CMGC_PRP4K (Serine/threonine-protein kinase PRP4 homolog)

Total number of chains: 23
Active chains: 1
Family: CMGC
Uniprot: PRP4K_HUMAN
Kinase Domain Residues: 687 - 1003
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 17 73.9% AF-Q13523-K3A
None None 5 21.7% 8H6E4Y
DFGout None 1 4.3% 6CNHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q13523-K3A 679 1007 1007.0 No_ligand No_ligand Active DFGin 6.401 13.759 BLAminus -142.91, -177.71 61.0, 69.2 -82.1, 16.93 298.94, 93.45 -64.36, -26.42 in-in in 8.554 Saltbr-in 2.741 HRD-in -84.48, -35.62 68.4, -31.26 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.0, -15.46 APE9-dihe-na -99.4, 122.88 APE8-dihe-in -56.99, 126.29 APE8-rot-in 288.27 APE67-dihe-in -71.73, -10.87 -44.48, -49.91 APE12-dist-in 12.256 APE11-dist-in 10.174 APE10-dist-in 4.953 APE9-dist-in 3.511 None None None AF2 -1.0 1.0 1.0 A 329 329 0 0 0 0 [[687, 1003]] 1.0 AF-Q13523-K3 CMGC_PRP4K_HUMAN CMGC 1.4e-82 283.2 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
4IFCA 668 1005 1007.0 ADP:1101 ATPlike Inactive DFGin 6.321 14.363 BLAminus -121.88, -179.85 58.81, 82.85 -100.37, 25.78 288.2, 87.48 -70.57, -26.82 in-in in 8.257 Saltbr-in 2.844 HRD-in -62.43, -44.6 59.26, 25.1 in-in-out SNCiio in-out ActLoopNT-in 2.816 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.15, 134.81 APE9-dihe-na 75.99, 141.41 APE8-dihe-in -55.8, 125.16 APE8-rot-in 286.42 APE67-dihe-in -66.36, -24.99 -29.31, -53.31 APE12-dist-out 15.538 APE11-dist-in 11.831 APE10-dist-out 8.871 APE9-dist-in 3.287 None PTR849 PTR849 XRAY 2.13 0.243 0.256 A 358 328 10 0 0 0 [[687, 1003]] 1.0 4ifc CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
4IFCB 670 1005 1007.0 ADP:1101 ATPlike Inactive DFGin 6.419 14.343 BLAminus -121.41, 176.18 59.35, 85.75 -102.3, 24.13 289.47, 86.91 -69.6, -26.74 in-in in 8.319 Saltbr-in 2.779 HRD-in -64.36, -42.37 58.06, 25.43 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.87, 139.78 APE9-dihe-na 75.02, 140.04 APE8-dihe-in -56.36, 124.13 APE8-rot-in 293.29 APE67-dihe-in -65.74, -25.94 -27.6, -52.65 APE12-dist-out 15.537 APE11-dist-in 11.809 APE10-dist-out 8.576 APE9-dist-in 3.251 None PTR849 PTR849 XRAY 2.13 0.243 0.256 B 358 330 6 0 0 0 [[687, 1003]] 1.0 4ifc CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
4IIRA 668 1005 1007.0 ANP:1101 ATPlike Inactive DFGin 6.315 14.281 BLAminus -120.02, 179.88 56.46, 83.55 -99.74, 23.13 289.68, 86.8 -67.87, -30.41 in-in in 8.339 Saltbr-in 2.91 HRD-in -69.64, -43.63 60.41, 19.82 in-in-out SNCiio in-out ActLoopNT-in 2.778 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -71.08, 135.09 APE9-dihe-na 76.0, 140.17 APE8-dihe-in -53.9, 125.75 APE8-rot-in 292.63 APE67-dihe-in -65.92, -24.69 -31.89, -51.26 APE12-dist-out 15.663 APE11-dist-in 11.805 APE10-dist-out 8.892 APE9-dist-in 3.194 None PTR849 PTR849 XRAY 2.0 0.244 0.265 A 358 326 12 0 0 0 [[687, 1003]] 1.0 4iir CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
4IIRB 670 1005 1007.0 ANP:1101 ATPlike Inactive DFGin 6.312 13.999 BLAminus -118.84, -178.78 57.41, 86.51 -103.95, 25.37 293.04, 89.03 -68.57, -33.53 in-in in 8.481 Saltbr-in 2.795 HRD-in -68.12, -42.18 57.06, 24.08 in-in-out SNCiio in-out ActLoopNT-in 2.804 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.62, 140.27 APE9-dihe-na 75.42, 141.56 APE8-dihe-in -56.4, 124.9 APE8-rot-in 292.41 APE67-dihe-in -64.45, -24.58 -31.45, -51.6 APE12-dist-out 15.602 APE11-dist-in 11.812 APE10-dist-out 8.604 APE9-dist-in 3.219 None PTR849 PTR849 XRAY 2.0 0.244 0.265 B 358 328 8 0 0 0 [[687, 1003]] 1.0 4iir CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
AF-Q13523-K1A 679 1007 1007.0 No_ligand No_ligand Inactive DFGin 6.351 14.272 BLAminus -138.29, 178.68 64.95, 71.06 -85.96, 17.7 297.58, 94.09 -63.67, -24.85 in-in in 8.693 Saltbr-in 2.72 HRD-in -79.05, -43.28 59.09, 16.2 in-in-out SNCiio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -60.62, 144.55 APE9-dihe-na 67.27, 142.33 APE8-dihe-in -53.44, 130.0 APE8-rot-in 288.65 APE67-dihe-in -70.59, -12.67 -44.5, -50.73 APE12-dist-out 15.666 APE11-dist-in 12.027 APE10-dist-out 8.633 APE9-dist-in 3.203 None None None AF2 -1.0 1.0 1.0 A 329 329 0 0 0 0 [[687, 1003]] 1.0 AF-Q13523-K1 CMGC_PRP4K_HUMAN CMGC 1.4e-82 283.2 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
4IANA 676 1005 1007.0 No_ligand No_ligand Inactive DFGin 6.264 14.25 BLAminus -138.29, -172.03 58.03, 77.71 -93.02, 29.56 290.25, 79.1 -84.33, 6.5 in-in in 8.428 Saltbr-in 2.471 HRD-in -82.92, -52.99 72.97, 11.65 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -57.99, 141.65 APE9-dihe-na 73.56, 140.05 APE8-dihe-in -56.48, 133.43 APE8-rot-in 298.95 APE67-dihe-in -59.65, -24.86 -47.31, -48.92 APE12-dist-out 15.71 APE11-dist-in 11.798 APE10-dist-out 8.604 APE9-dist-in 3.27 None PTR849 PTR849 XRAY 2.44 0.228 0.288 A 358 322 8 0 0 0 [[687, 1003]] 1.0 4ian CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
4IANB 676 1005 1007.0 No_ligand No_ligand Inactive DFGin 6.388 14.292 BLAminus -132.05, -176.22 53.02, 86.33 -102.09, 34.95 290.06, 73.31 -78.73, -8.0 in-in in 8.224 Saltbr-in 3.033 HRD-in -81.84, -41.07 64.16, 14.17 in-in-out SNCiio in-out ActLoopNT-in 2.891 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -77.25, 142.17 APE9-dihe-na 68.84, 150.3 APE8-dihe-in -65.75, 145.11 APE8-rot-in 302.81 APE67-dihe-in -59.71, -22.69 -51.21, -53.37 APE12-dist-out 15.574 APE11-dist-in 11.852 APE10-dist-out 8.721 APE9-dist-in 3.202 None PTR849 PTR849 XRAY 2.44 0.228 0.288 B 358 320 10 0 0 0 [[687, 1003]] 1.0 4ian CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
6QX9K 676 1005 1007.0 No_ligand No_ligand Inactive DFGin 6.264 14.25 BLAminus -138.31, -172.04 58.05, 77.66 -93.01, 29.54 290.24, 79.13 -84.27, 6.47 in-in in 8.428 Saltbr-in 2.472 HRD-in -82.92, -53.02 72.99, 11.64 in-in-out SNCiio in-out ActLoopNT-in 2.975 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -58.5, 141.61 APE9-dihe-na 73.64, 140.06 APE8-dihe-in -56.5, 133.45 APE8-rot-in 298.91 APE67-dihe-in -59.71, -24.84 -47.35, -48.86 APE12-dist-out 15.709 APE11-dist-in 11.782 APE10-dist-out 8.604 APE9-dist-in 3.27 None None None EM 3.28 999.0 999.0 K 1007 322 8 0 0 0 [[687, 1003]] 1.0 6qx9 CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
8Y6OQ 676 1005 1007.0 No_ligand No_ligand Inactive DFGin 6.231 14.51 BLAminus -136.42, -167.88 58.5, 63.67 -86.31, 27.27 292.65, 83.32 -74.4, -7.14 in-out in 8.691 Saltbr-out 5.754 HRD-in -63.63, -47.21 69.9, -3.54 out-in-out SNCoio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -65.55, 141.68 APE9-dihe-na 71.25, 152.06 APE8-dihe-in -59.06, 141.97 APE8-rot-in 300.77 APE67-dihe-in -63.37, -39.07 -59.11, -42.53 APE12-dist-out 15.781 APE11-dist-in 11.871 APE10-dist-out 8.846 APE9-dist-in 2.925 None None None EM 3.38 999.0 999.0 Q 1007 322 8 0 0 0 [[687, 1003]] 1.0 8y6o CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
6PK6A 668 1005 1007.0 OND:1102 Type1 Inactive DFGin 6.244 14.367 BLAminus -129.14, 178.29 58.69, 90.15 -100.68, 26.6 295.02, 86.44 -71.14, -23.92 in-in in 8.941 Saltbr-in 2.581 HRD-in -65.46, -52.97 68.11, 22.97 in-in-out SNCiio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -66.39, 136.15 APE9-dihe-na 78.75, 140.8 APE8-dihe-in -51.09, 131.73 APE8-rot-in 295.49 APE67-dihe-in -61.15, -25.28 -51.44, -46.39 APE12-dist-out 15.33 APE11-dist-in 11.435 APE10-dist-out 8.429 APE9-dist-in 3.186 None PTR849 PTR849 XRAY 2.1 0.19 0.216 A 351 338 0 0 0 0 [[687, 1003]] 1.0 6pk6 CMGC_PRP4K_HUMAN CMGC 1.8e-82 282.8 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
4IJPA 670 1005 1007.0 1EH:1101 Type1 Inactive DFGin 6.269 14.134 BLAminus -120.07, -179.17 57.34, 89.47 -105.01, 30.07 292.73, 88.87 -72.72, -40.96 in-in in 8.442 Saltbr-in 2.8 HRD-in -69.44, -44.55 60.22, 24.19 in-in-out SNCiio in-out ActLoopNT-in 2.801 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -70.05, 133.54 APE9-dihe-na 77.1, 139.86 APE8-dihe-in -56.06, 120.1 APE8-rot-in 289.26 APE67-dihe-in -66.02, -24.26 -25.4, -52.6 APE12-dist-out 15.277 APE11-dist-in 11.547 APE10-dist-out 8.515 APE9-dist-in 3.263 None PTR849 PTR849 XRAY 2.25 0.25 0.265 A 358 331 5 0 0 0 [[687, 1003]] 1.0 4ijp CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
4IJPB 668 1005 1007.0 1EH:1101 Type1 Inactive DFGin 6.257 13.796 BLAminus -123.19, -178.54 59.47, 88.37 -104.92, 29.29 295.55, 90.45 -75.18, -41.1 in-in in 8.468 Saltbr-in 2.764 HRD-in -65.53, -42.6 57.25, 24.23 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.97, 139.28 APE9-dihe-na 75.27, 139.8 APE8-dihe-in -54.35, 125.59 APE8-rot-in 291.63 APE67-dihe-in -66.12, -22.13 -29.58, -53.46 APE12-dist-out 15.257 APE11-dist-in 11.537 APE10-dist-out 8.214 APE9-dist-in 3.235 None PTR849 PTR849 XRAY 2.25 0.25 0.265 B 358 334 4 0 0 0 [[687, 1003]] 1.0 4ijp CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
6PJJA 674 1005 1007.0 OCJ:1101 Type1 Inactive DFGin 6.358 14.433 BLAminus -126.85, 176.67 63.84, 81.76 -98.22, 22.27 288.52, 82.8 -71.01, -25.61 in-in in 8.184 Saltbr-in 2.751 HRD-in -74.41, -50.7 75.06, 2.79 in-in-out SNCiio in-out ActLoopNT-in 2.819 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -79.9, 145.13 APE9-dihe-na 75.14, -155.75 APE8-dihe-in -99.39, 116.03 APE8-rot-in 316.18 APE67-dihe-in -60.93, -20.63 -51.4, -50.73 APE12-dist-out 14.629 APE11-dist-in 13.303 APE10-dist-in 7.754 APE9-dist-in 5.068 None PTR849 PTR849 XRAY 2.4 0.193 0.24 A 351 321 11 0 0 0 [[687, 1003]] 1.0 6pjj CMGC_PRP4K_HUMAN CMGC 4.2e-82 281.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
6PJJB 674 1005 1007.0 OCJ:1101 Type1 Inactive DFGin 6.103 14.095 BLAminus -131.74, 179.71 64.06, 85.53 -99.98, 24.17 294.1, 86.19 -66.81, -34.07 in-in in 8.424 Saltbr-in 2.715 HRD-in -69.89, -55.27 77.31, 3.09 in-in-out SNCiio in-out ActLoopNT-in 2.858 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -80.05, 142.34 APE9-dihe-na 80.09, -145.45 APE8-dihe-in -107.35, 111.82 APE8-rot-in 317.28 APE67-dihe-in -64.4, -24.77 -47.69, -50.51 APE12-dist-out 14.512 APE11-dist-in 13.208 APE10-dist-in 7.556 APE9-dist-in 5.164 None PTR849 PTR849 XRAY 2.4 0.193 0.24 B 351 326 6 0 0 0 [[687, 1003]] 1.0 6pjj CMGC_PRP4K_HUMAN CMGC 4.2e-82 281.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
6PJJC 673 1005 1007.0 OCJ:1101 Type1 Inactive DFGin 6.321 14.267 BLAminus -139.0, 178.72 63.76, 82.04 -97.87, 30.68 289.31, 99.15 -85.25, -26.51 in-in in 8.379 Saltbr-in 2.854 HRD-in -69.93, -54.15 77.47, 4.15 in-in-out SNCiio in-out ActLoopNT-in 2.836 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -82.96, -44.87 APE9-dihe-na -107.89, -130.39 APE8-dihe-in -105.67, 111.99 APE8-rot-in 305.26 APE67-dihe-in -64.05, -27.92 -54.59, -39.5 APE12-dist-out 14.688 APE11-dist-in 13.369 APE10-dist-in 7.899 APE9-dist-in 4.959 None PTR849 PTR849 XRAY 2.4 0.193 0.24 C 351 326 7 0 0 0 [[687, 1003]] 1.0 6pjj CMGC_PRP4K_HUMAN CMGC 4.2e-82 281.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
6PJJD 677 1005 1007.0 OCJ:1101 Type1 Inactive DFGin 6.244 14.11 BLAminus -131.32, 176.27 64.04, 84.71 -105.58, 14.72 294.46, 82.99 -64.51, -17.14 in-in in 8.428 Saltbr-in 2.965 HRD-in -72.34, -58.46 83.04, -1.08 in-in-out SNCiio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -83.28, -49.35 APE9-dihe-na -103.57, -126.96 APE8-dihe-in -109.62, 110.71 APE8-rot-in 297.04 APE67-dihe-in -63.34, -26.25 -49.76, -47.89 APE12-dist-out 14.78 APE11-dist-in 13.506 APE10-dist-out 8.062 APE9-dist-in 4.844 None PTR849 PTR849 XRAY 2.4 0.193 0.24 D 351 317 12 0 0 3 [[687, 1003]] 1.0 6pjj CMGC_PRP4K_HUMAN CMGC 4.2e-82 281.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
6CNHA 657 1005 1007.0 919:61101 Type2 Inactive DFGout 13.873 9.687 None -146.22, 178.88 -148.9, 133.4 -113.52, 999.0 289.34, 105.17 999.0, 999.0 in-in in 8.743 Saltbr-in 2.728 HRD-in -76.45, -58.34 75.69, 1.93 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -69.49 APE9-dihe-na -64.24, -27.34 APE8-dihe-out -53.85, -35.73 APE8-rot-in 287.32 APE67-dihe-in -65.75, -22.29 -59.96, -34.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8 None None None XRAY 2.0 0.183 0.206 A 351 319 21 0 0 14 [[687, 1003]] 1.0 6cnh CMGC_PRP4K_HUMAN CMGC 4.2e-82 281.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
8H6E4Y 676 1005 1007.0 No_ligand No_ligand Inactive None 999.0 999.0 None -138.28, -172.02 58.06, 77.63 -93.03, 29.53 999.0, 999.0 -84.26, 6.49 in-none in 8.43 Saltbr-none 999.0 HRD-in -82.98, -52.93 73.0, 11.65 none-in-out SNCnio in-out ActLoopNT-in 2.975 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioi APE10-dihe-na -58.47, 141.64 APE9-dihe-na 73.64, 139.99 APE8-dihe-in -56.42, 133.45 APE8-rot-none 999.0 APE67-dihe-in -59.66, -24.87 -47.33, -48.86 APE12-dist-out 15.71 APE11-dist-in 11.782 APE10-dist-out 8.605 APE9-dist-in 3.271 None None None EM 3.2 999.0 999.0 4Y 1007 322 8 0 0 0 [[687, 1003]] 1.0 8h6e CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
8H6J4Y 676 1005 1007.0 No_ligand No_ligand Inactive None 999.0 999.0 None -138.28, -172.02 58.06, 77.63 -93.03, 29.53 999.0, 999.0 -84.26, 6.49 in-none in 8.43 Saltbr-none 999.0 HRD-in -82.98, -52.93 73.0, 11.65 none-in-out SNCnio in-out ActLoopNT-in 2.975 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioi APE10-dihe-na -58.47, 141.64 APE9-dihe-na 73.64, 139.99 APE8-dihe-in -56.42, 133.45 APE8-rot-none 999.0 APE67-dihe-in -59.66, -24.87 -47.33, -48.86 APE12-dist-out 15.71 APE11-dist-in 11.782 APE10-dist-out 8.605 APE9-dist-in 3.271 None None None EM 3.25 999.0 999.0 4Y 1007 322 8 0 0 0 [[687, 1003]] 1.0 8h6j CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
8QXDK 676 1005 1007.0 No_ligand No_ligand Inactive None 999.0 999.0 None -139.78, -167.93 56.88, 61.75 -93.07, 25.58 999.0, 999.0 -72.57, -19.44 in-none in 8.817 Saltbr-none 999.0 HRD-in -77.51, -53.83 56.27, 34.7 none-in-out SNCnio in-out ActLoopNT-in 2.733 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioi APE10-dihe-na -90.29, -153.08 APE9-dihe-na -70.75, 169.13 APE8-dihe-in -67.25, 163.76 APE8-rot-none 999.0 APE67-dihe-in -71.6, -25.99 -71.3, -14.71 APE12-dist-out 15.484 APE11-dist-in 10.601 APE10-dist-out 10.666 APE9-dist-in 4.984 None None None EM 9.6 999.0 999.0 K 1007 322 8 0 0 0 [[687, 1003]] 1.0 8qxd CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
8R08K 676 1005 1007.0 No_ligand No_ligand Inactive None 999.0 999.0 None -139.2, -167.31 56.8, 61.61 -93.09, 25.55 999.0, 999.0 -73.48, -20.03 in-none in 8.497 Saltbr-none 999.0 HRD-in -77.57, -55.22 56.36, 37.26 none-in-out SNCnio in-out ActLoopNT-in 2.617 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioi APE10-dihe-na -90.69, -170.73 APE9-dihe-na -72.73, 164.45 APE8-dihe-in -70.25, 170.8 APE8-rot-none 999.0 APE67-dihe-in -71.09, -24.27 -68.63, -18.76 APE12-dist-out 15.767 APE11-dist-in 10.769 APE10-dist-out 11.051 APE9-dist-in 5.284 None None None EM 6.1 999.0 999.0 K 1007 322 8 0 0 0 [[687, 1003]] 1.0 8r08 CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
8R0AK 676 1005 1007.0 No_ligand No_ligand Inactive None 999.0 999.0 None -138.78, -168.54 56.69, 62.83 -94.96, 30.61 999.0, 999.0 -77.31, -9.08 in-none in 8.743 Saltbr-none 999.0 HRD-in -76.27, -55.98 56.63, 31.84 none-in-out SNCnio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioi APE10-dihe-na -81.65, -157.18 APE9-dihe-na -67.2, 168.42 APE8-dihe-in -69.49, 170.27 APE8-rot-none 999.0 APE67-dihe-in -71.69, -28.99 -75.21, -9.45 APE12-dist-out 15.111 APE11-dist-in 10.182 APE10-dist-out 9.996 APE9-dist-in 4.427 None None None EM 5.8 999.0 999.0 K 1007 322 8 0 0 0 [[687, 1003]] 1.0 8r0a CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog

CMGC_PRP4K (Serine/threonine-protein kinase PRP4 homolog)

Total number of chains: 25
Active chains: 1
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 17 68.0% AF-Q13523-K3A
None None 5 20.0% 8H6E4Y
DFGout None 3 12.0% 7Q4AB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PRP4K_HUMAN AF-Q13523-K3A Q13523 679 1007 1007.0 No_ligand No_ligand Active DFGin 6.401 13.759 BLAminus -142.91, -177.71 61.0, 69.2 -82.1, 16.93 298.94, 93.45 -64.36, -26.42 in-in in 8.554 Saltbr-in 2.741 HRD-in -84.48, -35.62 68.4, -31.26 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.0, -15.46 APE9-dihe-na -99.4, 122.88 APE8-dihe-in -56.99, 126.29 APE8-rot-in 288.27 APE67-dihe-in -71.73, -10.87 -44.48, -49.91 APE12-dist-in 12.256 APE11-dist-in 10.174 APE10-dist-in 4.953 APE9-dist-in 3.511 None None None AF2 -1.0 1.0 1.0 A 329 329 0 0 0 0 [[687, 1003]] 1.0 AF-Q13523-K3 Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.4e-82 283.2 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 4IFCA Q13523 668 1005 1007.0 ADP:1101 ATPlike Inactive DFGin 6.321 14.363 BLAminus -121.88, -179.85 58.81, 82.85 -100.37, 25.78 288.2, 87.48 -70.57, -26.82 in-in in 8.257 Saltbr-in 2.844 HRD-in -62.43, -44.6 59.26, 25.1 in-in-out SNCiio in-out ActLoopNT-in 2.816 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.15, 134.81 APE9-dihe-na 75.99, 141.41 APE8-dihe-in -55.8, 125.16 APE8-rot-in 286.42 APE67-dihe-in -66.36, -24.99 -29.31, -53.31 APE12-dist-out 15.538 APE11-dist-in 11.831 APE10-dist-out 8.871 APE9-dist-in 3.287 None PTR849 PTR849 XRAY 2.13 0.243 0.256 A 358 328 10 0 0 0 [[687, 1003]] 1.0 4ifc Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 4IFCB Q13523 670 1005 1007.0 ADP:1101 ATPlike Inactive DFGin 6.419 14.343 BLAminus -121.41, 176.18 59.35, 85.75 -102.3, 24.13 289.47, 86.91 -69.6, -26.74 in-in in 8.319 Saltbr-in 2.779 HRD-in -64.36, -42.37 58.06, 25.43 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.87, 139.78 APE9-dihe-na 75.02, 140.04 APE8-dihe-in -56.36, 124.13 APE8-rot-in 293.29 APE67-dihe-in -65.74, -25.94 -27.6, -52.65 APE12-dist-out 15.537 APE11-dist-in 11.809 APE10-dist-out 8.576 APE9-dist-in 3.251 None PTR849 PTR849 XRAY 2.13 0.243 0.256 B 358 330 6 0 0 0 [[687, 1003]] 1.0 4ifc Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 4IIRA Q13523 668 1005 1007.0 ANP:1101 ATPlike Inactive DFGin 6.315 14.281 BLAminus -120.02, 179.88 56.46, 83.55 -99.74, 23.13 289.68, 86.8 -67.87, -30.41 in-in in 8.339 Saltbr-in 2.91 HRD-in -69.64, -43.63 60.41, 19.82 in-in-out SNCiio in-out ActLoopNT-in 2.778 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -71.08, 135.09 APE9-dihe-na 76.0, 140.17 APE8-dihe-in -53.9, 125.75 APE8-rot-in 292.63 APE67-dihe-in -65.92, -24.69 -31.89, -51.26 APE12-dist-out 15.663 APE11-dist-in 11.805 APE10-dist-out 8.892 APE9-dist-in 3.194 None PTR849 PTR849 XRAY 2.0 0.244 0.265 A 358 326 12 0 0 0 [[687, 1003]] 1.0 4iir Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 4IIRB Q13523 670 1005 1007.0 ANP:1101 ATPlike Inactive DFGin 6.312 13.999 BLAminus -118.84, -178.78 57.41, 86.51 -103.95, 25.37 293.04, 89.03 -68.57, -33.53 in-in in 8.481 Saltbr-in 2.795 HRD-in -68.12, -42.18 57.06, 24.08 in-in-out SNCiio in-out ActLoopNT-in 2.804 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.62, 140.27 APE9-dihe-na 75.42, 141.56 APE8-dihe-in -56.4, 124.9 APE8-rot-in 292.41 APE67-dihe-in -64.45, -24.58 -31.45, -51.6 APE12-dist-out 15.602 APE11-dist-in 11.812 APE10-dist-out 8.604 APE9-dist-in 3.219 None PTR849 PTR849 XRAY 2.0 0.244 0.265 B 358 328 8 0 0 0 [[687, 1003]] 1.0 4iir Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN AF-Q13523-K1A Q13523 679 1007 1007.0 No_ligand No_ligand Inactive DFGin 6.351 14.272 BLAminus -138.29, 178.68 64.95, 71.06 -85.96, 17.7 297.58, 94.09 -63.67, -24.85 in-in in 8.693 Saltbr-in 2.72 HRD-in -79.05, -43.28 59.09, 16.2 in-in-out SNCiio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -60.62, 144.55 APE9-dihe-na 67.27, 142.33 APE8-dihe-in -53.44, 130.0 APE8-rot-in 288.65 APE67-dihe-in -70.59, -12.67 -44.5, -50.73 APE12-dist-out 15.666 APE11-dist-in 12.027 APE10-dist-out 8.633 APE9-dist-in 3.203 None None None AF2 -1.0 1.0 1.0 A 329 329 0 0 0 0 [[687, 1003]] 1.0 AF-Q13523-K1 Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.4e-82 283.2 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 4IANA Q13523 676 1005 1007.0 No_ligand No_ligand Inactive DFGin 6.264 14.25 BLAminus -138.29, -172.03 58.03, 77.71 -93.02, 29.56 290.25, 79.1 -84.33, 6.5 in-in in 8.428 Saltbr-in 2.471 HRD-in -82.92, -52.99 72.97, 11.65 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -57.99, 141.65 APE9-dihe-na 73.56, 140.05 APE8-dihe-in -56.48, 133.43 APE8-rot-in 298.95 APE67-dihe-in -59.65, -24.86 -47.31, -48.92 APE12-dist-out 15.71 APE11-dist-in 11.798 APE10-dist-out 8.604 APE9-dist-in 3.27 None PTR849 PTR849 XRAY 2.44 0.228 0.288 A 358 322 8 0 0 0 [[687, 1003]] 1.0 4ian Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 4IANB Q13523 676 1005 1007.0 No_ligand No_ligand Inactive DFGin 6.388 14.292 BLAminus -132.05, -176.22 53.02, 86.33 -102.09, 34.95 290.06, 73.31 -78.73, -8.0 in-in in 8.224 Saltbr-in 3.033 HRD-in -81.84, -41.07 64.16, 14.17 in-in-out SNCiio in-out ActLoopNT-in 2.891 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -77.25, 142.17 APE9-dihe-na 68.84, 150.3 APE8-dihe-in -65.75, 145.11 APE8-rot-in 302.81 APE67-dihe-in -59.71, -22.69 -51.21, -53.37 APE12-dist-out 15.574 APE11-dist-in 11.852 APE10-dist-out 8.721 APE9-dist-in 3.202 None PTR849 PTR849 XRAY 2.44 0.228 0.288 B 358 320 10 0 0 0 [[687, 1003]] 1.0 4ian Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 6QX9K Q13523 676 1005 1007.0 No_ligand No_ligand Inactive DFGin 6.264 14.25 BLAminus -138.31, -172.04 58.05, 77.66 -93.01, 29.54 290.24, 79.13 -84.27, 6.47 in-in in 8.428 Saltbr-in 2.472 HRD-in -82.92, -53.02 72.99, 11.64 in-in-out SNCiio in-out ActLoopNT-in 2.975 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -58.5, 141.61 APE9-dihe-na 73.64, 140.06 APE8-dihe-in -56.5, 133.45 APE8-rot-in 298.91 APE67-dihe-in -59.71, -24.84 -47.35, -48.86 APE12-dist-out 15.709 APE11-dist-in 11.782 APE10-dist-out 8.604 APE9-dist-in 3.27 None None None EM 3.28 999.0 999.0 K 1007 322 8 0 0 0 [[687, 1003]] 1.0 6qx9 Homo sapiens CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 8Y6OQ Q13523 676 1005 1007.0 No_ligand No_ligand Inactive DFGin 6.231 14.51 BLAminus -136.42, -167.88 58.5, 63.67 -86.31, 27.27 292.65, 83.32 -74.4, -7.14 in-out in 8.691 Saltbr-out 5.754 HRD-in -63.63, -47.21 69.9, -3.54 out-in-out SNCoio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -65.55, 141.68 APE9-dihe-na 71.25, 152.06 APE8-dihe-in -59.06, 141.97 APE8-rot-in 300.77 APE67-dihe-in -63.37, -39.07 -59.11, -42.53 APE12-dist-out 15.781 APE11-dist-in 11.871 APE10-dist-out 8.846 APE9-dist-in 2.925 None None None EM 3.38 999.0 999.0 Q 1007 322 8 0 0 0 [[687, 1003]] 1.0 8y6o Homo sapiens CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 6PK6A Q13523 668 1005 1007.0 OND:1102 Type1 Inactive DFGin 6.244 14.367 BLAminus -129.14, 178.29 58.69, 90.15 -100.68, 26.6 295.02, 86.44 -71.14, -23.92 in-in in 8.941 Saltbr-in 2.581 HRD-in -65.46, -52.97 68.11, 22.97 in-in-out SNCiio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -66.39, 136.15 APE9-dihe-na 78.75, 140.8 APE8-dihe-in -51.09, 131.73 APE8-rot-in 295.49 APE67-dihe-in -61.15, -25.28 -51.44, -46.39 APE12-dist-out 15.33 APE11-dist-in 11.435 APE10-dist-out 8.429 APE9-dist-in 3.186 None PTR849 PTR849 XRAY 2.1 0.19 0.216 A 351 338 0 0 0 0 [[687, 1003]] 1.0 6pk6 Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.8e-82 282.8 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 4IJPA Q13523 670 1005 1007.0 1EH:1101 Type1 Inactive DFGin 6.269 14.134 BLAminus -120.07, -179.17 57.34, 89.47 -105.01, 30.07 292.73, 88.87 -72.72, -40.96 in-in in 8.442 Saltbr-in 2.8 HRD-in -69.44, -44.55 60.22, 24.19 in-in-out SNCiio in-out ActLoopNT-in 2.801 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -70.05, 133.54 APE9-dihe-na 77.1, 139.86 APE8-dihe-in -56.06, 120.1 APE8-rot-in 289.26 APE67-dihe-in -66.02, -24.26 -25.4, -52.6 APE12-dist-out 15.277 APE11-dist-in 11.547 APE10-dist-out 8.515 APE9-dist-in 3.263 None PTR849 PTR849 XRAY 2.25 0.25 0.265 A 358 331 5 0 0 0 [[687, 1003]] 1.0 4ijp Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 4IJPB Q13523 668 1005 1007.0 1EH:1101 Type1 Inactive DFGin 6.257 13.796 BLAminus -123.19, -178.54 59.47, 88.37 -104.92, 29.29 295.55, 90.45 -75.18, -41.1 in-in in 8.468 Saltbr-in 2.764 HRD-in -65.53, -42.6 57.25, 24.23 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.97, 139.28 APE9-dihe-na 75.27, 139.8 APE8-dihe-in -54.35, 125.59 APE8-rot-in 291.63 APE67-dihe-in -66.12, -22.13 -29.58, -53.46 APE12-dist-out 15.257 APE11-dist-in 11.537 APE10-dist-out 8.214 APE9-dist-in 3.235 None PTR849 PTR849 XRAY 2.25 0.25 0.265 B 358 334 4 0 0 0 [[687, 1003]] 1.0 4ijp Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 6PJJA Q13523 674 1005 1007.0 OCJ:1101 Type1 Inactive DFGin 6.358 14.433 BLAminus -126.85, 176.67 63.84, 81.76 -98.22, 22.27 288.52, 82.8 -71.01, -25.61 in-in in 8.184 Saltbr-in 2.751 HRD-in -74.41, -50.7 75.06, 2.79 in-in-out SNCiio in-out ActLoopNT-in 2.819 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -79.9, 145.13 APE9-dihe-na 75.14, -155.75 APE8-dihe-in -99.39, 116.03 APE8-rot-in 316.18 APE67-dihe-in -60.93, -20.63 -51.4, -50.73 APE12-dist-out 14.629 APE11-dist-in 13.303 APE10-dist-in 7.754 APE9-dist-in 5.068 None PTR849 PTR849 XRAY 2.4 0.193 0.24 A 351 321 11 0 0 0 [[687, 1003]] 1.0 6pjj Homo sapiens CMGC_PRP4K_HUMAN CMGC 4.2e-82 281.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 6PJJB Q13523 674 1005 1007.0 OCJ:1101 Type1 Inactive DFGin 6.103 14.095 BLAminus -131.74, 179.71 64.06, 85.53 -99.98, 24.17 294.1, 86.19 -66.81, -34.07 in-in in 8.424 Saltbr-in 2.715 HRD-in -69.89, -55.27 77.31, 3.09 in-in-out SNCiio in-out ActLoopNT-in 2.858 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -80.05, 142.34 APE9-dihe-na 80.09, -145.45 APE8-dihe-in -107.35, 111.82 APE8-rot-in 317.28 APE67-dihe-in -64.4, -24.77 -47.69, -50.51 APE12-dist-out 14.512 APE11-dist-in 13.208 APE10-dist-in 7.556 APE9-dist-in 5.164 None PTR849 PTR849 XRAY 2.4 0.193 0.24 B 351 326 6 0 0 0 [[687, 1003]] 1.0 6pjj Homo sapiens CMGC_PRP4K_HUMAN CMGC 4.2e-82 281.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 6PJJC Q13523 673 1005 1007.0 OCJ:1101 Type1 Inactive DFGin 6.321 14.267 BLAminus -139.0, 178.72 63.76, 82.04 -97.87, 30.68 289.31, 99.15 -85.25, -26.51 in-in in 8.379 Saltbr-in 2.854 HRD-in -69.93, -54.15 77.47, 4.15 in-in-out SNCiio in-out ActLoopNT-in 2.836 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -82.96, -44.87 APE9-dihe-na -107.89, -130.39 APE8-dihe-in -105.67, 111.99 APE8-rot-in 305.26 APE67-dihe-in -64.05, -27.92 -54.59, -39.5 APE12-dist-out 14.688 APE11-dist-in 13.369 APE10-dist-in 7.899 APE9-dist-in 4.959 None PTR849 PTR849 XRAY 2.4 0.193 0.24 C 351 326 7 0 0 0 [[687, 1003]] 1.0 6pjj Homo sapiens CMGC_PRP4K_HUMAN CMGC 4.2e-82 281.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 6PJJD Q13523 677 1005 1007.0 OCJ:1101 Type1 Inactive DFGin 6.244 14.11 BLAminus -131.32, 176.27 64.04, 84.71 -105.58, 14.72 294.46, 82.99 -64.51, -17.14 in-in in 8.428 Saltbr-in 2.965 HRD-in -72.34, -58.46 83.04, -1.08 in-in-out SNCiio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -83.28, -49.35 APE9-dihe-na -103.57, -126.96 APE8-dihe-in -109.62, 110.71 APE8-rot-in 297.04 APE67-dihe-in -63.34, -26.25 -49.76, -47.89 APE12-dist-out 14.78 APE11-dist-in 13.506 APE10-dist-out 8.062 APE9-dist-in 4.844 None PTR849 PTR849 XRAY 2.4 0.193 0.24 D 351 317 12 0 0 3 [[687, 1003]] 1.0 6pjj Homo sapiens CMGC_PRP4K_HUMAN CMGC 4.2e-82 281.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 6CNHA Q13523 657 1005 1007.0 919:61101 Type2 Inactive DFGout 13.873 9.687 None -146.22, 178.88 -148.9, 133.4 -113.52, 999.0 289.34, 105.17 999.0, 999.0 in-in in 8.743 Saltbr-in 2.728 HRD-in -76.45, -58.34 75.69, 1.93 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -69.49 APE9-dihe-na -64.24, -27.34 APE8-dihe-out -53.85, -35.73 APE8-rot-in 287.32 APE67-dihe-in -65.75, -22.29 -59.96, -34.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8 None None None XRAY 2.0 0.183 0.206 A 351 319 21 0 0 14 [[687, 1003]] 1.0 6cnh Homo sapiens CMGC_PRP4K_HUMAN CMGC 4.2e-82 281.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 8H6E4Y Q13523 676 1005 1007.0 No_ligand No_ligand Inactive None 999.0 999.0 None -138.28, -172.02 58.06, 77.63 -93.03, 29.53 999.0, 999.0 -84.26, 6.49 in-none in 8.43 Saltbr-none 999.0 HRD-in -82.98, -52.93 73.0, 11.65 none-in-out SNCnio in-out ActLoopNT-in 2.975 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioi APE10-dihe-na -58.47, 141.64 APE9-dihe-na 73.64, 139.99 APE8-dihe-in -56.42, 133.45 APE8-rot-none 999.0 APE67-dihe-in -59.66, -24.87 -47.33, -48.86 APE12-dist-out 15.71 APE11-dist-in 11.782 APE10-dist-out 8.605 APE9-dist-in 3.271 None None None EM 3.2 999.0 999.0 4Y 1007 322 8 0 0 0 [[687, 1003]] 1.0 8h6e Homo sapiens CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 8H6J4Y Q13523 676 1005 1007.0 No_ligand No_ligand Inactive None 999.0 999.0 None -138.28, -172.02 58.06, 77.63 -93.03, 29.53 999.0, 999.0 -84.26, 6.49 in-none in 8.43 Saltbr-none 999.0 HRD-in -82.98, -52.93 73.0, 11.65 none-in-out SNCnio in-out ActLoopNT-in 2.975 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioi APE10-dihe-na -58.47, 141.64 APE9-dihe-na 73.64, 139.99 APE8-dihe-in -56.42, 133.45 APE8-rot-none 999.0 APE67-dihe-in -59.66, -24.87 -47.33, -48.86 APE12-dist-out 15.71 APE11-dist-in 11.782 APE10-dist-out 8.605 APE9-dist-in 3.271 None None None EM 3.25 999.0 999.0 4Y 1007 322 8 0 0 0 [[687, 1003]] 1.0 8h6j Homo sapiens CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 8QXDK Q13523 676 1005 1007.0 No_ligand No_ligand Inactive None 999.0 999.0 None -139.78, -167.93 56.88, 61.75 -93.07, 25.58 999.0, 999.0 -72.57, -19.44 in-none in 8.817 Saltbr-none 999.0 HRD-in -77.51, -53.83 56.27, 34.7 none-in-out SNCnio in-out ActLoopNT-in 2.733 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioi APE10-dihe-na -90.29, -153.08 APE9-dihe-na -70.75, 169.13 APE8-dihe-in -67.25, 163.76 APE8-rot-none 999.0 APE67-dihe-in -71.6, -25.99 -71.3, -14.71 APE12-dist-out 15.484 APE11-dist-in 10.601 APE10-dist-out 10.666 APE9-dist-in 4.984 None None None EM 9.6 999.0 999.0 K 1007 322 8 0 0 0 [[687, 1003]] 1.0 8qxd Homo sapiens CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 8R08K Q13523 676 1005 1007.0 No_ligand No_ligand Inactive None 999.0 999.0 None -139.2, -167.31 56.8, 61.61 -93.09, 25.55 999.0, 999.0 -73.48, -20.03 in-none in 8.497 Saltbr-none 999.0 HRD-in -77.57, -55.22 56.36, 37.26 none-in-out SNCnio in-out ActLoopNT-in 2.617 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioi APE10-dihe-na -90.69, -170.73 APE9-dihe-na -72.73, 164.45 APE8-dihe-in -70.25, 170.8 APE8-rot-none 999.0 APE67-dihe-in -71.09, -24.27 -68.63, -18.76 APE12-dist-out 15.767 APE11-dist-in 10.769 APE10-dist-out 11.051 APE9-dist-in 5.284 None None None EM 6.1 999.0 999.0 K 1007 322 8 0 0 0 [[687, 1003]] 1.0 8r08 Homo sapiens CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
PRP4K_HUMAN 8R0AK Q13523 676 1005 1007.0 No_ligand No_ligand Inactive None 999.0 999.0 None -138.78, -168.54 56.69, 62.83 -94.96, 30.61 999.0, 999.0 -77.31, -9.08 in-none in 8.743 Saltbr-none 999.0 HRD-in -76.27, -55.98 56.63, 31.84 none-in-out SNCnio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioi APE10-dihe-na -81.65, -157.18 APE9-dihe-na -67.2, 168.42 APE8-dihe-in -69.49, 170.27 APE8-rot-none 999.0 APE67-dihe-in -71.69, -28.99 -75.21, -9.45 APE12-dist-out 15.111 APE11-dist-in 10.182 APE10-dist-out 9.996 APE9-dist-in 4.427 None None None EM 5.8 999.0 999.0 K 1007 322 8 0 0 0 [[687, 1003]] 1.0 8r0a Homo sapiens CMGC_PRP4K_HUMAN CMGC 3e-81 278.6 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
S7UT92_TOXGG 7Q4AA S7UT92 547 894 928.0 A9I:60401 Type2 Inactive DFGout 13.918 6.471 None -144.58, 169.37 -127.36, 78.19 -137.7, 43.09 204.71, 49.1 -133.86, 14.15 in-in in 8.863 Saltbr-in 3.172 HRD-in -85.78, -56.82 71.39, 3.41 in-out-out SNCioo out-out ActLoopNT-out 15.854 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -75.04, -28.65 APE9-dihe-na -71.8, -42.93 APE8-dihe-out -60.42, -28.61 APE8-rot-in 298.14 APE67-dihe-in -57.17, -27.99 -58.12, -33.74 APE12-dist-out 4.299 APE11-dist-out 7.23 APE10-dist-out 11.069 APE9-dist-out 10.697 None PTR729 PTR729 XRAY 2.31 0.203 0.219 A 370 335 13 0 0 0 [[567, 890]] 1.0 7q4a Toxoplasma gondii CMGC_PRP4K_TOXGG CMGC 1.1e-76 264.2 5 301 297 713 714 715 717 719 597 612 616 692 694 693 695 751 739 734 733 732 731 730 729 728 648 non-specific serine/threonine protein kinase
S7UT92_TOXGG 7Q4AB S7UT92 546 891 928.0 A9I:60401 Type2 Inactive DFGout 14.783 8.528 None -128.62, 161.71 -121.05, 72.34 -64.49, -41.84 224.7, 141.1 77.82, -149.05 in-out in 9.27 Saltbr-out 6.62 HRD-in -81.37, -54.41 69.31, 7.54 out-out-out SNCooo out-out ActLoopNT-out 17.168 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -68.77, -39.97 APE9-dihe-na -67.6, -45.19 APE8-dihe-out -53.7, -30.61 APE8-rot-in 268.24 APE67-dihe-in -61.5, -20.2 -66.27, -26.95 APE12-dist-out 6.433 APE11-dist-in 10.061 APE10-dist-out 13.737 APE9-dist-out 11.524 None PTR729 PTR729 XRAY 2.31 0.203 0.219 B 370 346 0 0 0 0 [[567, 890]] 1.0 7q4a Toxoplasma gondii CMGC_PRP4K_TOXGG CMGC 1.1e-76 264.2 5 301 297 713 714 715 717 719 597 612 616 692 694 693 695 751 739 734 733 732 731 730 729 728 648 non-specific serine/threonine protein kinase

CMGC_PRP4K (Serine/threonine-protein kinase PRP4 homolog)

Total number of chains: 2
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 2 100.0% 7Q4AB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
S7UT92_TOXGG 7Q4AA S7UT92 547 894 928.0 A9I:60401 Type2 Inactive DFGout 13.918 6.471 None -144.58, 169.37 -127.36, 78.19 -137.7, 43.09 204.71, 49.1 -133.86, 14.15 in-in in 8.863 Saltbr-in 3.172 HRD-in -85.78, -56.82 71.39, 3.41 in-out-out SNCioo out-out ActLoopNT-out 15.854 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -75.04, -28.65 APE9-dihe-na -71.8, -42.93 APE8-dihe-out -60.42, -28.61 APE8-rot-in 298.14 APE67-dihe-in -57.17, -27.99 -58.12, -33.74 APE12-dist-out 4.299 APE11-dist-out 7.23 APE10-dist-out 11.069 APE9-dist-out 10.697 None PTR729 PTR729 XRAY 2.31 0.203 0.219 A 370 335 13 0 0 0 [[567, 890]] 1.0 7q4a Toxoplasma gondii CMGC_PRP4K_TOXGG CMGC 1.1e-76 264.2 5 301 297 713 714 715 717 719 597 612 616 692 694 693 695 751 739 734 733 732 731 730 729 728 648 non-specific serine/threonine protein kinase
S7UT92_TOXGG 7Q4AB S7UT92 546 891 928.0 A9I:60401 Type2 Inactive DFGout 14.783 8.528 None -128.62, 161.71 -121.05, 72.34 -64.49, -41.84 224.7, 141.1 77.82, -149.05 in-out in 9.27 Saltbr-out 6.62 HRD-in -81.37, -54.41 69.31, 7.54 out-out-out SNCooo out-out ActLoopNT-out 17.168 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -68.77, -39.97 APE9-dihe-na -67.6, -45.19 APE8-dihe-out -53.7, -30.61 APE8-rot-in 268.24 APE67-dihe-in -61.5, -20.2 -66.27, -26.95 APE12-dist-out 6.433 APE11-dist-in 10.061 APE10-dist-out 13.737 APE9-dist-out 11.524 None PTR729 PTR729 XRAY 2.31 0.203 0.219 B 370 346 0 0 0 0 [[567, 890]] 1.0 7q4a Toxoplasma gondii CMGC_PRP4K_TOXGG CMGC 1.1e-76 264.2 5 301 297 713 714 715 717 719 597 612 616 692 694 693 695 751 739 734 733 732 731 730 729 728 648 non-specific serine/threonine protein kinase