CK1_TTBK2 (Tau-tubulin kinase 2)

Total number of chains: 12
Active chains: 6
Family: CK1
Uniprot: TTBK2_HUMAN
Kinase Domain Residues: 21 - 282
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 6 50.0% 7Q8ZA
DFGin BLAminus 6 50.0% AF-Q6IQ55-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
6VRFA 9 298 1244.0 ADP:301 ATPlike Active DFGin 5.354 13.116 BLAminus -121.29, 164.21 73.75, 82.24 -97.72, 13.38 304.67, 116.94 -64.06, -29.66 in-in in 7.214 Saltbr-in 2.751 HRD-in -77.1, -49.95 73.69, -4.56 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.12, -30.06 APE9-dihe-na -84.65, -146.34 APE8-dihe-in -107.58, 129.44 APE8-rot-in 302.21 APE67-dihe-in -59.13, -37.2 -56.28, -42.66 APE12-dist-in 11.197 APE11-dist-in 11.387 APE10-dist-in 5.48 APE9-dist-in 3.784 None None None XRAY 1.5 0.175 0.209 A 299 287 3 0 0 0 [[21, 282]] 1.0 6vrf CK1_TTBK2_HUMAN CK1 7.7e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
6VRFB 9 298 1244.0 ADP:301 ATPlike Active DFGin 5.431 12.695 BLAminus -121.38, 163.64 74.07, 85.5 -102.64, 12.86 306.76, 116.33 -62.94, -32.7 in-in in 7.346 Saltbr-in 2.891 HRD-in -78.31, -51.54 73.55, 1.77 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.78, -23.36 APE9-dihe-na -86.88, -149.11 APE8-dihe-in -108.63, 128.02 APE8-rot-in 302.45 APE67-dihe-in -58.2, -36.14 -56.96, -43.7 APE12-dist-in 11.039 APE11-dist-in 11.244 APE10-dist-in 5.337 APE9-dist-in 3.712 None None None XRAY 1.5 0.175 0.209 B 299 287 3 0 0 0 [[21, 282]] 1.0 6vrf CK1_TTBK2_HUMAN CK1 7.7e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
AF-Q6IQ55-K1A 13 290 1244.0 No_ligand No_ligand Active DFGin 5.42 13.057 BLAminus -125.34, 163.32 59.02, 82.97 -85.83, 13.23 304.62, 110.5 -62.64, -23.0 in-in in 7.66 Saltbr-in 2.671 HRD-in -77.58, -46.09 62.6, 11.7 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.55, 150.46 APE9-dihe-na 95.71, -169.2 APE8-dihe-in -93.93, 122.69 APE8-rot-in 298.0 APE67-dihe-in -60.18, -42.44 -42.07, -42.28 APE12-dist-in 12.143 APE11-dist-in 11.713 APE10-dist-in 6.225 APE9-dist-in 3.206 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[21, 282]] 1.0 AF-Q6IQ55-K1 CK1_TTBK2_HUMAN CK1 5.9e-104 353.0 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
AF-Q6IQ55-K3A 13 290 1244.0 No_ligand No_ligand Active DFGin 5.344 13.066 BLAminus -130.3, 167.93 59.06, 68.0 -78.49, 16.74 309.93, 107.31 -64.05, -21.31 in-in in 7.453 Saltbr-in 2.658 HRD-in -79.71, -45.32 63.0, 13.33 in-in-in SNCiii in-in ActLoopNT-in 2.859 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.81, 151.44 APE9-dihe-na 96.06, -173.11 APE8-dihe-in -91.7, 117.54 APE8-rot-in 296.92 APE67-dihe-in -60.3, -41.6 -35.06, -45.13 APE12-dist-in 12.063 APE11-dist-in 11.637 APE10-dist-in 6.284 APE9-dist-in 3.088 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[21, 282]] 1.0 AF-Q6IQ55-K3 CK1_TTBK2_HUMAN CK1 5.9e-104 353.0 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
6U0KA 8 298 1244.0 DTQ:302 Type1 Active DFGin 5.446 13.006 BLAminus -119.74, 158.68 65.44, 93.77 -97.5, 16.58 303.39, 115.2 -64.55, -24.48 in-in in 7.363 Saltbr-in 2.686 HRD-in -77.31, -47.61 69.33, 3.91 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.86, 126.44 APE9-dihe-na 120.4, -155.7 APE8-dihe-in -106.9, 129.29 APE8-rot-in 301.05 APE67-dihe-in -61.62, -36.39 -57.04, -41.68 APE12-dist-in 11.648 APE11-dist-in 11.574 APE10-dist-in 6.085 APE9-dist-in 3.865 None None None XRAY 1.744 0.193 0.233 A 300 290 1 0 0 0 [[21, 282]] 1.0 6u0k CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
6U0KB 8 299 1244.0 DTQ:303 Type1 Active DFGin 5.539 12.963 BLAminus -121.87, 159.25 66.65, 95.14 -97.46, 15.84 302.12, 119.42 -64.27, -23.46 in-in in 7.473 Saltbr-in 2.692 HRD-in -78.29, -47.84 69.94, 2.28 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.42, 128.32 APE9-dihe-na 118.19, -156.28 APE8-dihe-in -104.4, 132.63 APE8-rot-in 299.38 APE67-dihe-in -60.41, -36.62 -56.84, -43.97 APE12-dist-in 11.752 APE11-dist-in 11.649 APE10-dist-in 6.264 APE9-dist-in 3.739 None None None XRAY 1.744 0.193 0.233 B 300 292 0 0 0 0 [[21, 282]] 1.0 6u0k CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
7Q8YA 6 299 1244.0 9IV:303 Type1 Inactive DFGin 5.001 12.736 ABAminus -96.43, -23.37 -148.68, 147.6 -137.42, 20.4 309.85, 104.45 -57.76, -38.41 in-in in 6.521 Saltbr-in 2.73 HRD-in -82.35, -54.44 77.13, -1.28 in-in-in SNCiii in-in ActLoopNT-in 2.831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.88, 1.77 APE9-dihe-na -80.07, -153.46 APE8-dihe-in -102.62, 129.14 APE8-rot-in 288.61 APE67-dihe-in -59.7, -42.15 -59.82, -42.6 APE12-dist-in 11.462 APE11-dist-in 10.2 APE10-dist-in 6.81 APE9-dist-in 4.624 None None None XRAY 1.6 0.179 0.205 A 300 294 0 0 0 0 [[21, 282]] 1.0 7q8y CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
7Q8YB 7 299 1244.0 9IV:303 Type1 Inactive DFGin 4.935 12.919 ABAminus -102.2, -23.11 -149.17, 143.47 -132.06, 19.74 312.12, 105.76 -58.08, -34.08 in-in in 6.548 Saltbr-in 2.708 HRD-in -76.93, -54.19 72.75, -0.27 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.41, 123.98 APE9-dihe-na 120.86, -146.42 APE8-dihe-in -111.89, 127.5 APE8-rot-in 302.95 APE67-dihe-in -58.34, -39.15 -55.33, -42.36 APE12-dist-in 11.668 APE11-dist-in 11.74 APE10-dist-in 6.207 APE9-dist-in 3.812 None None None XRAY 1.6 0.179 0.205 B 300 293 0 0 0 0 [[21, 282]] 1.0 7q8y CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
7Q8ZA 6 299 1244.0 9IK:303 Type1 Inactive DFGin 5.017 12.776 ABAminus -98.76, -21.03 -150.04, 145.16 -135.5, 21.52 309.75, 104.66 -59.56, -34.42 in-in in 6.586 Saltbr-in 2.759 HRD-in -78.99, -56.14 77.24, 1.29 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.67, 8.93 APE9-dihe-na -81.86, -158.53 APE8-dihe-in -100.31, 128.17 APE8-rot-in 295.73 APE67-dihe-in -59.12, -42.17 -58.09, -41.46 APE12-dist-in 11.47 APE11-dist-in 10.286 APE10-dist-in 6.841 APE9-dist-in 4.485 None None None XRAY 1.57 0.176 0.203 A 300 294 0 0 0 0 [[21, 282]] 1.0 7q8z CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
7Q8ZB 7 299 1244.0 9IK:303 Type1 Inactive DFGin 4.949 12.922 ABAminus -101.07, -22.21 -149.46, 144.85 -134.26, 19.31 310.97, 106.06 -61.4, -28.74 in-in in 6.587 Saltbr-in 2.718 HRD-in -75.6, -54.93 71.67, 2.23 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.36, 125.66 APE9-dihe-na 117.9, -151.49 APE8-dihe-in -109.06, 129.51 APE8-rot-in 301.71 APE67-dihe-in -55.77, -40.74 -55.26, -43.3 APE12-dist-in 11.45 APE11-dist-in 11.769 APE10-dist-in 6.316 APE9-dist-in 3.733 None None None XRAY 1.57 0.176 0.203 B 300 293 0 0 0 0 [[21, 282]] 1.0 7q8z CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
7Q90A 6 299 1244.0 9IS:302 Type1 Inactive DFGin 5.048 12.751 ABAminus -97.24, -21.72 -147.14, 147.68 -136.45, 16.85 308.85, 104.12 -53.18, -39.52 in-in in 6.579 Saltbr-in 2.794 HRD-in -78.08, -58.13 80.17, -0.76 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.4, 5.96 APE9-dihe-na -81.49, -157.52 APE8-dihe-in -99.56, 129.15 APE8-rot-in 282.09 APE67-dihe-in -59.83, -39.28 -57.37, -43.18 APE12-dist-in 11.419 APE11-dist-in 10.182 APE10-dist-in 6.8 APE9-dist-in 4.609 None None None XRAY 1.6 0.192 0.22 A 300 294 0 0 0 0 [[21, 282]] 1.0 7q90 CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
7Q90B 7 299 1244.0 9IS:302 Type1 Inactive DFGin 5.015 12.983 ABAminus -101.47, -22.02 -149.29, 145.34 -134.77, 21.17 309.91, 106.63 -62.42, -29.38 in-in in 6.543 Saltbr-in 2.757 HRD-in -77.26, -55.62 73.81, 1.12 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.92, 125.26 APE9-dihe-na 115.84, -153.34 APE8-dihe-in -112.74, 125.56 APE8-rot-in 299.92 APE67-dihe-in -56.42, -39.7 -53.02, -45.29 APE12-dist-in 11.158 APE11-dist-in 11.773 APE10-dist-in 6.287 APE9-dist-in 3.715 None None None XRAY 1.6 0.192 0.22 B 300 293 0 0 0 0 [[21, 282]] 1.0 7q90 CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2

CK1_TTBK2 (Tau-tubulin kinase 2)

Total number of chains: 12
Active chains: 6
Family: CK1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 6 50.0% 7Q8ZA
DFGin BLAminus 6 50.0% AF-Q6IQ55-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TTBK2_HUMAN 6VRFA Q6IQ55 9 298 1244.0 ADP:301 ATPlike Active DFGin 5.354 13.116 BLAminus -121.29, 164.21 73.75, 82.24 -97.72, 13.38 304.67, 116.94 -64.06, -29.66 in-in in 7.214 Saltbr-in 2.751 HRD-in -77.1, -49.95 73.69, -4.56 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.12, -30.06 APE9-dihe-na -84.65, -146.34 APE8-dihe-in -107.58, 129.44 APE8-rot-in 302.21 APE67-dihe-in -59.13, -37.2 -56.28, -42.66 APE12-dist-in 11.197 APE11-dist-in 11.387 APE10-dist-in 5.48 APE9-dist-in 3.784 None None None XRAY 1.5 0.175 0.209 A 299 287 3 0 0 0 [[21, 282]] 1.0 6vrf Homo sapiens CK1_TTBK2_HUMAN CK1 7.7e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
TTBK2_HUMAN 6VRFB Q6IQ55 9 298 1244.0 ADP:301 ATPlike Active DFGin 5.431 12.695 BLAminus -121.38, 163.64 74.07, 85.5 -102.64, 12.86 306.76, 116.33 -62.94, -32.7 in-in in 7.346 Saltbr-in 2.891 HRD-in -78.31, -51.54 73.55, 1.77 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.78, -23.36 APE9-dihe-na -86.88, -149.11 APE8-dihe-in -108.63, 128.02 APE8-rot-in 302.45 APE67-dihe-in -58.2, -36.14 -56.96, -43.7 APE12-dist-in 11.039 APE11-dist-in 11.244 APE10-dist-in 5.337 APE9-dist-in 3.712 None None None XRAY 1.5 0.175 0.209 B 299 287 3 0 0 0 [[21, 282]] 1.0 6vrf Homo sapiens CK1_TTBK2_HUMAN CK1 7.7e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
TTBK2_HUMAN AF-Q6IQ55-K1A Q6IQ55 13 290 1244.0 No_ligand No_ligand Active DFGin 5.42 13.057 BLAminus -125.34, 163.32 59.02, 82.97 -85.83, 13.23 304.62, 110.5 -62.64, -23.0 in-in in 7.66 Saltbr-in 2.671 HRD-in -77.58, -46.09 62.6, 11.7 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.55, 150.46 APE9-dihe-na 95.71, -169.2 APE8-dihe-in -93.93, 122.69 APE8-rot-in 298.0 APE67-dihe-in -60.18, -42.44 -42.07, -42.28 APE12-dist-in 12.143 APE11-dist-in 11.713 APE10-dist-in 6.225 APE9-dist-in 3.206 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[21, 282]] 1.0 AF-Q6IQ55-K1 Homo sapiens CK1_TTBK2_HUMAN CK1 5.9e-104 353.0 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
TTBK2_HUMAN AF-Q6IQ55-K3A Q6IQ55 13 290 1244.0 No_ligand No_ligand Active DFGin 5.344 13.066 BLAminus -130.3, 167.93 59.06, 68.0 -78.49, 16.74 309.93, 107.31 -64.05, -21.31 in-in in 7.453 Saltbr-in 2.658 HRD-in -79.71, -45.32 63.0, 13.33 in-in-in SNCiii in-in ActLoopNT-in 2.859 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.81, 151.44 APE9-dihe-na 96.06, -173.11 APE8-dihe-in -91.7, 117.54 APE8-rot-in 296.92 APE67-dihe-in -60.3, -41.6 -35.06, -45.13 APE12-dist-in 12.063 APE11-dist-in 11.637 APE10-dist-in 6.284 APE9-dist-in 3.088 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[21, 282]] 1.0 AF-Q6IQ55-K3 Homo sapiens CK1_TTBK2_HUMAN CK1 5.9e-104 353.0 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
TTBK2_HUMAN 6U0KA Q6IQ55 8 298 1244.0 DTQ:302 Type1 Active DFGin 5.446 13.006 BLAminus -119.74, 158.68 65.44, 93.77 -97.5, 16.58 303.39, 115.2 -64.55, -24.48 in-in in 7.363 Saltbr-in 2.686 HRD-in -77.31, -47.61 69.33, 3.91 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.86, 126.44 APE9-dihe-na 120.4, -155.7 APE8-dihe-in -106.9, 129.29 APE8-rot-in 301.05 APE67-dihe-in -61.62, -36.39 -57.04, -41.68 APE12-dist-in 11.648 APE11-dist-in 11.574 APE10-dist-in 6.085 APE9-dist-in 3.865 None None None XRAY 1.744 0.193 0.233 A 300 290 1 0 0 0 [[21, 282]] 1.0 6u0k Homo sapiens CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
TTBK2_HUMAN 6U0KB Q6IQ55 8 299 1244.0 DTQ:303 Type1 Active DFGin 5.539 12.963 BLAminus -121.87, 159.25 66.65, 95.14 -97.46, 15.84 302.12, 119.42 -64.27, -23.46 in-in in 7.473 Saltbr-in 2.692 HRD-in -78.29, -47.84 69.94, 2.28 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.42, 128.32 APE9-dihe-na 118.19, -156.28 APE8-dihe-in -104.4, 132.63 APE8-rot-in 299.38 APE67-dihe-in -60.41, -36.62 -56.84, -43.97 APE12-dist-in 11.752 APE11-dist-in 11.649 APE10-dist-in 6.264 APE9-dist-in 3.739 None None None XRAY 1.744 0.193 0.233 B 300 292 0 0 0 0 [[21, 282]] 1.0 6u0k Homo sapiens CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
TTBK2_HUMAN 7Q8YA Q6IQ55 6 299 1244.0 9IV:303 Type1 Inactive DFGin 5.001 12.736 ABAminus -96.43, -23.37 -148.68, 147.6 -137.42, 20.4 309.85, 104.45 -57.76, -38.41 in-in in 6.521 Saltbr-in 2.73 HRD-in -82.35, -54.44 77.13, -1.28 in-in-in SNCiii in-in ActLoopNT-in 2.831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.88, 1.77 APE9-dihe-na -80.07, -153.46 APE8-dihe-in -102.62, 129.14 APE8-rot-in 288.61 APE67-dihe-in -59.7, -42.15 -59.82, -42.6 APE12-dist-in 11.462 APE11-dist-in 10.2 APE10-dist-in 6.81 APE9-dist-in 4.624 None None None XRAY 1.6 0.179 0.205 A 300 294 0 0 0 0 [[21, 282]] 1.0 7q8y Homo sapiens CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
TTBK2_HUMAN 7Q8YB Q6IQ55 7 299 1244.0 9IV:303 Type1 Inactive DFGin 4.935 12.919 ABAminus -102.2, -23.11 -149.17, 143.47 -132.06, 19.74 312.12, 105.76 -58.08, -34.08 in-in in 6.548 Saltbr-in 2.708 HRD-in -76.93, -54.19 72.75, -0.27 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.41, 123.98 APE9-dihe-na 120.86, -146.42 APE8-dihe-in -111.89, 127.5 APE8-rot-in 302.95 APE67-dihe-in -58.34, -39.15 -55.33, -42.36 APE12-dist-in 11.668 APE11-dist-in 11.74 APE10-dist-in 6.207 APE9-dist-in 3.812 None None None XRAY 1.6 0.179 0.205 B 300 293 0 0 0 0 [[21, 282]] 1.0 7q8y Homo sapiens CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
TTBK2_HUMAN 7Q8ZA Q6IQ55 6 299 1244.0 9IK:303 Type1 Inactive DFGin 5.017 12.776 ABAminus -98.76, -21.03 -150.04, 145.16 -135.5, 21.52 309.75, 104.66 -59.56, -34.42 in-in in 6.586 Saltbr-in 2.759 HRD-in -78.99, -56.14 77.24, 1.29 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.67, 8.93 APE9-dihe-na -81.86, -158.53 APE8-dihe-in -100.31, 128.17 APE8-rot-in 295.73 APE67-dihe-in -59.12, -42.17 -58.09, -41.46 APE12-dist-in 11.47 APE11-dist-in 10.286 APE10-dist-in 6.841 APE9-dist-in 4.485 None None None XRAY 1.57 0.176 0.203 A 300 294 0 0 0 0 [[21, 282]] 1.0 7q8z Homo sapiens CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
TTBK2_HUMAN 7Q8ZB Q6IQ55 7 299 1244.0 9IK:303 Type1 Inactive DFGin 4.949 12.922 ABAminus -101.07, -22.21 -149.46, 144.85 -134.26, 19.31 310.97, 106.06 -61.4, -28.74 in-in in 6.587 Saltbr-in 2.718 HRD-in -75.6, -54.93 71.67, 2.23 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.36, 125.66 APE9-dihe-na 117.9, -151.49 APE8-dihe-in -109.06, 129.51 APE8-rot-in 301.71 APE67-dihe-in -55.77, -40.74 -55.26, -43.3 APE12-dist-in 11.45 APE11-dist-in 11.769 APE10-dist-in 6.316 APE9-dist-in 3.733 None None None XRAY 1.57 0.176 0.203 B 300 293 0 0 0 0 [[21, 282]] 1.0 7q8z Homo sapiens CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
TTBK2_HUMAN 7Q90A Q6IQ55 6 299 1244.0 9IS:302 Type1 Inactive DFGin 5.048 12.751 ABAminus -97.24, -21.72 -147.14, 147.68 -136.45, 16.85 308.85, 104.12 -53.18, -39.52 in-in in 6.579 Saltbr-in 2.794 HRD-in -78.08, -58.13 80.17, -0.76 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.4, 5.96 APE9-dihe-na -81.49, -157.52 APE8-dihe-in -99.56, 129.15 APE8-rot-in 282.09 APE67-dihe-in -59.83, -39.28 -57.37, -43.18 APE12-dist-in 11.419 APE11-dist-in 10.182 APE10-dist-in 6.8 APE9-dist-in 4.609 None None None XRAY 1.6 0.192 0.22 A 300 294 0 0 0 0 [[21, 282]] 1.0 7q90 Homo sapiens CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
TTBK2_HUMAN 7Q90B Q6IQ55 7 299 1244.0 9IS:302 Type1 Inactive DFGin 5.015 12.983 ABAminus -101.47, -22.02 -149.29, 145.34 -134.77, 21.17 309.91, 106.63 -62.42, -29.38 in-in in 6.543 Saltbr-in 2.757 HRD-in -77.26, -55.62 73.81, 1.12 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.92, 125.26 APE9-dihe-na 115.84, -153.34 APE8-dihe-in -112.74, 125.56 APE8-rot-in 299.92 APE67-dihe-in -56.42, -39.7 -53.02, -45.29 APE12-dist-in 11.158 APE11-dist-in 11.773 APE10-dist-in 6.287 APE9-dist-in 3.715 None None None XRAY 1.6 0.192 0.22 B 300 293 0 0 0 0 [[21, 282]] 1.0 7q90 Homo sapiens CK1_TTBK2_HUMAN CK1 7.8e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2

CK1_TTBK2 (Tau-tubulin kinase 2)

Total number of chains: 0
Active chains: 0
Family: CK1
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name