Ligand: 7DZ

Total number of chains: 6
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 66.7% 5UVFA
DFGin ABAminus 1 16.7% 5UU1A
DFGin None 1 16.7% 5UT1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CK1 VRK1 VRK1_HUMAN 5UVFA Q99986 20 341 396.0 7DZ:401 Type1 Inactive DFGin 8.0675 14.9851 BLAminus -116.03, 174.63 69.35, 93.67 -111.58, 17.18 296.91, 82.24 -59.96, -29.3 in-none in 8.0982 Saltbr-none 999.0 HRD-in -86.38, -53.2 77.43, -1.98 none-in-out SNCnio in-out ActLoopNT-in 2.7989 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.56, 12.28 APE9-dihe-na 82.85, -155.5 APE8-dihe-in -99.21, 123.02 APE8-rot-in 299.54 APE67-dihe-in -63.69, -28.35 -46.21, -50.09 APE12-dist-in 9.3979 APE11-dist-out 5.7198 APE10-dist-out 10.7602 APE9-dist-in 3.8991 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 A 364.0 317.0 5 35 35 0 [[37, 326]] 1.0 5uvf CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 5UVFB Q99986 21 341 396.0 7DZ:402 Type1 Inactive DFGin 7.9626 14.7542 BLAminus -115.7, 176.8 71.96, 96.31 -118.35, 14.05 295.68, 88.15 -59.17, -30.58 in-out in 8.1029 Saltbr-out 3.6842 HRD-in -86.18, -52.27 78.12, -1.25 out-in-out SNCoio in-out ActLoopNT-in 2.8261 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.45, -0.11 APE9-dihe-na 82.24, -156.58 APE8-dihe-in -99.4, 115.21 APE8-rot-in 299.7 APE67-dihe-in -66.33, -25.81 -39.2, -50.38 APE12-dist-in 10.3469 APE11-dist-out 5.2071 APE10-dist-out 10.7115 APE9-dist-in 3.8135 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 B 364.0 316.0 5 35 35 0 [[37, 326]] 1.0 5uvf CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 5UVFC Q99986 23 341 396.0 7DZ:402 Type1.5_Back Inactive DFGin 8.4477 14.5665 BLAminus -113.07, 179.96 62.11, 87.8 -103.99, 18.05 293.88, 84.68 -56.31, -38.97 in-in in 7.7111 Saltbr-in 3.0425 HRD-in -85.64, -52.86 76.73, -0.03 in-in-out SNCiio in-out ActLoopNT-in 2.9387 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -64.51, 153.81 APE9-dihe-na 95.53, -165.02 APE8-dihe-in -90.89, 115.81 APE8-rot-in 299.18 APE67-dihe-in -65.57, -30.05 -44.66, -48.36 APE12-dist-out 15.2248 APE11-dist-in 13.9435 APE10-dist-out 8.0924 APE9-dist-in 4.1905 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 C 364.0 301.0 18 35 35 0 [[37, 326]] 1.0 5uvf CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 5UVFD Q99986 25 341 396.0 7DZ:403 Type1.5_Back Inactive DFGin 8.3371 14.8622 BLAminus -114.11, 178.74 62.44, 88.7 -103.82, 25.96 292.76, 84.97 -61.85, -39.25 in-in in 8.0438 Saltbr-in 2.9375 HRD-in -87.55, -52.6 78.31, -2.58 in-in-out SNCiio in-out ActLoopNT-in 2.9815 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -66.42, 158.8 APE9-dihe-na 91.27, -165.7 APE8-dihe-in -91.48, 116.05 APE8-rot-in 297.62 APE67-dihe-in -68.39, -23.42 -44.65, -48.42 APE12-dist-out 15.1426 APE11-dist-in 13.7731 APE10-dist-in 7.9365 APE9-dist-in 4.1038 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 D 364.0 296.0 21 35 35 0 [[37, 326]] 1.0 5uvf CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK2 VRK2_HUMAN 5UU1A Q86Y07 14 328 508.0 7DZ:401 Type1.5_Back Inactive DFGin 8.4017 14.1464 ABAminus -105.17, 5.91 -139.93, 132.89 -129.79, 29.75 298.27, 85.6 -64.07, -29.29 in-in in 8.3215 Saltbr-in 2.7413 HRD-in -72.24, -51.92 73.83, 1.33 in-in-out SNCiio in-out ActLoopNT-in 2.8062 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -81.98, 168.28 APE9-dihe-na 87.0, -169.82 APE8-dihe-in -84.32, 117.18 APE8-rot-in 301.27 APE67-dihe-in -54.03, -35.31 -55.55, -41.02 APE12-dist-in 13.8145 APE11-dist-out 14.1872 APE10-dist-out 8.3917 APE9-dist-in 4.5395 None None None XRAY 2.0 0.184 0.221 A 324.0 315.0 0 35 35 0 [[29, 315]] 1.0 5uu1 CK1_VRK2_HUMAN CK1 1.6e-103 351.6 1.0 261.0 261.0 185 186 187 189 191 61 73 77 163 165 164 166.0 232 220 215 214 213 212 211 210 209 122 Serine/threonine-protein kinase VRK2
TYR JAK2-1 JAK2_HUMAN 5UT1A O60674 537 808 1132.0 7DZ:905 Type1 Pseudo DFGin 7.3785 13.4637 None -94.09, -179.69 -75.66, 158.87 -74.76, -6.96 27.15, 144.11 69.28, -174.72 in-na in 9.6956 Saltbr-na 999.0 HRD-in -82.87, -62.64 95.48, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.8118 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -38.46 APE9-dihe-out -62.2, -22.99 APE8-dihe-out -88.42, 4.71 APE8-rot-na 293.57 APE67-dihe-out -104.03, 27.01 -63.75, 135.14 APE12-dist-na 10.1099 APE11-dist-na 11.6437 APE10-dist-na 16.2104 APE9-dist-out 12.8829 W659A,W777A,F794H None None XRAY 1.95 0.165 0.202 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut1 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2

Ligand: 7DZ

Total number of chains: 6
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 66.7% 5UVFA
DFGin ABAminus 1 16.7% 5UU1A
DFGin None 1 16.7% 5UT1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CK1 VRK1 VRK1_HUMAN 5UVFA Q99986 20 341 396.0 7DZ:401 Type1 Inactive DFGin 8.0675 14.9851 BLAminus -116.03, 174.63 69.35, 93.67 -111.58, 17.18 296.91, 82.24 -59.96, -29.3 in-none in 8.0982 Saltbr-none 999.0 HRD-in -86.38, -53.2 77.43, -1.98 none-in-out SNCnio in-out ActLoopNT-in 2.7989 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.56, 12.28 APE9-dihe-na 82.85, -155.5 APE8-dihe-in -99.21, 123.02 APE8-rot-in 299.54 APE67-dihe-in -63.69, -28.35 -46.21, -50.09 APE12-dist-in 9.3979 APE11-dist-out 5.7198 APE10-dist-out 10.7602 APE9-dist-in 3.8991 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 A 364.0 317.0 5 35 35 0 [[37, 326]] 1.0 5uvf Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 5UVFB Q99986 21 341 396.0 7DZ:402 Type1 Inactive DFGin 7.9626 14.7542 BLAminus -115.7, 176.8 71.96, 96.31 -118.35, 14.05 295.68, 88.15 -59.17, -30.58 in-out in 8.1029 Saltbr-out 3.6842 HRD-in -86.18, -52.27 78.12, -1.25 out-in-out SNCoio in-out ActLoopNT-in 2.8261 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.45, -0.11 APE9-dihe-na 82.24, -156.58 APE8-dihe-in -99.4, 115.21 APE8-rot-in 299.7 APE67-dihe-in -66.33, -25.81 -39.2, -50.38 APE12-dist-in 10.3469 APE11-dist-out 5.2071 APE10-dist-out 10.7115 APE9-dist-in 3.8135 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 B 364.0 316.0 5 35 35 0 [[37, 326]] 1.0 5uvf Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 5UVFC Q99986 23 341 396.0 7DZ:402 Type1.5_Back Inactive DFGin 8.4477 14.5665 BLAminus -113.07, 179.96 62.11, 87.8 -103.99, 18.05 293.88, 84.68 -56.31, -38.97 in-in in 7.7111 Saltbr-in 3.0425 HRD-in -85.64, -52.86 76.73, -0.03 in-in-out SNCiio in-out ActLoopNT-in 2.9387 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -64.51, 153.81 APE9-dihe-na 95.53, -165.02 APE8-dihe-in -90.89, 115.81 APE8-rot-in 299.18 APE67-dihe-in -65.57, -30.05 -44.66, -48.36 APE12-dist-out 15.2248 APE11-dist-in 13.9435 APE10-dist-out 8.0924 APE9-dist-in 4.1905 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 C 364.0 301.0 18 35 35 0 [[37, 326]] 1.0 5uvf Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 5UVFD Q99986 25 341 396.0 7DZ:403 Type1.5_Back Inactive DFGin 8.3371 14.8622 BLAminus -114.11, 178.74 62.44, 88.7 -103.82, 25.96 292.76, 84.97 -61.85, -39.25 in-in in 8.0438 Saltbr-in 2.9375 HRD-in -87.55, -52.6 78.31, -2.58 in-in-out SNCiio in-out ActLoopNT-in 2.9815 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -66.42, 158.8 APE9-dihe-na 91.27, -165.7 APE8-dihe-in -91.48, 116.05 APE8-rot-in 297.62 APE67-dihe-in -68.39, -23.42 -44.65, -48.42 APE12-dist-out 15.1426 APE11-dist-in 13.7731 APE10-dist-in 7.9365 APE9-dist-in 4.1038 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.0 0.175 0.204 D 364.0 296.0 21 35 35 0 [[37, 326]] 1.0 5uvf Homo sapiens CK1_VRK1_HUMAN CK1 8.4e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK2 VRK2_HUMAN 5UU1A Q86Y07 14 328 508.0 7DZ:401 Type1.5_Back Inactive DFGin 8.4017 14.1464 ABAminus -105.17, 5.91 -139.93, 132.89 -129.79, 29.75 298.27, 85.6 -64.07, -29.29 in-in in 8.3215 Saltbr-in 2.7413 HRD-in -72.24, -51.92 73.83, 1.33 in-in-out SNCiio in-out ActLoopNT-in 2.8062 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -81.98, 168.28 APE9-dihe-na 87.0, -169.82 APE8-dihe-in -84.32, 117.18 APE8-rot-in 301.27 APE67-dihe-in -54.03, -35.31 -55.55, -41.02 APE12-dist-in 13.8145 APE11-dist-out 14.1872 APE10-dist-out 8.3917 APE9-dist-in 4.5395 None None None XRAY 2.0 0.184 0.221 A 324.0 315.0 0 35 35 0 [[29, 315]] 1.0 5uu1 Homo sapiens CK1_VRK2_HUMAN CK1 1.6e-103 351.6 1.0 261.0 261.0 185 186 187 189 191 61 73 77 163 165 164 166.0 232 220 215 214 213 212 211 210 209 122 Serine/threonine-protein kinase VRK2
TYR JAK2-1 JAK2_HUMAN 5UT1A O60674 537 808 1132.0 7DZ:905 Type1 Pseudo DFGin 7.3785 13.4637 None -94.09, -179.69 -75.66, 158.87 -74.76, -6.96 27.15, 144.11 69.28, -174.72 in-na in 9.6956 Saltbr-na 999.0 HRD-in -82.87, -62.64 95.48, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.8118 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -38.46 APE9-dihe-out -62.2, -22.99 APE8-dihe-out -88.42, 4.71 APE8-rot-na 293.57 APE67-dihe-out -104.03, 27.01 -63.75, 135.14 APE12-dist-na 10.1099 APE11-dist-na 11.6437 APE10-dist-na 16.2104 APE9-dist-out 12.8829 W659A,W777A,F794H None None XRAY 1.95 0.165 0.202 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut1 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2

Ligand: 7DZ

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name