Ligand: 23D

Total number of chains: 5
Active chains: 4
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 2F57B
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CK1 CSNK1G3 KC1G3_HUMAN 2IZTA Q9Y6M4 37 334 447.0 23D:1335 Type1 Inactive DFGin 6.803 14.964 BLAminus -127.0, 174.16 67.99, 81.44 -96.4, 17.96 279.44, 88.84 -62.75, -27.01 in-in in 7.857 Saltbr-in 2.467 HRD-in -94.1, -52.44 66.52, 13.21 in-in-out SNCiio in-out ActLoopNT-in 2.744 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -141.62, -28.86 APE9-dihe-na -82.64, -148.65 APE8-dihe-in -79.44, 123.62 APE8-rot-in 324.94 APE67-dihe-in -68.61, -36.95 -80.57, -23.18 APE12-dist-in 13.165 APE11-dist-in 12.856 APE10-dist-out 8.878 APE9-dist-in 5.926 None None None XRAY 2.0 0.225 0.277 A 330 296 2 0 0 0 [[43, 310]] 1.0 2izt CK1_CSNK1G3_HUMAN CK1 2.4e-115 390.4 1 261 261 184 185 186 188 190 72 86 90 159 161 160 162 231 219 214 213 212 211 210 209 208 117 Casein kinase I isoform gamma-3
CMGC CDK2 CDK2_HUMAN 6GUFA P24941 1 298 298.0 23D:60301 Type1 Active DFGin 6.774 15.293 BLAminus -136.48, -179.42 60.5, 81.44 -99.76, 28.15 284.82, 73.53 -62.92, -40.56 in-in in 8.646 Saltbr-in 3.324 HRD-in -59.96, -71.76 90.26, -6.29 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.04, 148.55 APE9-dihe-na 70.93, 137.33 APE8-dihe-in -58.72, 140.1 APE8-rot-in 293.64 APE67-dihe-in -64.27, -24.0 -45.62, -49.06 APE12-dist-in 13.023 APE11-dist-in 10.496 APE10-dist-in 7.369 APE9-dist-in 3.095 None TPO160 TPO160 XRAY 2.65 0.205 0.255 A 302 295 3 0 0 0 [[4, 286]] 1.0 6guf CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 6GUFC P24941 1 297 298.0 23D:60301 Type1 Active DFGin 6.746 15.266 BLAminus -135.63, -175.55 48.4, 82.88 -93.3, 27.13 285.35, 72.61 -62.17, -42.75 in-in in 8.586 Saltbr-in 3.342 HRD-in -80.32, -45.78 56.89, 22.74 in-in-in SNCiii in-in ActLoopNT-in 3.123 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 39.73, -119.25 APE9-dihe-na -76.13, 148.61 APE8-dihe-in -55.68, 139.82 APE8-rot-in 314.94 APE67-dihe-in -62.54, -25.92 -42.68, -48.85 APE12-dist-in 12.677 APE11-dist-in 9.575 APE10-dist-in 7.221 APE9-dist-in 3.473 None TPO160 TPO160 XRAY 2.65 0.205 0.255 C 302 297 0 0 0 0 [[4, 286]] 1.0 6guf CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
STE PAK4 PAK4_HUMAN 2CDZA O96013 299 590 591.0 23D:1591 Type1 Active DFGin 6.851 14.239 BLAminus -131.93, -172.68 60.56, 61.36 -89.92, 17.05 286.34, 82.19 -67.68, -14.12 in-in in 8.413 Saltbr-in 2.548 HRD-in -67.95, -51.01 69.05, 1.71 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.41, 141.72 APE9-dihe-na 145.87, -158.12 APE8-dihe-in -124.24, 119.58 APE8-rot-in 305.81 APE67-dihe-in -67.53, -21.67 -30.06, -59.48 APE12-dist-in 9.103 APE11-dist-in 11.374 APE10-dist-in 5.44 APE9-dist-in 3.375 None SEP474 SEP474 XRAY 2.3 0.202 0.248 A 303 290 2 0 0 0 [[321, 572]] 1.0 2cdz STE_PAK4_HUMAN STE 2e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK5 PAK5_HUMAN 2F57B Q9P286 425 718 719.0 23D:60001 Type1 Active DFGin 7.147 15.159 BLAminus -130.03, -174.06 58.73, 69.39 -94.87, 19.1 283.86, 78.72 -55.48, -32.98 in-in in 8.325 Saltbr-in 2.739 HRD-in -71.01, -50.04 72.02, 1.25 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.95, 140.47 APE9-dihe-na 141.83, -168.91 APE8-dihe-in -111.96, 119.79 APE8-rot-in 303.61 APE67-dihe-in -66.26, -20.96 -34.19, -58.65 APE12-dist-in 8.913 APE11-dist-in 11.471 APE10-dist-in 5.682 APE9-dist-in 3.406 None SEP602 SEP602 XRAY 1.8 0.155 0.185 B 317 294 0 0 0 0 [[449, 700]] 1.0 2f57 STE_PAK5_HUMAN STE 7.8e-89 303.4 5 257 253 585 586 587 589 591 478 494 498 565 567 566 568 625 613 608 607 606 605 604 603 602 524 Serine/threonine-protein kinase PAK 5

Ligand: 23D

Total number of chains: 5
Active chains: 4
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 2F57B
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CK1 CSNK1G3 KC1G3_HUMAN 2IZTA Q9Y6M4 37 334 447.0 23D:1335 Type1 Inactive DFGin 6.803 14.964 BLAminus -127.0, 174.16 67.99, 81.44 -96.4, 17.96 279.44, 88.84 -62.75, -27.01 in-in in 7.857 Saltbr-in 2.467 HRD-in -94.1, -52.44 66.52, 13.21 in-in-out SNCiio in-out ActLoopNT-in 2.744 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -141.62, -28.86 APE9-dihe-na -82.64, -148.65 APE8-dihe-in -79.44, 123.62 APE8-rot-in 324.94 APE67-dihe-in -68.61, -36.95 -80.57, -23.18 APE12-dist-in 13.165 APE11-dist-in 12.856 APE10-dist-out 8.878 APE9-dist-in 5.926 None None None XRAY 2.0 0.225 0.277 A 330 296 2 0 0 0 [[43, 310]] 1.0 2izt Homo sapiens CK1_CSNK1G3_HUMAN CK1 2.4e-115 390.4 1 261 261 184 185 186 188 190 72 86 90 159 161 160 162 231 219 214 213 212 211 210 209 208 117 Casein kinase I isoform gamma-3
CMGC CDK2 CDK2_HUMAN 6GUFA P24941 1 298 298.0 23D:60301 Type1 Active DFGin 6.774 15.293 BLAminus -136.48, -179.42 60.5, 81.44 -99.76, 28.15 284.82, 73.53 -62.92, -40.56 in-in in 8.646 Saltbr-in 3.324 HRD-in -59.96, -71.76 90.26, -6.29 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.04, 148.55 APE9-dihe-na 70.93, 137.33 APE8-dihe-in -58.72, 140.1 APE8-rot-in 293.64 APE67-dihe-in -64.27, -24.0 -45.62, -49.06 APE12-dist-in 13.023 APE11-dist-in 10.496 APE10-dist-in 7.369 APE9-dist-in 3.095 None TPO160 TPO160 XRAY 2.65 0.205 0.255 A 302 295 3 0 0 0 [[4, 286]] 1.0 6guf Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 6GUFC P24941 1 297 298.0 23D:60301 Type1 Active DFGin 6.746 15.266 BLAminus -135.63, -175.55 48.4, 82.88 -93.3, 27.13 285.35, 72.61 -62.17, -42.75 in-in in 8.586 Saltbr-in 3.342 HRD-in -80.32, -45.78 56.89, 22.74 in-in-in SNCiii in-in ActLoopNT-in 3.123 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 39.73, -119.25 APE9-dihe-na -76.13, 148.61 APE8-dihe-in -55.68, 139.82 APE8-rot-in 314.94 APE67-dihe-in -62.54, -25.92 -42.68, -48.85 APE12-dist-in 12.677 APE11-dist-in 9.575 APE10-dist-in 7.221 APE9-dist-in 3.473 None TPO160 TPO160 XRAY 2.65 0.205 0.255 C 302 297 0 0 0 0 [[4, 286]] 1.0 6guf Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
STE PAK4 PAK4_HUMAN 2CDZA O96013 299 590 591.0 23D:1591 Type1 Active DFGin 6.851 14.239 BLAminus -131.93, -172.68 60.56, 61.36 -89.92, 17.05 286.34, 82.19 -67.68, -14.12 in-in in 8.413 Saltbr-in 2.548 HRD-in -67.95, -51.01 69.05, 1.71 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.41, 141.72 APE9-dihe-na 145.87, -158.12 APE8-dihe-in -124.24, 119.58 APE8-rot-in 305.81 APE67-dihe-in -67.53, -21.67 -30.06, -59.48 APE12-dist-in 9.103 APE11-dist-in 11.374 APE10-dist-in 5.44 APE9-dist-in 3.375 None SEP474 SEP474 XRAY 2.3 0.202 0.248 A 303 290 2 0 0 0 [[321, 572]] 1.0 2cdz Homo sapiens STE_PAK4_HUMAN STE 2e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK5 PAK5_HUMAN 2F57B Q9P286 425 718 719.0 23D:60001 Type1 Active DFGin 7.147 15.159 BLAminus -130.03, -174.06 58.73, 69.39 -94.87, 19.1 283.86, 78.72 -55.48, -32.98 in-in in 8.325 Saltbr-in 2.739 HRD-in -71.01, -50.04 72.02, 1.25 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.95, 140.47 APE9-dihe-na 141.83, -168.91 APE8-dihe-in -111.96, 119.79 APE8-rot-in 303.61 APE67-dihe-in -66.26, -20.96 -34.19, -58.65 APE12-dist-in 8.913 APE11-dist-in 11.471 APE10-dist-in 5.682 APE9-dist-in 3.406 None SEP602 SEP602 XRAY 1.8 0.155 0.185 B 317 294 0 0 0 0 [[449, 700]] 1.0 2f57 Homo sapiens STE_PAK5_HUMAN STE 7.8e-89 303.4 5 257 253 585 586 587 589 591 478 494 498 565 567 566 568 625 613 608 607 606 605 604 603 602 524 Serine/threonine-protein kinase PAK 5

Ligand: 23D

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name