Hover over column headers for tooltip help
| PDB | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AF-P41279-K1A | 119 | 396 | 467.0 | No_ligand | No_ligand | Active | DFGin | 6.294 | 13.982 | BLAminus | -129.98, 170.56 | 63.15, 76.35 | -89.44, 13.76 | 292.02, 84.03 | -62.49, -20.45 | na-na | na | 8.348 | Saltbr-na | 4.854 | HRD-in | -76.0, -40.02 | 66.91, -3.01 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.894 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -130.22, 142.15 | APE9-dihe-na | 109.14, -178.88 | APE8-dihe-in | -88.67, 116.19 | APE8-rot-in | 300.57 | APE67-dihe-in | -71.19, -17.01 | -38.1, -48.69 | APE12-dist-in | 10.042 | APE11-dist-in | 11.282 | APE10-dist-in | 5.803 | APE9-dist-in | 3.073 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 278 | 278 | 0 | 0 | 0 | 0 | [[136, 388]] | 1.0 | AF-P41279-K1 | STE_MAP3K8_HUMAN | STE | 5.3e-75 | 258.0 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| AF-P41279-K3A | 119 | 396 | 467.0 | No_ligand | No_ligand | Active | DFGin | 5.942 | 13.983 | BLAminus | -131.03, 168.69 | 61.73, 83.17 | -92.92, 11.71 | 290.77, 81.48 | -62.9, -19.69 | na-na | na | 8.302 | Saltbr-na | 5.038 | HRD-in | -78.24, -37.73 | 70.07, -5.97 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.917 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -130.03, 134.67 | APE9-dihe-na | 113.33, -170.09 | APE8-dihe-in | -99.29, 119.72 | APE8-rot-in | 301.36 | APE67-dihe-in | -72.35, 0.42 | -41.59, -48.77 | APE12-dist-in | 10.179 | APE11-dist-in | 10.909 | APE10-dist-in | 5.58 | APE9-dist-in | 3.061 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 278 | 278 | 0 | 0 | 0 | 0 | [[136, 388]] | 1.0 | AF-P41279-K3 | STE_MAP3K8_HUMAN | STE | 5.3e-75 | 258.0 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| 4Y83A | 73 | 389 | 467.0 | 49B:401 | Type1 | Active | DFGin | 6.099 | 13.819 | BLAminus | -124.59, 171.95 | 65.19, 92.7 | -106.98, 18.83 | 296.59, 87.7 | -55.3, -38.71 | na-na | na | 7.963 | Saltbr-na | 3.95 | HRD-in | -58.39, -44.97 | 76.28, -1.41 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.985 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -121.5, 134.53 | APE9-dihe-na | 124.17, -161.58 | APE8-dihe-in | -108.22, 120.72 | APE8-rot-in | 305.37 | APE67-dihe-in | -53.37, -39.86 | -40.43, -53.79 | APE12-dist-in | 10.573 | APE11-dist-in | 11.435 | APE10-dist-in | 5.663 | APE9-dist-in | 3.595 | None | None | None | XRAY | 2.89 | 0.204 | 0.239 | A | 332 | 299 | 7 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 4y83 | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| 4Y85A | 73 | 390 | 467.0 | 499:401 | Type1 | Active | DFGin | 6.449 | 13.707 | BLAminus | -125.84, 169.57 | 64.84, 98.71 | -111.77, 16.68 | 296.07, 91.66 | -61.47, -26.58 | na-na | na | 7.574 | Saltbr-na | 2.805 | HRD-in | -62.46, -46.04 | 78.32, -7.97 | na-in-in | SNCaii | in-in | ActLoopNT-in | 3.022 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -113.49, 144.17 | APE9-dihe-na | 115.1, 178.84 | APE8-dihe-in | -97.8, 118.96 | APE8-rot-in | 303.98 | APE67-dihe-in | -55.87, -36.44 | -46.75, -46.09 | APE12-dist-in | 9.802 | APE11-dist-in | 11.436 | APE10-dist-in | 5.59 | APE9-dist-in | 3.585 | None | None | None | XRAY | 2.33 | 0.179 | 0.207 | A | 332 | 307 | 3 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 4y85 | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| 4Y85B | 73 | 390 | 467.0 | 499:401 | Type1 | Active | DFGin | 6.5 | 13.662 | BLAminus | -125.73, 169.75 | 64.0, 98.82 | -111.42, 16.46 | 295.94, 92.79 | -60.36, -27.43 | na-na | na | 7.477 | Saltbr-na | 2.771 | HRD-in | -63.07, -45.87 | 78.49, -7.37 | na-in-in | SNCaii | in-in | ActLoopNT-in | 3.021 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -113.8, 144.13 | APE9-dihe-na | 114.25, 178.8 | APE8-dihe-in | -97.63, 117.87 | APE8-rot-in | 304.63 | APE67-dihe-in | -56.41, -36.16 | -46.53, -45.15 | APE12-dist-in | 9.807 | APE11-dist-in | 11.421 | APE10-dist-in | 5.579 | APE9-dist-in | 3.591 | None | None | None | XRAY | 2.33 | 0.179 | 0.207 | B | 332 | 306 | 3 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 4y85 | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| 4Y85C | 73 | 390 | 467.0 | 499:401 | Type1 | Active | DFGin | 6.481 | 13.684 | BLAminus | -126.2, 169.22 | 64.27, 99.76 | -112.85, 16.66 | 296.43, 92.51 | -60.53, -27.85 | na-na | na | 7.595 | Saltbr-na | 2.776 | HRD-in | -62.99, -45.6 | 77.82, -6.53 | na-in-in | SNCaii | in-in | ActLoopNT-in | 3.009 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -114.65, 144.47 | APE9-dihe-na | 114.68, 178.91 | APE8-dihe-in | -96.47, 118.22 | APE8-rot-in | 303.78 | APE67-dihe-in | -57.1, -35.93 | -46.75, -44.73 | APE12-dist-in | 9.812 | APE11-dist-in | 11.348 | APE10-dist-in | 5.532 | APE9-dist-in | 3.587 | None | None | None | XRAY | 2.33 | 0.179 | 0.207 | C | 332 | 303 | 5 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 4y85 | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| 5IU2A | 73 | 389 | 467.0 | 6DA:401 | Type1 | Active | DFGin | 6.217 | 13.38 | BLAminus | -119.43, 179.9 | 58.81, 91.75 | -107.94, 18.73 | 286.21, 87.38 | -63.73, -34.5 | na-na | na | 7.574 | Saltbr-na | 6.299 | HRD-in | -63.94, -41.44 | 71.95, -5.73 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.978 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -120.95, 148.52 | APE9-dihe-na | 117.99, -173.86 | APE8-dihe-in | -98.16, 118.36 | APE8-rot-in | 303.49 | APE67-dihe-in | -67.23, -30.84 | -50.69, -43.49 | APE12-dist-in | 10.356 | APE11-dist-in | 11.669 | APE10-dist-in | 5.736 | APE9-dist-in | 3.892 | None | None | None | XRAY | 2.7 | 0.234 | 0.258 | A | 332 | 312 | 1 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 5iu2 | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| 5IU2B | 73 | 389 | 467.0 | 6DA:401 | Type1 | Active | DFGin | 6.221 | 13.396 | BLAminus | -119.23, -179.91 | 58.5, 91.68 | -107.71, 18.46 | 286.2, 87.57 | -62.89, -35.45 | na-na | na | 7.582 | Saltbr-na | 6.275 | HRD-in | -64.01, -41.46 | 71.78, -5.78 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.979 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -120.65, 148.65 | APE9-dihe-na | 118.1, -173.7 | APE8-dihe-in | -98.42, 118.25 | APE8-rot-in | 303.43 | APE67-dihe-in | -67.48, -31.08 | -50.5, -43.67 | APE12-dist-in | 10.454 | APE11-dist-in | 11.686 | APE10-dist-in | 5.742 | APE9-dist-in | 3.894 | None | None | None | XRAY | 2.7 | 0.234 | 0.258 | B | 332 | 313 | 1 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 5iu2 | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| 4Y83B | 73 | 390 | 467.0 | 49B:401 | Type1 | Inactive | DFGin | 6.109 | 13.833 | BLAminus | -124.82, 178.39 | 58.04, 91.08 | -107.1, 19.86 | 295.8, 87.89 | -54.55, -39.25 | na-na | na | 7.955 | Saltbr-na | 3.925 | HRD-out | -89.84, 93.56 | -65.3, 5.72 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.903 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -120.81, 133.53 | APE9-dihe-na | 123.34, -162.02 | APE8-dihe-in | -108.51, 121.14 | APE8-rot-in | 304.25 | APE67-dihe-in | -53.46, -41.03 | -40.77, -53.11 | APE12-dist-in | 10.439 | APE11-dist-in | 11.373 | APE10-dist-in | 5.664 | APE9-dist-in | 3.69 | None | None | None | XRAY | 2.89 | 0.204 | 0.239 | B | 332 | 302 | 6 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 4y83 | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| 4Y83C | 74 | 389 | 467.0 | 49B:401 | Type1 | Inactive | DFGin | 5.584 | 13.442 | BLAminus | -110.1, 168.68 | 58.93, 91.32 | -105.74, 14.12 | 293.23, 84.53 | -55.17, -37.01 | na-na | na | 7.936 | Saltbr-na | 999.0 | HRD-out | -77.01, 90.27 | -64.95, 5.59 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.848 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -119.68, 133.22 | APE9-dihe-na | 121.85, -162.73 | APE8-dihe-in | -109.52, 121.69 | APE8-rot-in | 305.8 | APE67-dihe-in | -52.55, -40.59 | -40.63, -53.14 | APE12-dist-in | 10.451 | APE11-dist-in | 11.379 | APE10-dist-in | 5.64 | APE9-dist-in | 3.679 | None | None | None | XRAY | 2.89 | 0.204 | 0.239 | C | 332 | 293 | 11 | 0 | 0 | 1 | [[136, 388]] | 1.0 | 4y83 | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
Hover over column headers for tooltip help
| SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M3K8_HUMAN | AF-P41279-K1A | P41279 | 119 | 396 | 467.0 | No_ligand | No_ligand | Active | DFGin | 6.294 | 13.982 | BLAminus | -129.98, 170.56 | 63.15, 76.35 | -89.44, 13.76 | 292.02, 84.03 | -62.49, -20.45 | na-na | na | 8.348 | Saltbr-na | 4.854 | HRD-in | -76.0, -40.02 | 66.91, -3.01 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.894 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -130.22, 142.15 | APE9-dihe-na | 109.14, -178.88 | APE8-dihe-in | -88.67, 116.19 | APE8-rot-in | 300.57 | APE67-dihe-in | -71.19, -17.01 | -38.1, -48.69 | APE12-dist-in | 10.042 | APE11-dist-in | 11.282 | APE10-dist-in | 5.803 | APE9-dist-in | 3.073 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 278 | 278 | 0 | 0 | 0 | 0 | [[136, 388]] | 1.0 | AF-P41279-K1 | Homo sapiens | STE_MAP3K8_HUMAN | STE | 5.3e-75 | 258.0 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| M3K8_HUMAN | AF-P41279-K3A | P41279 | 119 | 396 | 467.0 | No_ligand | No_ligand | Active | DFGin | 5.942 | 13.983 | BLAminus | -131.03, 168.69 | 61.73, 83.17 | -92.92, 11.71 | 290.77, 81.48 | -62.9, -19.69 | na-na | na | 8.302 | Saltbr-na | 5.038 | HRD-in | -78.24, -37.73 | 70.07, -5.97 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.917 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -130.03, 134.67 | APE9-dihe-na | 113.33, -170.09 | APE8-dihe-in | -99.29, 119.72 | APE8-rot-in | 301.36 | APE67-dihe-in | -72.35, 0.42 | -41.59, -48.77 | APE12-dist-in | 10.179 | APE11-dist-in | 10.909 | APE10-dist-in | 5.58 | APE9-dist-in | 3.061 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 278 | 278 | 0 | 0 | 0 | 0 | [[136, 388]] | 1.0 | AF-P41279-K3 | Homo sapiens | STE_MAP3K8_HUMAN | STE | 5.3e-75 | 258.0 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| M3K8_HUMAN | 4Y83A | P41279 | 73 | 389 | 467.0 | 49B:401 | Type1 | Active | DFGin | 6.099 | 13.819 | BLAminus | -124.59, 171.95 | 65.19, 92.7 | -106.98, 18.83 | 296.59, 87.7 | -55.3, -38.71 | na-na | na | 7.963 | Saltbr-na | 3.95 | HRD-in | -58.39, -44.97 | 76.28, -1.41 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.985 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -121.5, 134.53 | APE9-dihe-na | 124.17, -161.58 | APE8-dihe-in | -108.22, 120.72 | APE8-rot-in | 305.37 | APE67-dihe-in | -53.37, -39.86 | -40.43, -53.79 | APE12-dist-in | 10.573 | APE11-dist-in | 11.435 | APE10-dist-in | 5.663 | APE9-dist-in | 3.595 | None | None | None | XRAY | 2.89 | 0.204 | 0.239 | A | 332 | 299 | 7 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 4y83 | Homo sapiens | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| M3K8_HUMAN | 4Y85A | P41279 | 73 | 390 | 467.0 | 499:401 | Type1 | Active | DFGin | 6.449 | 13.707 | BLAminus | -125.84, 169.57 | 64.84, 98.71 | -111.77, 16.68 | 296.07, 91.66 | -61.47, -26.58 | na-na | na | 7.574 | Saltbr-na | 2.805 | HRD-in | -62.46, -46.04 | 78.32, -7.97 | na-in-in | SNCaii | in-in | ActLoopNT-in | 3.022 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -113.49, 144.17 | APE9-dihe-na | 115.1, 178.84 | APE8-dihe-in | -97.8, 118.96 | APE8-rot-in | 303.98 | APE67-dihe-in | -55.87, -36.44 | -46.75, -46.09 | APE12-dist-in | 9.802 | APE11-dist-in | 11.436 | APE10-dist-in | 5.59 | APE9-dist-in | 3.585 | None | None | None | XRAY | 2.33 | 0.179 | 0.207 | A | 332 | 307 | 3 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 4y85 | Homo sapiens | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| M3K8_HUMAN | 4Y85B | P41279 | 73 | 390 | 467.0 | 499:401 | Type1 | Active | DFGin | 6.5 | 13.662 | BLAminus | -125.73, 169.75 | 64.0, 98.82 | -111.42, 16.46 | 295.94, 92.79 | -60.36, -27.43 | na-na | na | 7.477 | Saltbr-na | 2.771 | HRD-in | -63.07, -45.87 | 78.49, -7.37 | na-in-in | SNCaii | in-in | ActLoopNT-in | 3.021 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -113.8, 144.13 | APE9-dihe-na | 114.25, 178.8 | APE8-dihe-in | -97.63, 117.87 | APE8-rot-in | 304.63 | APE67-dihe-in | -56.41, -36.16 | -46.53, -45.15 | APE12-dist-in | 9.807 | APE11-dist-in | 11.421 | APE10-dist-in | 5.579 | APE9-dist-in | 3.591 | None | None | None | XRAY | 2.33 | 0.179 | 0.207 | B | 332 | 306 | 3 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 4y85 | Homo sapiens | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| M3K8_HUMAN | 4Y85C | P41279 | 73 | 390 | 467.0 | 499:401 | Type1 | Active | DFGin | 6.481 | 13.684 | BLAminus | -126.2, 169.22 | 64.27, 99.76 | -112.85, 16.66 | 296.43, 92.51 | -60.53, -27.85 | na-na | na | 7.595 | Saltbr-na | 2.776 | HRD-in | -62.99, -45.6 | 77.82, -6.53 | na-in-in | SNCaii | in-in | ActLoopNT-in | 3.009 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -114.65, 144.47 | APE9-dihe-na | 114.68, 178.91 | APE8-dihe-in | -96.47, 118.22 | APE8-rot-in | 303.78 | APE67-dihe-in | -57.1, -35.93 | -46.75, -44.73 | APE12-dist-in | 9.812 | APE11-dist-in | 11.348 | APE10-dist-in | 5.532 | APE9-dist-in | 3.587 | None | None | None | XRAY | 2.33 | 0.179 | 0.207 | C | 332 | 303 | 5 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 4y85 | Homo sapiens | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| M3K8_HUMAN | 5IU2A | P41279 | 73 | 389 | 467.0 | 6DA:401 | Type1 | Active | DFGin | 6.217 | 13.38 | BLAminus | -119.43, 179.9 | 58.81, 91.75 | -107.94, 18.73 | 286.21, 87.38 | -63.73, -34.5 | na-na | na | 7.574 | Saltbr-na | 6.299 | HRD-in | -63.94, -41.44 | 71.95, -5.73 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.978 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -120.95, 148.52 | APE9-dihe-na | 117.99, -173.86 | APE8-dihe-in | -98.16, 118.36 | APE8-rot-in | 303.49 | APE67-dihe-in | -67.23, -30.84 | -50.69, -43.49 | APE12-dist-in | 10.356 | APE11-dist-in | 11.669 | APE10-dist-in | 5.736 | APE9-dist-in | 3.892 | None | None | None | XRAY | 2.7 | 0.234 | 0.258 | A | 332 | 312 | 1 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 5iu2 | Homo sapiens | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| M3K8_HUMAN | 5IU2B | P41279 | 73 | 389 | 467.0 | 6DA:401 | Type1 | Active | DFGin | 6.221 | 13.396 | BLAminus | -119.23, -179.91 | 58.5, 91.68 | -107.71, 18.46 | 286.2, 87.57 | -62.89, -35.45 | na-na | na | 7.582 | Saltbr-na | 6.275 | HRD-in | -64.01, -41.46 | 71.78, -5.78 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.979 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -120.65, 148.65 | APE9-dihe-na | 118.1, -173.7 | APE8-dihe-in | -98.42, 118.25 | APE8-rot-in | 303.43 | APE67-dihe-in | -67.48, -31.08 | -50.5, -43.67 | APE12-dist-in | 10.454 | APE11-dist-in | 11.686 | APE10-dist-in | 5.742 | APE9-dist-in | 3.894 | None | None | None | XRAY | 2.7 | 0.234 | 0.258 | B | 332 | 313 | 1 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 5iu2 | Homo sapiens | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| M3K8_HUMAN | 4Y83B | P41279 | 73 | 390 | 467.0 | 49B:401 | Type1 | Inactive | DFGin | 6.109 | 13.833 | BLAminus | -124.82, 178.39 | 58.04, 91.08 | -107.1, 19.86 | 295.8, 87.89 | -54.55, -39.25 | na-na | na | 7.955 | Saltbr-na | 3.925 | HRD-out | -89.84, 93.56 | -65.3, 5.72 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.903 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -120.81, 133.53 | APE9-dihe-na | 123.34, -162.02 | APE8-dihe-in | -108.51, 121.14 | APE8-rot-in | 304.25 | APE67-dihe-in | -53.46, -41.03 | -40.77, -53.11 | APE12-dist-in | 10.439 | APE11-dist-in | 11.373 | APE10-dist-in | 5.664 | APE9-dist-in | 3.69 | None | None | None | XRAY | 2.89 | 0.204 | 0.239 | B | 332 | 302 | 6 | 0 | 0 | 0 | [[136, 388]] | 1.0 | 4y83 | Homo sapiens | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| M3K8_HUMAN | 4Y83C | P41279 | 74 | 389 | 467.0 | 49B:401 | Type1 | Inactive | DFGin | 5.584 | 13.442 | BLAminus | -110.1, 168.68 | 58.93, 91.32 | -105.74, 14.12 | 293.23, 84.53 | -55.17, -37.01 | na-na | na | 7.936 | Saltbr-na | 999.0 | HRD-out | -77.01, 90.27 | -64.95, 5.59 | na-in-in | SNCaii | in-in | ActLoopNT-in | 2.848 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -119.68, 133.22 | APE9-dihe-na | 121.85, -162.73 | APE8-dihe-in | -109.52, 121.69 | APE8-rot-in | 305.8 | APE67-dihe-in | -52.55, -40.59 | -40.63, -53.14 | APE12-dist-in | 10.451 | APE11-dist-in | 11.379 | APE10-dist-in | 5.64 | APE9-dist-in | 3.679 | None | None | None | XRAY | 2.89 | 0.204 | 0.239 | C | 332 | 293 | 11 | 0 | 0 | 1 | [[136, 388]] | 1.0 | 4y83 | Homo sapiens | STE_MAP3K8_HUMAN | STE | 9.9e-75 | 257.3 | 7 | 256 | 250 | 269 | 270 | 271 | 273 | 275 | 167 | 178 | 182 | 250 | 252 | 251 | 253 | 309 | 297 | 292 | 291 | 290 | 289 | 288 | 287 | 286 | 208 | Mitogen-activated protein kinase kinase kinase 8 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
Hover over column headers for tooltip help
| SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
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