STE_STK25 (Serine/threonine-protein kinase 25)

Total number of chains: 5
Active chains: 3
Family: STE
Uniprot: STK25_HUMAN
Kinase Domain Residues: 20 - 270
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% AF-O00506-K1A
DFGinter None 1 20.0% 4NZWB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-O00506-K1A 12 278 426.0 No_ligand No_ligand Active DFGin 6.528 14.495 BLAminus -137.08, 175.58 56.63, 76.88 -89.16, 19.02 289.9, 83.83 -52.08, -37.11 in-in in 8.867 Saltbr-in 2.689 HRD-in -73.22, -40.97 64.41, 3.34 in-in-in SNCiii in-in ActLoopNT-in 2.78 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.37, 162.34 APE9-dihe-na 105.39, 169.62 APE8-dihe-in -77.06, 124.74 APE8-rot-in 307.36 APE67-dihe-in -71.93, -23.4 -47.04, -40.2 APE12-dist-in 8.427 APE11-dist-in 11.193 APE10-dist-in 5.316 APE9-dist-in 3.325 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[20, 270]] 1.0 AF-O00506-K1 STE_STK25_HUMAN STE 2.8e-101 344.1 1 257 257 157 158 159 161 163 49 66 70 137 139 138 140 197 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase 25
AF-O00506-K3A 12 278 426.0 No_ligand No_ligand Active DFGin 6.406 14.792 BLAminus -135.53, 177.76 59.63, 79.14 -101.37, 8.84 293.44, 93.94 -55.78, -34.16 in-in in 8.79 Saltbr-in 2.688 HRD-in -75.99, -40.92 64.99, -1.28 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.32, 154.47 APE9-dihe-na 116.47, 171.39 APE8-dihe-in -81.84, 124.48 APE8-rot-in 304.9 APE67-dihe-in -68.11, -28.01 -47.74, -41.27 APE12-dist-in 8.351 APE11-dist-in 11.08 APE10-dist-in 5.474 APE9-dist-in 3.241 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[20, 270]] 1.0 AF-O00506-K3 STE_STK25_HUMAN STE 2.8e-101 344.1 1 257 257 157 158 159 161 163 49 66 70 137 139 138 140 197 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase 25
7Z4VA 3 293 426.0 IB5:301 Type1 Active DFGin 6.681 15.039 BLAminus -133.73, 163.58 71.41, 87.86 -106.43, 18.84 293.27, 82.79 -56.78, -34.01 in-in in 9.361 Saltbr-in 3.44 HRD-in -60.02, -54.41 74.65, 0.93 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.23, 155.46 APE9-dihe-na 126.37, -174.38 APE8-dihe-in -108.09, 121.21 APE8-rot-in 310.16 APE67-dihe-in -56.6, -27.88 -38.79, -53.41 APE12-dist-in 8.116 APE11-dist-in 11.007 APE10-dist-in 5.166 APE9-dist-in 3.503 None TPO174 TPO174 XRAY 1.644 0.247 0.283 A 297 289 2 0 0 0 [[20, 270]] 1.0 7z4v STE_STK25_HUMAN STE 4.1e-101 343.6 1 257 257 157 158 159 161 163 49 66 70 137 139 138 140 197 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase 25
2XIKA 3 292 426.0 J60:1294 Type1 Inactive DFGin 6.626 14.386 BLAminus -126.86, 168.65 66.27, 89.07 -101.96, 19.17 296.65, 94.78 -54.6, -29.33 in-out in 8.932 Saltbr-out 4.219 HRD-in -68.38, -52.08 73.53, 0.66 out-in-in SNCoii in-in ActLoopNT-in 2.769 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.78, 159.13 APE9-dihe-na 121.05, -167.36 APE8-dihe-in -110.3, 123.41 APE8-rot-in 314.01 APE67-dihe-in -61.0, -29.26 -35.91, -52.02 APE12-dist-in 8.329 APE11-dist-in 11.009 APE10-dist-in 5.236 APE9-dist-in 3.552 None TPO174 TPO174 XRAY 1.97 0.191 0.233 A 294 289 1 0 0 0 [[20, 270]] 1.0 2xik STE_STK25_HUMAN STE 4e-101 343.6 1 257 257 157 158 159 161 163 49 66 70 137 139 138 140 197 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase 25
4NZWB 11 292 426.0 J60:1000 Type1 Inactive DFGinter 10.262 5.963 None -75.42, -140.49 -158.88, -45.92 -65.17, 119.32 317.26, 111.8 114.04, -12.12 out-out out 10.07 Saltbr-out 4.302 HRD-in -77.57, -31.02 67.3, -14.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -73.59 APE8-dihe-out 136.85, 83.49 APE8-rot-out 37.4 APE67-dihe-in -19.17, -28.72 -28.03, -93.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.737 D158A None None XRAY 3.583 0.214 0.275 B 295 266 16 0 0 14 [[20, 270]] 1.0 4nzw STE_STK25_HUMAN STE 9.7e-100 339.1 1 257 257 157 158 159 161 163 49 66 70 137 139 138 140 197 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase 25

STE_STK25 (Serine/threonine-protein kinase 25)

Total number of chains: 5
Active chains: 3
Family: STE
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% AF-O00506-K1A
DFGinter None 1 20.0% 4NZWB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STK25_HUMAN AF-O00506-K1A O00506 12 278 426.0 No_ligand No_ligand Active DFGin 6.528 14.495 BLAminus -137.08, 175.58 56.63, 76.88 -89.16, 19.02 289.9, 83.83 -52.08, -37.11 in-in in 8.867 Saltbr-in 2.689 HRD-in -73.22, -40.97 64.41, 3.34 in-in-in SNCiii in-in ActLoopNT-in 2.78 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.37, 162.34 APE9-dihe-na 105.39, 169.62 APE8-dihe-in -77.06, 124.74 APE8-rot-in 307.36 APE67-dihe-in -71.93, -23.4 -47.04, -40.2 APE12-dist-in 8.427 APE11-dist-in 11.193 APE10-dist-in 5.316 APE9-dist-in 3.325 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[20, 270]] 1.0 AF-O00506-K1 Homo sapiens STE_STK25_HUMAN STE 2.8e-101 344.1 1 257 257 157 158 159 161 163 49 66 70 137 139 138 140 197 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase 25
STK25_HUMAN AF-O00506-K3A O00506 12 278 426.0 No_ligand No_ligand Active DFGin 6.406 14.792 BLAminus -135.53, 177.76 59.63, 79.14 -101.37, 8.84 293.44, 93.94 -55.78, -34.16 in-in in 8.79 Saltbr-in 2.688 HRD-in -75.99, -40.92 64.99, -1.28 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.32, 154.47 APE9-dihe-na 116.47, 171.39 APE8-dihe-in -81.84, 124.48 APE8-rot-in 304.9 APE67-dihe-in -68.11, -28.01 -47.74, -41.27 APE12-dist-in 8.351 APE11-dist-in 11.08 APE10-dist-in 5.474 APE9-dist-in 3.241 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[20, 270]] 1.0 AF-O00506-K3 Homo sapiens STE_STK25_HUMAN STE 2.8e-101 344.1 1 257 257 157 158 159 161 163 49 66 70 137 139 138 140 197 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase 25
STK25_HUMAN 7Z4VA O00506 3 293 426.0 IB5:301 Type1 Active DFGin 6.681 15.039 BLAminus -133.73, 163.58 71.41, 87.86 -106.43, 18.84 293.27, 82.79 -56.78, -34.01 in-in in 9.361 Saltbr-in 3.44 HRD-in -60.02, -54.41 74.65, 0.93 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.23, 155.46 APE9-dihe-na 126.37, -174.38 APE8-dihe-in -108.09, 121.21 APE8-rot-in 310.16 APE67-dihe-in -56.6, -27.88 -38.79, -53.41 APE12-dist-in 8.116 APE11-dist-in 11.007 APE10-dist-in 5.166 APE9-dist-in 3.503 None TPO174 TPO174 XRAY 1.644 0.247 0.283 A 297 289 2 0 0 0 [[20, 270]] 1.0 7z4v Homo sapiens STE_STK25_HUMAN STE 4.1e-101 343.6 1 257 257 157 158 159 161 163 49 66 70 137 139 138 140 197 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase 25
STK25_HUMAN 2XIKA O00506 3 292 426.0 J60:1294 Type1 Inactive DFGin 6.626 14.386 BLAminus -126.86, 168.65 66.27, 89.07 -101.96, 19.17 296.65, 94.78 -54.6, -29.33 in-out in 8.932 Saltbr-out 4.219 HRD-in -68.38, -52.08 73.53, 0.66 out-in-in SNCoii in-in ActLoopNT-in 2.769 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.78, 159.13 APE9-dihe-na 121.05, -167.36 APE8-dihe-in -110.3, 123.41 APE8-rot-in 314.01 APE67-dihe-in -61.0, -29.26 -35.91, -52.02 APE12-dist-in 8.329 APE11-dist-in 11.009 APE10-dist-in 5.236 APE9-dist-in 3.552 None TPO174 TPO174 XRAY 1.97 0.191 0.233 A 294 289 1 0 0 0 [[20, 270]] 1.0 2xik Homo sapiens STE_STK25_HUMAN STE 4e-101 343.6 1 257 257 157 158 159 161 163 49 66 70 137 139 138 140 197 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase 25
STK25_HUMAN 4NZWB O00506 11 292 426.0 J60:1000 Type1 Inactive DFGinter 10.262 5.963 None -75.42, -140.49 -158.88, -45.92 -65.17, 119.32 317.26, 111.8 114.04, -12.12 out-out out 10.07 Saltbr-out 4.302 HRD-in -77.57, -31.02 67.3, -14.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -73.59 APE8-dihe-out 136.85, 83.49 APE8-rot-out 37.4 APE67-dihe-in -19.17, -28.72 -28.03, -93.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.737 D158A None None XRAY 3.583 0.214 0.275 B 295 266 16 0 0 14 [[20, 270]] 1.0 4nzw Homo sapiens STE_STK25_HUMAN STE 9.7e-100 339.1 1 257 257 157 158 159 161 163 49 66 70 137 139 138 140 197 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase 25

STE_STK25 (Serine/threonine-protein kinase 25)

Total number of chains: 0
Active chains: 0
Family: STE
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name