 7KC

Total number of chains: 4
Active chains: 2
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4KS7A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK MELK MELK_HUMAN 5MAGA Q14680 3 335 651.0 7KC:401 Type1 Inactive DFGin 6.692 14.987 BLAminus -126.92, 174.57 68.63, 74.58 -97.26, 21.55 288.43, 79.18 -64.62, -40.12 in-in in 9.052 Saltbr-in 2.829 HRD-in -73.74, -51.64 77.77, -11.12 in-in-out SNCiio in-out ActLoopNT-in 3.007 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.12 APE8-rot-out 175.02 APE67-dihe-in -58.72, -25.6 -61.09, -40.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.35 0.196 0.252 A 347 314 19 0 0 14 [[11, 263]] 1.0 5mag Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
STE PAK1 PAK1_HUMAN 4O0RA Q13153 249 541 545.0 7KC:601 Type1 Inactive DFGin 5.707 15.451 BLAminus -136.26, -173.63 66.36, 84.44 -105.38, 22.75 287.98, 73.0 -66.77, -24.67 out-out out 10.536 Saltbr-out 3.843 HRD-in -68.62, -53.92 75.41, -4.06 out-in-in SNCoii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.02, 160.09 APE9-dihe-na 121.29, -167.42 APE8-dihe-in -109.32, 127.14 APE8-rot-in 311.22 APE67-dihe-in -60.58, -24.43 -38.72, -62.41 APE12-dist-in 9.2 APE11-dist-in 11.87 APE10-dist-in 5.901 APE9-dist-in 3.361 None None None XRAY 2.4 0.208 0.242 A 300 293 0 0 0 0 [[270, 521]] 1.0 4o0r Homo sapiens STE_PAK1_HUMAN STE 3.4e-94 320.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 2X4ZA O96013 299 590 591.0 7KC:1593 Type1 Active DFGin 7.175 15.683 BLAminus -132.06, -173.98 55.27, 65.86 -89.03, 22.48 286.31, 71.15 -56.55, -18.72 out-in out 10.093 Saltbr-in 3.353 HRD-in -64.34, -55.81 75.26, 4.96 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.15, 164.59 APE9-dihe-na 116.46, -153.03 APE8-dihe-in -123.41, 117.02 APE8-rot-in 305.72 APE67-dihe-in -61.08, -22.54 -22.19, -62.41 APE12-dist-in 8.425 APE11-dist-in 11.116 APE10-dist-in 5.211 APE9-dist-in 3.362 P296G,Q297S,R298H,V299M SEP474 SEP474 XRAY 2.1 0.2 0.262 A 296 292 0 0 0 0 [[321, 572]] 1.0 2x4z Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK6 PAK6_HUMAN 4KS7A Q9NQU5 386 672 681.0 7KC:702 Type1 Active DFGin 6.399 14.07 BLAminus -131.53, -164.02 58.87, 58.03 -84.12, 9.46 299.86, 106.48 -62.0, -36.31 in-in in 6.648 Saltbr-in 2.782 HRD-in -71.32, -50.61 76.7, -3.92 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.42, 131.66 APE9-dihe-na 146.46, -164.78 APE8-dihe-in -110.2, 122.65 APE8-rot-in 303.96 APE67-dihe-in -64.79, -19.68 -38.25, -57.9 APE12-dist-in 9.528 APE11-dist-in 11.564 APE10-dist-in 5.907 APE9-dist-in 3.344 None SEP560 SEP560 XRAY 1.4 0.195 0.217 A 292 287 0 0 0 0 [[407, 658]] 1.0 4ks7 Homo sapiens STE_PAK6_HUMAN STE 2.4e-91 311.6 4 257 254 543 544 545 547 549 436 452 456 523 525 524 526 583 571 566 565 564 563 562 561 560 482 Serine/threonine-protein kinase PAK 6

Ligand: 7KC

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name