STE_STK39 (STE20/SPS1-related proline-alanine-rich protein kinase)

Total number of chains: 2
Active chains: 2
Uniprot: STK39_HUMAN
Kinase Domain Residues: 63 - 337
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-Q9UEW8-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STK39 AF-Q9UEW8-K1A Q9UEW8 55 345 545.0 No_ligand No_ligand Active DFGin 6.5435 13.8318 BLAminus -132.34, 178.01 60.16, 70.92 -81.51, 15.44 289.48, 87.63 -58.99, -25.5 in-in in 9.9444 Saltbr-in 3.5935 HRD-in -76.79, -48.39 67.76, 2.07 in-in-in SNCiii in-in ActLoopNT-in 2.8619 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.17, 156.23 APE9-dihe-na 110.04, 177.49 APE8-dihe-in -86.0, 128.39 APE8-rot-in 308.51 APE67-dihe-in -71.77, -24.1 -49.52, -42.19 APE12-dist-in 8.6806 APE11-dist-in 11.3509 APE10-dist-in 5.4463 APE9-dist-in 3.539 None None None AF2 -1.0 1.0 1.0 A 291.0 291.0 0 33 33 0 [[63, 337]] 1.0 AF-Q9UEW8-K1 STE_STK39_HUMAN STE 6.9e-91 310.0 1.0 257.0 257.0 209 210 211 213 215 92 109 113 189 191 190 192.0 255 242 237 236 235 234 233 232 231 139 STE20/SPS1-related proline-alanine-rich protein kinase
STK39 AF-Q9UEW8-K3A Q9UEW8 55 345 545.0 No_ligand No_ligand Active DFGin 6.5097 13.5398 BLAminus -129.87, 177.58 58.94, 74.1 -83.27, 12.66 293.38, 95.59 -59.64, -24.2 in-in in 9.9039 Saltbr-in 3.1121 HRD-in -79.06, -47.79 69.75, -6.59 in-in-in SNCiii in-in ActLoopNT-in 2.8571 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.65, 147.94 APE9-dihe-na 122.45, 171.58 APE8-dihe-in -80.78, 125.86 APE8-rot-in 305.44 APE67-dihe-in -68.26, -26.31 -49.36, -42.89 APE12-dist-in 8.9213 APE11-dist-in 11.4245 APE10-dist-in 5.7627 APE9-dist-in 3.2452 None None None AF2 -1.0 1.0 1.0 A 291.0 291.0 0 33 33 0 [[63, 337]] 1.0 AF-Q9UEW8-K3 STE_STK39_HUMAN STE 6.9e-91 310.0 1.0 257.0 257.0 209 210 211 213 215 92 109 113 189 191 190 192.0 255 242 237 236 235 234 233 232 231 139 STE20/SPS1-related proline-alanine-rich protein kinase

STE_STK39 (STE20/SPS1-related proline-alanine-rich protein kinase)

Total number of chains: 6
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 33.3% AF-Q9UEW8-K1A
DFGin BLBtrans 2 33.3% 5D9HB
DFGin None 2 33.3% 5DBXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STK39 STK39_HUMAN AF-Q9UEW8-K1A Q9UEW8 55 345 545.0 No_ligand No_ligand Active DFGin 6.5435 13.8318 BLAminus -132.34, 178.01 60.16, 70.92 -81.51, 15.44 289.48, 87.63 -58.99, -25.5 in-in in 9.9444 Saltbr-in 3.5935 HRD-in -76.79, -48.39 67.76, 2.07 in-in-in SNCiii in-in ActLoopNT-in 2.8619 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.17, 156.23 APE9-dihe-na 110.04, 177.49 APE8-dihe-in -86.0, 128.39 APE8-rot-in 308.51 APE67-dihe-in -71.77, -24.1 -49.52, -42.19 APE12-dist-in 8.6806 APE11-dist-in 11.3509 APE10-dist-in 5.4463 APE9-dist-in 3.539 None None None AF2 -1.0 1.0 1.0 A 291.0 291.0 0 33 33 0 [[63, 337]] 1.0 AF-Q9UEW8-K1 Homo sapiens STE_STK39_HUMAN STE 6.9e-91 310.0 1.0 257.0 257.0 209 210 211 213 215 92 109 113 189 191 190 192.0 255 242 237 236 235 234 233 232 231 139 STE20/SPS1-related proline-alanine-rich protein kinase
STK39 STK39_HUMAN AF-Q9UEW8-K3A Q9UEW8 55 345 545.0 No_ligand No_ligand Active DFGin 6.5097 13.5398 BLAminus -129.87, 177.58 58.94, 74.1 -83.27, 12.66 293.38, 95.59 -59.64, -24.2 in-in in 9.9039 Saltbr-in 3.1121 HRD-in -79.06, -47.79 69.75, -6.59 in-in-in SNCiii in-in ActLoopNT-in 2.8571 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.65, 147.94 APE9-dihe-na 122.45, 171.58 APE8-dihe-in -80.78, 125.86 APE8-rot-in 305.44 APE67-dihe-in -68.26, -26.31 -49.36, -42.89 APE12-dist-in 8.9213 APE11-dist-in 11.4245 APE10-dist-in 5.7627 APE9-dist-in 3.2452 None None None AF2 -1.0 1.0 1.0 A 291.0 291.0 0 33 33 0 [[63, 337]] 1.0 AF-Q9UEW8-K3 Homo sapiens STE_STK39_HUMAN STE 6.9e-91 310.0 1.0 257.0 257.0 209 210 211 213 215 92 109 113 189 191 190 192.0 255 242 237 236 235 234 233 232 231 139 STE20/SPS1-related proline-alanine-rich protein kinase
STK39 STK39_MOUSE 5D9HA Q9Z1W9 65 363 556.0 ATP:501 ATPlike Inactive DFGin 5.6858 16.4373 BLBtrans -110.31, 163.68 60.83, 61.1 -112.91, 152.73 160.61, 82.83 89.94, -129.86 out-out out 13.6821 Saltbr-out 14.1755 HRD-in -79.34, -55.51 78.38, -0.69 out-out-out SNCooo out-out ActLoopNT-out 7.7526 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 89.3 APE9-dihe-na 145.31, -162.33 APE8-dihe-in -128.36, 135.86 APE8-rot-out 189.19 APE67-dihe-in -54.38, -21.28 -96.66, 16.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 27.0541 APE9-dist-out 28.5465 None None None XRAY 3.1 0.24 0.269 A 348.0 290.0 9 33 26 7 [[75, 349]] 1.0 5d9h Mus musculus STE_STK39_MOUSE STE 1.3e-90 309.2 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STK39 STK39_MOUSE 5D9HB Q9Z1W9 65 364 556.0 ATP:501 ATPlike Inactive DFGin 5.6862 16.5571 BLBtrans -110.27, 163.88 60.61, 61.2 -112.96, 152.81 160.68, 82.77 89.89, -127.48 out-out out 13.7117 Saltbr-out 13.1009 HRD-in -78.11, -50.69 74.23, -12.16 out-out-out SNCooo out-out ActLoopNT-out 7.9127 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.15 APE8-dihe-in -87.12, 142.28 APE8-rot-out 185.38 APE67-dihe-in -78.59, -19.5 -91.99, 27.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.7069 None None None XRAY 3.1 0.24 0.269 B 348.0 293.0 7 33 26 7 [[75, 349]] 1.0 5d9h Mus musculus STE_STK39_MOUSE STE 1.3e-90 309.2 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STK39 STK39_MOUSE 5DBXA Q9Z1W9 65 365 556.0 ANP:401 ATPlike Inactive DFGin 6.8713 15.5873 None -61.74, 151.25 -53.68, 129.38 -99.47, -2.77 72.69, 109.41 -58.5, -56.73 out-out out 16.0249 Saltbr-out 17.4351 HRD-in -69.21, -49.56 75.54, -19.7 out-out-out SNCooo out-out ActLoopNT-out 5.6736 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -90.7, -9.1 APE9-dihe-na -96.35, 164.45 APE8-dihe-in -91.01, 125.18 APE8-rot-in 324.0 APE67-dihe-in -65.76, -19.67 -49.27, -43.15 APE12-dist-none 999.0 APE11-dist-out 25.0408 APE10-dist-out 28.2167 APE9-dist-out 27.3477 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 A 328.0 288.0 13 33 20 13 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STK39 STK39_MOUSE 5DBXB Q9Z1W9 65 364 556.0 ANP:401 ATPlike Inactive DFGin 6.3307 15.0679 None -67.52, 160.16 -60.64, 125.44 -102.44, -1.98 62.33, 96.08 -52.97, -52.55 out-out out 14.0364 Saltbr-out 13.266 HRD-in -73.49, -48.67 74.98, -19.73 out-out-out SNCooo out-out ActLoopNT-out 5.6752 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -104.19, 109.41 APE9-dihe-na 87.86, -153.92 APE8-dihe-in -128.52, 139.93 APE8-rot-in 317.58 APE67-dihe-in -74.81, -17.12 -52.01, -48.65 APE12-dist-none 999.0 APE11-dist-out 25.567 APE10-dist-out 25.1599 APE9-dist-out 27.7398 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 B 328.0 286.0 14 33 23 10 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase

STE_STK39 (STE20/SPS1-related proline-alanine-rich protein kinase)

Total number of chains: 4
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBtrans 2 50.0% 5D9HB
DFGin None 2 50.0% 5DBXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STK39 STK39_MOUSE 5D9HA Q9Z1W9 65 363 556.0 ATP:501 ATPlike Inactive DFGin 5.6858 16.4373 BLBtrans -110.31, 163.68 60.83, 61.1 -112.91, 152.73 160.61, 82.83 89.94, -129.86 out-out out 13.6821 Saltbr-out 14.1755 HRD-in -79.34, -55.51 78.38, -0.69 out-out-out SNCooo out-out ActLoopNT-out 7.7526 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 89.3 APE9-dihe-na 145.31, -162.33 APE8-dihe-in -128.36, 135.86 APE8-rot-out 189.19 APE67-dihe-in -54.38, -21.28 -96.66, 16.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 27.0541 APE9-dist-out 28.5465 None None None XRAY 3.1 0.24 0.269 A 348.0 290.0 9 33 26 7 [[75, 349]] 1.0 5d9h Mus musculus STE_STK39_MOUSE STE 1.3e-90 309.2 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STK39 STK39_MOUSE 5D9HB Q9Z1W9 65 364 556.0 ATP:501 ATPlike Inactive DFGin 5.6862 16.5571 BLBtrans -110.27, 163.88 60.61, 61.2 -112.96, 152.81 160.68, 82.77 89.89, -127.48 out-out out 13.7117 Saltbr-out 13.1009 HRD-in -78.11, -50.69 74.23, -12.16 out-out-out SNCooo out-out ActLoopNT-out 7.9127 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.15 APE8-dihe-in -87.12, 142.28 APE8-rot-out 185.38 APE67-dihe-in -78.59, -19.5 -91.99, 27.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.7069 None None None XRAY 3.1 0.24 0.269 B 348.0 293.0 7 33 26 7 [[75, 349]] 1.0 5d9h Mus musculus STE_STK39_MOUSE STE 1.3e-90 309.2 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STK39 STK39_MOUSE 5DBXA Q9Z1W9 65 365 556.0 ANP:401 ATPlike Inactive DFGin 6.8713 15.5873 None -61.74, 151.25 -53.68, 129.38 -99.47, -2.77 72.69, 109.41 -58.5, -56.73 out-out out 16.0249 Saltbr-out 17.4351 HRD-in -69.21, -49.56 75.54, -19.7 out-out-out SNCooo out-out ActLoopNT-out 5.6736 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -90.7, -9.1 APE9-dihe-na -96.35, 164.45 APE8-dihe-in -91.01, 125.18 APE8-rot-in 324.0 APE67-dihe-in -65.76, -19.67 -49.27, -43.15 APE12-dist-none 999.0 APE11-dist-out 25.0408 APE10-dist-out 28.2167 APE9-dist-out 27.3477 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 A 328.0 288.0 13 33 20 13 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STK39 STK39_MOUSE 5DBXB Q9Z1W9 65 364 556.0 ANP:401 ATPlike Inactive DFGin 6.3307 15.0679 None -67.52, 160.16 -60.64, 125.44 -102.44, -1.98 62.33, 96.08 -52.97, -52.55 out-out out 14.0364 Saltbr-out 13.266 HRD-in -73.49, -48.67 74.98, -19.73 out-out-out SNCooo out-out ActLoopNT-out 5.6752 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -104.19, 109.41 APE9-dihe-na 87.86, -153.92 APE8-dihe-in -128.52, 139.93 APE8-rot-in 317.58 APE67-dihe-in -74.81, -17.12 -52.01, -48.65 APE12-dist-none 999.0 APE11-dist-out 25.567 APE10-dist-out 25.1599 APE9-dist-out 27.7398 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 B 328.0 286.0 14 33 23 10 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase