Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TKL | BRAF | BRAF_HUMAN | 6U2HC | P15056 | 448 | 733 | 766.0 | 29L:60801 | Type1 | Inactive | DFGin | 6.75 | 14.236 | BLAminus | -140.81, -173.87 | 57.62, 73.3 | -90.9, 27.8 | 291.38, 51.17 | -64.94, -25.09 | in-in | in | 8.624 | Saltbr-in | 2.732 | HRD-in | -81.66, -40.52 | 63.75, 1.44 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.831 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, -6.73 | APE8-dihe-in | -77.44, 81.11 | APE8-rot-in | 298.33 | APE67-dihe-in | -77.58, -10.43 | -81.03, -23.85 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 9.369 | None | SEP729 | SEP729 | XRAY | 2.5 | 0.222 | 0.263 | C | 290 | 275 | 11 | 0 | 0 | 11 | [[457, 716]] | 1.0 | 6u2h | TKL_BRAF_HUMAN | TKL | 5.2e-84 | 287.9 | 4 | 267 | 264 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 6U2HD | P15056 | 448 | 733 | 766.0 | 29L:60801 | Type1 | Inactive | DFGin | 6.362 | 13.853 | BLAminus | -135.68, 175.39 | 64.72, 81.19 | -94.93, 22.46 | 283.79, 66.21 | -67.34, -30.28 | in-in | in | 8.599 | Saltbr-in | 2.78 | HRD-in | -78.94, -38.38 | 63.06, 1.76 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.96 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iioo | APE10-dihe-na | 55.45, -147.38 | APE9-dihe-na | -70.68, -35.18 | APE8-dihe-in | -76.57, 92.11 | APE8-rot-out | 85.56 | APE67-dihe-in | -62.26, -37.46 | -120.91, -2.65 | APE12-dist-in | 8.832 | APE11-dist-in | 9.503 | APE10-dist-out | 11.387 | APE9-dist-out | 11.583 | None | SEP729 | SEP729 | XRAY | 2.5 | 0.222 | 0.263 | D | 290 | 283 | 3 | 0 | 0 | 3 | [[457, 716]] | 1.0 | 6u2h | TKL_BRAF_HUMAN | TKL | 5.2e-84 | 287.9 | 4 | 267 | 264 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 7SHVA | P15056 | 449 | 721 | 766.0 | 29L:60801 | Type1 | Inactive | DFGin | 7.149 | 13.975 | BLAminus | -147.63, -169.13 | 58.79, 78.75 | -106.95, 34.37 | 285.73, 83.49 | -85.44, -39.06 | in-in | in | 8.58 | Saltbr-in | 2.607 | HRD-in | -66.2, -50.26 | 77.35, -0.9 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.912 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnio | APE10-dihe-na | 999.0, -52.91 | APE9-dihe-na | 60.55, -7.98 | APE8-dihe-in | -83.24, 65.36 | APE8-rot-out | 38.35 | APE67-dihe-in | -63.32, -24.58 | -66.92, -44.45 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-in | 7.959 | APE9-dist-out | 9.497 | None | None | None | XRAY | 2.88 | 0.221 | 0.242 | A | 308 | 261 | 12 | 0 | 0 | 12 | [[457, 716]] | 1.0 | 7shv | TKL_BRAF_HUMAN | TKL | 1.1e-81 | 280.3 | 4 | 266 | 263 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 4MNFA | P15056 | 449 | 720 | 766.0 | 29L:801 | Type1 | None | DFGin | 6.831 | 14.084 | BLAminus | -138.14, -173.65 | 64.87, 78.28 | -102.21, 29.93 | 290.33, 73.26 | -66.38, -51.46 | in-in | in | 8.582 | Saltbr-in | 2.768 | HRD-in | -70.14, -50.01 | 76.68, -10.07 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.834 | ActLoopCT-none | nonTYR | APEdihe_aanii | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 142.76 | APE8-rot-in | 296.87 | APE67-dihe-in | -62.48, -28.21 | -57.0, -49.39 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | V600E | None | None | XRAY | 2.802 | 0.215 | 0.275 | A | 329 | 257 | 15 | 0 | 0 | 15 | [[457, 716]] | 1.0 | 4mnf | TKL_BRAF_HUMAN | TKL | 1.4e-81 | 279.9 | 4 | 266 | 263 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 4MNFB | P15056 | 449 | 720 | 766.0 | 29L:801 | Type1 | Inactive | DFGin | 6.486 | 13.922 | BLAminus | -122.68, -176.93 | 63.73, 92.47 | -110.65, 27.31 | 288.5, 68.83 | -50.42, -45.23 | in-in | in | 8.699 | Saltbr-in | 2.866 | HRD-in | -76.32, -52.93 | 74.07, 3.14 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.063 | ActLoopCT-out | nonTYR | APEdihe_aanoi | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 13.12 | APE8-rot-out | 79.33 | APE67-dihe-in | -65.4, -15.67 | -79.06, -24.24 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | V600E | None | None | XRAY | 2.802 | 0.215 | 0.275 | B | 329 | 257 | 15 | 0 | 0 | 15 | [[457, 716]] | 1.0 | 4mnf | TKL_BRAF_HUMAN | TKL | 1.4e-81 | 279.9 | 4 | 266 | 263 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 7SHVB | P15056 | 449 | 721 | 766.0 | 29L:60801 | Type1.5_Back | Inactive | DFGin | 6.736 | 14.171 | BLAminus | -147.31, -168.46 | 59.95, 68.87 | -90.82, 20.67 | 284.09, 50.14 | -57.74, -56.04 | in-in | in | 8.771 | Saltbr-in | 2.802 | HRD-in | -76.59, -37.99 | 67.86, -2.2 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.859 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_nnio | APE10-dihe-na | 999.0, -136.62 | APE9-dihe-na | -141.24, 15.82 | APE8-dihe-in | -103.28, 75.96 | APE8-rot-in | 280.52 | APE67-dihe-in | -56.94, -26.52 | -73.16, -41.98 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-in | 7.391 | APE9-dist-out | 9.402 | None | None | None | XRAY | 2.88 | 0.221 | 0.242 | B | 308 | 262 | 11 | 0 | 0 | 11 | [[457, 716]] | 1.0 | 7shv | TKL_BRAF_HUMAN | TKL | 1.1e-81 | 280.3 | 4 | 266 | 263 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | RAF1 | RAF1_HUMAN | 8CHFA | P04049 | 341 | 626 | 648.0 | 29L:60701 | Type1 | Inactive | DFGin | 6.919 | 13.798 | None | -77.69, -137.87 | -62.1, 150.83 | -123.34, 43.11 | 304.09, 90.48 | -53.76, -47.63 | in-out | in | 8.592 | Saltbr-out | 6.69 | HRD-in | -62.51, -43.32 | 69.96, -9.45 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.826 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iiio | APE10-dihe-na | 55.74, 2.9 | APE9-dihe-na | 55.92, 40.68 | APE8-dihe-in | -131.33, 94.1 | APE8-rot-out | 59.25 | APE67-dihe-inflip | 81.42, -0.92 | -97.97, 165.62 | APE12-dist-in | 7.349 | APE11-dist-in | 11.631 | APE10-dist-in | 6.943 | APE9-dist-out | 10.157 | Y341D | SEP621 | SEP621 | EM | 4.25 | 0.445 | 999.0 | A | 648 | 280 | 6 | 0 | 0 | 6 | [[349, 608]] | 1.0 | 8chf | TKL_RAF1_HUMAN | TKL | 3e-80 | 275.8 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 8CHFB | P04049 | 341 | 626 | 648.0 | 29L:60701 | Type1 | Inactive | DFGin | 6.919 | 13.798 | None | -77.67, -137.85 | -62.16, 150.83 | -123.29, 43.03 | 304.08, 90.5 | -53.73, -47.64 | in-out | in | 8.592 | Saltbr-out | 6.691 | HRD-in | -62.53, -43.31 | 69.92, -9.4 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.827 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iiio | APE10-dihe-na | 55.74, 2.9 | APE9-dihe-na | 55.89, 40.65 | APE8-dihe-in | -131.28, 94.15 | APE8-rot-out | 59.25 | APE67-dihe-inflip | 81.39, -0.89 | -98.01, 165.61 | APE12-dist-in | 7.349 | APE11-dist-in | 11.631 | APE10-dist-in | 6.942 | APE9-dist-out | 10.157 | Y341D | SEP621 | SEP621 | EM | 4.25 | 0.445 | 999.0 | B | 648 | 280 | 6 | 0 | 0 | 6 | [[349, 608]] | 1.0 | 8chf | TKL_RAF1_HUMAN | TKL | 3e-80 | 275.8 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TKL | BRAF | BRAF_HUMAN | 6U2HC | P15056 | 448 | 733 | 766.0 | 29L:60801 | Type1 | Inactive | DFGin | 6.75 | 14.236 | BLAminus | -140.81, -173.87 | 57.62, 73.3 | -90.9, 27.8 | 291.38, 51.17 | -64.94, -25.09 | in-in | in | 8.624 | Saltbr-in | 2.732 | HRD-in | -81.66, -40.52 | 63.75, 1.44 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.831 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, -6.73 | APE8-dihe-in | -77.44, 81.11 | APE8-rot-in | 298.33 | APE67-dihe-in | -77.58, -10.43 | -81.03, -23.85 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 9.369 | None | SEP729 | SEP729 | XRAY | 2.5 | 0.222 | 0.263 | C | 290 | 275 | 11 | 0 | 0 | 11 | [[457, 716]] | 1.0 | 6u2h | Homo sapiens | TKL_BRAF_HUMAN | TKL | 5.2e-84 | 287.9 | 4 | 267 | 264 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 6U2HD | P15056 | 448 | 733 | 766.0 | 29L:60801 | Type1 | Inactive | DFGin | 6.362 | 13.853 | BLAminus | -135.68, 175.39 | 64.72, 81.19 | -94.93, 22.46 | 283.79, 66.21 | -67.34, -30.28 | in-in | in | 8.599 | Saltbr-in | 2.78 | HRD-in | -78.94, -38.38 | 63.06, 1.76 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.96 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iioo | APE10-dihe-na | 55.45, -147.38 | APE9-dihe-na | -70.68, -35.18 | APE8-dihe-in | -76.57, 92.11 | APE8-rot-out | 85.56 | APE67-dihe-in | -62.26, -37.46 | -120.91, -2.65 | APE12-dist-in | 8.832 | APE11-dist-in | 9.503 | APE10-dist-out | 11.387 | APE9-dist-out | 11.583 | None | SEP729 | SEP729 | XRAY | 2.5 | 0.222 | 0.263 | D | 290 | 283 | 3 | 0 | 0 | 3 | [[457, 716]] | 1.0 | 6u2h | Homo sapiens | TKL_BRAF_HUMAN | TKL | 5.2e-84 | 287.9 | 4 | 267 | 264 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 7SHVA | P15056 | 449 | 721 | 766.0 | 29L:60801 | Type1 | Inactive | DFGin | 7.149 | 13.975 | BLAminus | -147.63, -169.13 | 58.79, 78.75 | -106.95, 34.37 | 285.73, 83.49 | -85.44, -39.06 | in-in | in | 8.58 | Saltbr-in | 2.607 | HRD-in | -66.2, -50.26 | 77.35, -0.9 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.912 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnio | APE10-dihe-na | 999.0, -52.91 | APE9-dihe-na | 60.55, -7.98 | APE8-dihe-in | -83.24, 65.36 | APE8-rot-out | 38.35 | APE67-dihe-in | -63.32, -24.58 | -66.92, -44.45 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-in | 7.959 | APE9-dist-out | 9.497 | None | None | None | XRAY | 2.88 | 0.221 | 0.242 | A | 308 | 261 | 12 | 0 | 0 | 12 | [[457, 716]] | 1.0 | 7shv | Homo sapiens | TKL_BRAF_HUMAN | TKL | 1.1e-81 | 280.3 | 4 | 266 | 263 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 4MNFA | P15056 | 449 | 720 | 766.0 | 29L:801 | Type1 | None | DFGin | 6.831 | 14.084 | BLAminus | -138.14, -173.65 | 64.87, 78.28 | -102.21, 29.93 | 290.33, 73.26 | -66.38, -51.46 | in-in | in | 8.582 | Saltbr-in | 2.768 | HRD-in | -70.14, -50.01 | 76.68, -10.07 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.834 | ActLoopCT-none | nonTYR | APEdihe_aanii | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 142.76 | APE8-rot-in | 296.87 | APE67-dihe-in | -62.48, -28.21 | -57.0, -49.39 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | V600E | None | None | XRAY | 2.802 | 0.215 | 0.275 | A | 329 | 257 | 15 | 0 | 0 | 15 | [[457, 716]] | 1.0 | 4mnf | Homo sapiens | TKL_BRAF_HUMAN | TKL | 1.4e-81 | 279.9 | 4 | 266 | 263 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 4MNFB | P15056 | 449 | 720 | 766.0 | 29L:801 | Type1 | Inactive | DFGin | 6.486 | 13.922 | BLAminus | -122.68, -176.93 | 63.73, 92.47 | -110.65, 27.31 | 288.5, 68.83 | -50.42, -45.23 | in-in | in | 8.699 | Saltbr-in | 2.866 | HRD-in | -76.32, -52.93 | 74.07, 3.14 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.063 | ActLoopCT-out | nonTYR | APEdihe_aanoi | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 13.12 | APE8-rot-out | 79.33 | APE67-dihe-in | -65.4, -15.67 | -79.06, -24.24 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | V600E | None | None | XRAY | 2.802 | 0.215 | 0.275 | B | 329 | 257 | 15 | 0 | 0 | 15 | [[457, 716]] | 1.0 | 4mnf | Homo sapiens | TKL_BRAF_HUMAN | TKL | 1.4e-81 | 279.9 | 4 | 266 | 263 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 7SHVB | P15056 | 449 | 721 | 766.0 | 29L:60801 | Type1.5_Back | Inactive | DFGin | 6.736 | 14.171 | BLAminus | -147.31, -168.46 | 59.95, 68.87 | -90.82, 20.67 | 284.09, 50.14 | -57.74, -56.04 | in-in | in | 8.771 | Saltbr-in | 2.802 | HRD-in | -76.59, -37.99 | 67.86, -2.2 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.859 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_nnio | APE10-dihe-na | 999.0, -136.62 | APE9-dihe-na | -141.24, 15.82 | APE8-dihe-in | -103.28, 75.96 | APE8-rot-in | 280.52 | APE67-dihe-in | -56.94, -26.52 | -73.16, -41.98 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-in | 7.391 | APE9-dist-out | 9.402 | None | None | None | XRAY | 2.88 | 0.221 | 0.242 | B | 308 | 262 | 11 | 0 | 0 | 11 | [[457, 716]] | 1.0 | 7shv | Homo sapiens | TKL_BRAF_HUMAN | TKL | 1.1e-81 | 280.3 | 4 | 266 | 263 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | RAF1 | RAF1_HUMAN | 8CHFA | P04049 | 341 | 626 | 648.0 | 29L:60701 | Type1 | Inactive | DFGin | 6.919 | 13.798 | None | -77.69, -137.87 | -62.1, 150.83 | -123.34, 43.11 | 304.09, 90.48 | -53.76, -47.63 | in-out | in | 8.592 | Saltbr-out | 6.69 | HRD-in | -62.51, -43.32 | 69.96, -9.45 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.826 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iiio | APE10-dihe-na | 55.74, 2.9 | APE9-dihe-na | 55.92, 40.68 | APE8-dihe-in | -131.33, 94.1 | APE8-rot-out | 59.25 | APE67-dihe-inflip | 81.42, -0.92 | -97.97, 165.62 | APE12-dist-in | 7.349 | APE11-dist-in | 11.631 | APE10-dist-in | 6.943 | APE9-dist-out | 10.157 | Y341D | SEP621 | SEP621 | EM | 4.25 | 0.445 | 999.0 | A | 648 | 280 | 6 | 0 | 0 | 6 | [[349, 608]] | 1.0 | 8chf | Homo sapiens | TKL_RAF1_HUMAN | TKL | 3e-80 | 275.8 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 8CHFB | P04049 | 341 | 626 | 648.0 | 29L:60701 | Type1 | Inactive | DFGin | 6.919 | 13.798 | None | -77.67, -137.85 | -62.16, 150.83 | -123.29, 43.03 | 304.08, 90.5 | -53.73, -47.64 | in-out | in | 8.592 | Saltbr-out | 6.691 | HRD-in | -62.53, -43.31 | 69.92, -9.4 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.827 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iiio | APE10-dihe-na | 55.74, 2.9 | APE9-dihe-na | 55.89, 40.65 | APE8-dihe-in | -131.28, 94.15 | APE8-rot-out | 59.25 | APE67-dihe-inflip | 81.39, -0.89 | -98.01, 165.61 | APE12-dist-in | 7.349 | APE11-dist-in | 11.631 | APE10-dist-in | 6.942 | APE9-dist-out | 10.157 | Y341D | SEP621 | SEP621 | EM | 4.25 | 0.445 | 999.0 | B | 648 | 280 | 6 | 0 | 0 | 6 | [[349, 608]] | 1.0 | 8chf | Homo sapiens | TKL_RAF1_HUMAN | TKL | 3e-80 | 275.8 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
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Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
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