OTHER_WNK3 (Serine/threonine-protein kinase WNK3)

Total number of chains: 17
Active chains: 4
Family: OTHER
Uniprot: WNK3_HUMAN
Kinase Domain Residues: 146 - 405
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 10 58.8% AF-Q9BYP7-K1A
DFGin BLBminus 4 23.5% 5O1VA
DFGin None 2 11.8% 5O23A
DFGin BLBtrans 1 5.9% 5O2BA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
5O26A 135 414 1800.0 ANP:501 ATPlike Active DFGin 6.954 12.201 BLAminus -125.28, -164.72 58.79, 65.89 -88.2, 18.66 305.61, 176.73 -69.56, -20.03 na-na na 15.898 Saltbr-na 999.0 HRD-in -66.1, -48.87 66.45, 11.22 na-in-in SNCaii in-in ActLoopNT-in 3.021 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.2, 167.0 APE9-dihe-na 127.63, -163.54 APE8-dihe-in -104.53, 119.98 APE8-rot-in 309.3 APE67-dihe-in -64.09, -19.44 -52.49, -34.59 APE12-dist-in 8.873 APE11-dist-in 11.829 APE10-dist-in 6.326 APE9-dist-in 3.706 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 A 284 273 7 0 0 0 [[146, 405]] 1.0 5o26 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
5O26B 136 413 1800.0 ANP:501 ATPlike Active DFGin 7.182 12.078 BLAminus -111.0, -167.63 57.49, 63.76 -86.7, 17.71 307.84, 173.05 -70.2, -27.96 na-na na 15.641 Saltbr-na 999.0 HRD-in -66.99, -53.82 74.22, 8.4 na-in-in SNCaii in-in ActLoopNT-in 3.073 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.41, 145.08 APE9-dihe-na 140.9, -162.45 APE8-dihe-in -99.46, 120.61 APE8-rot-in 305.94 APE67-dihe-in -65.71, -19.72 -54.06, -31.08 APE12-dist-in 8.136 APE11-dist-in 11.827 APE10-dist-in 6.044 APE9-dist-in 3.51 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 B 284 267 11 0 0 0 [[146, 405]] 1.0 5o26 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
AF-Q9BYP7-K1A 138 413 1800.0 No_ligand No_ligand Active DFGin 6.889 12.98 BLAminus -127.86, -170.31 51.19, 67.07 -80.59, 16.08 296.42, 165.8 -59.91, -12.24 na-na na 11.853 Saltbr-na 999.0 HRD-in -74.15, -43.46 63.54, 6.1 na-in-in SNCaii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.95, 159.33 APE9-dihe-na 112.64, 174.47 APE8-dihe-in -75.54, 119.36 APE8-rot-in 288.71 APE67-dihe-in -65.88, -24.09 -50.36, -35.91 APE12-dist-in 9.157 APE11-dist-in 12.176 APE10-dist-in 6.319 APE9-dist-in 3.709 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[146, 405]] 1.0 AF-Q9BYP7-K1 OTHER_WNK3_HUMAN WNK 2.3e-178 596.7 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
AF-Q9BYP7-K3A 138 413 1800.0 No_ligand No_ligand Active DFGin 6.845 13.242 BLAminus -122.36, -167.46 54.43, 50.12 -69.12, 12.6 299.84, 170.73 -69.16, -10.15 na-na na 14.056 Saltbr-na 999.0 HRD-in -73.96, -43.62 65.21, -17.19 na-in-in SNCaii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.38, 130.65 APE9-dihe-na 151.91, -174.28 APE8-dihe-in -95.75, 116.01 APE8-rot-in 302.1 APE67-dihe-in -70.78, -17.78 -50.96, -34.06 APE12-dist-in 9.807 APE11-dist-in 12.352 APE10-dist-in 6.577 APE9-dist-in 3.816 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[146, 405]] 1.0 AF-Q9BYP7-K3 OTHER_WNK3_HUMAN WNK 2.3e-178 596.7 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
5O21A 135 407 1800.0 No_ligand No_ligand Inactive DFGin 7.089 13.04 BLAminus -130.22, -166.98 56.55, 36.65 -72.32, -23.91 287.14, 0.0 -71.99, -51.91 na-na na 14.042 Saltbr-na 999.0 HRD-in -65.7, -53.34 78.52, -13.63 na-out-out SNCaoo out-out ActLoopNT-out 6.167 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -100.81, -13.76 APE9-dihe-na -67.15, 136.06 APE8-dihe-in -100.83, 102.01 APE8-rot-in 297.43 APE67-dihe-in -61.6, -28.57 -61.68, -28.02 APE12-dist-out 14.232 APE11-dist-in 10.957 APE10-dist-in 7.138 APE9-dist-out 6.373 None SEP304 SEP304 XRAY 2.06 0.182 0.221 A 285 273 0 0 0 0 [[146, 405]] 1.0 5o21 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
5O21B 135 408 1800.0 No_ligand No_ligand Inactive DFGin 7.243 13.16 BLAminus -129.31, -170.95 59.13, 36.62 -71.75, -29.06 285.2, 175.91 -68.89, -49.7 na-na na 14.095 Saltbr-na 999.0 HRD-in -65.4, -53.37 78.35, -11.45 na-out-out SNCaoo out-out ActLoopNT-out 6.118 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -97.26, -16.45 APE9-dihe-na -65.22, 137.04 APE8-dihe-in -103.34, 104.84 APE8-rot-in 297.31 APE67-dihe-in -63.5, -19.78 -64.45, -33.71 APE12-dist-out 14.237 APE11-dist-in 10.939 APE10-dist-in 7.15 APE9-dist-out 6.327 None SEP304 SEP304 XRAY 2.06 0.182 0.221 B 285 274 0 0 0 0 [[146, 405]] 1.0 5o21 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
8EDHC 136 407 1800.0 No_ligand No_ligand Inactive DFGin 7.051 13.367 BLAminus -110.82, -163.79 56.99, 35.55 -66.18, -50.38 272.7, 99.71 -65.98, -44.91 na-na na 15.574 Saltbr-na 999.0 HRD-in -67.12, -48.65 66.19, 5.82 na-out-none SNCaon out-none ActLoopNT-out 6.321 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 101.07, -30.02 999.0, 70.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S308A None None XRAY 3.111 0.196 0.291 C 292 261 11 0 0 11 [[146, 405]] 1.0 8edh OTHER_WNK3_HUMAN WNK 9.9e-178 594.8 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
9D7QA 130 407 1800.0 No_ligand No_ligand Inactive DFGin 6.731 12.085 BLAminus -119.7, -152.41 38.07, 75.05 -85.05, -42.94 283.7, 178.43 -104.28, -8.03 na-na na 14.691 Saltbr-na 999.0 HRD-in -54.92, -50.52 71.24, 2.32 na-out-none SNCaon out-none ActLoopNT-out 7.637 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -174.1 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 E314A None None XRAY 3.301 0.181 0.27 A 280 267 11 0 0 11 [[146, 405]] 1.0 9d7q OTHER_WNK3_HUMAN WNK 3.7e-176 589.5 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
9D7QB 132 407 1800.0 No_ligand No_ligand Inactive DFGin 7.61 13.056 BLAminus -122.92, -158.49 49.74, 40.74 -65.83, -46.73 276.93, 168.69 -83.68, -10.9 na-na na 15.765 Saltbr-na 999.0 HRD-in -75.84, -54.93 87.41, -18.52 na-out-none SNCaon out-none ActLoopNT-out 6.809 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 E314A None None XRAY 3.301 0.181 0.27 B 280 265 11 0 0 11 [[146, 405]] 1.0 9d7q OTHER_WNK3_HUMAN WNK 3.7e-176 589.5 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
8EDHA 137 406 1800.0 WGK:1901 Type1 Inactive DFGin 7.094 13.222 BLAminus -113.28, -158.85 38.61, 44.98 -66.43, -55.5 297.69, 174.74 -65.27, -44.78 na-na na 15.081 Saltbr-na 999.0 HRD-in -66.58, -45.78 72.18, -7.88 na-out-none SNCaon out-none ActLoopNT-out 7.431 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 135.32 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S308A None None XRAY 3.111 0.196 0.291 A 292 255 15 0 0 12 [[146, 405]] 1.0 8edh OTHER_WNK3_HUMAN WNK 9.9e-178 594.8 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
5O1VA 134 412 1800.0 No_ligand No_ligand Inactive DFGin 7.418 15.265 BLBminus -126.78, -175.31 62.8, 27.49 -57.54, 129.59 281.55, 176.13 75.06, -4.41 na-na na 15.67 Saltbr-na 999.0 HRD-in -67.39, -48.91 79.12, -13.95 na-out-out SNCaoo out-out ActLoopNT-out 9.243 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -59.36, 127.09 APE9-dihe-na 140.24, 170.44 APE8-dihe-in -110.71, 124.87 APE8-rot-in 299.46 APE67-dihe-in -59.06, -27.71 -49.77, -43.12 APE12-dist-out 21.907 APE11-dist-out 22.498 APE10-dist-out 27.88 APE9-dist-out 23.796 None SEP304 SEP304 XRAY 1.723 0.175 0.208 A 285 279 0 0 0 0 [[146, 405]] 1.0 5o1v OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
5O1VB 134 410 1800.0 No_ligand No_ligand Inactive DFGin 7.539 15.413 BLBminus -132.28, -167.25 59.98, 27.87 -57.12, 126.45 269.15, 178.63 74.16, -3.88 na-na na 15.777 Saltbr-na 999.0 HRD-in -66.75, -47.84 75.78, -12.44 na-out-out SNCaoo out-out ActLoopNT-out 9.4 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -178.61 APE8-dihe-in -106.7, 136.81 APE8-rot-out 140.72 APE67-dihe-in -66.36, -20.87 -59.17, -44.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 23.68 None SEP304 SEP304 XRAY 1.723 0.175 0.208 B 285 271 6 0 0 6 [[146, 405]] 1.0 5o1v OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
5O2CA 129 496 1800.0 No_ligand No_ligand Inactive DFGin 6.879 13.12 BLBminus -135.93, -172.46 48.56, 54.24 -57.69, 139.99 308.96, 31.31 -79.16, 114.12 na-na na 13.659 Saltbr-na 999.0 HRD-in -61.64, -49.66 75.9, -16.67 na-out-out SNCaoo out-out ActLoopNT-out 9.116 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.48, -58.95 APE9-dihe-na -60.57, 154.77 APE8-dihe-in -112.79, 108.55 APE8-rot-in 304.36 APE67-dihe-in -53.4, -39.45 -41.38, -41.92 APE12-dist-out 15.301 APE11-dist-in 13.166 APE10-dist-out 8.658 APE9-dist-in 5.904 None None None XRAY 2.4 0.189 0.254 A 380 368 0 0 0 0 [[146, 405]] 1.0 5o2c OTHER_WNK3_HUMAN WNK 6.9e-178 595.4 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
5O2BB 135 406 1800.0 KS1:60501 Type1 Inactive DFGin 7.27 14.975 BLBminus -132.95, -165.51 54.58, 28.52 -62.06, 130.41 264.18, 3.23 73.33, -0.53 na-na na 15.516 Saltbr-na 999.0 HRD-in -65.47, -46.21 70.06, -0.64 na-out-none SNCaon out-none ActLoopNT-out 9.655 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 102.28 APE8-rot-in 305.72 APE67-dihe-in -65.53, -27.3 -60.31, -23.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.038 0.201 0.24 B 285 257 15 0 0 10 [[146, 405]] 1.0 5o2b OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
5O2BA 132 414 1800.0 KS1:60501 Type1 Inactive DFGin 6.818 15.282 BLBtrans -124.49, -166.05 54.45, 24.2 -67.59, 128.42 183.67, 57.58 81.34, -10.84 na-na na 15.093 Saltbr-na 999.0 HRD-in -62.07, -49.99 74.44, -8.41 na-out-out SNCaoo out-out ActLoopNT-out 8.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -72.1 APE9-dihe-na -158.08, -158.78 APE8-dihe-in -120.02, 111.61 APE8-rot-in 313.49 APE67-dihe-in -62.37, -25.73 -46.14, -41.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 24.027 APE9-dist-out 23.146 None None None XRAY 2.038 0.201 0.24 A 285 268 15 0 0 8 [[146, 405]] 1.0 5o2b OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
5O23A 136 405 1800.0 No_ligand No_ligand Inactive DFGin 6.267 15.747 None -58.12, 150.75 -62.49, 153.69 -74.35, -24.44 301.07, 176.19 -64.82, -47.37 na-na na 15.546 Saltbr-na 999.0 HRD-in -69.6, -49.52 69.26, 5.04 na-out-out SNCaoo out-out ActLoopNT-out 6.392 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -117.39, 18.0 APE9-dihe-na -73.23, 148.07 APE8-dihe-in -120.2, 82.68 APE8-rot-out 60.44 APE67-dihe-in -69.8, -9.43 -68.14, -14.79 APE12-dist-out 16.581 APE11-dist-out 14.432 APE10-dist-out 11.091 APE9-dist-out 8.804 None SEP304 SEP304 XRAY 2.25 0.207 0.239 A 285 270 0 0 0 0 [[146, 405]] 1.0 5o23 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
5O23B 132 408 1800.0 No_ligand No_ligand Inactive DFGin 5.937 15.615 None -58.71, 149.58 -63.07, 151.65 -71.84, -20.45 305.92, 177.41 -66.4, -56.29 na-na na 16.051 Saltbr-na 999.0 HRD-in -79.22, -48.18 69.94, -5.08 na-out-out SNCaoo out-out ActLoopNT-out 6.617 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -117.39, 20.94 APE9-dihe-na -70.16, 151.66 APE8-dihe-in -125.85, 83.91 APE8-rot-out 52.59 APE67-dihe-in -66.53, -19.04 -68.8, -9.41 APE12-dist-out 16.409 APE11-dist-out 14.19 APE10-dist-out 10.908 APE9-dist-out 8.448 None SEP304 SEP304 XRAY 2.25 0.207 0.239 B 285 277 0 0 0 0 [[146, 405]] 1.0 5o23 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3

OTHER_WNK3 (Serine/threonine-protein kinase WNK3)

Total number of chains: 17
Active chains: 4
Family: OTHER
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 10 58.8% AF-Q9BYP7-K1A
DFGin BLBminus 4 23.5% 5O1VA
DFGin None 2 11.8% 5O23A
DFGin BLBtrans 1 5.9% 5O2BA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
WNK3_HUMAN 5O26A Q9BYP7 135 414 1800.0 ANP:501 ATPlike Active DFGin 6.954 12.201 BLAminus -125.28, -164.72 58.79, 65.89 -88.2, 18.66 305.61, 176.73 -69.56, -20.03 na-na na 15.898 Saltbr-na 999.0 HRD-in -66.1, -48.87 66.45, 11.22 na-in-in SNCaii in-in ActLoopNT-in 3.021 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.2, 167.0 APE9-dihe-na 127.63, -163.54 APE8-dihe-in -104.53, 119.98 APE8-rot-in 309.3 APE67-dihe-in -64.09, -19.44 -52.49, -34.59 APE12-dist-in 8.873 APE11-dist-in 11.829 APE10-dist-in 6.326 APE9-dist-in 3.706 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 A 284 273 7 0 0 0 [[146, 405]] 1.0 5o26 Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 5O26B Q9BYP7 136 413 1800.0 ANP:501 ATPlike Active DFGin 7.182 12.078 BLAminus -111.0, -167.63 57.49, 63.76 -86.7, 17.71 307.84, 173.05 -70.2, -27.96 na-na na 15.641 Saltbr-na 999.0 HRD-in -66.99, -53.82 74.22, 8.4 na-in-in SNCaii in-in ActLoopNT-in 3.073 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.41, 145.08 APE9-dihe-na 140.9, -162.45 APE8-dihe-in -99.46, 120.61 APE8-rot-in 305.94 APE67-dihe-in -65.71, -19.72 -54.06, -31.08 APE12-dist-in 8.136 APE11-dist-in 11.827 APE10-dist-in 6.044 APE9-dist-in 3.51 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 B 284 267 11 0 0 0 [[146, 405]] 1.0 5o26 Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN AF-Q9BYP7-K1A Q9BYP7 138 413 1800.0 No_ligand No_ligand Active DFGin 6.889 12.98 BLAminus -127.86, -170.31 51.19, 67.07 -80.59, 16.08 296.42, 165.8 -59.91, -12.24 na-na na 11.853 Saltbr-na 999.0 HRD-in -74.15, -43.46 63.54, 6.1 na-in-in SNCaii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.95, 159.33 APE9-dihe-na 112.64, 174.47 APE8-dihe-in -75.54, 119.36 APE8-rot-in 288.71 APE67-dihe-in -65.88, -24.09 -50.36, -35.91 APE12-dist-in 9.157 APE11-dist-in 12.176 APE10-dist-in 6.319 APE9-dist-in 3.709 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[146, 405]] 1.0 AF-Q9BYP7-K1 Homo sapiens OTHER_WNK3_HUMAN WNK 2.3e-178 596.7 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN AF-Q9BYP7-K3A Q9BYP7 138 413 1800.0 No_ligand No_ligand Active DFGin 6.845 13.242 BLAminus -122.36, -167.46 54.43, 50.12 -69.12, 12.6 299.84, 170.73 -69.16, -10.15 na-na na 14.056 Saltbr-na 999.0 HRD-in -73.96, -43.62 65.21, -17.19 na-in-in SNCaii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.38, 130.65 APE9-dihe-na 151.91, -174.28 APE8-dihe-in -95.75, 116.01 APE8-rot-in 302.1 APE67-dihe-in -70.78, -17.78 -50.96, -34.06 APE12-dist-in 9.807 APE11-dist-in 12.352 APE10-dist-in 6.577 APE9-dist-in 3.816 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[146, 405]] 1.0 AF-Q9BYP7-K3 Homo sapiens OTHER_WNK3_HUMAN WNK 2.3e-178 596.7 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 5O21A Q9BYP7 135 407 1800.0 No_ligand No_ligand Inactive DFGin 7.089 13.04 BLAminus -130.22, -166.98 56.55, 36.65 -72.32, -23.91 287.14, 0.0 -71.99, -51.91 na-na na 14.042 Saltbr-na 999.0 HRD-in -65.7, -53.34 78.52, -13.63 na-out-out SNCaoo out-out ActLoopNT-out 6.167 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -100.81, -13.76 APE9-dihe-na -67.15, 136.06 APE8-dihe-in -100.83, 102.01 APE8-rot-in 297.43 APE67-dihe-in -61.6, -28.57 -61.68, -28.02 APE12-dist-out 14.232 APE11-dist-in 10.957 APE10-dist-in 7.138 APE9-dist-out 6.373 None SEP304 SEP304 XRAY 2.06 0.182 0.221 A 285 273 0 0 0 0 [[146, 405]] 1.0 5o21 Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 5O21B Q9BYP7 135 408 1800.0 No_ligand No_ligand Inactive DFGin 7.243 13.16 BLAminus -129.31, -170.95 59.13, 36.62 -71.75, -29.06 285.2, 175.91 -68.89, -49.7 na-na na 14.095 Saltbr-na 999.0 HRD-in -65.4, -53.37 78.35, -11.45 na-out-out SNCaoo out-out ActLoopNT-out 6.118 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -97.26, -16.45 APE9-dihe-na -65.22, 137.04 APE8-dihe-in -103.34, 104.84 APE8-rot-in 297.31 APE67-dihe-in -63.5, -19.78 -64.45, -33.71 APE12-dist-out 14.237 APE11-dist-in 10.939 APE10-dist-in 7.15 APE9-dist-out 6.327 None SEP304 SEP304 XRAY 2.06 0.182 0.221 B 285 274 0 0 0 0 [[146, 405]] 1.0 5o21 Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 8EDHC Q9BYP7 136 407 1800.0 No_ligand No_ligand Inactive DFGin 7.051 13.367 BLAminus -110.82, -163.79 56.99, 35.55 -66.18, -50.38 272.7, 99.71 -65.98, -44.91 na-na na 15.574 Saltbr-na 999.0 HRD-in -67.12, -48.65 66.19, 5.82 na-out-none SNCaon out-none ActLoopNT-out 6.321 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 101.07, -30.02 999.0, 70.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S308A None None XRAY 3.111 0.196 0.291 C 292 261 11 0 0 11 [[146, 405]] 1.0 8edh Homo sapiens OTHER_WNK3_HUMAN WNK 9.9e-178 594.8 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 9D7QA Q9BYP7 130 407 1800.0 No_ligand No_ligand Inactive DFGin 6.731 12.085 BLAminus -119.7, -152.41 38.07, 75.05 -85.05, -42.94 283.7, 178.43 -104.28, -8.03 na-na na 14.691 Saltbr-na 999.0 HRD-in -54.92, -50.52 71.24, 2.32 na-out-none SNCaon out-none ActLoopNT-out 7.637 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -174.1 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 E314A None None XRAY 3.301 0.181 0.27 A 280 267 11 0 0 11 [[146, 405]] 1.0 9d7q Homo sapiens OTHER_WNK3_HUMAN WNK 3.7e-176 589.5 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 9D7QB Q9BYP7 132 407 1800.0 No_ligand No_ligand Inactive DFGin 7.61 13.056 BLAminus -122.92, -158.49 49.74, 40.74 -65.83, -46.73 276.93, 168.69 -83.68, -10.9 na-na na 15.765 Saltbr-na 999.0 HRD-in -75.84, -54.93 87.41, -18.52 na-out-none SNCaon out-none ActLoopNT-out 6.809 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 E314A None None XRAY 3.301 0.181 0.27 B 280 265 11 0 0 11 [[146, 405]] 1.0 9d7q Homo sapiens OTHER_WNK3_HUMAN WNK 3.7e-176 589.5 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 8EDHA Q9BYP7 137 406 1800.0 WGK:1901 Type1 Inactive DFGin 7.094 13.222 BLAminus -113.28, -158.85 38.61, 44.98 -66.43, -55.5 297.69, 174.74 -65.27, -44.78 na-na na 15.081 Saltbr-na 999.0 HRD-in -66.58, -45.78 72.18, -7.88 na-out-none SNCaon out-none ActLoopNT-out 7.431 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 135.32 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S308A None None XRAY 3.111 0.196 0.291 A 292 255 15 0 0 12 [[146, 405]] 1.0 8edh Homo sapiens OTHER_WNK3_HUMAN WNK 9.9e-178 594.8 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 5O1VA Q9BYP7 134 412 1800.0 No_ligand No_ligand Inactive DFGin 7.418 15.265 BLBminus -126.78, -175.31 62.8, 27.49 -57.54, 129.59 281.55, 176.13 75.06, -4.41 na-na na 15.67 Saltbr-na 999.0 HRD-in -67.39, -48.91 79.12, -13.95 na-out-out SNCaoo out-out ActLoopNT-out 9.243 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -59.36, 127.09 APE9-dihe-na 140.24, 170.44 APE8-dihe-in -110.71, 124.87 APE8-rot-in 299.46 APE67-dihe-in -59.06, -27.71 -49.77, -43.12 APE12-dist-out 21.907 APE11-dist-out 22.498 APE10-dist-out 27.88 APE9-dist-out 23.796 None SEP304 SEP304 XRAY 1.723 0.175 0.208 A 285 279 0 0 0 0 [[146, 405]] 1.0 5o1v Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 5O1VB Q9BYP7 134 410 1800.0 No_ligand No_ligand Inactive DFGin 7.539 15.413 BLBminus -132.28, -167.25 59.98, 27.87 -57.12, 126.45 269.15, 178.63 74.16, -3.88 na-na na 15.777 Saltbr-na 999.0 HRD-in -66.75, -47.84 75.78, -12.44 na-out-out SNCaoo out-out ActLoopNT-out 9.4 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -178.61 APE8-dihe-in -106.7, 136.81 APE8-rot-out 140.72 APE67-dihe-in -66.36, -20.87 -59.17, -44.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 23.68 None SEP304 SEP304 XRAY 1.723 0.175 0.208 B 285 271 6 0 0 6 [[146, 405]] 1.0 5o1v Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 5O2CA Q9BYP7 129 496 1800.0 No_ligand No_ligand Inactive DFGin 6.879 13.12 BLBminus -135.93, -172.46 48.56, 54.24 -57.69, 139.99 308.96, 31.31 -79.16, 114.12 na-na na 13.659 Saltbr-na 999.0 HRD-in -61.64, -49.66 75.9, -16.67 na-out-out SNCaoo out-out ActLoopNT-out 9.116 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.48, -58.95 APE9-dihe-na -60.57, 154.77 APE8-dihe-in -112.79, 108.55 APE8-rot-in 304.36 APE67-dihe-in -53.4, -39.45 -41.38, -41.92 APE12-dist-out 15.301 APE11-dist-in 13.166 APE10-dist-out 8.658 APE9-dist-in 5.904 None None None XRAY 2.4 0.189 0.254 A 380 368 0 0 0 0 [[146, 405]] 1.0 5o2c Homo sapiens OTHER_WNK3_HUMAN WNK 6.9e-178 595.4 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 5O2BB Q9BYP7 135 406 1800.0 KS1:60501 Type1 Inactive DFGin 7.27 14.975 BLBminus -132.95, -165.51 54.58, 28.52 -62.06, 130.41 264.18, 3.23 73.33, -0.53 na-na na 15.516 Saltbr-na 999.0 HRD-in -65.47, -46.21 70.06, -0.64 na-out-none SNCaon out-none ActLoopNT-out 9.655 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 102.28 APE8-rot-in 305.72 APE67-dihe-in -65.53, -27.3 -60.31, -23.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.038 0.201 0.24 B 285 257 15 0 0 10 [[146, 405]] 1.0 5o2b Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 5O2BA Q9BYP7 132 414 1800.0 KS1:60501 Type1 Inactive DFGin 6.818 15.282 BLBtrans -124.49, -166.05 54.45, 24.2 -67.59, 128.42 183.67, 57.58 81.34, -10.84 na-na na 15.093 Saltbr-na 999.0 HRD-in -62.07, -49.99 74.44, -8.41 na-out-out SNCaoo out-out ActLoopNT-out 8.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -72.1 APE9-dihe-na -158.08, -158.78 APE8-dihe-in -120.02, 111.61 APE8-rot-in 313.49 APE67-dihe-in -62.37, -25.73 -46.14, -41.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 24.027 APE9-dist-out 23.146 None None None XRAY 2.038 0.201 0.24 A 285 268 15 0 0 8 [[146, 405]] 1.0 5o2b Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 5O23A Q9BYP7 136 405 1800.0 No_ligand No_ligand Inactive DFGin 6.267 15.747 None -58.12, 150.75 -62.49, 153.69 -74.35, -24.44 301.07, 176.19 -64.82, -47.37 na-na na 15.546 Saltbr-na 999.0 HRD-in -69.6, -49.52 69.26, 5.04 na-out-out SNCaoo out-out ActLoopNT-out 6.392 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -117.39, 18.0 APE9-dihe-na -73.23, 148.07 APE8-dihe-in -120.2, 82.68 APE8-rot-out 60.44 APE67-dihe-in -69.8, -9.43 -68.14, -14.79 APE12-dist-out 16.581 APE11-dist-out 14.432 APE10-dist-out 11.091 APE9-dist-out 8.804 None SEP304 SEP304 XRAY 2.25 0.207 0.239 A 285 270 0 0 0 0 [[146, 405]] 1.0 5o23 Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
WNK3_HUMAN 5O23B Q9BYP7 132 408 1800.0 No_ligand No_ligand Inactive DFGin 5.937 15.615 None -58.71, 149.58 -63.07, 151.65 -71.84, -20.45 305.92, 177.41 -66.4, -56.29 na-na na 16.051 Saltbr-na 999.0 HRD-in -79.22, -48.18 69.94, -5.08 na-out-out SNCaoo out-out ActLoopNT-out 6.617 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -117.39, 20.94 APE9-dihe-na -70.16, 151.66 APE8-dihe-in -125.85, 83.91 APE8-rot-out 52.59 APE67-dihe-in -66.53, -19.04 -68.8, -9.41 APE12-dist-out 16.409 APE11-dist-out 14.19 APE10-dist-out 10.908 APE9-dist-out 8.448 None SEP304 SEP304 XRAY 2.25 0.207 0.239 B 285 277 0 0 0 0 [[146, 405]] 1.0 5o23 Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3

OTHER_WNK3 (Serine/threonine-protein kinase WNK3)

Total number of chains: 0
Active chains: 0
Family: OTHER
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name