Ligand: 6QB (Ravoxertinib)

Total number of chains: 3
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 6OPHA
DFGin BLBtrans 1 33.3% 5K4JA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC CDK2 CDK2_HUMAN 5K4JA 1.6 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_nooo 6QB Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC MAPK1 MK01_HUMAN 5K4IA 1.76 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanio APEdist_nnnn 6QB Type1 9 - 358 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6OPHA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QB Type1 11 - 358 0 TPO185,PTR187 None Mitogen-activated protein kinase 1

Ligand: 6QB (Ravoxertinib)

Total number of chains: 3
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 6OPHA
DFGin BLBtrans 1 33.3% 5K4JA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CDK2 CDK2_HUMAN 5K4JA 1.6 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_nooo 6QB Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC MAPK1 MK01_HUMAN 5K4IA 1.76 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanio APEdist_nnnn 6QB Type1 9 - 358 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 6OPHA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6QB Type1 11 - 358 0 TPO185,PTR187 None Mitogen-activated protein kinase 1 Homo sapiens

Ligand: 6QB (Ravoxertinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Advanced page
Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism