TKL_IRAK1 (Interleukin-1 receptor-associated kinase 1)

Total number of chains: 4
Active chains: 4
Uniprot: IRAK1_HUMAN
Kinase Domain Residues: 207 - 521
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% AF-P51617-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
IRAK1 AF-P51617-K1A P51617 199 528 712.0 No_ligand No_ligand Active DFGin 6.549 15.1683 BLAminus -135.65, -175.93 65.96, 63.73 -82.47, 9.35 284.87, 71.75 -63.89, -21.87 in-in in 8.644 Saltbr-in 3.3407 HRD-in -69.75, -45.84 75.77, 2.59 in-in-in SNCiii in-in ActLoopNT-in 2.8524 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.58, 162.27 APE9-dihe-na 109.89, -179.69 APE8-dihe-in -93.45, 109.19 APE8-rot-in 308.1 APE67-dihe-in -62.11, -19.32 -47.97, -35.4 APE12-dist-in 10.8061 APE11-dist-in 11.3027 APE10-dist-in 6.0538 APE9-dist-in 3.9587 None None None AF2 -1.0 1.0 1.0 A 331.0 331.0 0 37 37 0 [[211, 520]] 1.0 AF-P51617-K1 TKL_IRAK1_HUMAN TKL 3e-84 288.7 4.0 267.0 264.0 357 358 359 361 363 239 259 263 337 339 338 340.0 406 394 389 388 387 386 385 384 383 289 Interleukin-1 receptor-associated kinase 1
IRAK1 AF-P51617-K3A P51617 199 528 712.0 No_ligand No_ligand Active DFGin 6.7762 14.2366 BLAminus -131.34, -173.68 60.62, 63.43 -80.68, 10.98 288.52, 80.54 -61.22, -24.25 in-in in 8.5143 Saltbr-in 2.8734 HRD-in -74.42, -43.42 74.34, 2.65 in-in-in SNCiii in-in ActLoopNT-in 2.8188 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.89, 154.73 APE9-dihe-na 108.93, 178.44 APE8-dihe-in -86.76, 108.89 APE8-rot-in 309.71 APE67-dihe-in -65.47, -22.8 -48.18, -33.72 APE12-dist-in 11.5447 APE11-dist-in 11.5048 APE10-dist-in 6.2877 APE9-dist-in 4.2279 None None None AF2 -1.0 1.0 1.0 A 331.0 331.0 0 37 37 0 [[211, 520]] 1.0 AF-P51617-K3 TKL_IRAK1_HUMAN TKL 3e-84 288.7 4.0 267.0 264.0 357 358 359 361 363 239 259 263 337 339 338 340.0 406 394 389 388 387 386 385 384 383 289 Interleukin-1 receptor-associated kinase 1
IRAK1 6BFNA P51617 194 526 712.0 DL1:60601 Type1 Active DFGin 6.4728 15.0069 BLAminus -110.63, -164.34 53.57, 66.04 -89.98, 6.39 276.1, 69.05 -60.37, -23.25 in-in in 8.5837 Saltbr-in 2.8934 HRD-in -63.56, -57.45 82.57, -20.38 in-in-in SNCiii in-in ActLoopNT-in 2.6791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.15, 120.12 APE9-dihe-na 147.8, -171.52 APE8-dihe-in -97.13, 117.07 APE8-rot-in 305.84 APE67-dihe-in -59.67, -35.36 -56.27, -25.11 APE12-dist-in 11.7031 APE11-dist-in 11.5338 APE10-dist-in 6.1498 APE9-dist-in 5.0432 None None None XRAY 2.26 0.186 0.227 A 342.0 300.0 33 37 21 16 [[211, 520]] 1.0 6bfn TKL_IRAK1_HUMAN TKL 3.3e-84 288.5 4.0 267.0 264.0 357 358 359 361 363 239 259 263 337 339 338 340.0 406 394 389 388 387 386 385 384 383 289 Interleukin-1 receptor-associated kinase 1
IRAK1 6BFNB P51617 194 526 712.0 DL1:60601 Type1 Active DFGin 6.3066 14.9365 BLAminus -109.87, -162.2 55.1, 63.78 -90.57, 8.87 274.01, 68.59 -61.57, -25.0 in-in in 8.5865 Saltbr-in 3.0341 HRD-in -64.2, -59.54 86.78, -23.84 in-in-in SNCiii in-in ActLoopNT-in 2.7254 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.09, 160.52 APE9-dihe-na 107.57, -176.31 APE8-dihe-in -92.98, 122.19 APE8-rot-in 303.15 APE67-dihe-in -66.3, -30.72 -60.6, -25.29 APE12-dist-in 11.3679 APE11-dist-in 11.2313 APE10-dist-in 6.3049 APE9-dist-in 4.9528 None None None XRAY 2.26 0.186 0.227 B 342.0 294.0 39 37 21 16 [[211, 520]] 1.0 6bfn TKL_IRAK1_HUMAN TKL 3.3e-84 288.5 4.0 267.0 264.0 357 358 359 361 363 239 259 263 337 339 338 340.0 406 394 389 388 387 386 385 384 383 289 Interleukin-1 receptor-associated kinase 1

TKL_IRAK1 (Interleukin-1 receptor-associated kinase 1)

Total number of chains: 4
Active chains: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% AF-P51617-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
IRAK1 IRAK1_HUMAN AF-P51617-K1A P51617 199 528 712.0 No_ligand No_ligand Active DFGin 6.549 15.1683 BLAminus -135.65, -175.93 65.96, 63.73 -82.47, 9.35 284.87, 71.75 -63.89, -21.87 in-in in 8.644 Saltbr-in 3.3407 HRD-in -69.75, -45.84 75.77, 2.59 in-in-in SNCiii in-in ActLoopNT-in 2.8524 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.58, 162.27 APE9-dihe-na 109.89, -179.69 APE8-dihe-in -93.45, 109.19 APE8-rot-in 308.1 APE67-dihe-in -62.11, -19.32 -47.97, -35.4 APE12-dist-in 10.8061 APE11-dist-in 11.3027 APE10-dist-in 6.0538 APE9-dist-in 3.9587 None None None AF2 -1.0 1.0 1.0 A 331.0 331.0 0 37 37 0 [[211, 520]] 1.0 AF-P51617-K1 Homo sapiens TKL_IRAK1_HUMAN TKL 3e-84 288.7 4.0 267.0 264.0 357 358 359 361 363 239 259 263 337 339 338 340.0 406 394 389 388 387 386 385 384 383 289 Interleukin-1 receptor-associated kinase 1
IRAK1 IRAK1_HUMAN AF-P51617-K3A P51617 199 528 712.0 No_ligand No_ligand Active DFGin 6.7762 14.2366 BLAminus -131.34, -173.68 60.62, 63.43 -80.68, 10.98 288.52, 80.54 -61.22, -24.25 in-in in 8.5143 Saltbr-in 2.8734 HRD-in -74.42, -43.42 74.34, 2.65 in-in-in SNCiii in-in ActLoopNT-in 2.8188 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.89, 154.73 APE9-dihe-na 108.93, 178.44 APE8-dihe-in -86.76, 108.89 APE8-rot-in 309.71 APE67-dihe-in -65.47, -22.8 -48.18, -33.72 APE12-dist-in 11.5447 APE11-dist-in 11.5048 APE10-dist-in 6.2877 APE9-dist-in 4.2279 None None None AF2 -1.0 1.0 1.0 A 331.0 331.0 0 37 37 0 [[211, 520]] 1.0 AF-P51617-K3 Homo sapiens TKL_IRAK1_HUMAN TKL 3e-84 288.7 4.0 267.0 264.0 357 358 359 361 363 239 259 263 337 339 338 340.0 406 394 389 388 387 386 385 384 383 289 Interleukin-1 receptor-associated kinase 1
IRAK1 IRAK1_HUMAN 6BFNA P51617 194 526 712.0 DL1:60601 Type1 Active DFGin 6.4728 15.0069 BLAminus -110.63, -164.34 53.57, 66.04 -89.98, 6.39 276.1, 69.05 -60.37, -23.25 in-in in 8.5837 Saltbr-in 2.8934 HRD-in -63.56, -57.45 82.57, -20.38 in-in-in SNCiii in-in ActLoopNT-in 2.6791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.15, 120.12 APE9-dihe-na 147.8, -171.52 APE8-dihe-in -97.13, 117.07 APE8-rot-in 305.84 APE67-dihe-in -59.67, -35.36 -56.27, -25.11 APE12-dist-in 11.7031 APE11-dist-in 11.5338 APE10-dist-in 6.1498 APE9-dist-in 5.0432 None None None XRAY 2.26 0.186 0.227 A 342.0 300.0 33 37 21 16 [[211, 520]] 1.0 6bfn Homo sapiens TKL_IRAK1_HUMAN TKL 3.3e-84 288.5 4.0 267.0 264.0 357 358 359 361 363 239 259 263 337 339 338 340.0 406 394 389 388 387 386 385 384 383 289 Interleukin-1 receptor-associated kinase 1
IRAK1 IRAK1_HUMAN 6BFNB P51617 194 526 712.0 DL1:60601 Type1 Active DFGin 6.3066 14.9365 BLAminus -109.87, -162.2 55.1, 63.78 -90.57, 8.87 274.01, 68.59 -61.57, -25.0 in-in in 8.5865 Saltbr-in 3.0341 HRD-in -64.2, -59.54 86.78, -23.84 in-in-in SNCiii in-in ActLoopNT-in 2.7254 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.09, 160.52 APE9-dihe-na 107.57, -176.31 APE8-dihe-in -92.98, 122.19 APE8-rot-in 303.15 APE67-dihe-in -66.3, -30.72 -60.6, -25.29 APE12-dist-in 11.3679 APE11-dist-in 11.2313 APE10-dist-in 6.3049 APE9-dist-in 4.9528 None None None XRAY 2.26 0.186 0.227 B 342.0 294.0 39 37 21 16 [[211, 520]] 1.0 6bfn Homo sapiens TKL_IRAK1_HUMAN TKL 3.3e-84 288.5 4.0 267.0 264.0 357 358 359 361 363 239 259 263 337 339 338 340.0 406 394 389 388 387 386 385 384 383 289 Interleukin-1 receptor-associated kinase 1

TKL_IRAK1 (Interleukin-1 receptor-associated kinase 1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name