Ligand: 4GF

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4YP8C
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 4YP8A Q9NWZ3 164 459 460.0 4GF:501 Type1 Active DFGin 6.842 14.163 BLAminus -130.64, 178.89 61.7, 76.88 -103.53, 25.67 310.66, 96.36 -67.74, -31.55 in-in in 8.778 Saltbr-in 3.549 HRD-in -57.79, -50.73 76.7, -3.88 in-in-in SNCiii in-in ActLoopNT-in 2.775 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.21, 150.97 APE9-dihe-na 140.01, -173.97 APE8-dihe-in -103.61, 115.43 APE8-rot-in 309.9 APE67-dihe-in -66.28, -16.88 -42.43, -50.13 APE12-dist-in 10.008 APE11-dist-in 11.614 APE10-dist-in 6.326 APE9-dist-in 3.918 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 A 301 287 9 0 0 4 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8B Q9NWZ3 161 459 460.0 4GF:501 Type1 Inactive DFGin 6.917 14.444 BLAminus -129.86, 179.56 60.17, 77.95 -104.22, 26.32 310.53, 95.0 -66.78, -33.18 in-out in 8.685 Saltbr-out 3.962 HRD-in -57.85, -50.75 76.66, -4.15 out-in-in SNCoii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.74, 150.82 APE9-dihe-na 140.12, -173.75 APE8-dihe-in -103.4, 115.49 APE8-rot-in 310.63 APE67-dihe-in -65.34, -17.03 -41.64, -51.23 APE12-dist-in 10.045 APE11-dist-in 11.581 APE10-dist-in 6.319 APE9-dist-in 3.905 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 B 301 281 18 0 0 6 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8C Q9NWZ3 164 460 460.0 4GF:501 Type1 Inactive DFGin 6.821 14.409 BLAminus -129.81, 179.51 59.35, 79.05 -103.24, 26.6 309.61, 96.69 -66.38, -34.02 in-out in 8.851 Saltbr-out 4.684 HRD-in -59.31, -50.52 77.45, -5.42 out-in-in SNCoii in-in ActLoopNT-in 2.789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.88, 150.51 APE9-dihe-na 141.79, -174.18 APE8-dihe-in -103.25, 114.63 APE8-rot-in 311.45 APE67-dihe-in -64.61, -17.76 -41.38, -51.75 APE12-dist-in 10.149 APE11-dist-in 11.626 APE10-dist-in 6.34 APE9-dist-in 3.945 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 C 301 290 7 0 0 4 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8D Q9NWZ3 164 459 460.0 4GF:501 Type1 Inactive DFGin 6.854 14.319 BLAminus -129.62, 178.91 61.84, 77.53 -103.67, 26.43 310.15, 95.74 -66.28, -34.21 in-out in 8.915 Saltbr-out 3.802 HRD-in -59.75, -49.91 75.93, -3.95 out-in-in SNCoii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.59, 153.02 APE9-dihe-na 138.42, -174.86 APE8-dihe-in -103.4, 114.55 APE8-rot-in 310.75 APE67-dihe-in -64.11, -17.03 -41.21, -51.68 APE12-dist-in 10.015 APE11-dist-in 11.585 APE10-dist-in 6.327 APE9-dist-in 3.922 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 D 301 288 8 0 0 4 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

Ligand: 4GF

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4YP8C
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 4YP8A Q9NWZ3 164 459 460.0 4GF:501 Type1 Active DFGin 6.842 14.163 BLAminus -130.64, 178.89 61.7, 76.88 -103.53, 25.67 310.66, 96.36 -67.74, -31.55 in-in in 8.778 Saltbr-in 3.549 HRD-in -57.79, -50.73 76.7, -3.88 in-in-in SNCiii in-in ActLoopNT-in 2.775 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.21, 150.97 APE9-dihe-na 140.01, -173.97 APE8-dihe-in -103.61, 115.43 APE8-rot-in 309.9 APE67-dihe-in -66.28, -16.88 -42.43, -50.13 APE12-dist-in 10.008 APE11-dist-in 11.614 APE10-dist-in 6.326 APE9-dist-in 3.918 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 A 301 287 9 0 0 4 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8B Q9NWZ3 161 459 460.0 4GF:501 Type1 Inactive DFGin 6.917 14.444 BLAminus -129.86, 179.56 60.17, 77.95 -104.22, 26.32 310.53, 95.0 -66.78, -33.18 in-out in 8.685 Saltbr-out 3.962 HRD-in -57.85, -50.75 76.66, -4.15 out-in-in SNCoii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.74, 150.82 APE9-dihe-na 140.12, -173.75 APE8-dihe-in -103.4, 115.49 APE8-rot-in 310.63 APE67-dihe-in -65.34, -17.03 -41.64, -51.23 APE12-dist-in 10.045 APE11-dist-in 11.581 APE10-dist-in 6.319 APE9-dist-in 3.905 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 B 301 281 18 0 0 6 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8C Q9NWZ3 164 460 460.0 4GF:501 Type1 Inactive DFGin 6.821 14.409 BLAminus -129.81, 179.51 59.35, 79.05 -103.24, 26.6 309.61, 96.69 -66.38, -34.02 in-out in 8.851 Saltbr-out 4.684 HRD-in -59.31, -50.52 77.45, -5.42 out-in-in SNCoii in-in ActLoopNT-in 2.789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.88, 150.51 APE9-dihe-na 141.79, -174.18 APE8-dihe-in -103.25, 114.63 APE8-rot-in 311.45 APE67-dihe-in -64.61, -17.76 -41.38, -51.75 APE12-dist-in 10.149 APE11-dist-in 11.626 APE10-dist-in 6.34 APE9-dist-in 3.945 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 C 301 290 7 0 0 4 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8D Q9NWZ3 164 459 460.0 4GF:501 Type1 Inactive DFGin 6.854 14.319 BLAminus -129.62, 178.91 61.84, 77.53 -103.67, 26.43 310.15, 95.74 -66.28, -34.21 in-out in 8.915 Saltbr-out 3.802 HRD-in -59.75, -49.91 75.93, -3.95 out-in-in SNCoii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.59, 153.02 APE9-dihe-na 138.42, -174.86 APE8-dihe-in -103.4, 114.55 APE8-rot-in 310.75 APE67-dihe-in -64.11, -17.03 -41.21, -51.68 APE12-dist-in 10.015 APE11-dist-in 11.585 APE10-dist-in 6.327 APE9-dist-in 3.922 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 D 301 288 8 0 0 4 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

Ligand: 4GF

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name