CMGC_HIPK2 (Homeodomain-interacting protein kinase 2)

Total number of chains: 4
Active chains: 3
Uniprot: HIPK2_HUMAN
Kinase Domain Residues: 199 - 527
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% AF-Q9H2X6-K1A

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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q9H2X6-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 191 - 535 0 None None Homeodomain-interacting protein kinase 2
AF-Q9H2X6-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 191 - 535 0 None None Homeodomain-interacting protein kinase 2
7NCFA 2.72 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii U82 Type1 183 - 535 0 PTR361,SEP441 None Homeodomain-interacting protein kinase 2
6P5SA 2.194 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 3NG Type1 185 - 535 0 PTR361,SEP441 None Homeodomain-interacting protein kinase 2

CMGC_HIPK2 (Homeodomain-interacting protein kinase 2)

Total number of chains: 4
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% AF-Q9H2X6-K1A

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
HIPK2_HUMAN AF-Q9H2X6-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 191 - 535 0 None None Homeodomain-interacting protein kinase 2 Homo sapiens
HIPK2_HUMAN AF-Q9H2X6-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 191 - 535 0 None None Homeodomain-interacting protein kinase 2 Homo sapiens
HIPK2_HUMAN 7NCFA 2.72 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii U82 Type1 183 - 535 0 PTR361,SEP441 None Homeodomain-interacting protein kinase 2 Homo sapiens
HIPK2_HUMAN 6P5SA 2.194 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 3NG Type1 185 - 535 0 PTR361,SEP441 None Homeodomain-interacting protein kinase 2 Homo sapiens

CMGC_HIPK2 (Homeodomain-interacting protein kinase 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism