STE_MAP4K3 (Mitogen-activated protein kinase kinase kinase kinase 3)

Total number of chains: 3
Active chains: 2
Uniprot: M4K3_HUMAN
Kinase Domain Residues: 16 - 273
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-Q8IVH8-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP4K3 AF-Q8IVH8-K1A Q8IVH8 8 281 894.0 No_ligand No_ligand Active DFGin 6.0587 13.8866 BLAminus -135.09, 176.01 60.66, 69.27 -88.36, 10.08 297.84, 97.93 -55.05, -43.84 in-in in 8.0711 Saltbr-in 2.7199 HRD-in -86.04, -45.82 66.69, 5.33 in-in-in SNCiii in-in ActLoopNT-in 2.8691 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.39, 153.76 APE9-dihe-na 120.56, 171.92 APE8-dihe-in -77.71, 132.65 APE8-rot-in 305.52 APE67-dihe-inflip 73.55, -40.51 -49.39, 160.24 APE12-dist-in 8.6508 APE11-dist-in 11.6998 APE10-dist-in 5.9401 APE9-dist-in 3.4578 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[16, 273]] 1.0 AF-Q8IVH8-K1 STE_MAP4K3_HUMAN STE 4.8e-100 340.1 1.0 257.0 257.0 153 154 155 157 159 45 61 65 133 135 134 136.0 196 181 176 175 174 173 172 171 170 91 Mitogen-activated protein kinase kinase kinase kinase 3
MAP4K3 AF-Q8IVH8-K3A Q8IVH8 8 281 894.0 No_ligand No_ligand Active DFGin 5.9406 14.1137 BLAminus -134.97, 173.95 56.18, 72.0 -81.54, 10.65 291.54, 92.93 -56.77, -30.5 in-in in 8.6221 Saltbr-in 2.758 HRD-in -85.79, -43.85 66.49, 5.16 in-in-in SNCiii in-in ActLoopNT-in 2.8379 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.4, 148.67 APE9-dihe-na 124.7, 168.17 APE8-dihe-in -75.56, 128.13 APE8-rot-in 303.25 APE67-dihe-in -73.59, -25.55 -47.62, -47.17 APE12-dist-in 8.8934 APE11-dist-in 11.6597 APE10-dist-in 5.9505 APE9-dist-in 3.2463 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[16, 273]] 1.0 AF-Q8IVH8-K3 STE_MAP4K3_HUMAN STE 4.8e-100 340.1 1.0 257.0 257.0 153 154 155 157 159 45 61 65 133 135 134 136.0 196 181 176 175 174 173 172 171 170 91 Mitogen-activated protein kinase kinase kinase kinase 3
MAP4K3 5J5TA Q8IVH8 13 314 894.0 6G2:60901 Type1 Inactive DFGin 5.4947 14.4062 BLAminus -133.74, -174.95 58.65, 76.08 -85.06, 24.09 282.49, 138.47 -72.44, -40.9 in-in in 8.894 Saltbr-in 2.8847 HRD-in -85.23, -48.27 63.88, 9.52 in-out-out SNCioo out-out ActLoopNT-out 6.1691 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -96.97, 101.49 APE9-dihe-na 94.22, -173.9 APE8-dihe-in -104.6, 125.99 APE8-rot-in 324.59 APE67-dihe-in -65.49, -27.15 -52.11, -46.45 APE12-dist-out 21.3856 APE11-dist-out 23.7405 APE10-dist-out 23.7438 APE9-dist-out 27.7918 S170A TPO145 TPO145 XRAY 2.85 0.177 0.206 A 370.0 297.0 3 28 25 3 [[16, 273]] 1.0 5j5t STE_MAP4K3_HUMAN STE 3.6e-99 337.3 1.0 257.0 257.0 153 154 155 157 159 45 61 65 133 135 134 136.0 196 181 176 175 174 173 172 171 170 91 Mitogen-activated protein kinase kinase kinase kinase 3

STE_MAP4K3 (Mitogen-activated protein kinase kinase kinase kinase 3)

Total number of chains: 3
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-Q8IVH8-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP4K3 M4K3_HUMAN AF-Q8IVH8-K1A Q8IVH8 8 281 894.0 No_ligand No_ligand Active DFGin 6.0587 13.8866 BLAminus -135.09, 176.01 60.66, 69.27 -88.36, 10.08 297.84, 97.93 -55.05, -43.84 in-in in 8.0711 Saltbr-in 2.7199 HRD-in -86.04, -45.82 66.69, 5.33 in-in-in SNCiii in-in ActLoopNT-in 2.8691 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.39, 153.76 APE9-dihe-na 120.56, 171.92 APE8-dihe-in -77.71, 132.65 APE8-rot-in 305.52 APE67-dihe-inflip 73.55, -40.51 -49.39, 160.24 APE12-dist-in 8.6508 APE11-dist-in 11.6998 APE10-dist-in 5.9401 APE9-dist-in 3.4578 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[16, 273]] 1.0 AF-Q8IVH8-K1 Homo sapiens STE_MAP4K3_HUMAN STE 4.8e-100 340.1 1.0 257.0 257.0 153 154 155 157 159 45 61 65 133 135 134 136.0 196 181 176 175 174 173 172 171 170 91 Mitogen-activated protein kinase kinase kinase kinase 3
MAP4K3 M4K3_HUMAN AF-Q8IVH8-K3A Q8IVH8 8 281 894.0 No_ligand No_ligand Active DFGin 5.9406 14.1137 BLAminus -134.97, 173.95 56.18, 72.0 -81.54, 10.65 291.54, 92.93 -56.77, -30.5 in-in in 8.6221 Saltbr-in 2.758 HRD-in -85.79, -43.85 66.49, 5.16 in-in-in SNCiii in-in ActLoopNT-in 2.8379 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.4, 148.67 APE9-dihe-na 124.7, 168.17 APE8-dihe-in -75.56, 128.13 APE8-rot-in 303.25 APE67-dihe-in -73.59, -25.55 -47.62, -47.17 APE12-dist-in 8.8934 APE11-dist-in 11.6597 APE10-dist-in 5.9505 APE9-dist-in 3.2463 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[16, 273]] 1.0 AF-Q8IVH8-K3 Homo sapiens STE_MAP4K3_HUMAN STE 4.8e-100 340.1 1.0 257.0 257.0 153 154 155 157 159 45 61 65 133 135 134 136.0 196 181 176 175 174 173 172 171 170 91 Mitogen-activated protein kinase kinase kinase kinase 3
MAP4K3 M4K3_HUMAN 5J5TA Q8IVH8 13 314 894.0 6G2:60901 Type1 Inactive DFGin 5.4947 14.4062 BLAminus -133.74, -174.95 58.65, 76.08 -85.06, 24.09 282.49, 138.47 -72.44, -40.9 in-in in 8.894 Saltbr-in 2.8847 HRD-in -85.23, -48.27 63.88, 9.52 in-out-out SNCioo out-out ActLoopNT-out 6.1691 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -96.97, 101.49 APE9-dihe-na 94.22, -173.9 APE8-dihe-in -104.6, 125.99 APE8-rot-in 324.59 APE67-dihe-in -65.49, -27.15 -52.11, -46.45 APE12-dist-out 21.3856 APE11-dist-out 23.7405 APE10-dist-out 23.7438 APE9-dist-out 27.7918 S170A TPO145 TPO145 XRAY 2.85 0.177 0.206 A 370.0 297.0 3 28 25 3 [[16, 273]] 1.0 5j5t Homo sapiens STE_MAP4K3_HUMAN STE 3.6e-99 337.3 1.0 257.0 257.0 153 154 155 157 159 45 61 65 133 135 134 136.0 196 181 176 175 174 173 172 171 170 91 Mitogen-activated protein kinase kinase kinase kinase 3

STE_MAP4K3 (Mitogen-activated protein kinase kinase kinase kinase 3)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name