Ligand: 477

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 2 66.7% 3V8TB
DFGin BLAminus 1 33.3% 3VF9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR ITK ITK_HUMAN 3V8TA Q08881 357 618 620.0 477:60701 Type1 Inactive DFGin 4.2315 14.4642 BLAplus -118.95, 167.7 48.94, 50.18 -99.3, 5.63 54.69, 89.09 -99.94, 4.7 out-out out 10.0529 Saltbr-out 4.3112 HRD-in -68.26, -49.95 78.02, -22.27 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 178.92 APE8-rot-na 331.13 APE67-dihe-in -62.92, -38.74 -155.44, -29.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.221 0.248 A 266.0 236.0 26 29 12 17 [[363, 614]] 1.0 3v8t TYR_ITK_HUMAN TYR 9.4e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 3V8TB Q08881 357 619 620.0 477:60701 Type1 Inactive DFGin 4.2401 14.4304 BLAplus -118.41, 168.07 51.0, 46.57 -97.03, 4.16 57.29, 90.12 -98.81, 3.03 out-none out 10.0608 Saltbr-none 999.0 HRD-in -66.81, -51.51 78.21, -18.77 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.89 APE8-rot-na 330.19 APE67-dihe-in -61.4, -24.89 -59.94, -28.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.221 0.248 B 266.0 242.0 21 29 13 16 [[363, 614]] 1.0 3v8t TYR_ITK_HUMAN TYR 9.4e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR SYK KSYK_HUMAN 3VF9A P43405 364 635 635.0 477:701 Type1 None DFGin 6.3963 14.6399 BLAminus -128.07, -174.94 57.37, 81.54 -100.98, 31.05 291.59, 91.29 -68.94, -37.68 in-none in 7.996 Saltbr-none 999.0 HRD-in -72.91, -49.87 65.85, 9.08 none-in-in SNCnii in-in ActLoopNT-in 3.0228 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.57, 94.78 APE9-dihe-in -116.96, 141.01 APE8-dihe-in -83.94, 81.53 APE8-rot-na 20.28 APE67-dihe-in -58.58, -19.75 -44.92, -48.84 APE12-dist-na 13.2066 APE11-dist-na 10.5082 APE10-dist-na 9.8773 APE9-dist-in 6.6964 None None None XRAY 2.3 0.255 0.267 A 299.0 265.0 7 31 31 0 [[370, 628]] 1.0 3vf9 TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

Ligand: 477

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 2 66.7% 3V8TB
DFGin BLAminus 1 33.3% 3VF9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR ITK ITK_HUMAN 3V8TA Q08881 357 618 620.0 477:60701 Type1 Inactive DFGin 4.2315 14.4642 BLAplus -118.95, 167.7 48.94, 50.18 -99.3, 5.63 54.69, 89.09 -99.94, 4.7 out-out out 10.0529 Saltbr-out 4.3112 HRD-in -68.26, -49.95 78.02, -22.27 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 178.92 APE8-rot-na 331.13 APE67-dihe-in -62.92, -38.74 -155.44, -29.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.221 0.248 A 266.0 236.0 26 29 12 17 [[363, 614]] 1.0 3v8t Homo sapiens TYR_ITK_HUMAN TYR 9.4e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 3V8TB Q08881 357 619 620.0 477:60701 Type1 Inactive DFGin 4.2401 14.4304 BLAplus -118.41, 168.07 51.0, 46.57 -97.03, 4.16 57.29, 90.12 -98.81, 3.03 out-none out 10.0608 Saltbr-none 999.0 HRD-in -66.81, -51.51 78.21, -18.77 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.89 APE8-rot-na 330.19 APE67-dihe-in -61.4, -24.89 -59.94, -28.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.221 0.248 B 266.0 242.0 21 29 13 16 [[363, 614]] 1.0 3v8t Homo sapiens TYR_ITK_HUMAN TYR 9.4e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR SYK KSYK_HUMAN 3VF9A P43405 364 635 635.0 477:701 Type1 None DFGin 6.3963 14.6399 BLAminus -128.07, -174.94 57.37, 81.54 -100.98, 31.05 291.59, 91.29 -68.94, -37.68 in-none in 7.996 Saltbr-none 999.0 HRD-in -72.91, -49.87 65.85, 9.08 none-in-in SNCnii in-in ActLoopNT-in 3.0228 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.57, 94.78 APE9-dihe-in -116.96, 141.01 APE8-dihe-in -83.94, 81.53 APE8-rot-na 20.28 APE67-dihe-in -58.58, -19.75 -44.92, -48.84 APE12-dist-na 13.2066 APE11-dist-na 10.5082 APE10-dist-na 9.8773 APE9-dist-in 6.6964 None None None XRAY 2.3 0.255 0.267 A 299.0 265.0 7 31 31 0 [[370, 628]] 1.0 3vf9 Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

Ligand: 477

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name