CMGC_HIPK2 (Homeodomain-interacting protein kinase 2)

Total number of chains: 4
Active chains: 3
Uniprot: HIPK2_HUMAN
Kinase Domain Residues: 199 - 527
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% AF-Q9H2X6-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
HIPK2 AF-Q9H2X6-K1A Q9H2X6 191 535 1198.0 No_ligand No_ligand Active DFGin 7.5163 13.9773 BLAminus -125.05, 175.92 60.54, 70.25 -77.2, 18.8 293.75, 93.23 -64.52, -25.77 in-in in 8.6662 Saltbr-in 2.6721 HRD-in -71.4, -43.45 63.58, 10.26 in-in-in SNCiii in-in ActLoopNT-in 2.8406 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.59, 170.34 APE9-dihe-na 62.08, 151.07 APE8-dihe-in -68.61, 137.52 APE8-rot-in 294.0 APE67-dihe-in -66.4, -20.77 -54.89, -41.95 APE12-dist-in 10.2618 APE11-dist-in 11.1318 APE10-dist-in 7.4012 APE9-dist-in 3.1231 None None None AF2 -1.0 1.0 1.0 A 345.0 345.0 0 26 26 0 [[199, 527]] 1.0 AF-Q9H2X6-K1 CMGC_HIPK2_HUMAN CMGC 1.7e-92 316.0 1.0 301.0 301.0 345 346 347 349 351 228 243 247 321 323 322 324.0 383 371 366 365 364 363 362 361 360 278 Homeodomain-interacting protein kinase 2
HIPK2 AF-Q9H2X6-K3A Q9H2X6 191 535 1198.0 No_ligand No_ligand Active DFGin 7.1087 13.8008 BLAminus -128.07, 177.8 59.6, 62.5 -69.76, 16.43 299.12, 97.4 -64.51, -25.2 in-in in 8.6225 Saltbr-in 2.7033 HRD-in -74.1, -44.15 64.13, 4.48 in-in-in SNCiii in-in ActLoopNT-in 2.8578 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.22, 165.11 APE9-dihe-na 60.35, 142.55 APE8-dihe-in -63.29, 138.8 APE8-rot-in 290.03 APE67-dihe-in -68.82, -17.24 -53.14, -48.62 APE12-dist-in 10.0049 APE11-dist-in 10.758 APE10-dist-in 7.4352 APE9-dist-in 3.1655 None None None AF2 -1.0 1.0 1.0 A 345.0 345.0 0 26 26 0 [[199, 527]] 1.0 AF-Q9H2X6-K3 CMGC_HIPK2_HUMAN CMGC 1.7e-92 316.0 1.0 301.0 301.0 345 346 347 349 351 228 243 247 321 323 322 324.0 383 371 366 365 364 363 362 361 360 278 Homeodomain-interacting protein kinase 2
HIPK2 7NCFA Q9H2X6 183 535 1198.0 U82:60601 Type1 Active DFGin 7.2255 14.2127 BLAminus -118.17, 173.98 61.05, 85.84 -99.85, 27.99 301.19, 72.73 -62.95, -40.46 in-in in 8.4748 Saltbr-in 2.7796 HRD-in -71.54, -58.4 80.34, 5.46 in-in-in SNCiii in-in ActLoopNT-in 2.7264 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.13, 161.95 APE9-dihe-na 79.47, 149.02 APE8-dihe-in -56.13, 135.75 APE8-rot-in 277.64 APE67-dihe-in -61.56, -31.21 -55.68, -44.85 APE12-dist-in 10.8226 APE11-dist-in 11.3402 APE10-dist-in 7.9499 APE9-dist-in 3.301 None PTR361,SEP441 PTR361,SEP441 XRAY 2.72 0.197 0.251 A 367.0 353.0 0 26 26 0 [[199, 527]] 1.0 7ncf CMGC_HIPK2_HUMAN CMGC 2.1e-92 315.7 1.0 301.0 301.0 345 346 347 349 351 228 243 247 321 323 322 324.0 383 371 366 365 364 363 362 361 360 278 Homeodomain-interacting protein kinase 2
HIPK2 6P5SA Q9H2X6 185 535 1198.0 3NG:601 Type1 Inactive DFGin 7.2975 14.2301 BLAminus -121.5, -179.79 64.91, 82.62 -96.84, 22.58 294.47, 82.62 -64.48, -30.53 in-in in 8.9707 Saltbr-in 2.7611 HRD-in -77.76, -49.7 67.78, 8.12 in-in-out SNCiio in-out ActLoopNT-in 2.6387 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.93, 168.02 APE9-dihe-na 68.38, 155.05 APE8-dihe-in -77.17, 138.14 APE8-rot-out 185.94 APE67-dihe-in -61.16, -24.2 -57.86, -43.21 APE12-dist-in 10.5837 APE11-dist-in 11.1051 APE10-dist-in 7.4946 APE9-dist-in 3.2425 None PTR361,SEP441 PTR361,SEP441 XRAY 2.194 0.2 0.238 A 390.0 333.0 18 26 20 6 [[199, 527]] 1.0 6p5s CMGC_HIPK2_HUMAN CMGC 2.6e-92 315.4 1.0 301.0 301.0 345 346 347 349 351 228 243 247 321 323 322 324.0 383 371 366 365 364 363 362 361 360 278 Homeodomain-interacting protein kinase 2

CMGC_HIPK2 (Homeodomain-interacting protein kinase 2)

Total number of chains: 4
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% AF-Q9H2X6-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
HIPK2 HIPK2_HUMAN AF-Q9H2X6-K1A Q9H2X6 191 535 1198.0 No_ligand No_ligand Active DFGin 7.5163 13.9773 BLAminus -125.05, 175.92 60.54, 70.25 -77.2, 18.8 293.75, 93.23 -64.52, -25.77 in-in in 8.6662 Saltbr-in 2.6721 HRD-in -71.4, -43.45 63.58, 10.26 in-in-in SNCiii in-in ActLoopNT-in 2.8406 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.59, 170.34 APE9-dihe-na 62.08, 151.07 APE8-dihe-in -68.61, 137.52 APE8-rot-in 294.0 APE67-dihe-in -66.4, -20.77 -54.89, -41.95 APE12-dist-in 10.2618 APE11-dist-in 11.1318 APE10-dist-in 7.4012 APE9-dist-in 3.1231 None None None AF2 -1.0 1.0 1.0 A 345.0 345.0 0 26 26 0 [[199, 527]] 1.0 AF-Q9H2X6-K1 Homo sapiens CMGC_HIPK2_HUMAN CMGC 1.7e-92 316.0 1.0 301.0 301.0 345 346 347 349 351 228 243 247 321 323 322 324.0 383 371 366 365 364 363 362 361 360 278 Homeodomain-interacting protein kinase 2
HIPK2 HIPK2_HUMAN AF-Q9H2X6-K3A Q9H2X6 191 535 1198.0 No_ligand No_ligand Active DFGin 7.1087 13.8008 BLAminus -128.07, 177.8 59.6, 62.5 -69.76, 16.43 299.12, 97.4 -64.51, -25.2 in-in in 8.6225 Saltbr-in 2.7033 HRD-in -74.1, -44.15 64.13, 4.48 in-in-in SNCiii in-in ActLoopNT-in 2.8578 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.22, 165.11 APE9-dihe-na 60.35, 142.55 APE8-dihe-in -63.29, 138.8 APE8-rot-in 290.03 APE67-dihe-in -68.82, -17.24 -53.14, -48.62 APE12-dist-in 10.0049 APE11-dist-in 10.758 APE10-dist-in 7.4352 APE9-dist-in 3.1655 None None None AF2 -1.0 1.0 1.0 A 345.0 345.0 0 26 26 0 [[199, 527]] 1.0 AF-Q9H2X6-K3 Homo sapiens CMGC_HIPK2_HUMAN CMGC 1.7e-92 316.0 1.0 301.0 301.0 345 346 347 349 351 228 243 247 321 323 322 324.0 383 371 366 365 364 363 362 361 360 278 Homeodomain-interacting protein kinase 2
HIPK2 HIPK2_HUMAN 7NCFA Q9H2X6 183 535 1198.0 U82:60601 Type1 Active DFGin 7.2255 14.2127 BLAminus -118.17, 173.98 61.05, 85.84 -99.85, 27.99 301.19, 72.73 -62.95, -40.46 in-in in 8.4748 Saltbr-in 2.7796 HRD-in -71.54, -58.4 80.34, 5.46 in-in-in SNCiii in-in ActLoopNT-in 2.7264 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.13, 161.95 APE9-dihe-na 79.47, 149.02 APE8-dihe-in -56.13, 135.75 APE8-rot-in 277.64 APE67-dihe-in -61.56, -31.21 -55.68, -44.85 APE12-dist-in 10.8226 APE11-dist-in 11.3402 APE10-dist-in 7.9499 APE9-dist-in 3.301 None PTR361,SEP441 PTR361,SEP441 XRAY 2.72 0.197 0.251 A 367.0 353.0 0 26 26 0 [[199, 527]] 1.0 7ncf Homo sapiens CMGC_HIPK2_HUMAN CMGC 2.1e-92 315.7 1.0 301.0 301.0 345 346 347 349 351 228 243 247 321 323 322 324.0 383 371 366 365 364 363 362 361 360 278 Homeodomain-interacting protein kinase 2
HIPK2 HIPK2_HUMAN 6P5SA Q9H2X6 185 535 1198.0 3NG:601 Type1 Inactive DFGin 7.2975 14.2301 BLAminus -121.5, -179.79 64.91, 82.62 -96.84, 22.58 294.47, 82.62 -64.48, -30.53 in-in in 8.9707 Saltbr-in 2.7611 HRD-in -77.76, -49.7 67.78, 8.12 in-in-out SNCiio in-out ActLoopNT-in 2.6387 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.93, 168.02 APE9-dihe-na 68.38, 155.05 APE8-dihe-in -77.17, 138.14 APE8-rot-out 185.94 APE67-dihe-in -61.16, -24.2 -57.86, -43.21 APE12-dist-in 10.5837 APE11-dist-in 11.1051 APE10-dist-in 7.4946 APE9-dist-in 3.2425 None PTR361,SEP441 PTR361,SEP441 XRAY 2.194 0.2 0.238 A 390.0 333.0 18 26 20 6 [[199, 527]] 1.0 6p5s Homo sapiens CMGC_HIPK2_HUMAN CMGC 2.6e-92 315.4 1.0 301.0 301.0 345 346 347 349 351 228 243 247 321 323 322 324.0 383 371 366 365 364 363 362 361 360 278 Homeodomain-interacting protein kinase 2

CMGC_HIPK2 (Homeodomain-interacting protein kinase 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name