CK1_TTBK1 (Tau-tubulin kinase 1)

Total number of chains: 22
Active chains: 11
Uniprot: TTBK1_HUMAN
Kinase Domain Residues: 34 - 295
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 15 68.2% AF-Q5TCY1-K1A
DFGin ABAminus 7 31.8% 7Q8WA

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TTBK1 4BTJA Q5TCY1 21 312 1321.0 ADP:61337 ATPlike Active DFGin 5.5128 12.6986 BLAminus -122.16, 167.53 65.74, 92.18 -107.62, 12.94 309.85, 113.04 -64.35, -28.29 in-in in 7.1274 Saltbr-in 2.7571 HRD-in -79.44, -52.71 73.3, -5.89 in-in-in SNCiii in-in ActLoopNT-in 2.8215 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.78, 143.11 APE9-dihe-na 98.14, -168.76 APE8-dihe-in -84.14, 153.12 APE8-rot-in 322.08 APE67-dihe-in -60.57, -38.77 -75.21, -43.81 APE12-dist-in 11.388 APE11-dist-in 11.4495 APE10-dist-in 5.9453 APE9-dist-in 3.4123 None None None XRAY 2.16 0.179 0.197 A 337.0 292.0 0 34 34 0 [[34, 295]] 1.0 4btj CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 4BTJB Q5TCY1 21 313 1321.0 ATP:61338 ATPlike Active DFGin 5.3516 12.7176 BLAminus -122.53, 168.88 60.17, 88.3 -98.51, 13.52 307.1, 115.33 -64.8, -32.06 in-in in 7.1484 Saltbr-in 2.816 HRD-in -78.94, -51.75 72.7, -0.47 in-in-in SNCiii in-in ActLoopNT-in 2.7477 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.82, -14.94 APE9-dihe-na -62.51, -161.18 APE8-dihe-in -100.71, 125.28 APE8-rot-in 309.68 APE67-dihe-in -55.66, -43.07 -52.23, -50.62 APE12-dist-in 11.0775 APE11-dist-in 10.8163 APE10-dist-in 6.4629 APE9-dist-in 4.3282 None None None XRAY 2.16 0.179 0.197 B 337.0 293.0 0 34 34 0 [[34, 295]] 1.0 4btj CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 AF-Q5TCY1-K1A Q5TCY1 26 303 1321.0 No_ligand No_ligand Active DFGin 5.3367 13.0382 BLAminus -126.4, 165.52 59.38, 78.34 -86.96, 17.26 311.46, 102.59 -63.46, -23.27 in-in in 7.6722 Saltbr-in 2.6726 HRD-in -79.49, -46.56 61.9, 10.94 in-in-in SNCiii in-in ActLoopNT-in 2.8223 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.43, 149.14 APE9-dihe-na 93.61, -174.61 APE8-dihe-in -89.85, 120.07 APE8-rot-in 296.05 APE67-dihe-in -60.5, -43.77 -41.09, -42.27 APE12-dist-in 12.1531 APE11-dist-in 11.8418 APE10-dist-in 6.5104 APE9-dist-in 3.0896 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 34 34 0 [[34, 295]] 1.0 AF-Q5TCY1-K1 CK1_TTBK1_HUMAN CK1 2.8e-105 357.3 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 AF-Q5TCY1-K3A Q5TCY1 26 303 1321.0 No_ligand No_ligand Active DFGin 5.0755 12.9035 BLAminus -132.81, 166.07 61.77, 68.33 -79.51, 17.77 316.45, 102.96 -62.44, -21.38 in-in in 7.5185 Saltbr-in 2.7228 HRD-in -78.83, -45.46 63.42, 14.03 in-in-in SNCiii in-in ActLoopNT-in 2.8772 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.42, 153.33 APE9-dihe-na 93.05, -168.25 APE8-dihe-in -99.73, 121.23 APE8-rot-in 296.03 APE67-dihe-in -59.72, -40.23 -36.34, -46.02 APE12-dist-in 11.9582 APE11-dist-in 11.6035 APE10-dist-in 6.3514 APE9-dist-in 3.0954 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 34 34 0 [[34, 295]] 1.0 AF-Q5TCY1-K3 CK1_TTBK1_HUMAN CK1 2.8e-105 357.3 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 4NFNA Q5TCY1 22 314 1321.0 2KC:401 Type1 Active DFGin 5.0902 13.2283 BLAminus -120.26, 155.4 74.79, 104.42 -104.96, 15.96 305.81, 130.33 -59.64, -28.41 in-in in 7.5992 Saltbr-in 2.9018 HRD-in -77.67, -51.81 76.49, -0.88 in-in-in SNCiii in-in ActLoopNT-in 2.8616 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.64, -24.29 APE9-dihe-na -71.51, 172.8 APE8-dihe-in -63.21, 134.36 APE8-rot-in 305.32 APE67-dihe-in -56.49, -37.98 -57.6, -43.65 APE12-dist-in 12.173 APE11-dist-in 10.8073 APE10-dist-in 5.8075 APE9-dist-in 3.5935 None None None XRAY 1.42 0.186 0.209 A 309.0 293.0 0 34 34 0 [[34, 295]] 1.0 4nfn CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 7ZHNA Q5TCY1 21 313 1321.0 VP7:408 Type1.5_Back Active DFGin 5.0249 12.8876 BLAminus -116.11, 166.82 62.56, 88.08 -91.08, 16.97 304.5, 148.28 -62.34, -27.17 in-in in 7.555 Saltbr-in 3.1247 HRD-in -74.6, -52.17 71.85, -1.49 in-in-in SNCiii in-in ActLoopNT-in 2.8796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.98, 14.93 APE9-dihe-na -96.02, -164.08 APE8-dihe-in -81.59, 139.66 APE8-rot-in 308.88 APE67-dihe-in -55.87, -41.23 -72.9, -45.61 APE12-dist-in 11.6853 APE11-dist-in 10.7461 APE10-dist-in 7.3552 APE9-dist-in 4.7699 None None None XRAY 1.85 0.192 0.214 A 309.0 293.0 0 34 34 0 [[34, 295]] 1.0 7zhn CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 7ZHOA Q5TCY1 21 317 1321.0 IQR:406 Type1.5_Back Active DFGin 4.8493 12.8986 BLAminus -119.79, 164.61 65.52, 89.5 -96.84, 15.41 302.27, 145.06 -58.97, -25.64 in-in in 7.59 Saltbr-in 2.9223 HRD-in -71.36, -55.45 76.96, -3.55 in-in-in SNCiii in-in ActLoopNT-in 2.8345 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.46, 19.42 APE9-dihe-na -83.72, -173.22 APE8-dihe-in -73.11, 131.26 APE8-rot-in 310.73 APE67-dihe-in -62.77, -37.89 -59.17, -48.03 APE12-dist-in 11.9359 APE11-dist-in 10.7929 APE10-dist-in 7.5922 APE9-dist-in 4.4555 None None None XRAY 2.08 0.199 0.258 A 309.0 297.0 0 34 34 0 [[34, 295]] 1.0 7zho CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 7ZHPA Q5TCY1 21 313 1321.0 IQY:408 Type1.5_Back Active DFGin 5.0703 12.9058 BLAminus -121.58, 161.86 64.77, 88.82 -90.91, 14.99 305.45, 149.37 -56.17, -32.14 in-in in 7.6055 Saltbr-in 3.091 HRD-in -74.4, -53.84 72.83, 0.5 in-in-in SNCiii in-in ActLoopNT-in 2.9238 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.84, 15.43 APE9-dihe-na -95.79, -166.47 APE8-dihe-in -79.16, 140.05 APE8-rot-in 308.62 APE67-dihe-in -58.4, -37.71 -70.96, -47.53 APE12-dist-in 11.6935 APE11-dist-in 10.6532 APE10-dist-in 7.3164 APE9-dist-in 4.8131 None None None XRAY 1.8 0.179 0.218 A 309.0 293.0 0 34 34 0 [[34, 295]] 1.0 7zhp CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 7ZHQA Q5TCY1 21 313 1321.0 IRD:411 Type1.5_Back Active DFGin 5.0231 12.9381 BLAminus -118.09, 163.41 62.35, 86.51 -86.61, 16.6 306.9, 150.38 -62.4, -25.46 in-in in 7.5444 Saltbr-in 3.1074 HRD-in -73.02, -53.46 71.73, 2.6 in-in-in SNCiii in-in ActLoopNT-in 2.8473 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.49, 13.74 APE9-dihe-na -92.06, -167.02 APE8-dihe-in -78.75, 141.63 APE8-rot-in 309.76 APE67-dihe-in -59.65, -39.41 -71.9, -46.23 APE12-dist-in 11.7452 APE11-dist-in 10.6976 APE10-dist-in 7.4647 APE9-dist-in 4.7941 None None None XRAY 1.8 0.176 0.212 A 309.0 293.0 0 34 34 0 [[34, 295]] 1.0 7zhq CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 7JXXA Q5TCY1 22 312 1321.0 VP7:401 Type1.5_Back Active DFGin 4.9875 13.1515 BLAminus -120.2, 166.56 63.95, 77.7 -83.36, 17.51 304.81, 143.19 -64.15, -23.18 in-in in 7.7984 Saltbr-in 2.8995 HRD-in -78.09, -49.62 70.95, -0.29 in-in-in SNCiii in-in ActLoopNT-in 2.8619 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.39, 4.01 APE9-dihe-na -81.86, -153.93 APE8-dihe-in -94.75, 127.55 APE8-rot-in 306.03 APE67-dihe-in -57.22, -40.76 -61.4, -44.59 APE12-dist-in 11.8025 APE11-dist-in 11.1538 APE10-dist-in 7.0567 APE9-dist-in 4.1626 None None None XRAY 1.56 0.181 0.213 A 332.0 288.0 3 34 32 2 [[34, 295]] 1.0 7jxx CK1_TTBK1_HUMAN CK1 5.4e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 7JXYA Q5TCY1 23 312 1321.0 VSY:401 Type1.5_Back Active DFGin 5.1883 12.9724 BLAminus -126.15, 162.08 61.71, 73.13 -79.38, 19.02 306.92, 132.15 -66.41, -25.75 in-in in 7.5008 Saltbr-in 2.5773 HRD-in -78.39, -56.83 75.59, -1.64 in-in-in SNCiii in-in ActLoopNT-in 2.7658 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.15, 19.65 APE9-dihe-na -93.03, -160.9 APE8-dihe-in -89.25, 133.96 APE8-rot-in 303.71 APE67-dihe-in -61.16, -39.65 -70.58, -37.14 APE12-dist-in 11.0932 APE11-dist-in 9.9271 APE10-dist-in 7.3391 APE9-dist-in 5.0773 None None None XRAY 2.15 0.202 0.241 A 332.0 290.0 0 34 34 0 [[34, 295]] 1.0 7jxy CK1_TTBK1_HUMAN CK1 5.4e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 8XPZA Q5TCY1 20 312 1321.0 No_ligand No_ligand Inactive DFGin 5.4903 13.2771 ABAminus -112.42, -68.42 -105.57, 117.82 -105.42, 23.49 306.05, 115.55 -74.33, -26.86 in-out in 7.232 Saltbr-out 3.8093 HRD-in -77.67, -54.89 73.75, -3.24 out-in-in SNCoii in-in ActLoopNT-in 2.7053 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.6, 66.96 APE9-dihe-na -159.3, 162.76 APE8-dihe-in -40.62, 125.89 APE8-rot-in 304.05 APE67-dihe-in -56.35, -41.24 -95.38, -15.05 APE12-dist-in 11.7793 APE11-dist-in 10.6179 APE10-dist-in 7.5994 APE9-dist-in 5.6599 None None None XRAY 2.6 0.205 0.273 A 332.0 293.0 0 34 34 0 [[34, 295]] 1.0 8xpz CK1_TTBK1_HUMAN CK1 5.4e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 7QHWAAA Q5TCY1 21 313 1321.0 CGI:60401 Type1 Inactive DFGin 4.9672 12.7097 ABAminus -105.99, -54.43 -117.69, 139.75 -124.41, 25.52 308.06, 124.91 -59.89, -33.37 in-in in 8.1297 Saltbr-in 2.9192 HRD-in -78.49, -67.3 91.25, -6.06 in-in-in SNCiii in-in ActLoopNT-in 2.6813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.68, 31.58 APE9-dihe-na -108.12, -164.86 APE8-dihe-in -85.37, 122.83 APE8-rot-in 273.99 APE67-dihe-in -67.77, -34.37 -61.3, -37.1 APE12-dist-in 11.3164 APE11-dist-in 10.7522 APE10-dist-in 7.8355 APE9-dist-in 4.9753 None None None XRAY 2.8 0.201 0.229 AAA 293.0 293.0 0 34 34 0 [[34, 295]] 1.0 7qhw CK1_TTBK1_HUMAN CK1 3.5e-105 357.0 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 7QHWCCC Q5TCY1 21 312 1321.0 CGI:60401 Type1 Inactive DFGin 5.4815 13.0139 ABAminus -101.4, -48.82 -116.79, 155.75 -144.69, 18.36 300.63, 109.79 -60.79, -44.89 in-in in 6.7332 Saltbr-in 3.1821 HRD-in -74.29, -58.91 83.21, -0.97 in-in-in SNCiii in-in ActLoopNT-in 2.7881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.56, 129.37 APE9-dihe-na 111.17, -167.67 APE8-dihe-in -87.68, 143.89 APE8-rot-in 328.9 APE67-dihe-in -65.12, -36.11 -62.74, -41.31 APE12-dist-in 11.1088 APE11-dist-in 11.3475 APE10-dist-in 5.5765 APE9-dist-in 3.8299 None None None XRAY 2.8 0.201 0.229 CCC 293.0 292.0 0 34 34 0 [[34, 295]] 1.0 7qhw CK1_TTBK1_HUMAN CK1 3.5e-105 357.0 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 7Q8VA Q5TCY1 21 312 1321.0 9IV:402 Type1 Inactive DFGin 4.956 12.4872 ABAminus -96.4, -34.81 -145.41, 147.15 -136.52, 21.39 310.35, 107.49 -68.54, -19.14 in-in in 6.8994 Saltbr-in 3.2476 HRD-in -76.22, -55.35 75.88, 0.13 in-in-in SNCiii in-in ActLoopNT-in 2.9352 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.07, -12.61 APE9-dihe-na -78.61, -166.5 APE8-dihe-in -86.61, 134.33 APE8-rot-in 307.3 APE67-dihe-in -56.23, -43.38 -59.6, -46.19 APE12-dist-in 11.9662 APE11-dist-in 10.9299 APE10-dist-in 6.5071 APE9-dist-in 4.0188 None None None XRAY 2.13 0.19 0.244 A 309.0 292.0 0 34 34 0 [[34, 295]] 1.0 7q8v CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 7Q8WA Q5TCY1 21 312 1321.0 9IO:401 Type1 Inactive DFGin 4.8926 12.4703 ABAminus -98.05, -31.21 -147.77, 142.79 -130.18, 19.09 313.28, 104.57 -70.63, -19.85 in-in in 6.7563 Saltbr-in 2.6268 HRD-in -76.21, -57.9 79.45, 0.88 in-in-in SNCiii in-in ActLoopNT-in 2.9193 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.16, -14.89 APE9-dihe-na -76.14, -161.02 APE8-dihe-in -85.92, 136.48 APE8-rot-in 299.81 APE67-dihe-in -59.44, -38.28 -61.97, -43.61 APE12-dist-in 12.0205 APE11-dist-in 10.9268 APE10-dist-in 6.5402 APE9-dist-in 4.1228 None None None XRAY 2.02 0.181 0.226 A 309.0 292.0 0 34 34 0 [[34, 295]] 1.0 7q8w CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 4BTMA Q5TCY1 21 312 1321.0 F8E:61340 Type1 Inactive DFGin 5.1931 13.0872 ABAminus -87.51, -38.6 -130.1, 153.66 -137.47, 17.33 306.64, 106.71 -55.68, -37.7 in-in in 6.7527 Saltbr-in 2.8106 HRD-in -79.32, -52.34 70.89, -1.31 in-in-in SNCiii in-in ActLoopNT-in 2.7708 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.55, 138.7 APE9-dihe-na 94.4, -167.99 APE8-dihe-in -70.04, 153.15 APE8-rot-in 354.1 APE67-dihe-in -61.29, -42.31 -78.6, -39.13 APE12-dist-in 11.4729 APE11-dist-in 11.512 APE10-dist-in 5.8936 APE9-dist-in 3.5494 None None None XRAY 2.54 0.179 0.208 A 337.0 292.0 0 34 34 0 [[34, 295]] 1.0 4btm CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 4BTMB Q5TCY1 21 313 1321.0 F8E:61341 Type1 Inactive DFGin 5.2064 12.6793 ABAminus -86.02, -41.24 -128.78, 151.96 -135.53, 18.31 305.99, 109.04 -66.23, -30.03 in-in in 7.5363 Saltbr-in 2.4941 HRD-in -79.73, -53.03 71.56, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.56, 0.53 APE9-dihe-na -73.71, -164.34 APE8-dihe-in -91.45, 125.08 APE8-rot-in 300.42 APE67-dihe-in -61.86, -42.57 -52.56, -43.08 APE12-dist-in 11.3884 APE11-dist-in 10.7961 APE10-dist-in 7.2357 APE9-dist-in 4.2859 None None None XRAY 2.54 0.179 0.208 B 337.0 293.0 0 34 34 0 [[34, 295]] 1.0 4btm CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 9HHWA Q5TCY1 21 313 1321.0 A1IU7:401 Type1 Inactive DFGin 4.7786 12.4589 BLAminus -119.65, 161.56 63.39, 128.7 -125.69, 18.13 312.4, 104.6 -46.82, -54.2 in-out in 7.3206 Saltbr-out 4.4935 HRD-in -79.43, -43.59 68.09, -25.52 out-in-in SNCoii in-in ActLoopNT-in 2.9307 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.65, 45.07 APE9-dihe-na -140.16, -146.04 APE8-dihe-in -106.43, 129.3 APE8-rot-in 286.78 APE67-dihe-in -50.95, -32.2 -69.05, -48.52 APE12-dist-in 11.904 APE11-dist-in 10.9615 APE10-dist-in 6.9142 APE9-dist-in 5.404 None None None XRAY 3.0 0.234 0.286 A 309.0 293.0 0 34 34 0 [[34, 295]] 1.0 9hhw CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 4BTKA Q5TCY1 22 311 1321.0 DTQ:61337 Type1.5_Back Inactive DFGin 5.4717 12.8127 BLAminus -121.56, 166.57 53.63, 97.12 -99.35, 18.48 304.76, 110.89 -59.84, -26.48 in-in in 7.207 Saltbr-in 2.7729 HRD-in -77.94, -50.73 70.91, -2.54 in-in-out SNCiio in-out ActLoopNT-in 2.8487 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -104.79, -26.19 APE9-dihe-na -66.74, -163.96 APE8-dihe-in -90.09, 140.06 APE8-rot-out 123.33 APE67-dihe-in -50.85, -41.59 -63.33, -48.74 APE12-dist-in 11.8309 APE11-dist-in 10.5368 APE10-dist-in 6.3834 APE9-dist-in 4.5617 None None None XRAY 2.0 0.192 0.249 A 337.0 287.0 3 34 34 0 [[34, 295]] 1.0 4btk CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 4NFMA Q5TCY1 22 314 1321.0 No_ligand No_ligand None DFGin 5.273 12.877 BLAminus -120.48, 172.2 50.57, 99.12 -99.16, 15.76 304.55, 118.22 -58.69, -37.53 in-none in 7.2904 Saltbr-none 999.0 HRD-in -72.88, -53.79 71.04, -1.8 none-in-in SNCnii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.78, 8.91 APE9-dihe-na -84.35, -161.43 APE8-dihe-in -79.51, 135.82 APE8-rot-in 299.35 APE67-dihe-in -48.61, -43.6 -70.15, -45.53 APE12-dist-in 11.8007 APE11-dist-in 10.6625 APE10-dist-in 7.491 APE9-dist-in 4.743 None None None XRAY 2.12 0.206 0.241 A 332.0 293.0 0 34 34 0 [[34, 295]] 1.0 4nfm CK1_TTBK1_HUMAN CK1 5.4e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 7JXYB Q5TCY1 20 312 1321.0 VSY:401 Type1.5_Back None DFGin 5.0369 12.8206 BLAminus -128.48, 167.02 61.02, 73.97 -81.31, 25.0 308.05, 139.51 -71.44, -25.56 in-in in 7.5178 Saltbr-in 2.808 HRD-in -80.36, -54.74 76.29, -0.77 in-in-none SNCiin in-none ActLoopNT-in 2.7253 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_iini APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -77.25 APE8-dihe-in -84.51, 130.82 APE8-rot-in 316.52 APE67-dihe-in -60.95, -38.13 -60.87, -44.59 APE12-dist-in 11.6274 APE11-dist-in 11.1786 APE10-dist-none 999.0 APE9-dist-in 4.2281 None None None XRAY 2.15 0.202 0.241 B 332.0 288.0 5 34 29 5 [[34, 295]] 1.0 7jxy CK1_TTBK1_HUMAN CK1 5.4e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1

CK1_TTBK1 (Tau-tubulin kinase 1)

Total number of chains: 22
Active chains: 11
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 15 68.2% AF-Q5TCY1-K1A
DFGin ABAminus 7 31.8% 7Q8WA

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TTBK1 TTBK1_HUMAN 4BTJA Q5TCY1 21 312 1321.0 ADP:61337 ATPlike Active DFGin 5.5128 12.6986 BLAminus -122.16, 167.53 65.74, 92.18 -107.62, 12.94 309.85, 113.04 -64.35, -28.29 in-in in 7.1274 Saltbr-in 2.7571 HRD-in -79.44, -52.71 73.3, -5.89 in-in-in SNCiii in-in ActLoopNT-in 2.8215 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.78, 143.11 APE9-dihe-na 98.14, -168.76 APE8-dihe-in -84.14, 153.12 APE8-rot-in 322.08 APE67-dihe-in -60.57, -38.77 -75.21, -43.81 APE12-dist-in 11.388 APE11-dist-in 11.4495 APE10-dist-in 5.9453 APE9-dist-in 3.4123 None None None XRAY 2.16 0.179 0.197 A 337.0 292.0 0 34 34 0 [[34, 295]] 1.0 4btj Homo sapiens CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 4BTJB Q5TCY1 21 313 1321.0 ATP:61338 ATPlike Active DFGin 5.3516 12.7176 BLAminus -122.53, 168.88 60.17, 88.3 -98.51, 13.52 307.1, 115.33 -64.8, -32.06 in-in in 7.1484 Saltbr-in 2.816 HRD-in -78.94, -51.75 72.7, -0.47 in-in-in SNCiii in-in ActLoopNT-in 2.7477 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.82, -14.94 APE9-dihe-na -62.51, -161.18 APE8-dihe-in -100.71, 125.28 APE8-rot-in 309.68 APE67-dihe-in -55.66, -43.07 -52.23, -50.62 APE12-dist-in 11.0775 APE11-dist-in 10.8163 APE10-dist-in 6.4629 APE9-dist-in 4.3282 None None None XRAY 2.16 0.179 0.197 B 337.0 293.0 0 34 34 0 [[34, 295]] 1.0 4btj Homo sapiens CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN AF-Q5TCY1-K1A Q5TCY1 26 303 1321.0 No_ligand No_ligand Active DFGin 5.3367 13.0382 BLAminus -126.4, 165.52 59.38, 78.34 -86.96, 17.26 311.46, 102.59 -63.46, -23.27 in-in in 7.6722 Saltbr-in 2.6726 HRD-in -79.49, -46.56 61.9, 10.94 in-in-in SNCiii in-in ActLoopNT-in 2.8223 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.43, 149.14 APE9-dihe-na 93.61, -174.61 APE8-dihe-in -89.85, 120.07 APE8-rot-in 296.05 APE67-dihe-in -60.5, -43.77 -41.09, -42.27 APE12-dist-in 12.1531 APE11-dist-in 11.8418 APE10-dist-in 6.5104 APE9-dist-in 3.0896 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 34 34 0 [[34, 295]] 1.0 AF-Q5TCY1-K1 Homo sapiens CK1_TTBK1_HUMAN CK1 2.8e-105 357.3 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN AF-Q5TCY1-K3A Q5TCY1 26 303 1321.0 No_ligand No_ligand Active DFGin 5.0755 12.9035 BLAminus -132.81, 166.07 61.77, 68.33 -79.51, 17.77 316.45, 102.96 -62.44, -21.38 in-in in 7.5185 Saltbr-in 2.7228 HRD-in -78.83, -45.46 63.42, 14.03 in-in-in SNCiii in-in ActLoopNT-in 2.8772 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.42, 153.33 APE9-dihe-na 93.05, -168.25 APE8-dihe-in -99.73, 121.23 APE8-rot-in 296.03 APE67-dihe-in -59.72, -40.23 -36.34, -46.02 APE12-dist-in 11.9582 APE11-dist-in 11.6035 APE10-dist-in 6.3514 APE9-dist-in 3.0954 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 34 34 0 [[34, 295]] 1.0 AF-Q5TCY1-K3 Homo sapiens CK1_TTBK1_HUMAN CK1 2.8e-105 357.3 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 4NFNA Q5TCY1 22 314 1321.0 2KC:401 Type1 Active DFGin 5.0902 13.2283 BLAminus -120.26, 155.4 74.79, 104.42 -104.96, 15.96 305.81, 130.33 -59.64, -28.41 in-in in 7.5992 Saltbr-in 2.9018 HRD-in -77.67, -51.81 76.49, -0.88 in-in-in SNCiii in-in ActLoopNT-in 2.8616 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.64, -24.29 APE9-dihe-na -71.51, 172.8 APE8-dihe-in -63.21, 134.36 APE8-rot-in 305.32 APE67-dihe-in -56.49, -37.98 -57.6, -43.65 APE12-dist-in 12.173 APE11-dist-in 10.8073 APE10-dist-in 5.8075 APE9-dist-in 3.5935 None None None XRAY 1.42 0.186 0.209 A 309.0 293.0 0 34 34 0 [[34, 295]] 1.0 4nfn Homo sapiens CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 7ZHNA Q5TCY1 21 313 1321.0 VP7:408 Type1.5_Back Active DFGin 5.0249 12.8876 BLAminus -116.11, 166.82 62.56, 88.08 -91.08, 16.97 304.5, 148.28 -62.34, -27.17 in-in in 7.555 Saltbr-in 3.1247 HRD-in -74.6, -52.17 71.85, -1.49 in-in-in SNCiii in-in ActLoopNT-in 2.8796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.98, 14.93 APE9-dihe-na -96.02, -164.08 APE8-dihe-in -81.59, 139.66 APE8-rot-in 308.88 APE67-dihe-in -55.87, -41.23 -72.9, -45.61 APE12-dist-in 11.6853 APE11-dist-in 10.7461 APE10-dist-in 7.3552 APE9-dist-in 4.7699 None None None XRAY 1.85 0.192 0.214 A 309.0 293.0 0 34 34 0 [[34, 295]] 1.0 7zhn Homo sapiens CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 7ZHOA Q5TCY1 21 317 1321.0 IQR:406 Type1.5_Back Active DFGin 4.8493 12.8986 BLAminus -119.79, 164.61 65.52, 89.5 -96.84, 15.41 302.27, 145.06 -58.97, -25.64 in-in in 7.59 Saltbr-in 2.9223 HRD-in -71.36, -55.45 76.96, -3.55 in-in-in SNCiii in-in ActLoopNT-in 2.8345 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.46, 19.42 APE9-dihe-na -83.72, -173.22 APE8-dihe-in -73.11, 131.26 APE8-rot-in 310.73 APE67-dihe-in -62.77, -37.89 -59.17, -48.03 APE12-dist-in 11.9359 APE11-dist-in 10.7929 APE10-dist-in 7.5922 APE9-dist-in 4.4555 None None None XRAY 2.08 0.199 0.258 A 309.0 297.0 0 34 34 0 [[34, 295]] 1.0 7zho Homo sapiens CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 7ZHPA Q5TCY1 21 313 1321.0 IQY:408 Type1.5_Back Active DFGin 5.0703 12.9058 BLAminus -121.58, 161.86 64.77, 88.82 -90.91, 14.99 305.45, 149.37 -56.17, -32.14 in-in in 7.6055 Saltbr-in 3.091 HRD-in -74.4, -53.84 72.83, 0.5 in-in-in SNCiii in-in ActLoopNT-in 2.9238 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.84, 15.43 APE9-dihe-na -95.79, -166.47 APE8-dihe-in -79.16, 140.05 APE8-rot-in 308.62 APE67-dihe-in -58.4, -37.71 -70.96, -47.53 APE12-dist-in 11.6935 APE11-dist-in 10.6532 APE10-dist-in 7.3164 APE9-dist-in 4.8131 None None None XRAY 1.8 0.179 0.218 A 309.0 293.0 0 34 34 0 [[34, 295]] 1.0 7zhp Homo sapiens CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 7ZHQA Q5TCY1 21 313 1321.0 IRD:411 Type1.5_Back Active DFGin 5.0231 12.9381 BLAminus -118.09, 163.41 62.35, 86.51 -86.61, 16.6 306.9, 150.38 -62.4, -25.46 in-in in 7.5444 Saltbr-in 3.1074 HRD-in -73.02, -53.46 71.73, 2.6 in-in-in SNCiii in-in ActLoopNT-in 2.8473 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.49, 13.74 APE9-dihe-na -92.06, -167.02 APE8-dihe-in -78.75, 141.63 APE8-rot-in 309.76 APE67-dihe-in -59.65, -39.41 -71.9, -46.23 APE12-dist-in 11.7452 APE11-dist-in 10.6976 APE10-dist-in 7.4647 APE9-dist-in 4.7941 None None None XRAY 1.8 0.176 0.212 A 309.0 293.0 0 34 34 0 [[34, 295]] 1.0 7zhq Homo sapiens CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 7JXXA Q5TCY1 22 312 1321.0 VP7:401 Type1.5_Back Active DFGin 4.9875 13.1515 BLAminus -120.2, 166.56 63.95, 77.7 -83.36, 17.51 304.81, 143.19 -64.15, -23.18 in-in in 7.7984 Saltbr-in 2.8995 HRD-in -78.09, -49.62 70.95, -0.29 in-in-in SNCiii in-in ActLoopNT-in 2.8619 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.39, 4.01 APE9-dihe-na -81.86, -153.93 APE8-dihe-in -94.75, 127.55 APE8-rot-in 306.03 APE67-dihe-in -57.22, -40.76 -61.4, -44.59 APE12-dist-in 11.8025 APE11-dist-in 11.1538 APE10-dist-in 7.0567 APE9-dist-in 4.1626 None None None XRAY 1.56 0.181 0.213 A 332.0 288.0 3 34 32 2 [[34, 295]] 1.0 7jxx Homo sapiens CK1_TTBK1_HUMAN CK1 5.4e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 7JXYA Q5TCY1 23 312 1321.0 VSY:401 Type1.5_Back Active DFGin 5.1883 12.9724 BLAminus -126.15, 162.08 61.71, 73.13 -79.38, 19.02 306.92, 132.15 -66.41, -25.75 in-in in 7.5008 Saltbr-in 2.5773 HRD-in -78.39, -56.83 75.59, -1.64 in-in-in SNCiii in-in ActLoopNT-in 2.7658 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.15, 19.65 APE9-dihe-na -93.03, -160.9 APE8-dihe-in -89.25, 133.96 APE8-rot-in 303.71 APE67-dihe-in -61.16, -39.65 -70.58, -37.14 APE12-dist-in 11.0932 APE11-dist-in 9.9271 APE10-dist-in 7.3391 APE9-dist-in 5.0773 None None None XRAY 2.15 0.202 0.241 A 332.0 290.0 0 34 34 0 [[34, 295]] 1.0 7jxy Homo sapiens CK1_TTBK1_HUMAN CK1 5.4e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 8XPZA Q5TCY1 20 312 1321.0 No_ligand No_ligand Inactive DFGin 5.4903 13.2771 ABAminus -112.42, -68.42 -105.57, 117.82 -105.42, 23.49 306.05, 115.55 -74.33, -26.86 in-out in 7.232 Saltbr-out 3.8093 HRD-in -77.67, -54.89 73.75, -3.24 out-in-in SNCoii in-in ActLoopNT-in 2.7053 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.6, 66.96 APE9-dihe-na -159.3, 162.76 APE8-dihe-in -40.62, 125.89 APE8-rot-in 304.05 APE67-dihe-in -56.35, -41.24 -95.38, -15.05 APE12-dist-in 11.7793 APE11-dist-in 10.6179 APE10-dist-in 7.5994 APE9-dist-in 5.6599 None None None XRAY 2.6 0.205 0.273 A 332.0 293.0 0 34 34 0 [[34, 295]] 1.0 8xpz Homo sapiens CK1_TTBK1_HUMAN CK1 5.4e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 7QHWAAA Q5TCY1 21 313 1321.0 CGI:60401 Type1 Inactive DFGin 4.9672 12.7097 ABAminus -105.99, -54.43 -117.69, 139.75 -124.41, 25.52 308.06, 124.91 -59.89, -33.37 in-in in 8.1297 Saltbr-in 2.9192 HRD-in -78.49, -67.3 91.25, -6.06 in-in-in SNCiii in-in ActLoopNT-in 2.6813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.68, 31.58 APE9-dihe-na -108.12, -164.86 APE8-dihe-in -85.37, 122.83 APE8-rot-in 273.99 APE67-dihe-in -67.77, -34.37 -61.3, -37.1 APE12-dist-in 11.3164 APE11-dist-in 10.7522 APE10-dist-in 7.8355 APE9-dist-in 4.9753 None None None XRAY 2.8 0.201 0.229 AAA 293.0 293.0 0 34 34 0 [[34, 295]] 1.0 7qhw Homo sapiens CK1_TTBK1_HUMAN CK1 3.5e-105 357.0 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 7QHWCCC Q5TCY1 21 312 1321.0 CGI:60401 Type1 Inactive DFGin 5.4815 13.0139 ABAminus -101.4, -48.82 -116.79, 155.75 -144.69, 18.36 300.63, 109.79 -60.79, -44.89 in-in in 6.7332 Saltbr-in 3.1821 HRD-in -74.29, -58.91 83.21, -0.97 in-in-in SNCiii in-in ActLoopNT-in 2.7881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.56, 129.37 APE9-dihe-na 111.17, -167.67 APE8-dihe-in -87.68, 143.89 APE8-rot-in 328.9 APE67-dihe-in -65.12, -36.11 -62.74, -41.31 APE12-dist-in 11.1088 APE11-dist-in 11.3475 APE10-dist-in 5.5765 APE9-dist-in 3.8299 None None None XRAY 2.8 0.201 0.229 CCC 293.0 292.0 0 34 34 0 [[34, 295]] 1.0 7qhw Homo sapiens CK1_TTBK1_HUMAN CK1 3.5e-105 357.0 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 7Q8VA Q5TCY1 21 312 1321.0 9IV:402 Type1 Inactive DFGin 4.956 12.4872 ABAminus -96.4, -34.81 -145.41, 147.15 -136.52, 21.39 310.35, 107.49 -68.54, -19.14 in-in in 6.8994 Saltbr-in 3.2476 HRD-in -76.22, -55.35 75.88, 0.13 in-in-in SNCiii in-in ActLoopNT-in 2.9352 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.07, -12.61 APE9-dihe-na -78.61, -166.5 APE8-dihe-in -86.61, 134.33 APE8-rot-in 307.3 APE67-dihe-in -56.23, -43.38 -59.6, -46.19 APE12-dist-in 11.9662 APE11-dist-in 10.9299 APE10-dist-in 6.5071 APE9-dist-in 4.0188 None None None XRAY 2.13 0.19 0.244 A 309.0 292.0 0 34 34 0 [[34, 295]] 1.0 7q8v Homo sapiens CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 7Q8WA Q5TCY1 21 312 1321.0 9IO:401 Type1 Inactive DFGin 4.8926 12.4703 ABAminus -98.05, -31.21 -147.77, 142.79 -130.18, 19.09 313.28, 104.57 -70.63, -19.85 in-in in 6.7563 Saltbr-in 2.6268 HRD-in -76.21, -57.9 79.45, 0.88 in-in-in SNCiii in-in ActLoopNT-in 2.9193 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.16, -14.89 APE9-dihe-na -76.14, -161.02 APE8-dihe-in -85.92, 136.48 APE8-rot-in 299.81 APE67-dihe-in -59.44, -38.28 -61.97, -43.61 APE12-dist-in 12.0205 APE11-dist-in 10.9268 APE10-dist-in 6.5402 APE9-dist-in 4.1228 None None None XRAY 2.02 0.181 0.226 A 309.0 292.0 0 34 34 0 [[34, 295]] 1.0 7q8w Homo sapiens CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 4BTMA Q5TCY1 21 312 1321.0 F8E:61340 Type1 Inactive DFGin 5.1931 13.0872 ABAminus -87.51, -38.6 -130.1, 153.66 -137.47, 17.33 306.64, 106.71 -55.68, -37.7 in-in in 6.7527 Saltbr-in 2.8106 HRD-in -79.32, -52.34 70.89, -1.31 in-in-in SNCiii in-in ActLoopNT-in 2.7708 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.55, 138.7 APE9-dihe-na 94.4, -167.99 APE8-dihe-in -70.04, 153.15 APE8-rot-in 354.1 APE67-dihe-in -61.29, -42.31 -78.6, -39.13 APE12-dist-in 11.4729 APE11-dist-in 11.512 APE10-dist-in 5.8936 APE9-dist-in 3.5494 None None None XRAY 2.54 0.179 0.208 A 337.0 292.0 0 34 34 0 [[34, 295]] 1.0 4btm Homo sapiens CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 4BTMB Q5TCY1 21 313 1321.0 F8E:61341 Type1 Inactive DFGin 5.2064 12.6793 ABAminus -86.02, -41.24 -128.78, 151.96 -135.53, 18.31 305.99, 109.04 -66.23, -30.03 in-in in 7.5363 Saltbr-in 2.4941 HRD-in -79.73, -53.03 71.56, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.56, 0.53 APE9-dihe-na -73.71, -164.34 APE8-dihe-in -91.45, 125.08 APE8-rot-in 300.42 APE67-dihe-in -61.86, -42.57 -52.56, -43.08 APE12-dist-in 11.3884 APE11-dist-in 10.7961 APE10-dist-in 7.2357 APE9-dist-in 4.2859 None None None XRAY 2.54 0.179 0.208 B 337.0 293.0 0 34 34 0 [[34, 295]] 1.0 4btm Homo sapiens CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 9HHWA Q5TCY1 21 313 1321.0 A1IU7:401 Type1 Inactive DFGin 4.7786 12.4589 BLAminus -119.65, 161.56 63.39, 128.7 -125.69, 18.13 312.4, 104.6 -46.82, -54.2 in-out in 7.3206 Saltbr-out 4.4935 HRD-in -79.43, -43.59 68.09, -25.52 out-in-in SNCoii in-in ActLoopNT-in 2.9307 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.65, 45.07 APE9-dihe-na -140.16, -146.04 APE8-dihe-in -106.43, 129.3 APE8-rot-in 286.78 APE67-dihe-in -50.95, -32.2 -69.05, -48.52 APE12-dist-in 11.904 APE11-dist-in 10.9615 APE10-dist-in 6.9142 APE9-dist-in 5.404 None None None XRAY 3.0 0.234 0.286 A 309.0 293.0 0 34 34 0 [[34, 295]] 1.0 9hhw Homo sapiens CK1_TTBK1_HUMAN CK1 4.2e-105 356.8 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 4BTKA Q5TCY1 22 311 1321.0 DTQ:61337 Type1.5_Back Inactive DFGin 5.4717 12.8127 BLAminus -121.56, 166.57 53.63, 97.12 -99.35, 18.48 304.76, 110.89 -59.84, -26.48 in-in in 7.207 Saltbr-in 2.7729 HRD-in -77.94, -50.73 70.91, -2.54 in-in-out SNCiio in-out ActLoopNT-in 2.8487 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -104.79, -26.19 APE9-dihe-na -66.74, -163.96 APE8-dihe-in -90.09, 140.06 APE8-rot-out 123.33 APE67-dihe-in -50.85, -41.59 -63.33, -48.74 APE12-dist-in 11.8309 APE11-dist-in 10.5368 APE10-dist-in 6.3834 APE9-dist-in 4.5617 None None None XRAY 2.0 0.192 0.249 A 337.0 287.0 3 34 34 0 [[34, 295]] 1.0 4btk Homo sapiens CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 4NFMA Q5TCY1 22 314 1321.0 No_ligand No_ligand None DFGin 5.273 12.877 BLAminus -120.48, 172.2 50.57, 99.12 -99.16, 15.76 304.55, 118.22 -58.69, -37.53 in-none in 7.2904 Saltbr-none 999.0 HRD-in -72.88, -53.79 71.04, -1.8 none-in-in SNCnii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.78, 8.91 APE9-dihe-na -84.35, -161.43 APE8-dihe-in -79.51, 135.82 APE8-rot-in 299.35 APE67-dihe-in -48.61, -43.6 -70.15, -45.53 APE12-dist-in 11.8007 APE11-dist-in 10.6625 APE10-dist-in 7.491 APE9-dist-in 4.743 None None None XRAY 2.12 0.206 0.241 A 332.0 293.0 0 34 34 0 [[34, 295]] 1.0 4nfm Homo sapiens CK1_TTBK1_HUMAN CK1 5.4e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
TTBK1 TTBK1_HUMAN 7JXYB Q5TCY1 20 312 1321.0 VSY:401 Type1.5_Back None DFGin 5.0369 12.8206 BLAminus -128.48, 167.02 61.02, 73.97 -81.31, 25.0 308.05, 139.51 -71.44, -25.56 in-in in 7.5178 Saltbr-in 2.808 HRD-in -80.36, -54.74 76.29, -0.77 in-in-none SNCiin in-none ActLoopNT-in 2.7253 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_iini APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -77.25 APE8-dihe-in -84.51, 130.82 APE8-rot-in 316.52 APE67-dihe-in -60.95, -38.13 -60.87, -44.59 APE12-dist-in 11.6274 APE11-dist-in 11.1786 APE10-dist-none 999.0 APE9-dist-in 4.2281 None None None XRAY 2.15 0.202 0.241 B 332.0 288.0 5 34 29 5 [[34, 295]] 1.0 7jxy Homo sapiens CK1_TTBK1_HUMAN CK1 5.4e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1

CK1_TTBK1 (Tau-tubulin kinase 1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name