Ligand: 3JW (Baricitinib)

Total number of chains: 4
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 3 75.0% 6VN8A
DFGin BLAminus 1 25.0% 4W9XA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
OTHER BMP2K BMP2K_HUMAN 4W9XA 2.14 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3JW Type1 39 - 342 0 None K320A,K321A BMP-2-inducible protein kinase
TYR JAK2-2 JAK2_HUMAN 6VN8A 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3JW Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VN8B 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3JW Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6WTOA 1.74 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 3JW Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2

Ligand: 3JW (Baricitinib)

Total number of chains: 4
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 3 75.0% 6VN8A
DFGin BLAminus 1 25.0% 4W9XA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
OTHER BMP2K BMP2K_HUMAN 4W9XA 2.14 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3JW Type1 39 - 342 0 None K320A,K321A BMP-2-inducible protein kinase Homo sapiens
TYR JAK2-2 JAK2_HUMAN 6VN8A 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3JW Type1 840 - 1132 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-2 JAK2_HUMAN 6VN8B 1.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3JW Type1 843 - 1131 0 PTR1007 None Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-2 JAK2_HUMAN 6WTOA 1.74 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 3JW Type1 843 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens

Ligand: 3JW (Baricitinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism