OTHER_TLK2 (Serine/threonine-protein kinase tousled-like 2)

Total number of chains: 3
Active chains: 2
Uniprot: TLK2_HUMAN
Kinase Domain Residues: 462 - 741
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-Q86UE8-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TLK2 AF-Q86UE8-K1A Q86UE8 454 749 772.0 No_ligand No_ligand Active DFGin 6.1722 14.7647 BLAminus -133.44, 173.75 65.52, 77.57 -86.26, 14.3 290.35, 85.15 -60.94, -21.52 in-in in 9.646 Saltbr-in 2.968 HRD-in -67.77, -42.33 69.71, -22.37 in-in-in SNCiii in-in ActLoopNT-in 2.8564 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -87.36, 150.82 APE9-dihe-na 103.81, -179.58 APE8-dihe-in -98.64, 104.09 APE8-rot-in 310.42 APE67-dihe-in -62.26, -26.61 -57.48, -33.84 APE12-dist-in 12.5152 APE11-dist-in 11.2028 APE10-dist-in 6.511 APE9-dist-in 5.1031 None None None AF2 -1.0 1.0 1.0 A 296.0 296.0 0 35 35 0 [[462, 741]] 1.0 AF-Q86UE8-K1 OTHER_TLK2_HUMAN CAMK 8.4e-55 191.8 1.0 256.0 256.0 612 613 614 616 618 491 514 518 589 591 590 592.0 663 647 642 641 640 639 638 637 636 545 Serine/threonine-protein kinase tousled-like 2
TLK2 AF-Q86UE8-K3A Q86UE8 454 749 772.0 No_ligand No_ligand Active DFGin 6.0041 14.8208 BLAminus -138.69, -179.61 62.35, 72.79 -84.32, 12.52 293.62, 90.0 -58.65, -30.26 in-in in 9.9659 Saltbr-in 3.544 HRD-in -65.79, -40.16 70.43, -37.62 in-in-in SNCiii in-in ActLoopNT-in 2.8173 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.14, 149.84 APE9-dihe-na 93.2, -177.93 APE8-dihe-in -97.14, 108.48 APE8-rot-in 311.99 APE67-dihe-in -63.12, -30.35 -57.44, -34.76 APE12-dist-in 12.5144 APE11-dist-in 11.135 APE10-dist-in 6.4728 APE9-dist-in 5.7381 None None None AF2 -1.0 1.0 1.0 A 296.0 296.0 0 35 35 0 [[462, 741]] 1.0 AF-Q86UE8-K3 OTHER_TLK2_HUMAN CAMK 8.4e-55 191.8 1.0 256.0 256.0 612 613 614 616 618 491 514 518 589 591 590 592.0 663 647 642 641 640 639 638 637 636 545 Serine/threonine-protein kinase tousled-like 2
TLK2 5O0YA Q86UE8 456 743 772.0 AGS:801 ATPlike Inactive DFGin 5.8382 16.6964 BLAminus -154.54, -173.82 64.72, 68.79 -84.13, 30.07 299.95, 83.25 -66.33, -38.04 out-out out 11.511 Saltbr-out 5.9716 HRD-out -83.23, 94.84 -74.56, -13.23 out-in-in SNCoii in-in ActLoopNT-in 2.8579 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.76, 159.55 APE9-dihe-na 89.86, 175.53 APE8-dihe-in -96.42, 113.01 APE8-rot-in 322.47 APE67-dihe-in -58.01, -37.07 -65.88, -24.96 APE12-dist-in 12.0821 APE11-dist-in 11.0119 APE10-dist-in 6.4189 APE9-dist-in 5.7404 None None None XRAY 2.86 0.184 0.21 A 579.0 288.0 0 35 35 0 [[462, 741]] 1.0 5o0y OTHER_TLK2_HUMAN CAMK 6.6e-54 190.4 1.0 256.0 256.0 612 613 614 616 618 491 514 518 589 591 590 592.0 663 647 642 641 640 639 638 637 636 545 Serine/threonine-protein kinase tousled-like 2

OTHER_TLK2 (Serine/threonine-protein kinase tousled-like 2)

Total number of chains: 3
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-Q86UE8-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TLK2 TLK2_HUMAN AF-Q86UE8-K1A Q86UE8 454 749 772.0 No_ligand No_ligand Active DFGin 6.1722 14.7647 BLAminus -133.44, 173.75 65.52, 77.57 -86.26, 14.3 290.35, 85.15 -60.94, -21.52 in-in in 9.646 Saltbr-in 2.968 HRD-in -67.77, -42.33 69.71, -22.37 in-in-in SNCiii in-in ActLoopNT-in 2.8564 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -87.36, 150.82 APE9-dihe-na 103.81, -179.58 APE8-dihe-in -98.64, 104.09 APE8-rot-in 310.42 APE67-dihe-in -62.26, -26.61 -57.48, -33.84 APE12-dist-in 12.5152 APE11-dist-in 11.2028 APE10-dist-in 6.511 APE9-dist-in 5.1031 None None None AF2 -1.0 1.0 1.0 A 296.0 296.0 0 35 35 0 [[462, 741]] 1.0 AF-Q86UE8-K1 Homo sapiens OTHER_TLK2_HUMAN CAMK 8.4e-55 191.8 1.0 256.0 256.0 612 613 614 616 618 491 514 518 589 591 590 592.0 663 647 642 641 640 639 638 637 636 545 Serine/threonine-protein kinase tousled-like 2
TLK2 TLK2_HUMAN AF-Q86UE8-K3A Q86UE8 454 749 772.0 No_ligand No_ligand Active DFGin 6.0041 14.8208 BLAminus -138.69, -179.61 62.35, 72.79 -84.32, 12.52 293.62, 90.0 -58.65, -30.26 in-in in 9.9659 Saltbr-in 3.544 HRD-in -65.79, -40.16 70.43, -37.62 in-in-in SNCiii in-in ActLoopNT-in 2.8173 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.14, 149.84 APE9-dihe-na 93.2, -177.93 APE8-dihe-in -97.14, 108.48 APE8-rot-in 311.99 APE67-dihe-in -63.12, -30.35 -57.44, -34.76 APE12-dist-in 12.5144 APE11-dist-in 11.135 APE10-dist-in 6.4728 APE9-dist-in 5.7381 None None None AF2 -1.0 1.0 1.0 A 296.0 296.0 0 35 35 0 [[462, 741]] 1.0 AF-Q86UE8-K3 Homo sapiens OTHER_TLK2_HUMAN CAMK 8.4e-55 191.8 1.0 256.0 256.0 612 613 614 616 618 491 514 518 589 591 590 592.0 663 647 642 641 640 639 638 637 636 545 Serine/threonine-protein kinase tousled-like 2
TLK2 TLK2_HUMAN 5O0YA Q86UE8 456 743 772.0 AGS:801 ATPlike Inactive DFGin 5.8382 16.6964 BLAminus -154.54, -173.82 64.72, 68.79 -84.13, 30.07 299.95, 83.25 -66.33, -38.04 out-out out 11.511 Saltbr-out 5.9716 HRD-out -83.23, 94.84 -74.56, -13.23 out-in-in SNCoii in-in ActLoopNT-in 2.8579 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.76, 159.55 APE9-dihe-na 89.86, 175.53 APE8-dihe-in -96.42, 113.01 APE8-rot-in 322.47 APE67-dihe-in -58.01, -37.07 -65.88, -24.96 APE12-dist-in 12.0821 APE11-dist-in 11.0119 APE10-dist-in 6.4189 APE9-dist-in 5.7404 None None None XRAY 2.86 0.184 0.21 A 579.0 288.0 0 35 35 0 [[462, 741]] 1.0 5o0y Homo sapiens OTHER_TLK2_HUMAN CAMK 6.6e-54 190.4 1.0 256.0 256.0 612 613 614 616 618 491 514 518 589 591 590 592.0 663 647 642 641 640 639 638 637 636 545 Serine/threonine-protein kinase tousled-like 2

OTHER_TLK2 (Serine/threonine-protein kinase tousled-like 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name