TYR_MUSK (Muscle, skeletal receptor tyrosine-protein kinase)

Total number of chains: 2
Active chains: 2
Family: TYR
Uniprot: MUSK_HUMAN
Kinase Domain Residues: 575 - 858
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-O15146-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-O15146-K1A 567 866 869.0 No_ligand No_ligand Active DFGin 7.047 14.316 BLAminus -136.33, -176.02 51.58, 75.98 -93.58, 10.42 286.95, 85.45 -67.59, -29.91 in-in in 8.375 Saltbr-in 2.744 HRD-in -74.55, -38.23 65.86, -21.88 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.97, 125.48 APE9-dihe-in -126.2, 136.81 APE8-dihe-in -81.44, 69.98 APE8-rot-na 36.22 APE67-dihe-in -73.1, -13.51 -41.87, -41.27 APE12-dist-na 13.66 APE11-dist-na 8.225 APE10-dist-na 9.226 APE9-dist-in 6.605 None None None AF2 -1.0 1.0 1.0 A 300 300 0 0 0 0 [[575, 858]] 1.0 AF-O15146-K1 TYR_MUSK_HUMAN TYR 1.4e-97 332.0 1 260 260 742 743 744 746 748 609 626 630 722 724 723 725 784 772 767 766 765 764 763 762 761 656 Muscle, skeletal receptor tyrosine-protein kinase
AF-O15146-K3A 567 866 869.0 No_ligand No_ligand Active DFGin 7.035 14.265 BLAminus -140.06, -176.0 54.95, 63.3 -81.97, 11.46 289.53, 82.9 -60.6, -32.88 in-in in 8.338 Saltbr-in 2.735 HRD-in -82.38, -40.47 68.87, -18.92 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.07, 131.68 APE9-dihe-in -109.98, 122.37 APE8-dihe-in -76.85, 75.34 APE8-rot-na 32.55 APE67-dihe-in -72.18, -15.34 -43.2, -42.48 APE12-dist-na 12.838 APE11-dist-na 7.874 APE10-dist-na 8.886 APE9-dist-in 6.256 None None None AF2 -1.0 1.0 1.0 A 300 300 0 0 0 0 [[575, 858]] 1.0 AF-O15146-K3 TYR_MUSK_HUMAN TYR 1.4e-97 332.0 1 260 260 742 743 744 746 748 609 626 630 722 724 723 725 784 772 767 766 765 764 763 762 761 656 Muscle, skeletal receptor tyrosine-protein kinase

TYR_MUSK (Muscle, skeletal receptor tyrosine-protein kinase)

Total number of chains: 3
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% AF-O15146-K1A
DFGinter None 1 33.3% 1LUFA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MUSK_HUMAN AF-O15146-K1A O15146 567 866 869.0 No_ligand No_ligand Active DFGin 7.047 14.316 BLAminus -136.33, -176.02 51.58, 75.98 -93.58, 10.42 286.95, 85.45 -67.59, -29.91 in-in in 8.375 Saltbr-in 2.744 HRD-in -74.55, -38.23 65.86, -21.88 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.97, 125.48 APE9-dihe-in -126.2, 136.81 APE8-dihe-in -81.44, 69.98 APE8-rot-na 36.22 APE67-dihe-in -73.1, -13.51 -41.87, -41.27 APE12-dist-na 13.66 APE11-dist-na 8.225 APE10-dist-na 9.226 APE9-dist-in 6.605 None None None AF2 -1.0 1.0 1.0 A 300 300 0 0 0 0 [[575, 858]] 1.0 AF-O15146-K1 Homo sapiens TYR_MUSK_HUMAN TYR 1.4e-97 332.0 1 260 260 742 743 744 746 748 609 626 630 722 724 723 725 784 772 767 766 765 764 763 762 761 656 Muscle, skeletal receptor tyrosine-protein kinase
MUSK_HUMAN AF-O15146-K3A O15146 567 866 869.0 No_ligand No_ligand Active DFGin 7.035 14.265 BLAminus -140.06, -176.0 54.95, 63.3 -81.97, 11.46 289.53, 82.9 -60.6, -32.88 in-in in 8.338 Saltbr-in 2.735 HRD-in -82.38, -40.47 68.87, -18.92 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.07, 131.68 APE9-dihe-in -109.98, 122.37 APE8-dihe-in -76.85, 75.34 APE8-rot-na 32.55 APE67-dihe-in -72.18, -15.34 -43.2, -42.48 APE12-dist-na 12.838 APE11-dist-na 7.874 APE10-dist-na 8.886 APE9-dist-in 6.256 None None None AF2 -1.0 1.0 1.0 A 300 300 0 0 0 0 [[575, 858]] 1.0 AF-O15146-K3 Homo sapiens TYR_MUSK_HUMAN TYR 1.4e-97 332.0 1 260 260 742 743 744 746 748 609 626 630 722 724 723 725 784 772 767 766 765 764 763 762 761 656 Muscle, skeletal receptor tyrosine-protein kinase
MUSK_RAT 1LUFA Q62838 560 860 868.0 No_ligand No_ligand Inactive DFGinter 10.747 6.618 None -156.55, -169.71 -170.83, 84.62 -80.52, -3.72 280.77, 72.0 68.08, 27.29 in-in in 8.975 Saltbr-in 3.432 HRD-in -65.48, -48.59 74.12, -6.34 in-out-in SNCioi out-in ActLoopNT-out 15.566 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.03, 128.61 APE9-dihe-in -122.59, 147.16 APE8-dihe-in -78.26, 60.9 APE8-rot-na 36.06 APE67-dihe-in -61.04, -10.56 -37.4, -50.92 APE12-dist-na 999.0 APE11-dist-na 15.136 APE10-dist-na 11.63 APE9-dist-in 7.438 None None None XRAY 2.05 0.231 0.246 A 343 275 26 0 0 4 [[574, 857]] 1.0 1luf Rattus norvegicus TYR_MUSK_RAT TYR 1.9e-96 328.3 1 260 260 741 742 743 745 747 608 625 629 721 723 722 724 783 771 766 765 764 763 762 761 760 655 Muscle, skeletal receptor tyrosine protein kinase

TYR_MUSK (Muscle, skeletal receptor tyrosine-protein kinase)

Total number of chains: 1
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter None 1 100.0% 1LUFA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MUSK_RAT 1LUFA Q62838 560 860 868.0 No_ligand No_ligand Inactive DFGinter 10.747 6.618 None -156.55, -169.71 -170.83, 84.62 -80.52, -3.72 280.77, 72.0 68.08, 27.29 in-in in 8.975 Saltbr-in 3.432 HRD-in -65.48, -48.59 74.12, -6.34 in-out-in SNCioi out-in ActLoopNT-out 15.566 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.03, 128.61 APE9-dihe-in -122.59, 147.16 APE8-dihe-in -78.26, 60.9 APE8-rot-na 36.06 APE67-dihe-in -61.04, -10.56 -37.4, -50.92 APE12-dist-na 999.0 APE11-dist-na 15.136 APE10-dist-na 11.63 APE9-dist-in 7.438 None None None XRAY 2.05 0.231 0.246 A 343 275 26 0 0 4 [[574, 857]] 1.0 1luf Rattus norvegicus TYR_MUSK_RAT TYR 1.9e-96 328.3 1 260 260 741 742 743 745 747 608 625 629 721 723 722 724 783 771 766 765 764 763 762 761 760 655 Muscle, skeletal receptor tyrosine protein kinase