KinCore

STE_MAP3K8 (Mitogen-activated protein kinase kinase kinase 8)

Total number of chains: 10

Active chains: 8

Uniprot: M3K8_HUMAN

Kinase Domain Residues: 127 - 388

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	10	100.0%	AF-P41279-K1A

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PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein
AF-P41279-K1A	-1.0	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	119 - 396	0	None	None	Mitogen-activated protein kinase kinase kinase 8
AF-P41279-K3A	-1.0	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	119 - 396	0	None	None	Mitogen-activated protein kinase kinase kinase 8
4Y83A	2.89	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	49B	Type1	73 - 389	0	None	None	Mitogen-activated protein kinase kinase kinase 8
4Y85A	2.33	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	499	Type1	73 - 390	0	None	None	Mitogen-activated protein kinase kinase kinase 8
4Y85B	2.33	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	499	Type1	73 - 390	0	None	None	Mitogen-activated protein kinase kinase kinase 8
4Y85C	2.33	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	499	Type1	73 - 390	0	None	None	Mitogen-activated protein kinase kinase kinase 8
5IU2A	2.7	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	6DA	Type1	73 - 389	0	None	None	Mitogen-activated protein kinase kinase kinase 8
5IU2B	2.7	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	6DA	Type1	73 - 389	0	None	None	Mitogen-activated protein kinase kinase kinase 8
4Y83B	2.89	Inactive	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	49B	Type1	73 - 390	0	None	None	Mitogen-activated protein kinase kinase kinase 8
4Y83C	2.89	Inactive	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	49B	Type1	74 - 389	0	None	None	Mitogen-activated protein kinase kinase kinase 8

STE_MAP3K8 (Mitogen-activated protein kinase kinase kinase 8)

Total number of chains: 10

Active chains: 8

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	10	100.0%	AF-P41279-K1A

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UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism
M3K8_HUMAN	AF-P41279-K1A	-1.0	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	119 - 396	0	None	None	Mitogen-activated protein kinase kinase kinase 8	Homo sapiens
M3K8_HUMAN	AF-P41279-K3A	-1.0	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	119 - 396	0	None	None	Mitogen-activated protein kinase kinase kinase 8	Homo sapiens
M3K8_HUMAN	4Y83A	2.89	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	49B	Type1	73 - 389	0	None	None	Mitogen-activated protein kinase kinase kinase 8	Homo sapiens
M3K8_HUMAN	4Y85A	2.33	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	499	Type1	73 - 390	0	None	None	Mitogen-activated protein kinase kinase kinase 8	Homo sapiens
M3K8_HUMAN	4Y85B	2.33	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	499	Type1	73 - 390	0	None	None	Mitogen-activated protein kinase kinase kinase 8	Homo sapiens
M3K8_HUMAN	4Y85C	2.33	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	499	Type1	73 - 390	0	None	None	Mitogen-activated protein kinase kinase kinase 8	Homo sapiens
M3K8_HUMAN	5IU2A	2.7	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	6DA	Type1	73 - 389	0	None	None	Mitogen-activated protein kinase kinase kinase 8	Homo sapiens
M3K8_HUMAN	5IU2B	2.7	Active	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	6DA	Type1	73 - 389	0	None	None	Mitogen-activated protein kinase kinase kinase 8	Homo sapiens
M3K8_HUMAN	4Y83B	2.89	Inactive	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	49B	Type1	73 - 390	0	None	None	Mitogen-activated protein kinase kinase kinase 8	Homo sapiens
M3K8_HUMAN	4Y83C	2.89	Inactive	DFGin‑BLAminus	in-na	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	49B	Type1	74 - 389	0	None	None	Mitogen-activated protein kinase kinase kinase 8	Homo sapiens

STE_MAP3K8 (Mitogen-activated protein kinase kinase kinase 8)

Total number of chains: 0

Active chains: 0

Spatial label	Dihedral label	Number of Chains	Percent	Representative

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UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism