| Gene | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TTBK2 | 6VRFA | Q6IQ55 | 9 | 298 | 1244.0 | ADP:301 | ATPlike | Active | DFGin | 5.3543 | 13.1161 | BLAminus | -121.29, 164.21 | 73.75, 82.24 | -97.72, 13.38 | 304.67, 116.94 | -64.06, -29.66 | in-in | in | 7.2137 | Saltbr-in | 2.7506 | HRD-in | -77.1, -49.95 | 73.69, -4.56 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8129 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -108.12, -30.06 | APE9-dihe-na | -84.65, -146.34 | APE8-dihe-in | -107.58, 129.44 | APE8-rot-in | 302.21 | APE67-dihe-in | -59.13, -37.2 | -56.28, -42.66 | APE12-dist-in | 11.1967 | APE11-dist-in | 11.3871 | APE10-dist-in | 5.4802 | APE9-dist-in | 3.7845 | None | None | None | XRAY | 1.5 | 0.175 | 0.209 | A | 299.0 | 287.0 | 3 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 6vrf | CK1_TTBK2_HUMAN | CK1 | 7.7e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | 6VRFB | Q6IQ55 | 9 | 298 | 1244.0 | ADP:301 | ATPlike | Active | DFGin | 5.4311 | 12.6951 | BLAminus | -121.38, 163.64 | 74.07, 85.5 | -102.64, 12.86 | 306.76, 116.33 | -62.94, -32.7 | in-in | in | 7.3455 | Saltbr-in | 2.8906 | HRD-in | -78.31, -51.54 | 73.55, 1.77 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8595 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -109.78, -23.36 | APE9-dihe-na | -86.88, -149.11 | APE8-dihe-in | -108.63, 128.02 | APE8-rot-in | 302.45 | APE67-dihe-in | -58.2, -36.14 | -56.96, -43.7 | APE12-dist-in | 11.0394 | APE11-dist-in | 11.2442 | APE10-dist-in | 5.3369 | APE9-dist-in | 3.7117 | None | None | None | XRAY | 1.5 | 0.175 | 0.209 | B | 299.0 | 287.0 | 3 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 6vrf | CK1_TTBK2_HUMAN | CK1 | 7.7e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | AF-Q6IQ55-K1A | Q6IQ55 | 13 | 290 | 1244.0 | No_ligand | No_ligand | Active | DFGin | 5.4204 | 13.057 | BLAminus | -125.34, 163.32 | 59.02, 82.97 | -85.83, 13.23 | 304.62, 110.5 | -62.64, -23.0 | in-in | in | 7.6596 | Saltbr-in | 2.6707 | HRD-in | -77.58, -46.09 | 62.6, 11.7 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8303 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -135.55, 150.46 | APE9-dihe-na | 95.71, -169.2 | APE8-dihe-in | -93.93, 122.69 | APE8-rot-in | 298.0 | APE67-dihe-in | -60.18, -42.44 | -42.07, -42.28 | APE12-dist-in | 12.1427 | APE11-dist-in | 11.7126 | APE10-dist-in | 6.2252 | APE9-dist-in | 3.2057 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 278.0 | 278.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | AF-Q6IQ55-K1 | CK1_TTBK2_HUMAN | CK1 | 5.9e-104 | 353.0 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | AF-Q6IQ55-K3A | Q6IQ55 | 13 | 290 | 1244.0 | No_ligand | No_ligand | Active | DFGin | 5.344 | 13.0659 | BLAminus | -130.3, 167.93 | 59.06, 68.0 | -78.49, 16.74 | 309.93, 107.31 | -64.05, -21.31 | in-in | in | 7.453 | Saltbr-in | 2.6583 | HRD-in | -79.71, -45.32 | 63.0, 13.33 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8593 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -138.81, 151.44 | APE9-dihe-na | 96.06, -173.11 | APE8-dihe-in | -91.7, 117.54 | APE8-rot-in | 296.92 | APE67-dihe-in | -60.3, -41.6 | -35.06, -45.13 | APE12-dist-in | 12.0634 | APE11-dist-in | 11.6366 | APE10-dist-in | 6.2838 | APE9-dist-in | 3.0877 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 278.0 | 278.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | AF-Q6IQ55-K3 | CK1_TTBK2_HUMAN | CK1 | 5.9e-104 | 353.0 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | 6U0KA | Q6IQ55 | 8 | 298 | 1244.0 | DTQ:302 | Type1 | Active | DFGin | 5.4455 | 13.0064 | BLAminus | -119.74, 158.68 | 65.44, 93.77 | -97.5, 16.58 | 303.39, 115.2 | -64.55, -24.48 | in-in | in | 7.3634 | Saltbr-in | 2.6861 | HRD-in | -77.31, -47.61 | 69.33, 3.91 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8535 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -119.86, 126.44 | APE9-dihe-na | 120.4, -155.7 | APE8-dihe-in | -106.9, 129.29 | APE8-rot-in | 301.05 | APE67-dihe-in | -61.62, -36.39 | -57.04, -41.68 | APE12-dist-in | 11.6476 | APE11-dist-in | 11.5741 | APE10-dist-in | 6.085 | APE9-dist-in | 3.8654 | None | None | None | XRAY | 1.744 | 0.193 | 0.233 | A | 300.0 | 290.0 | 1 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 6u0k | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | 6U0KB | Q6IQ55 | 8 | 299 | 1244.0 | DTQ:303 | Type1 | Active | DFGin | 5.539 | 12.9635 | BLAminus | -121.87, 159.25 | 66.65, 95.14 | -97.46, 15.84 | 302.12, 119.42 | -64.27, -23.46 | in-in | in | 7.473 | Saltbr-in | 2.6919 | HRD-in | -78.29, -47.84 | 69.94, 2.28 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.843 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -122.42, 128.32 | APE9-dihe-na | 118.19, -156.28 | APE8-dihe-in | -104.4, 132.63 | APE8-rot-in | 299.38 | APE67-dihe-in | -60.41, -36.62 | -56.84, -43.97 | APE12-dist-in | 11.7517 | APE11-dist-in | 11.6488 | APE10-dist-in | 6.2643 | APE9-dist-in | 3.7387 | None | None | None | XRAY | 1.744 | 0.193 | 0.233 | B | 300.0 | 292.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 6u0k | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | 7Q8YA | Q6IQ55 | 6 | 299 | 1244.0 | 9IV:303 | Type1 | Inactive | DFGin | 5.001 | 12.7358 | ABAminus | -96.43, -23.37 | -148.68, 147.6 | -137.42, 20.4 | 309.85, 104.45 | -57.76, -38.41 | in-in | in | 6.5214 | Saltbr-in | 2.7297 | HRD-in | -82.35, -54.44 | 77.13, -1.28 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8314 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -121.88, 1.77 | APE9-dihe-na | -80.07, -153.46 | APE8-dihe-in | -102.62, 129.14 | APE8-rot-in | 288.61 | APE67-dihe-in | -59.7, -42.15 | -59.82, -42.6 | APE12-dist-in | 11.462 | APE11-dist-in | 10.2001 | APE10-dist-in | 6.8104 | APE9-dist-in | 4.6242 | None | None | None | XRAY | 1.6 | 0.179 | 0.205 | A | 300.0 | 294.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 7q8y | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | 7Q8YB | Q6IQ55 | 7 | 299 | 1244.0 | 9IV:303 | Type1 | Inactive | DFGin | 4.9351 | 12.9188 | ABAminus | -102.2, -23.11 | -149.17, 143.47 | -132.06, 19.74 | 312.12, 105.76 | -58.08, -34.08 | in-in | in | 6.5484 | Saltbr-in | 2.7075 | HRD-in | -76.93, -54.19 | 72.75, -0.27 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8566 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -120.41, 123.98 | APE9-dihe-na | 120.86, -146.42 | APE8-dihe-in | -111.89, 127.5 | APE8-rot-in | 302.95 | APE67-dihe-in | -58.34, -39.15 | -55.33, -42.36 | APE12-dist-in | 11.6684 | APE11-dist-in | 11.7396 | APE10-dist-in | 6.2067 | APE9-dist-in | 3.8124 | None | None | None | XRAY | 1.6 | 0.179 | 0.205 | B | 300.0 | 293.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 7q8y | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | 7Q8ZA | Q6IQ55 | 6 | 299 | 1244.0 | 9IK:303 | Type1 | Inactive | DFGin | 5.0166 | 12.7763 | ABAminus | -98.76, -21.03 | -150.04, 145.16 | -135.5, 21.52 | 309.75, 104.66 | -59.56, -34.42 | in-in | in | 6.5861 | Saltbr-in | 2.7589 | HRD-in | -78.99, -56.14 | 77.24, 1.29 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8828 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -124.67, 8.93 | APE9-dihe-na | -81.86, -158.53 | APE8-dihe-in | -100.31, 128.17 | APE8-rot-in | 295.73 | APE67-dihe-in | -59.12, -42.17 | -58.09, -41.46 | APE12-dist-in | 11.4705 | APE11-dist-in | 10.2859 | APE10-dist-in | 6.8411 | APE9-dist-in | 4.4846 | None | None | None | XRAY | 1.57 | 0.176 | 0.203 | A | 300.0 | 294.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 7q8z | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | 7Q8ZB | Q6IQ55 | 7 | 299 | 1244.0 | 9IK:303 | Type1 | Inactive | DFGin | 4.9485 | 12.9219 | ABAminus | -101.07, -22.21 | -149.46, 144.85 | -134.26, 19.31 | 310.97, 106.06 | -61.4, -28.74 | in-in | in | 6.5872 | Saltbr-in | 2.7183 | HRD-in | -75.6, -54.93 | 71.67, 2.23 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8459 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -126.36, 125.66 | APE9-dihe-na | 117.9, -151.49 | APE8-dihe-in | -109.06, 129.51 | APE8-rot-in | 301.71 | APE67-dihe-in | -55.77, -40.74 | -55.26, -43.3 | APE12-dist-in | 11.4504 | APE11-dist-in | 11.7694 | APE10-dist-in | 6.316 | APE9-dist-in | 3.7334 | None | None | None | XRAY | 1.57 | 0.176 | 0.203 | B | 300.0 | 293.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 7q8z | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | 7Q90A | Q6IQ55 | 6 | 299 | 1244.0 | 9IS:302 | Type1 | Inactive | DFGin | 5.0476 | 12.7511 | ABAminus | -97.24, -21.72 | -147.14, 147.68 | -136.45, 16.85 | 308.85, 104.12 | -53.18, -39.52 | in-in | in | 6.5794 | Saltbr-in | 2.7943 | HRD-in | -78.08, -58.13 | 80.17, -0.76 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8458 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -124.4, 5.96 | APE9-dihe-na | -81.49, -157.52 | APE8-dihe-in | -99.56, 129.15 | APE8-rot-in | 282.09 | APE67-dihe-in | -59.83, -39.28 | -57.37, -43.18 | APE12-dist-in | 11.4186 | APE11-dist-in | 10.1819 | APE10-dist-in | 6.7996 | APE9-dist-in | 4.6086 | None | None | None | XRAY | 1.6 | 0.192 | 0.22 | A | 300.0 | 294.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 7q90 | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | 7Q90B | Q6IQ55 | 7 | 299 | 1244.0 | 9IS:302 | Type1 | Inactive | DFGin | 5.0146 | 12.9833 | ABAminus | -101.47, -22.02 | -149.29, 145.34 | -134.77, 21.17 | 309.91, 106.63 | -62.42, -29.38 | in-in | in | 6.5426 | Saltbr-in | 2.7571 | HRD-in | -77.26, -55.62 | 73.81, 1.12 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8558 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -125.92, 125.26 | APE9-dihe-na | 115.84, -153.34 | APE8-dihe-in | -112.74, 125.56 | APE8-rot-in | 299.92 | APE67-dihe-in | -56.42, -39.7 | -53.02, -45.29 | APE12-dist-in | 11.1578 | APE11-dist-in | 11.7734 | APE10-dist-in | 6.2872 | APE9-dist-in | 3.7154 | None | None | None | XRAY | 1.6 | 0.192 | 0.22 | B | 300.0 | 293.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 7q90 | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TTBK2 | TTBK2_HUMAN | 6VRFA | Q6IQ55 | 9 | 298 | 1244.0 | ADP:301 | ATPlike | Active | DFGin | 5.3543 | 13.1161 | BLAminus | -121.29, 164.21 | 73.75, 82.24 | -97.72, 13.38 | 304.67, 116.94 | -64.06, -29.66 | in-in | in | 7.2137 | Saltbr-in | 2.7506 | HRD-in | -77.1, -49.95 | 73.69, -4.56 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8129 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -108.12, -30.06 | APE9-dihe-na | -84.65, -146.34 | APE8-dihe-in | -107.58, 129.44 | APE8-rot-in | 302.21 | APE67-dihe-in | -59.13, -37.2 | -56.28, -42.66 | APE12-dist-in | 11.1967 | APE11-dist-in | 11.3871 | APE10-dist-in | 5.4802 | APE9-dist-in | 3.7845 | None | None | None | XRAY | 1.5 | 0.175 | 0.209 | A | 299.0 | 287.0 | 3 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 6vrf | Homo sapiens | CK1_TTBK2_HUMAN | CK1 | 7.7e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | TTBK2_HUMAN | 6VRFB | Q6IQ55 | 9 | 298 | 1244.0 | ADP:301 | ATPlike | Active | DFGin | 5.4311 | 12.6951 | BLAminus | -121.38, 163.64 | 74.07, 85.5 | -102.64, 12.86 | 306.76, 116.33 | -62.94, -32.7 | in-in | in | 7.3455 | Saltbr-in | 2.8906 | HRD-in | -78.31, -51.54 | 73.55, 1.77 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8595 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -109.78, -23.36 | APE9-dihe-na | -86.88, -149.11 | APE8-dihe-in | -108.63, 128.02 | APE8-rot-in | 302.45 | APE67-dihe-in | -58.2, -36.14 | -56.96, -43.7 | APE12-dist-in | 11.0394 | APE11-dist-in | 11.2442 | APE10-dist-in | 5.3369 | APE9-dist-in | 3.7117 | None | None | None | XRAY | 1.5 | 0.175 | 0.209 | B | 299.0 | 287.0 | 3 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 6vrf | Homo sapiens | CK1_TTBK2_HUMAN | CK1 | 7.7e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | TTBK2_HUMAN | AF-Q6IQ55-K1A | Q6IQ55 | 13 | 290 | 1244.0 | No_ligand | No_ligand | Active | DFGin | 5.4204 | 13.057 | BLAminus | -125.34, 163.32 | 59.02, 82.97 | -85.83, 13.23 | 304.62, 110.5 | -62.64, -23.0 | in-in | in | 7.6596 | Saltbr-in | 2.6707 | HRD-in | -77.58, -46.09 | 62.6, 11.7 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8303 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -135.55, 150.46 | APE9-dihe-na | 95.71, -169.2 | APE8-dihe-in | -93.93, 122.69 | APE8-rot-in | 298.0 | APE67-dihe-in | -60.18, -42.44 | -42.07, -42.28 | APE12-dist-in | 12.1427 | APE11-dist-in | 11.7126 | APE10-dist-in | 6.2252 | APE9-dist-in | 3.2057 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 278.0 | 278.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | AF-Q6IQ55-K1 | Homo sapiens | CK1_TTBK2_HUMAN | CK1 | 5.9e-104 | 353.0 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | TTBK2_HUMAN | AF-Q6IQ55-K3A | Q6IQ55 | 13 | 290 | 1244.0 | No_ligand | No_ligand | Active | DFGin | 5.344 | 13.0659 | BLAminus | -130.3, 167.93 | 59.06, 68.0 | -78.49, 16.74 | 309.93, 107.31 | -64.05, -21.31 | in-in | in | 7.453 | Saltbr-in | 2.6583 | HRD-in | -79.71, -45.32 | 63.0, 13.33 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8593 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -138.81, 151.44 | APE9-dihe-na | 96.06, -173.11 | APE8-dihe-in | -91.7, 117.54 | APE8-rot-in | 296.92 | APE67-dihe-in | -60.3, -41.6 | -35.06, -45.13 | APE12-dist-in | 12.0634 | APE11-dist-in | 11.6366 | APE10-dist-in | 6.2838 | APE9-dist-in | 3.0877 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 278.0 | 278.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | AF-Q6IQ55-K3 | Homo sapiens | CK1_TTBK2_HUMAN | CK1 | 5.9e-104 | 353.0 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | TTBK2_HUMAN | 6U0KA | Q6IQ55 | 8 | 298 | 1244.0 | DTQ:302 | Type1 | Active | DFGin | 5.4455 | 13.0064 | BLAminus | -119.74, 158.68 | 65.44, 93.77 | -97.5, 16.58 | 303.39, 115.2 | -64.55, -24.48 | in-in | in | 7.3634 | Saltbr-in | 2.6861 | HRD-in | -77.31, -47.61 | 69.33, 3.91 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8535 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -119.86, 126.44 | APE9-dihe-na | 120.4, -155.7 | APE8-dihe-in | -106.9, 129.29 | APE8-rot-in | 301.05 | APE67-dihe-in | -61.62, -36.39 | -57.04, -41.68 | APE12-dist-in | 11.6476 | APE11-dist-in | 11.5741 | APE10-dist-in | 6.085 | APE9-dist-in | 3.8654 | None | None | None | XRAY | 1.744 | 0.193 | 0.233 | A | 300.0 | 290.0 | 1 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 6u0k | Homo sapiens | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | TTBK2_HUMAN | 6U0KB | Q6IQ55 | 8 | 299 | 1244.0 | DTQ:303 | Type1 | Active | DFGin | 5.539 | 12.9635 | BLAminus | -121.87, 159.25 | 66.65, 95.14 | -97.46, 15.84 | 302.12, 119.42 | -64.27, -23.46 | in-in | in | 7.473 | Saltbr-in | 2.6919 | HRD-in | -78.29, -47.84 | 69.94, 2.28 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.843 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -122.42, 128.32 | APE9-dihe-na | 118.19, -156.28 | APE8-dihe-in | -104.4, 132.63 | APE8-rot-in | 299.38 | APE67-dihe-in | -60.41, -36.62 | -56.84, -43.97 | APE12-dist-in | 11.7517 | APE11-dist-in | 11.6488 | APE10-dist-in | 6.2643 | APE9-dist-in | 3.7387 | None | None | None | XRAY | 1.744 | 0.193 | 0.233 | B | 300.0 | 292.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 6u0k | Homo sapiens | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | TTBK2_HUMAN | 7Q8YA | Q6IQ55 | 6 | 299 | 1244.0 | 9IV:303 | Type1 | Inactive | DFGin | 5.001 | 12.7358 | ABAminus | -96.43, -23.37 | -148.68, 147.6 | -137.42, 20.4 | 309.85, 104.45 | -57.76, -38.41 | in-in | in | 6.5214 | Saltbr-in | 2.7297 | HRD-in | -82.35, -54.44 | 77.13, -1.28 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8314 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -121.88, 1.77 | APE9-dihe-na | -80.07, -153.46 | APE8-dihe-in | -102.62, 129.14 | APE8-rot-in | 288.61 | APE67-dihe-in | -59.7, -42.15 | -59.82, -42.6 | APE12-dist-in | 11.462 | APE11-dist-in | 10.2001 | APE10-dist-in | 6.8104 | APE9-dist-in | 4.6242 | None | None | None | XRAY | 1.6 | 0.179 | 0.205 | A | 300.0 | 294.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 7q8y | Homo sapiens | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | TTBK2_HUMAN | 7Q8YB | Q6IQ55 | 7 | 299 | 1244.0 | 9IV:303 | Type1 | Inactive | DFGin | 4.9351 | 12.9188 | ABAminus | -102.2, -23.11 | -149.17, 143.47 | -132.06, 19.74 | 312.12, 105.76 | -58.08, -34.08 | in-in | in | 6.5484 | Saltbr-in | 2.7075 | HRD-in | -76.93, -54.19 | 72.75, -0.27 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8566 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -120.41, 123.98 | APE9-dihe-na | 120.86, -146.42 | APE8-dihe-in | -111.89, 127.5 | APE8-rot-in | 302.95 | APE67-dihe-in | -58.34, -39.15 | -55.33, -42.36 | APE12-dist-in | 11.6684 | APE11-dist-in | 11.7396 | APE10-dist-in | 6.2067 | APE9-dist-in | 3.8124 | None | None | None | XRAY | 1.6 | 0.179 | 0.205 | B | 300.0 | 293.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 7q8y | Homo sapiens | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | TTBK2_HUMAN | 7Q8ZA | Q6IQ55 | 6 | 299 | 1244.0 | 9IK:303 | Type1 | Inactive | DFGin | 5.0166 | 12.7763 | ABAminus | -98.76, -21.03 | -150.04, 145.16 | -135.5, 21.52 | 309.75, 104.66 | -59.56, -34.42 | in-in | in | 6.5861 | Saltbr-in | 2.7589 | HRD-in | -78.99, -56.14 | 77.24, 1.29 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8828 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -124.67, 8.93 | APE9-dihe-na | -81.86, -158.53 | APE8-dihe-in | -100.31, 128.17 | APE8-rot-in | 295.73 | APE67-dihe-in | -59.12, -42.17 | -58.09, -41.46 | APE12-dist-in | 11.4705 | APE11-dist-in | 10.2859 | APE10-dist-in | 6.8411 | APE9-dist-in | 4.4846 | None | None | None | XRAY | 1.57 | 0.176 | 0.203 | A | 300.0 | 294.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 7q8z | Homo sapiens | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | TTBK2_HUMAN | 7Q8ZB | Q6IQ55 | 7 | 299 | 1244.0 | 9IK:303 | Type1 | Inactive | DFGin | 4.9485 | 12.9219 | ABAminus | -101.07, -22.21 | -149.46, 144.85 | -134.26, 19.31 | 310.97, 106.06 | -61.4, -28.74 | in-in | in | 6.5872 | Saltbr-in | 2.7183 | HRD-in | -75.6, -54.93 | 71.67, 2.23 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8459 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -126.36, 125.66 | APE9-dihe-na | 117.9, -151.49 | APE8-dihe-in | -109.06, 129.51 | APE8-rot-in | 301.71 | APE67-dihe-in | -55.77, -40.74 | -55.26, -43.3 | APE12-dist-in | 11.4504 | APE11-dist-in | 11.7694 | APE10-dist-in | 6.316 | APE9-dist-in | 3.7334 | None | None | None | XRAY | 1.57 | 0.176 | 0.203 | B | 300.0 | 293.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 7q8z | Homo sapiens | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | TTBK2_HUMAN | 7Q90A | Q6IQ55 | 6 | 299 | 1244.0 | 9IS:302 | Type1 | Inactive | DFGin | 5.0476 | 12.7511 | ABAminus | -97.24, -21.72 | -147.14, 147.68 | -136.45, 16.85 | 308.85, 104.12 | -53.18, -39.52 | in-in | in | 6.5794 | Saltbr-in | 2.7943 | HRD-in | -78.08, -58.13 | 80.17, -0.76 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8458 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -124.4, 5.96 | APE9-dihe-na | -81.49, -157.52 | APE8-dihe-in | -99.56, 129.15 | APE8-rot-in | 282.09 | APE67-dihe-in | -59.83, -39.28 | -57.37, -43.18 | APE12-dist-in | 11.4186 | APE11-dist-in | 10.1819 | APE10-dist-in | 6.7996 | APE9-dist-in | 4.6086 | None | None | None | XRAY | 1.6 | 0.192 | 0.22 | A | 300.0 | 294.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 7q90 | Homo sapiens | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| TTBK2 | TTBK2_HUMAN | 7Q90B | Q6IQ55 | 7 | 299 | 1244.0 | 9IS:302 | Type1 | Inactive | DFGin | 5.0146 | 12.9833 | ABAminus | -101.47, -22.02 | -149.29, 145.34 | -134.77, 21.17 | 309.91, 106.63 | -62.42, -29.38 | in-in | in | 6.5426 | Saltbr-in | 2.7571 | HRD-in | -77.26, -55.62 | 73.81, 1.12 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8558 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -125.92, 125.26 | APE9-dihe-na | 115.84, -153.34 | APE8-dihe-in | -112.74, 125.56 | APE8-rot-in | 299.92 | APE67-dihe-in | -56.42, -39.7 | -53.02, -45.29 | APE12-dist-in | 11.1578 | APE11-dist-in | 11.7734 | APE10-dist-in | 6.2872 | APE9-dist-in | 3.7154 | None | None | None | XRAY | 1.6 | 0.192 | 0.22 | B | 300.0 | 293.0 | 0 | 34 | 34 | 0 | [[21, 282]] | 1.0 | 7q90 | Homo sapiens | CK1_TTBK2_HUMAN | CK1 | 7.8e-104 | 352.6 | 1.0 | 262.0 | 262.0 | 162 | 163 | 164 | 166 | 168 | 50 | 64 | 68 | 138 | 140 | 139 | 141.0 | 208 | 196 | 191 | 190 | 189 | 188 | 187 | 186 | 185 | 95 | Tau-tubulin kinase 2 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|