TYR_MUSK (Muscle, skeletal receptor tyrosine-protein kinase)

Total number of chains: 2
Active chains: 2
Uniprot: MUSK_HUMAN
Kinase Domain Residues: 575 - 858
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-O15146-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MUSK AF-O15146-K1A O15146 567 866 869.0 No_ligand No_ligand Active DFGin 7.0474 14.3165 BLAminus -136.33, -176.02 51.58, 75.98 -93.58, 10.42 286.95, 85.45 -67.59, -29.91 in-in in 8.3751 Saltbr-in 2.7439 HRD-in -74.55, -38.23 65.86, -21.88 in-in-in SNCiii in-in ActLoopNT-in 2.8836 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.97, 125.48 APE9-dihe-in -126.2, 136.81 APE8-dihe-in -81.44, 69.98 APE8-rot-na 36.22 APE67-dihe-in -73.1, -13.51 -41.87, -41.27 APE12-dist-na 13.6602 APE11-dist-na 8.2252 APE10-dist-na 9.2262 APE9-dist-in 6.6053 None None None AF2 -1.0 1.0 1.0 A 300.0 300.0 0 30 30 0 [[575, 858]] 1.0 AF-O15146-K1 TYR_MUSK_HUMAN TYR 1.4e-97 332.0 1.0 260.0 260.0 742 743 744 746 748 609 626 630 722 724 723 725.0 784 772 767 766 765 764 763 762 761 656 Muscle, skeletal receptor tyrosine-protein kinase
MUSK AF-O15146-K3A O15146 567 866 869.0 No_ligand No_ligand Active DFGin 7.0348 14.2647 BLAminus -140.06, -176.0 54.95, 63.3 -81.97, 11.46 289.53, 82.9 -60.6, -32.88 in-in in 8.338 Saltbr-in 2.7347 HRD-in -82.38, -40.47 68.87, -18.92 in-in-in SNCiii in-in ActLoopNT-in 2.9013 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.07, 131.68 APE9-dihe-in -109.98, 122.37 APE8-dihe-in -76.85, 75.34 APE8-rot-na 32.55 APE67-dihe-in -72.18, -15.34 -43.2, -42.48 APE12-dist-na 12.8377 APE11-dist-na 7.8741 APE10-dist-na 8.8863 APE9-dist-in 6.2559 None None None AF2 -1.0 1.0 1.0 A 300.0 300.0 0 30 30 0 [[575, 858]] 1.0 AF-O15146-K3 TYR_MUSK_HUMAN TYR 1.4e-97 332.0 1.0 260.0 260.0 742 743 744 746 748 609 626 630 722 724 723 725.0 784 772 767 766 765 764 763 762 761 656 Muscle, skeletal receptor tyrosine-protein kinase

TYR_MUSK (Muscle, skeletal receptor tyrosine-protein kinase)

Total number of chains: 3
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% AF-O15146-K1A
DFGinter None 1 33.3% 1LUFA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MUSK MUSK_HUMAN AF-O15146-K1A O15146 567 866 869.0 No_ligand No_ligand Active DFGin 7.0474 14.3165 BLAminus -136.33, -176.02 51.58, 75.98 -93.58, 10.42 286.95, 85.45 -67.59, -29.91 in-in in 8.3751 Saltbr-in 2.7439 HRD-in -74.55, -38.23 65.86, -21.88 in-in-in SNCiii in-in ActLoopNT-in 2.8836 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.97, 125.48 APE9-dihe-in -126.2, 136.81 APE8-dihe-in -81.44, 69.98 APE8-rot-na 36.22 APE67-dihe-in -73.1, -13.51 -41.87, -41.27 APE12-dist-na 13.6602 APE11-dist-na 8.2252 APE10-dist-na 9.2262 APE9-dist-in 6.6053 None None None AF2 -1.0 1.0 1.0 A 300.0 300.0 0 30 30 0 [[575, 858]] 1.0 AF-O15146-K1 Homo sapiens TYR_MUSK_HUMAN TYR 1.4e-97 332.0 1.0 260.0 260.0 742 743 744 746 748 609 626 630 722 724 723 725.0 784 772 767 766 765 764 763 762 761 656 Muscle, skeletal receptor tyrosine-protein kinase
MUSK MUSK_HUMAN AF-O15146-K3A O15146 567 866 869.0 No_ligand No_ligand Active DFGin 7.0348 14.2647 BLAminus -140.06, -176.0 54.95, 63.3 -81.97, 11.46 289.53, 82.9 -60.6, -32.88 in-in in 8.338 Saltbr-in 2.7347 HRD-in -82.38, -40.47 68.87, -18.92 in-in-in SNCiii in-in ActLoopNT-in 2.9013 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.07, 131.68 APE9-dihe-in -109.98, 122.37 APE8-dihe-in -76.85, 75.34 APE8-rot-na 32.55 APE67-dihe-in -72.18, -15.34 -43.2, -42.48 APE12-dist-na 12.8377 APE11-dist-na 7.8741 APE10-dist-na 8.8863 APE9-dist-in 6.2559 None None None AF2 -1.0 1.0 1.0 A 300.0 300.0 0 30 30 0 [[575, 858]] 1.0 AF-O15146-K3 Homo sapiens TYR_MUSK_HUMAN TYR 1.4e-97 332.0 1.0 260.0 260.0 742 743 744 746 748 609 626 630 722 724 723 725.0 784 772 767 766 765 764 763 762 761 656 Muscle, skeletal receptor tyrosine-protein kinase
MUSK MUSK_RAT 1LUFA Q62838 560 860 868.0 No_ligand No_ligand Inactive DFGinter 10.7474 6.6179 None -156.55, -169.71 -170.83, 84.62 -80.52, -3.72 280.77, 72.0 68.08, 27.29 in-in in 8.9753 Saltbr-in 3.4318 HRD-in -65.48, -48.59 74.12, -6.34 in-out-in SNCioi out-in ActLoopNT-out 15.5664 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.03, 128.61 APE9-dihe-in -122.59, 147.16 APE8-dihe-in -78.26, 60.9 APE8-rot-na 36.06 APE67-dihe-in -61.04, -10.56 -37.4, -50.92 APE12-dist-na 999.0 APE11-dist-na 15.1362 APE10-dist-na 11.6302 APE9-dist-in 7.4379 None None None XRAY 2.05 0.231 0.246 A 343.0 275.0 26 30 26 4 [[574, 857]] 1.0 1luf Rattus norvegicus TYR_MUSK_RAT TYR 1.9e-96 328.3 1.0 260.0 260.0 741 742 743 745 747 608 625 629 721 723 722 724.0 783 771 766 765 764 763 762 761 760 655 Muscle, skeletal receptor tyrosine protein kinase

TYR_MUSK (Muscle, skeletal receptor tyrosine-protein kinase)

Total number of chains: 1
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter None 1 100.0% 1LUFA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MUSK MUSK_RAT 1LUFA Q62838 560 860 868.0 No_ligand No_ligand Inactive DFGinter 10.7474 6.6179 None -156.55, -169.71 -170.83, 84.62 -80.52, -3.72 280.77, 72.0 68.08, 27.29 in-in in 8.9753 Saltbr-in 3.4318 HRD-in -65.48, -48.59 74.12, -6.34 in-out-in SNCioi out-in ActLoopNT-out 15.5664 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.03, 128.61 APE9-dihe-in -122.59, 147.16 APE8-dihe-in -78.26, 60.9 APE8-rot-na 36.06 APE67-dihe-in -61.04, -10.56 -37.4, -50.92 APE12-dist-na 999.0 APE11-dist-na 15.1362 APE10-dist-na 11.6302 APE9-dist-in 7.4379 None None None XRAY 2.05 0.231 0.246 A 343.0 275.0 26 30 26 4 [[574, 857]] 1.0 1luf Rattus norvegicus TYR_MUSK_RAT TYR 1.9e-96 328.3 1.0 260.0 260.0 741 742 743 745 747 608 625 629 721 723 722 724.0 783 771 766 765 764 763 762 761 760 655 Muscle, skeletal receptor tyrosine protein kinase