CAMK_RPS6KA1-2 (Ribosomal protein S6 kinase alpha-1)

Total number of chains: 10
Active chains: 2
Family: CAMK
Uniprot: KS6A1_HUMAN
Kinase Domain Residues: 418 - 675
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 60.0% AF-Q15418-K2A
DFGin ABAminus 4 40.0% 2WNTB

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q15418-K2A 410 683 735.0 No_ligand No_ligand Active DFGin 6.642 14.09 BLAminus -126.21, 179.26 57.08, 67.05 -75.1, 22.9 287.48, 76.88 -58.82, -29.2 in-in in 8.892 Saltbr-in 2.739 HRD-in -76.33, -42.0 69.77, -2.48 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.48, 128.95 APE9-dihe-na -170.39, 159.86 APE8-dihe-in -93.38, 131.54 APE8-rot-in 299.75 APE67-dihe-in -74.29, -9.58 -51.89, -40.62 APE12-dist-in 8.881 APE11-dist-in 10.755 APE10-dist-in 4.92 APE9-dist-in 4.081 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K2 CAMK_RPS6KA1-2_HUMAN CAMK 6.5e-88 300.3 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
AF-Q15418-K4A 410 683 735.0 No_ligand No_ligand Active DFGin 6.457 14.262 BLAminus -131.98, -176.82 54.0, 62.76 -70.03, 23.23 286.1, 80.23 -67.75, -25.43 in-in in 8.928 Saltbr-in 2.718 HRD-in -78.48, -40.45 68.79, 2.02 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.11, 131.7 APE9-dihe-na -172.39, 156.57 APE8-dihe-in -86.39, 129.69 APE8-rot-in 298.28 APE67-dihe-in -79.01, -8.51 -53.84, -37.0 APE12-dist-in 8.92 APE11-dist-in 10.964 APE10-dist-in 5.083 APE9-dist-in 4.033 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K4 CAMK_RPS6KA1-2_HUMAN CAMK 6.5e-88 300.3 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
2WNTA 416 708 735.0 No_ligand No_ligand Inactive DFGin 6.939 14.504 ABAminus -121.8, -11.4 -135.67, 111.94 -112.4, 33.03 285.69, 74.59 -78.61, -9.65 in-in in 9.453 Saltbr-in 3.257 HRD-in -81.66, -44.71 69.32, -5.3 in-in-out SNCiio in-out ActLoopNT-in 2.744 ActLoopCT-out nonTYR APEdihe_aanin APEdist_oooo APE10-dihe-na -71.04, -60.43 APE9-dihe-na -44.7, -57.24 APE8-dihe-none -64.35, 999.0 APE8-rot-in 304.93 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-out 19.194 APE11-dist-out 18.026 APE10-dist-out 22.723 APE9-dist-out 23.817 None None None XRAY 2.4 0.193 0.24 A 330 281 12 0 0 7 [[62, 321], [418, 675]] 2.0 2wnt CAMK_RPS6KA1-2_HUMAN CAMK 1.3e-87 299.5 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
2WNTB 415 709 735.0 No_ligand No_ligand Inactive DFGin 7.047 14.393 ABAminus -122.55, -11.0 -132.86, 101.14 -101.04, 29.72 286.6, 76.36 -77.85, -10.16 in-in in 8.943 Saltbr-in 2.722 HRD-in -81.14, -44.87 70.38, -5.82 in-in-out SNCiio in-out ActLoopNT-in 2.803 ActLoopCT-out nonTYR APEdihe_aannn APEdist_oooo APE10-dihe-na -56.15, -84.12 APE9-dihe-na -32.95, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-out 19.122 APE11-dist-out 18.373 APE10-dist-out 22.18 APE9-dist-out 23.739 None None None XRAY 2.4 0.193 0.24 B 330 285 10 0 0 8 [[62, 321], [418, 675]] 2.0 2wnt CAMK_RPS6KA1-2_HUMAN CAMK 1.3e-87 299.5 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
3RNYA 418 707 735.0 No_ligand No_ligand Inactive DFGin 7.081 14.23 ABAminus -101.99, -18.79 -123.23, 126.93 -117.95, 22.69 287.63, 82.2 -66.26, -24.29 in-in in 8.867 Saltbr-in 2.795 HRD-in -86.89, -54.4 70.65, 10.34 in-in-out SNCiio in-out ActLoopNT-in 3.162 ActLoopCT-out nonTYR APEdihe_aannn APEdist_oooo APE10-dihe-na -58.14, -38.55 APE9-dihe-na -99.28, 44.87 APE8-dihe-none 61.13, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-out 19.177 APE11-dist-out 18.841 APE10-dist-out 22.882 APE9-dist-out 24.002 None None None XRAY 2.7 0.191 0.238 A 346 264 26 0 0 6 [[62, 321], [418, 675]] 2.0 3rny CAMK_RPS6KA1-2_HUMAN CAMK 1.5e-87 299.2 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
3RNYB 419 708 735.0 No_ligand No_ligand Inactive DFGin 6.938 14.077 ABAminus -101.19, -19.56 -123.16, 131.28 -115.82, 14.75 285.83, 84.78 -51.72, -20.54 in-in in 8.936 Saltbr-in 2.746 HRD-in -78.3, -58.96 79.29, -1.39 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aannn APEdist_oooo APE10-dihe-na -58.98, -37.26 APE9-dihe-na -100.34, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-out 19.084 APE11-dist-out 18.654 APE10-dist-out 22.835 APE9-dist-out 23.927 None None None XRAY 2.7 0.191 0.238 B 346 271 20 0 0 8 [[62, 321], [418, 675]] 2.0 3rny CAMK_RPS6KA1-2_HUMAN CAMK 1.5e-87 299.2 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
8WF4A 416 708 735.0 No_ligand No_ligand Inactive DFGin 6.873 14.268 BLAminus -132.2, 168.02 61.98, 80.12 -95.33, 47.72 288.21, 72.67 -75.09, -43.86 in-in in 8.931 Saltbr-in 3.023 HRD-in -91.65, -53.79 65.02, 27.25 in-in-out SNCiio in-out ActLoopNT-in 3.031 ActLoopCT-out nonTYR APEdihe_aanin APEdist_oooo APE10-dihe-na -63.47, -48.15 APE9-dihe-na -65.73, -53.01 APE8-dihe-none -75.73, 999.0 APE8-rot-in 314.22 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-out 19.529 APE11-dist-out 18.51 APE10-dist-out 22.934 APE9-dist-out 23.948 None None None XRAY 2.65 0.242 0.309 A 325 288 5 0 0 5 [[62, 321], [418, 675]] 2.0 8wf4 CAMK_RPS6KA1-2_HUMAN CAMK 1.2e-87 299.5 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
8WF4B 415 708 735.0 No_ligand No_ligand Inactive DFGin 6.979 14.544 BLAminus -125.83, 167.04 58.74, 89.44 -102.41, 49.79 288.54, 71.75 -76.23, -32.17 in-in in 9.323 Saltbr-in 3.315 HRD-in -83.99, -50.78 65.74, 29.2 in-in-out SNCiio in-out ActLoopNT-in 2.963 ActLoopCT-out nonTYR APEdihe_aaiin APEdist_oooo APE10-dihe-na -63.66, -48.16 APE9-dihe-na -71.85, -44.04 APE8-dihe-in -57.61, 137.83 APE8-rot-in 304.67 APE67-dihe-none 999.0, 999.0 -136.47, 999.0 APE12-dist-out 18.692 APE11-dist-out 18.594 APE10-dist-out 22.451 APE9-dist-out 24.098 None None None XRAY 2.65 0.242 0.309 B 325 290 4 0 0 4 [[62, 321], [418, 675]] 2.0 8wf4 CAMK_RPS6KA1-2_HUMAN CAMK 1.2e-87 299.5 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
4NIFA 413 728 735.0 No_ligand No_ligand Inactive DFGin 6.868 14.611 BLAminus -123.07, -176.37 48.87, 75.9 -90.5, 26.09 285.58, 73.35 -57.93, -22.0 in-in in 9.099 Saltbr-in 2.64 HRD-in -82.17, -49.47 73.17, -4.09 in-in-out SNCiio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aannn APEdist_oooo APE10-dihe-na -76.32, -82.9 APE9-dihe-na -107.74, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-out 18.74 APE11-dist-out 18.053 APE10-dist-out 22.399 APE9-dist-out 24.655 None None None XRAY 2.15 0.161 0.208 A 333 313 3 0 0 3 [[62, 321], [418, 675]] 2.0 4nif CAMK_RPS6KA1-2_HUMAN CAMK 1.3e-87 299.4 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
4NIFD 413 728 735.0 No_ligand No_ligand Inactive DFGin 6.821 14.509 BLAminus -125.54, -177.7 51.84, 74.57 -89.95, 24.53 284.87, 75.41 -55.2, -23.55 in-in in 9.009 Saltbr-in 2.701 HRD-in -81.48, -48.04 74.24, -5.51 in-in-out SNCiio in-out ActLoopNT-in 2.963 ActLoopCT-out nonTYR APEdihe_aannn APEdist_ooon APE10-dihe-na -107.68, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -123.59 999.0, 999.0 APE12-dist-out 18.96 APE11-dist-out 17.915 APE10-dist-out 22.588 APE9-dist-none 999.0 None None None XRAY 2.15 0.161 0.208 D 333 313 3 0 0 3 [[62, 321], [418, 675]] 2.0 4nif CAMK_RPS6KA1-2_HUMAN CAMK 1.3e-87 299.4 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1

CAMK_RPS6KA1-2 (Ribosomal protein S6 kinase alpha-1)

Total number of chains: 10
Active chains: 2
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 60.0% AF-Q15418-K2A
DFGin ABAminus 4 40.0% 2WNTB

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
KS6A1_HUMAN AF-Q15418-K2A Q15418 410 683 735.0 No_ligand No_ligand Active DFGin 6.642 14.09 BLAminus -126.21, 179.26 57.08, 67.05 -75.1, 22.9 287.48, 76.88 -58.82, -29.2 in-in in 8.892 Saltbr-in 2.739 HRD-in -76.33, -42.0 69.77, -2.48 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.48, 128.95 APE9-dihe-na -170.39, 159.86 APE8-dihe-in -93.38, 131.54 APE8-rot-in 299.75 APE67-dihe-in -74.29, -9.58 -51.89, -40.62 APE12-dist-in 8.881 APE11-dist-in 10.755 APE10-dist-in 4.92 APE9-dist-in 4.081 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K2 Homo sapiens CAMK_RPS6KA1-2_HUMAN CAMK 6.5e-88 300.3 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
KS6A1_HUMAN AF-Q15418-K4A Q15418 410 683 735.0 No_ligand No_ligand Active DFGin 6.457 14.262 BLAminus -131.98, -176.82 54.0, 62.76 -70.03, 23.23 286.1, 80.23 -67.75, -25.43 in-in in 8.928 Saltbr-in 2.718 HRD-in -78.48, -40.45 68.79, 2.02 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.11, 131.7 APE9-dihe-na -172.39, 156.57 APE8-dihe-in -86.39, 129.69 APE8-rot-in 298.28 APE67-dihe-in -79.01, -8.51 -53.84, -37.0 APE12-dist-in 8.92 APE11-dist-in 10.964 APE10-dist-in 5.083 APE9-dist-in 4.033 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K4 Homo sapiens CAMK_RPS6KA1-2_HUMAN CAMK 6.5e-88 300.3 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
KS6A1_HUMAN 2WNTA Q15418 416 708 735.0 No_ligand No_ligand Inactive DFGin 6.939 14.504 ABAminus -121.8, -11.4 -135.67, 111.94 -112.4, 33.03 285.69, 74.59 -78.61, -9.65 in-in in 9.453 Saltbr-in 3.257 HRD-in -81.66, -44.71 69.32, -5.3 in-in-out SNCiio in-out ActLoopNT-in 2.744 ActLoopCT-out nonTYR APEdihe_aanin APEdist_oooo APE10-dihe-na -71.04, -60.43 APE9-dihe-na -44.7, -57.24 APE8-dihe-none -64.35, 999.0 APE8-rot-in 304.93 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-out 19.194 APE11-dist-out 18.026 APE10-dist-out 22.723 APE9-dist-out 23.817 None None None XRAY 2.4 0.193 0.24 A 330 281 12 0 0 7 [[62, 321], [418, 675]] 2.0 2wnt Homo sapiens CAMK_RPS6KA1-2_HUMAN CAMK 1.3e-87 299.5 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
KS6A1_HUMAN 2WNTB Q15418 415 709 735.0 No_ligand No_ligand Inactive DFGin 7.047 14.393 ABAminus -122.55, -11.0 -132.86, 101.14 -101.04, 29.72 286.6, 76.36 -77.85, -10.16 in-in in 8.943 Saltbr-in 2.722 HRD-in -81.14, -44.87 70.38, -5.82 in-in-out SNCiio in-out ActLoopNT-in 2.803 ActLoopCT-out nonTYR APEdihe_aannn APEdist_oooo APE10-dihe-na -56.15, -84.12 APE9-dihe-na -32.95, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-out 19.122 APE11-dist-out 18.373 APE10-dist-out 22.18 APE9-dist-out 23.739 None None None XRAY 2.4 0.193 0.24 B 330 285 10 0 0 8 [[62, 321], [418, 675]] 2.0 2wnt Homo sapiens CAMK_RPS6KA1-2_HUMAN CAMK 1.3e-87 299.5 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
KS6A1_HUMAN 3RNYA Q15418 418 707 735.0 No_ligand No_ligand Inactive DFGin 7.081 14.23 ABAminus -101.99, -18.79 -123.23, 126.93 -117.95, 22.69 287.63, 82.2 -66.26, -24.29 in-in in 8.867 Saltbr-in 2.795 HRD-in -86.89, -54.4 70.65, 10.34 in-in-out SNCiio in-out ActLoopNT-in 3.162 ActLoopCT-out nonTYR APEdihe_aannn APEdist_oooo APE10-dihe-na -58.14, -38.55 APE9-dihe-na -99.28, 44.87 APE8-dihe-none 61.13, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-out 19.177 APE11-dist-out 18.841 APE10-dist-out 22.882 APE9-dist-out 24.002 None None None XRAY 2.7 0.191 0.238 A 346 264 26 0 0 6 [[62, 321], [418, 675]] 2.0 3rny Homo sapiens CAMK_RPS6KA1-2_HUMAN CAMK 1.5e-87 299.2 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
KS6A1_HUMAN 3RNYB Q15418 419 708 735.0 No_ligand No_ligand Inactive DFGin 6.938 14.077 ABAminus -101.19, -19.56 -123.16, 131.28 -115.82, 14.75 285.83, 84.78 -51.72, -20.54 in-in in 8.936 Saltbr-in 2.746 HRD-in -78.3, -58.96 79.29, -1.39 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aannn APEdist_oooo APE10-dihe-na -58.98, -37.26 APE9-dihe-na -100.34, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-out 19.084 APE11-dist-out 18.654 APE10-dist-out 22.835 APE9-dist-out 23.927 None None None XRAY 2.7 0.191 0.238 B 346 271 20 0 0 8 [[62, 321], [418, 675]] 2.0 3rny Homo sapiens CAMK_RPS6KA1-2_HUMAN CAMK 1.5e-87 299.2 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
KS6A1_HUMAN 8WF4A Q15418 416 708 735.0 No_ligand No_ligand Inactive DFGin 6.873 14.268 BLAminus -132.2, 168.02 61.98, 80.12 -95.33, 47.72 288.21, 72.67 -75.09, -43.86 in-in in 8.931 Saltbr-in 3.023 HRD-in -91.65, -53.79 65.02, 27.25 in-in-out SNCiio in-out ActLoopNT-in 3.031 ActLoopCT-out nonTYR APEdihe_aanin APEdist_oooo APE10-dihe-na -63.47, -48.15 APE9-dihe-na -65.73, -53.01 APE8-dihe-none -75.73, 999.0 APE8-rot-in 314.22 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-out 19.529 APE11-dist-out 18.51 APE10-dist-out 22.934 APE9-dist-out 23.948 None None None XRAY 2.65 0.242 0.309 A 325 288 5 0 0 5 [[62, 321], [418, 675]] 2.0 8wf4 Homo sapiens CAMK_RPS6KA1-2_HUMAN CAMK 1.2e-87 299.5 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
KS6A1_HUMAN 8WF4B Q15418 415 708 735.0 No_ligand No_ligand Inactive DFGin 6.979 14.544 BLAminus -125.83, 167.04 58.74, 89.44 -102.41, 49.79 288.54, 71.75 -76.23, -32.17 in-in in 9.323 Saltbr-in 3.315 HRD-in -83.99, -50.78 65.74, 29.2 in-in-out SNCiio in-out ActLoopNT-in 2.963 ActLoopCT-out nonTYR APEdihe_aaiin APEdist_oooo APE10-dihe-na -63.66, -48.16 APE9-dihe-na -71.85, -44.04 APE8-dihe-in -57.61, 137.83 APE8-rot-in 304.67 APE67-dihe-none 999.0, 999.0 -136.47, 999.0 APE12-dist-out 18.692 APE11-dist-out 18.594 APE10-dist-out 22.451 APE9-dist-out 24.098 None None None XRAY 2.65 0.242 0.309 B 325 290 4 0 0 4 [[62, 321], [418, 675]] 2.0 8wf4 Homo sapiens CAMK_RPS6KA1-2_HUMAN CAMK 1.2e-87 299.5 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
KS6A1_HUMAN 4NIFA Q15418 413 728 735.0 No_ligand No_ligand Inactive DFGin 6.868 14.611 BLAminus -123.07, -176.37 48.87, 75.9 -90.5, 26.09 285.58, 73.35 -57.93, -22.0 in-in in 9.099 Saltbr-in 2.64 HRD-in -82.17, -49.47 73.17, -4.09 in-in-out SNCiio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aannn APEdist_oooo APE10-dihe-na -76.32, -82.9 APE9-dihe-na -107.74, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-out 18.74 APE11-dist-out 18.053 APE10-dist-out 22.399 APE9-dist-out 24.655 None None None XRAY 2.15 0.161 0.208 A 333 313 3 0 0 3 [[62, 321], [418, 675]] 2.0 4nif Homo sapiens CAMK_RPS6KA1-2_HUMAN CAMK 1.3e-87 299.4 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
KS6A1_HUMAN 4NIFD Q15418 413 728 735.0 No_ligand No_ligand Inactive DFGin 6.821 14.509 BLAminus -125.54, -177.7 51.84, 74.57 -89.95, 24.53 284.87, 75.41 -55.2, -23.55 in-in in 9.009 Saltbr-in 2.701 HRD-in -81.48, -48.04 74.24, -5.51 in-in-out SNCiio in-out ActLoopNT-in 2.963 ActLoopCT-out nonTYR APEdihe_aannn APEdist_ooon APE10-dihe-na -107.68, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -123.59 999.0, 999.0 APE12-dist-out 18.96 APE11-dist-out 17.915 APE10-dist-out 22.588 APE9-dist-none 999.0 None None None XRAY 2.15 0.161 0.208 D 333 313 3 0 0 3 [[62, 321], [418, 675]] 2.0 4nif Homo sapiens CAMK_RPS6KA1-2_HUMAN CAMK 1.3e-87 299.4 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1

CAMK_RPS6KA1-2 (Ribosomal protein S6 kinase alpha-1)

Total number of chains: 0
Active chains: 0
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name