AGC_RPS6KA5-1 (Ribosomal protein S6 kinase alpha-5)

Total number of chains: 3
Active chains: 2
Uniprot: KS6A5_HUMAN
Kinase Domain Residues: 49 - 318
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% AF-O75582-K1A
DFGinter None 1 33.3% 1VZOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RPS6KA5-1 AF-O75582-K1A O75582 41 326 802.0 No_ligand No_ligand Active DFGin 6.7799 13.7903 BLAminus -122.36, -163.26 38.53, 66.9 -78.09, 17.93 295.37, 82.19 -64.85, -18.18 in-in in 8.7965 Saltbr-in 2.6254 HRD-in -82.76, -49.06 64.23, 11.02 in-in-in SNCiii in-in ActLoopNT-in 2.8888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.62, 163.8 APE9-dihe-na 113.59, 179.22 APE8-dihe-in -90.62, 126.59 APE8-rot-in 304.99 APE67-dihe-in -61.69, -29.36 -58.71, -34.47 APE12-dist-in 8.4062 APE11-dist-in 11.5603 APE10-dist-in 5.8061 APE9-dist-in 3.5572 None None None AF2 -1.0 1.0 1.0 A 286.0 286.0 0 29 29 0 [[49, 318], [423, 687]] 2.0 AF-O75582-K1 AGC_RPS6KA5-1_HUMAN AGC 2e-93 318.2 1.0 260.0 260.0 194 195 196 198 200 81 101 105 174 176 175 177.0 237 223 218 217 216 215 214 213 212 132 Ribosomal protein S6 kinase alpha-5
RPS6KA5-1 AF-O75582-K3A O75582 41 326 802.0 No_ligand No_ligand Active DFGin 6.1857 13.3584 BLAminus -132.07, -177.35 48.31, 79.01 -81.08, 17.52 302.26, 93.07 -63.99, -14.82 in-in in 8.7021 Saltbr-in 2.5771 HRD-in -86.05, -53.15 68.0, 7.54 in-in-in SNCiii in-in ActLoopNT-in 2.9142 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.1, 160.71 APE9-dihe-na 110.46, -176.37 APE8-dihe-in -88.86, 131.0 APE8-rot-in 291.71 APE67-dihe-in -59.57, -30.36 -60.19, -36.11 APE12-dist-in 8.1155 APE11-dist-in 11.4064 APE10-dist-in 5.697 APE9-dist-in 3.5899 None None None AF2 -1.0 1.0 1.0 A 286.0 286.0 0 29 29 0 [[49, 318], [423, 687]] 2.0 AF-O75582-K3 AGC_RPS6KA5-1_HUMAN AGC 2e-93 318.2 1.0 260.0 260.0 194 195 196 198 200 81 101 105 174 176 175 177.0 237 223 218 217 216 215 214 213 212 132 Ribosomal protein S6 kinase alpha-5
RPS6KA5-1 1VZOA O75582 24 345 802.0 No_ligand No_ligand Inactive DFGinter 7.0116 10.8574 None -86.08, 7.16 -135.82, 179.44 -156.19, 30.86 46.84, 81.68 100.81, 7.87 out-out out 18.1112 Saltbr-out 19.3431 HRD-in -69.35, -43.67 69.6, -31.81 out-out-out SNCooo out-out ActLoopNT-out 10.2634 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -83.3, -23.05 APE9-dihe-na -99.28, -166.51 APE8-dihe-in -67.08, 145.98 APE8-rot-out 174.8 APE67-dihe-in -63.46, -19.35 -108.6, 7.57 APE12-dist-in 13.9798 APE11-dist-out 18.8286 APE10-dist-out 17.8337 APE9-dist-out 11.153 S212D None None XRAY 1.8 0.208 0.242 A 355.0 319.0 3 29 29 0 [[49, 318], [423, 687]] 2.0 1vzo AGC_RPS6KA5-1_HUMAN AGC 7.1e-93 316.4 1.0 260.0 260.0 194 195 196 198 200 81 101 105 174 176 175 177.0 237 223 218 217 216 215 214 213 212 132 Ribosomal protein S6 kinase alpha-5

AGC_RPS6KA5-1 (Ribosomal protein S6 kinase alpha-5)

Total number of chains: 3
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% AF-O75582-K1A
DFGinter None 1 33.3% 1VZOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RPS6KA5-1 KS6A5_HUMAN AF-O75582-K1A O75582 41 326 802.0 No_ligand No_ligand Active DFGin 6.7799 13.7903 BLAminus -122.36, -163.26 38.53, 66.9 -78.09, 17.93 295.37, 82.19 -64.85, -18.18 in-in in 8.7965 Saltbr-in 2.6254 HRD-in -82.76, -49.06 64.23, 11.02 in-in-in SNCiii in-in ActLoopNT-in 2.8888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.62, 163.8 APE9-dihe-na 113.59, 179.22 APE8-dihe-in -90.62, 126.59 APE8-rot-in 304.99 APE67-dihe-in -61.69, -29.36 -58.71, -34.47 APE12-dist-in 8.4062 APE11-dist-in 11.5603 APE10-dist-in 5.8061 APE9-dist-in 3.5572 None None None AF2 -1.0 1.0 1.0 A 286.0 286.0 0 29 29 0 [[49, 318], [423, 687]] 2.0 AF-O75582-K1 Homo sapiens AGC_RPS6KA5-1_HUMAN AGC 2e-93 318.2 1.0 260.0 260.0 194 195 196 198 200 81 101 105 174 176 175 177.0 237 223 218 217 216 215 214 213 212 132 Ribosomal protein S6 kinase alpha-5
RPS6KA5-1 KS6A5_HUMAN AF-O75582-K3A O75582 41 326 802.0 No_ligand No_ligand Active DFGin 6.1857 13.3584 BLAminus -132.07, -177.35 48.31, 79.01 -81.08, 17.52 302.26, 93.07 -63.99, -14.82 in-in in 8.7021 Saltbr-in 2.5771 HRD-in -86.05, -53.15 68.0, 7.54 in-in-in SNCiii in-in ActLoopNT-in 2.9142 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.1, 160.71 APE9-dihe-na 110.46, -176.37 APE8-dihe-in -88.86, 131.0 APE8-rot-in 291.71 APE67-dihe-in -59.57, -30.36 -60.19, -36.11 APE12-dist-in 8.1155 APE11-dist-in 11.4064 APE10-dist-in 5.697 APE9-dist-in 3.5899 None None None AF2 -1.0 1.0 1.0 A 286.0 286.0 0 29 29 0 [[49, 318], [423, 687]] 2.0 AF-O75582-K3 Homo sapiens AGC_RPS6KA5-1_HUMAN AGC 2e-93 318.2 1.0 260.0 260.0 194 195 196 198 200 81 101 105 174 176 175 177.0 237 223 218 217 216 215 214 213 212 132 Ribosomal protein S6 kinase alpha-5
RPS6KA5-1 KS6A5_HUMAN 1VZOA O75582 24 345 802.0 No_ligand No_ligand Inactive DFGinter 7.0116 10.8574 None -86.08, 7.16 -135.82, 179.44 -156.19, 30.86 46.84, 81.68 100.81, 7.87 out-out out 18.1112 Saltbr-out 19.3431 HRD-in -69.35, -43.67 69.6, -31.81 out-out-out SNCooo out-out ActLoopNT-out 10.2634 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -83.3, -23.05 APE9-dihe-na -99.28, -166.51 APE8-dihe-in -67.08, 145.98 APE8-rot-out 174.8 APE67-dihe-in -63.46, -19.35 -108.6, 7.57 APE12-dist-in 13.9798 APE11-dist-out 18.8286 APE10-dist-out 17.8337 APE9-dist-out 11.153 S212D None None XRAY 1.8 0.208 0.242 A 355.0 319.0 3 29 29 0 [[49, 318], [423, 687]] 2.0 1vzo Homo sapiens AGC_RPS6KA5-1_HUMAN AGC 7.1e-93 316.4 1.0 260.0 260.0 194 195 196 198 200 81 101 105 174 176 175 177.0 237 223 218 217 216 215 214 213 212 132 Ribosomal protein S6 kinase alpha-5

AGC_RPS6KA5-1 (Ribosomal protein S6 kinase alpha-5)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name