TYR_HCK (Tyrosine-protein kinase HCK)

Total number of chains: 46
Active chains: 3
Uniprot: HCK_HUMAN
Kinase Domain Residues: 262 - 513
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 25 54.3% 5H0BA
DFGin BLBtrans 8 17.4% 3VRZB
DFGin BLAminus 7 15.2% AF-P08631-K1A
DFGin None 6 13.0% 3VS1B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
HCK AF-P08631-K1A P08631 254 521 526.0 No_ligand No_ligand Active DFGin 6.3113 14.1319 BLAminus -122.14, -160.92 37.16, 68.25 -80.85, 14.5 295.64, 94.86 -58.22, -33.85 in-in in 7.9212 Saltbr-in 2.6368 HRD-in -85.47, -46.06 65.16, 2.97 in-in-in SNCiii in-in ActLoopNT-in 2.8724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.0, 134.26 APE9-dihe-in -122.88, 155.02 APE8-dihe-in -71.54, 86.49 APE8-rot-na 31.06 APE67-dihe-in -70.36, -19.34 -41.02, -38.85 APE12-dist-na 14.8879 APE11-dist-na 10.1199 APE10-dist-na 12.5311 APE9-dist-in 6.6015 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 29 29 0 [[262, 513]] 1.0 AF-P08631-K1 TYR_HCK_HUMAN TYR 2.6e-96 327.8 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK AF-P08631-K3A P08631 254 521 526.0 No_ligand No_ligand Active DFGin 6.2128 13.9113 BLAminus -135.77, -176.37 61.31, 47.91 -67.27, 12.49 301.02, 98.33 -59.04, -30.46 in-in in 7.9067 Saltbr-in 2.7462 HRD-in -90.59, -44.18 68.72, -6.91 in-in-in SNCiii in-in ActLoopNT-in 2.8904 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.25, 132.34 APE9-dihe-in -123.62, 153.73 APE8-dihe-in -75.72, 83.5 APE8-rot-na 34.41 APE67-dihe-in -64.86, -17.62 -42.96, -41.09 APE12-dist-na 14.811 APE11-dist-na 10.0573 APE10-dist-na 11.8279 APE9-dist-in 6.5182 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 29 29 0 [[262, 513]] 1.0 AF-P08631-K3 TYR_HCK_HUMAN TYR 2.6e-96 327.8 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 2HK5A P08631 247 514 526.0 1BM:60499 Type1.5_Back Active DFGin 6.0374 14.0118 BLAminus -125.02, -169.05 46.01, 87.48 -101.95, 25.89 305.09, 88.79 -63.71, -34.22 in-in in 8.5319 Saltbr-in 2.7821 HRD-in -102.54, -51.97 77.09, -2.67 in-in-in SNCiii in-in ActLoopNT-in 2.9506 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.11, 141.59 APE9-dihe-in -137.5, 148.55 APE8-dihe-in -58.4, 107.06 APE8-rot-na 16.93 APE67-dihe-in -69.15, -18.5 -57.53, -42.26 APE12-dist-na 15.0339 APE11-dist-na 10.4791 APE10-dist-na 13.177 APE9-dist-in 6.9159 None None None XRAY 2.0 0.201 0.25 A 270.0 268.0 0 29 29 0 [[262, 513]] 1.0 2hk5 TYR_HCK_HUMAN TYR 2.6e-96 327.8 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 1AD5A P08631 79 526 526.0 ANP:60001 ATPlike Inactive DFGin 6.8776 13.5562 BLAminus -111.54, 157.75 55.86, 95.53 -99.86, -56.89 321.06, 144.41 -91.88, 132.97 out-out out 13.5916 Saltbr-out 14.4523 HRD-out -92.59, 96.14 -56.64, -30.38 out-out-out SNCooo out-out ActLoopNT-out 11.4135 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.24, 53.46 APE9-dihe-in -96.28, 143.43 APE8-dihe-out -62.47, 38.68 APE8-rot-na 35.25 APE67-dihe-in -59.4, -26.12 -40.35, -46.47 APE12-dist-na 11.6595 APE11-dist-na 16.6044 APE10-dist-na 16.1334 APE9-dist-out 10.4142 None PTR522 PTR522 XRAY 2.6 0.239 0.307 A 438.0 438.0 0 29 29 0 [[262, 513]] 1.0 1ad5 TYR_HCK_HUMAN TYR 1.4e-88 303.1 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 1AD5B P08631 79 526 526.0 ANP:60532 ATPlike Inactive DFGin 6.635 13.5293 BLAminus -108.53, 152.83 57.68, 95.37 -100.87, -57.78 321.85, 133.69 -88.86, 132.45 out-out out 13.5911 Saltbr-out 14.3339 HRD-out -97.62, 96.0 -55.31, -32.54 out-out-out SNCooo out-out ActLoopNT-out 11.4801 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.78, 54.95 APE9-dihe-in -97.18, 143.16 APE8-dihe-out -68.08, 36.88 APE8-rot-na 32.16 APE67-dihe-in -59.62, -27.02 -36.62, -45.49 APE12-dist-na 11.6841 APE11-dist-na 16.5851 APE10-dist-na 16.2062 APE9-dist-out 10.5337 None PTR522 PTR522 XRAY 2.6 0.239 0.307 B 438.0 438.0 0 29 29 0 [[262, 513]] 1.0 1ad5 TYR_HCK_HUMAN TYR 1.4e-88 303.1 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 2HCKA P08631 79 526 526.0 QUE:60001 Type1 Inactive DFGin 6.8835 12.5651 BLAminus -135.76, 164.51 54.3, 68.19 -77.81, -69.05 321.97, 16.74 -94.78, 122.42 out-out out 13.2106 Saltbr-out 14.3378 HRD-out -102.03, 93.6 -54.25, 0.34 out-out-out SNCooo out-out ActLoopNT-out 11.4885 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -143.26, 34.29 APE9-dihe-in -78.64, 135.24 APE8-dihe-out -35.07, 8.77 APE8-rot-na 20.27 APE67-dihe-in -59.37, -32.12 -13.52, -63.84 APE12-dist-na 12.2557 APE11-dist-na 16.8036 APE10-dist-na 16.1956 APE9-dist-out 9.9055 None PTR522 PTR522 XRAY 3.0 0.228 0.311 A 438.0 438.0 0 29 29 0 [[262, 513]] 1.0 2hck TYR_HCK_HUMAN TYR 1.4e-88 303.1 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 2HCKB P08631 79 526 526.0 QUE:60532 Type1 Inactive DFGin 6.1601 13.0826 BLAminus -141.04, 165.96 51.23, 63.5 -82.56, -71.35 330.45, 4.54 -82.38, 116.43 out-out out 13.5095 Saltbr-out 14.9112 HRD-out -122.75, 94.61 -56.98, 8.3 out-out-out SNCooo out-out ActLoopNT-out 12.0275 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -128.02, 26.89 APE9-dihe-in -77.78, 149.77 APE8-dihe-out -49.68, 1.53 APE8-rot-na 15.16 APE67-dihe-out -63.87, -24.64 2.1, -68.98 APE12-dist-na 12.2521 APE11-dist-na 17.3047 APE10-dist-na 16.4343 APE9-dist-out 10.2218 None PTR522 PTR522 XRAY 3.0 0.228 0.311 B 438.0 438.0 0 29 29 0 [[262, 513]] 1.0 2hck TYR_HCK_HUMAN TYR 1.4e-88 303.1 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 5ZJ6A P08631 248 518 526.0 VSE:60601 Type1 Inactive DFGin 5.3351 13.0525 BLBplus -114.95, 163.29 60.26, 24.97 -64.12, 121.71 39.09, 88.22 79.49, -5.11 out-out out 14.0956 Saltbr-out 14.1936 HRD-in -73.59, -54.91 86.39, -11.4 out-out-out SNCooo out-out ActLoopNT-out 7.3139 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -71.95, -51.49 APE9-dihe-in -118.55, 145.05 APE8-dihe-in -85.67, 130.57 APE8-rot-na 32.67 APE67-dihe-in -73.71, -13.22 -54.97, -44.28 APE12-dist-na 16.603 APE11-dist-na 15.4722 APE10-dist-na 10.7965 APE9-dist-in 6.3027 None None None XRAY 1.696 0.208 0.24 A 287.0 271.0 0 29 29 0 [[262, 513]] 1.0 5zj6 TYR_HCK_HUMAN TYR 3.3e-96 327.5 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 1QCFA P08631 81 526 526.0 PP1:60532 Type1 Inactive DFGin 4.9808 13.2184 BLBplus -122.28, 162.63 66.05, 14.52 -58.73, 126.22 40.94, 93.39 78.61, -11.82 out-out out 13.8541 Saltbr-out 14.605 HRD-in -71.4, -55.63 83.68, -15.14 out-out-out SNCooo out-out ActLoopNT-out 7.337 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.4, -24.56 APE9-dihe-in -80.87, 135.02 APE8-dihe-in -72.72, 52.96 APE8-rot-na 38.75 APE67-dihe-in -60.55, -20.73 -46.63, -48.12 APE12-dist-na 17.7105 APE11-dist-na 18.8098 APE10-dist-na 13.6061 APE9-dist-out 8.6423 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.0 0.215 0.257 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 1qcf TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS2A P08631 81 526 526.0 VSB:60601 Type1 Inactive DFGin 5.5175 12.5421 BLBplus -126.13, 168.77 60.55, 22.01 -69.92, 133.32 46.99, 86.38 78.45, -37.41 out-out out 13.5267 Saltbr-out 15.5989 HRD-in -85.68, -45.22 76.56, -16.0 out-out-none SNCoon out-none ActLoopNT-out 6.9595 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.36 APE8-rot-na 338.28 APE67-dihe-in -69.46, -15.36 -72.31, -17.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.609 0.279 0.279 A 454.0 430.0 13 29 16 13 [[262, 513]] 1.0 3vs2 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS5A P08631 81 526 526.0 VSG:60601 Type1 Inactive DFGin 5.3025 12.7869 BLBplus -113.17, 163.39 44.9, 47.31 -70.54, 124.98 29.01, 97.87 91.21, -36.02 out-out out 13.8811 Saltbr-out 13.6733 HRD-in -80.1, -56.21 84.49, -32.57 out-out-none SNCoon out-none ActLoopNT-out 6.9642 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 38.63 APE8-rot-na 346.37 APE67-dihe-in -64.79, -16.3 -91.95, -10.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.851 0.309 0.309 A 454.0 429.0 13 29 16 13 [[262, 513]] 1.0 3vs5 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS5B P08631 81 526 526.0 VSG:60601 Type1 Inactive DFGin 5.4472 12.5823 BLBplus -103.49, 162.99 68.58, 22.76 -66.54, 121.33 37.51, 94.92 89.07, -18.65 out-out out 13.3899 Saltbr-out 15.2332 HRD-in -74.25, -62.25 87.12, -19.0 out-out-none SNCoon out-none ActLoopNT-out 7.0627 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 0.98 APE8-rot-na 18.82 APE67-dihe-in -69.89, 0.28 -92.91, -10.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.851 0.309 0.309 B 454.0 427.0 13 29 16 13 [[262, 513]] 1.0 3vs5 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS7B P08631 81 526 526.0 KS1:60601 Type1 Inactive DFGin 5.7675 11.4394 BLBplus -102.99, 166.51 26.69, 56.44 -48.57, 110.73 13.09, 67.36 46.85, 38.89 out-out out 13.8824 Saltbr-out 9.7121 HRD-in -118.73, -5.37 61.6, -75.75 out-out-none SNCoon out-none ActLoopNT-out 8.6935 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -27.55 APE8-rot-na 331.6 APE67-dihe-in -67.6, -20.33 -137.5, 6.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 3.001 0.29 0.29 B 454.0 426.0 15 29 14 15 [[262, 513]] 1.0 3vs7 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 4LUDA P08631 81 526 526.0 SK8:60603 Type1 Inactive DFGin 5.6892 15.9043 BLBplus -116.28, 150.35 49.81, 43.36 -87.12, 142.97 63.18, 99.69 99.14, -26.26 out-out out 13.412 Saltbr-out 13.2246 HRD-in -86.33, -45.0 75.85, -22.84 out-out-none SNCoon out-none ActLoopNT-out 7.3437 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 27.69 APE8-rot-na 31.21 APE67-dihe-in -65.55, -26.53 -70.89, -24.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.85 0.215 0.261 A 454.0 421.0 20 29 16 13 [[262, 513]] 1.0 4lud TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 4LUDB P08631 81 524 526.0 SK8:60601 Type1 Inactive DFGin 4.7253 13.6615 BLBplus -114.11, 155.75 54.4, 45.03 -86.4, 134.52 55.73, 98.16 92.31, -27.22 out-out out 13.8813 Saltbr-out 14.0633 HRD-in -87.61, -43.81 76.82, -22.41 out-out-none SNCoon out-none ActLoopNT-out 7.3226 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 28.06 APE8-rot-na 31.21 APE67-dihe-in -64.0, -26.01 -70.38, -21.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.85 0.215 0.261 B 454.0 409.0 15 29 16 13 [[262, 513]] 1.0 4lud TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 5H0GA P08631 81 526 526.0 OOU:60601 Type1 Inactive DFGin 5.2194 12.8655 BLBplus -114.86, 166.88 60.14, 23.7 -65.58, 123.61 41.31, 90.91 79.47, -5.9 out-out out 13.8355 Saltbr-out 14.4677 HRD-in -74.56, -54.56 85.66, -16.83 out-out-out SNCooo out-out ActLoopNT-out 7.3017 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -56.03, -58.81 APE9-dihe-in -120.65, 154.72 APE8-dihe-in -92.18, 119.14 APE8-rot-na 33.08 APE67-dihe-in -67.75, -14.83 -50.37, -44.57 APE12-dist-na 17.1599 APE11-dist-na 16.4386 APE10-dist-na 11.4684 APE9-dist-in 6.9005 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 1.8 0.183 0.224 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 5h0g TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 5ZJ6B P08631 249 518 526.0 VSE:60601 Type1.5_Back Inactive DFGin 5.2974 12.9925 BLBplus -118.41, 160.6 63.16, 25.41 -63.98, 121.7 38.72, 89.85 78.05, -3.85 out-out out 14.1267 Saltbr-out 14.3758 HRD-in -77.39, -53.67 86.07, -14.13 out-out-out SNCooo out-out ActLoopNT-out 7.3995 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.8, -50.61 APE9-dihe-in -118.54, 142.1 APE8-dihe-in -83.18, 129.22 APE8-rot-na 29.87 APE67-dihe-in -70.77, -17.72 -53.15, -41.64 APE12-dist-na 16.6098 APE11-dist-na 15.4604 APE10-dist-na 10.8036 APE9-dist-in 6.3182 None None None XRAY 1.696 0.208 0.24 B 287.0 270.0 0 29 29 0 [[262, 513]] 1.0 5zj6 TYR_HCK_HUMAN TYR 3.3e-96 327.5 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 9BYJA P08631 81 526 526.0 VSE:60601 Type1.5_Back Inactive DFGin 5.4202 12.6438 BLBplus -125.53, 164.62 65.89, 20.8 -62.8, 120.35 41.87, 89.23 80.88, -7.85 out-out out 13.565 Saltbr-out 14.7462 HRD-in -74.56, -57.47 88.73, -16.79 out-out-out SNCooo out-out ActLoopNT-out 7.2394 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.18, -27.82 APE9-dihe-in -112.35, 133.23 APE8-dihe-in -75.16, 116.15 APE8-rot-na 30.36 APE67-dihe-in -68.49, -15.64 -50.64, -44.35 APE12-dist-na 16.2999 APE11-dist-na 15.1608 APE10-dist-na 9.7617 APE9-dist-in 6.1557 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 1.8 0.2 0.219 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 9byj TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VRYA P08631 81 526 526.0 B43:60601 Type1.5_Back Inactive DFGin 5.3033 12.6289 BLBplus -119.81, 168.31 60.84, 32.96 -79.15, 125.05 35.96, 87.52 75.63, 2.45 out-out out 13.4698 Saltbr-out 14.2418 HRD-in -83.86, -50.67 75.41, -10.82 out-out-out SNCooo out-out ActLoopNT-out 7.0493 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 44.99 APE8-dihe-in -86.53, 62.73 APE8-rot-na 37.21 APE67-dihe-in -73.89, -9.73 -67.84, -18.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.664 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.481 0.281 0.281 A 454.0 428.0 12 29 17 12 [[262, 513]] 1.0 3vry TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VRYB P08631 81 526 526.0 B43:60602 Type1.5_Back Inactive DFGin 5.5286 12.7355 BLBplus -124.73, 163.97 61.97, 27.82 -75.15, 120.98 41.12, 86.83 77.64, 7.73 out-out out 13.5709 Saltbr-out 14.2814 HRD-in -92.65, -52.42 79.61, -13.54 out-out-out SNCooo out-out ActLoopNT-out 7.1623 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.27 APE8-dihe-in -82.4, 85.69 APE8-rot-na 32.14 APE67-dihe-in -71.65, -3.94 -95.0, -13.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3431 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.481 0.281 0.281 B 454.0 434.0 12 29 17 12 [[262, 513]] 1.0 3vry TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS3A P08631 81 526 526.0 VSE:60601 Type1.5_Back Inactive DFGin 5.5067 12.703 BLBplus -113.89, 168.6 61.04, 21.1 -67.43, 128.3 47.77, 89.98 67.78, 34.56 out-out out 13.8346 Saltbr-out 15.043 HRD-in -96.96, -54.21 81.88, -16.05 out-out-out SNCooo out-out ActLoopNT-out 7.2454 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 144.12 APE8-dihe-in -128.46, 60.71 APE8-rot-na 31.05 APE67-dihe-in -71.07, -14.35 -69.43, -16.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.3677 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.17 0.279 0.279 A 454.0 434.0 12 29 17 12 [[262, 513]] 1.0 3vs3 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS3B P08631 81 526 526.0 VSE:60601 Type1.5_Back Inactive DFGin 5.3646 12.6117 BLBplus -119.71, 171.03 60.1, 22.2 -67.88, 124.89 43.05, 86.27 84.83, -11.09 out-out out 13.6909 Saltbr-out 14.613 HRD-in -90.51, -51.33 80.7, -19.73 out-out-out SNCooo out-out ActLoopNT-out 7.5216 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 176.56 APE9-dihe-in -71.84, 130.34 APE8-dihe-in -72.47, 67.45 APE8-rot-na 28.63 APE67-dihe-in -66.79, -16.88 -59.5, -36.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.2488 APE9-dist-out 9.4057 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.17 0.279 0.279 B 454.0 431.0 10 29 19 10 [[262, 513]] 1.0 3vs3 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS4A P08631 81 526 526.0 VSF:60603 Type1.5_Back Inactive DFGin 5.2959 12.6167 BLBplus -129.05, 156.5 78.18, 7.28 -55.31, 122.08 48.34, 94.72 91.65, -36.18 out-out out 13.5298 Saltbr-out 14.391 HRD-in -89.51, -57.9 84.08, -11.13 out-out-out SNCooo out-out ActLoopNT-out 6.8746 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 47.3 APE8-dihe-in -93.7, 67.91 APE8-rot-na 28.82 APE67-dihe-in -68.45, -16.47 -64.44, -22.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.6975 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.747 0.265 0.265 A 454.0 429.0 11 29 18 11 [[262, 513]] 1.0 3vs4 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS4B P08631 81 526 526.0 VSF:60603 Type1.5_Back Inactive DFGin 5.2845 12.6652 BLBplus -120.89, 167.83 61.49, 15.86 -62.02, 121.53 47.24, 95.4 75.03, 10.7 out-out out 13.7661 Saltbr-out 15.0419 HRD-in -94.45, -46.27 74.87, -7.2 out-out-out SNCooo out-out ActLoopNT-out 7.1349 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 48.23 APE8-dihe-in -84.31, 74.96 APE8-rot-na 34.0 APE67-dihe-in -71.24, -2.76 -88.69, -13.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.5953 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.747 0.265 0.265 B 454.0 434.0 12 29 17 12 [[262, 513]] 1.0 3vs4 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS6A P08631 81 526 526.0 VSH:60603 Type1.5_Back Inactive DFGin 5.5738 13.0065 BLBplus -118.63, 173.06 55.31, 21.4 -65.15, 123.93 39.6, 95.61 74.91, -1.15 out-out out 13.9136 Saltbr-out 14.5656 HRD-in -84.94, -50.54 80.12, -18.35 out-out-out SNCooo out-out ActLoopNT-out 7.1467 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -64.17 APE8-dihe-in -74.02, 58.62 APE8-rot-na 33.3 APE67-dihe-in -64.63, -21.22 -73.45, -22.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.9247 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.373 0.28 0.28 A 454.0 434.0 12 29 17 12 [[262, 513]] 1.0 3vs6 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS6B P08631 81 526 526.0 VSH:60603 Type1.5_Back Inactive DFGin 5.7234 13.1865 BLBplus -116.1, 166.06 60.58, 23.3 -65.66, 128.54 39.99, 90.02 65.39, 33.14 out-out out 13.738 Saltbr-out 14.163 HRD-in -89.01, -50.06 78.41, -20.06 out-out-out SNCooo out-out ActLoopNT-out 7.5082 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.18 APE8-dihe-in -84.44, 55.22 APE8-rot-na 34.46 APE67-dihe-in -66.08, -19.87 -67.04, -14.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.8679 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.373 0.28 0.28 B 454.0 434.0 12 29 17 12 [[262, 513]] 1.0 3vs6 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 4LUEA P08631 81 525 526.0 VSE:60602 Type1.5_Back Inactive DFGin 5.4708 12.767 BLBplus -122.72, 161.78 60.91, 25.36 -68.49, 129.05 43.25, 85.69 79.66, -15.83 out-out out 13.7253 Saltbr-out 15.2762 HRD-in -84.46, -56.17 83.88, -6.66 out-out-none SNCoon out-none ActLoopNT-out 7.1075 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.88 APE8-rot-na 30.04 APE67-dihe-in -72.15, -20.12 -64.45, -27.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 3.04 0.208 0.256 A 454.0 422.0 19 29 16 13 [[262, 513]] 1.0 4lue TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 4LUEB P08631 81 525 526.0 VSE:60603 Type1.5_Back Inactive DFGin 5.4871 12.7203 BLBplus -122.08, 162.6 61.61, 26.01 -68.05, 129.15 43.17, 85.26 79.37, -16.77 out-out out 13.8589 Saltbr-out 13.9045 HRD-in -86.09, -56.89 84.27, -5.71 out-out-none SNCoon out-none ActLoopNT-out 7.0522 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.26 APE8-rot-na 30.0 APE67-dihe-in -72.01, -19.64 -64.44, -29.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 3.04 0.208 0.256 B 454.0 417.0 24 29 16 13 [[262, 513]] 1.0 4lue TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 5H09A P08631 81 526 526.0 OOO:60601 Type1.5_Back Inactive DFGin 5.3227 12.8413 BLBplus -119.41, 164.45 62.61, 23.39 -67.49, 124.25 40.02, 90.79 79.63, -8.11 out-out out 13.8946 Saltbr-out 14.3235 HRD-in -72.48, -55.6 87.36, -12.88 out-out-out SNCooo out-out ActLoopNT-out 7.301 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.96, -40.82 APE9-dihe-in -128.15, 146.91 APE8-dihe-in -82.62, 123.41 APE8-rot-na 28.7 APE67-dihe-in -68.7, -17.07 -52.89, -42.17 APE12-dist-na 16.8064 APE11-dist-na 15.6245 APE10-dist-na 11.169 APE9-dist-in 6.4908 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 1.945 0.192 0.223 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 5h09 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 5H0BA P08631 81 526 526.0 OOQ:60601 Type1.5_Back Inactive DFGin 5.1947 12.968 BLBplus -120.19, 167.13 61.98, 21.03 -65.87, 121.12 41.37, 91.21 83.04, -7.66 out-out out 13.916 Saltbr-out 14.5003 HRD-in -74.41, -54.69 86.34, -12.23 out-out-out SNCooo out-out ActLoopNT-out 7.3031 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -81.72, -39.23 APE9-dihe-in -136.84, 153.35 APE8-dihe-in -86.74, 125.6 APE8-rot-na 30.3 APE67-dihe-in -69.37, -17.33 -50.9, -41.62 APE12-dist-na 16.9696 APE11-dist-na 15.8556 APE10-dist-na 11.3843 APE9-dist-in 6.7676 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 1.651 0.181 0.205 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 5h0b TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 5H0EA P08631 81 526 526.0 OOS:60601 Type1.5_Back Inactive DFGin 5.3327 12.9353 BLBplus -121.03, 169.99 58.79, 24.6 -66.39, 120.74 38.13, 94.8 84.92, -10.16 out-out out 13.845 Saltbr-out 14.2465 HRD-in -74.39, -53.63 84.89, -9.61 out-out-out SNCooo out-out ActLoopNT-out 7.1685 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -75.99, -39.62 APE9-dihe-in -133.04, 151.48 APE8-dihe-in -86.73, 118.64 APE8-rot-na 27.16 APE67-dihe-in -70.28, -17.08 -49.56, -42.7 APE12-dist-na 17.0207 APE11-dist-na 15.6757 APE10-dist-na 11.2666 APE9-dist-in 6.5657 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.1 0.188 0.226 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 5h0e TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 5H0HA P08631 81 526 526.0 OOV:60601 Type1.5_Back Inactive DFGin 5.1742 12.8501 BLBplus -121.84, 166.14 63.19, 20.31 -64.42, 123.79 41.33, 90.61 78.85, -6.45 out-out out 13.8276 Saltbr-out 14.3333 HRD-in -74.28, -54.85 86.89, -14.03 out-out-out SNCooo out-out ActLoopNT-out 7.3415 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -75.07, -42.41 APE9-dihe-in -128.28, 151.93 APE8-dihe-in -86.13, 127.03 APE8-rot-na 29.7 APE67-dihe-in -68.31, -17.39 -50.74, -43.04 APE12-dist-na 16.6688 APE11-dist-na 15.8323 APE10-dist-na 11.0795 APE9-dist-in 6.4987 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 1.72 0.186 0.224 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 5h0h TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 2C0IB P08631 81 526 526.0 L1G:61506 Type1 Inactive DFGin 6.4691 17.7266 BLBtrans -118.5, 156.15 76.55, 12.4 -65.22, 111.07 174.33, 50.9 114.94, -35.19 out-out out 14.021 Saltbr-out 15.5699 HRD-out -104.67, 98.76 -75.08, 8.06 out-out-none SNCoon out-none ActLoopNT-out 6.8918 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 15.64 APE8-rot-na 330.95 APE67-dihe-in -62.78, -19.75 -60.97, -25.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.3 0.224 0.274 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 2c0i TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 2C0OB P08631 81 526 526.0 L2G:61506 Type1 Inactive DFGin 6.7063 17.7058 BLBtrans -110.11, 165.43 71.01, 15.69 -62.58, 118.15 183.74, 34.04 90.09, -15.98 out-out out 14.2265 Saltbr-out 13.9175 HRD-out -123.92, 88.64 -59.99, -10.92 out-out-none SNCoon out-none ActLoopNT-out 6.6926 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 85.76 APE8-rot-na 331.38 APE67-dihe-in -49.13, -29.59 -92.66, -35.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.85 0.204 0.273 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 2c0o TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 2C0IA P08631 81 526 526.0 L1G:61506 Type1.5_Front Inactive DFGin 6.7692 17.7438 BLBtrans -115.37, 154.0 70.82, 18.12 -65.91, 121.57 184.38, 41.99 105.96, -38.14 out-out out 13.4018 Saltbr-out 13.3108 HRD-in -75.63, -56.77 92.51, -29.31 out-out-none SNCoon out-none ActLoopNT-out 6.4934 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.77 APE8-rot-na 14.74 APE67-dihe-in -66.54, -21.29 -71.46, -21.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.3 0.224 0.274 A 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 2c0i TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 2C0OA P08631 81 526 526.0 L2G:61506 Type1.5_Front Inactive DFGin 6.6226 17.5579 BLBtrans -102.76, 170.81 68.33, 6.06 -62.19, 117.6 178.08, 53.25 105.15, -37.25 out-out out 13.4254 Saltbr-out 14.0408 HRD-in -86.82, -49.88 88.79, -24.67 out-out-none SNCoon out-none ActLoopNT-out 6.5433 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 93.2 APE8-rot-na 27.76 APE67-dihe-in -65.03, -25.33 -76.85, -18.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.85 0.204 0.273 A 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 2c0o TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 2C0TA P08631 81 526 526.0 L3G:61506 Type1.5_Front Inactive DFGin 6.5841 17.8458 BLBtrans -103.62, 161.87 63.4, 18.68 -68.73, 122.03 173.01, 50.25 109.42, -49.86 out-out out 13.2929 Saltbr-out 13.4528 HRD-in -82.0, -51.15 69.41, -3.28 out-out-none SNCoon out-none ActLoopNT-out 6.0662 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 73.05 APE8-rot-na 27.06 APE67-dihe-in -75.03, -15.66 -73.32, -16.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.15 0.197 0.253 A 454.0 427.0 13 29 16 13 [[262, 513]] 1.0 2c0t TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 2C0TB P08631 81 526 526.0 L3G:61506 Type1.5_Front Inactive DFGin 6.7091 17.8655 BLBtrans -104.05, 163.35 58.02, 34.32 -79.78, 115.19 166.03, 51.93 89.06, 7.58 out-out out 14.2057 Saltbr-out 14.127 HRD-in -92.96, -48.52 72.3, -13.86 out-out-none SNCoon out-none ActLoopNT-out 7.0744 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 168.21 APE8-rot-na 23.75 APE67-dihe-in -65.46, -15.21 -125.7, -33.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.15 0.197 0.253 B 454.0 429.0 13 29 16 13 [[262, 513]] 1.0 2c0t TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VRZA P08631 81 526 526.0 VRZ:60603 Type1.5_Front Inactive DFGin 6.6529 17.6049 BLBtrans -107.49, 162.36 65.41, 22.25 -66.55, 118.82 172.12, 49.89 104.47, -23.12 out-out out 13.7038 Saltbr-out 14.1613 HRD-in -91.87, -51.27 85.65, -25.59 out-out-none SNCoon out-none ActLoopNT-out 6.9471 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 57.56 APE8-rot-na 29.34 APE67-dihe-in -64.65, 2.38 -52.77, -22.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.218 0.267 0.267 A 454.0 429.0 13 29 16 13 [[262, 513]] 1.0 3vrz TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VRZB P08631 81 526 526.0 VRZ:60603 Type1.5_Front Inactive DFGin 6.4964 17.5037 BLBtrans -106.94, 168.11 63.9, 13.84 -60.21, 119.93 180.64, 41.8 108.28, -25.57 out-out out 13.2287 Saltbr-out 13.4672 HRD-in -97.14, -43.33 79.11, -20.29 out-out-out SNCooo out-out ActLoopNT-out 6.263 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.9 APE8-dihe-in -90.85, 64.85 APE8-rot-na 34.91 APE67-dihe-in -66.47, -19.82 -63.44, -23.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.4917 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.218 0.267 0.267 B 454.0 430.0 12 29 17 12 [[262, 513]] 1.0 3vrz TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS0A P08631 81 526 526.0 VS0:60602 Type1 Inactive DFGin 5.5705 16.6537 None -129.57, 162.1 -82.47, -42.29 67.42, 124.57 160.77, 70.48 69.5, 30.08 out-out out 14.2453 Saltbr-out 14.6605 HRD-in -88.57, -37.73 75.77, -11.97 out-out-none SNCoon out-none ActLoopNT-out 7.1153 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -2.1 APE8-rot-na 22.57 APE67-dihe-in -68.2, -25.74 -107.06, -1.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.934 0.295 0.295 A 454.0 428.0 13 29 16 13 [[262, 513]] 1.0 3vs0 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS0B P08631 81 526 526.0 VS0:60602 Type1 Inactive DFGin 6.0642 17.1807 None -111.8, 150.48 -110.07, -32.77 65.61, 113.92 163.11, 68.65 100.74, -23.61 out-out out 14.2153 Saltbr-out 14.3341 HRD-in -78.42, -39.25 73.05, -7.55 out-out-none SNCoon out-none ActLoopNT-out 6.5568 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 18.88 APE8-rot-na 26.41 APE67-dihe-in -67.85, -25.96 -92.49, -6.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.934 0.295 0.295 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 3vs0 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS1B P08631 81 526 526.0 VSA:60602 Type1 Inactive DFGin 6.7322 16.9114 None -77.82, 121.43 -54.05, 124.88 82.63, -74.78 150.57, 57.75 -49.96, -36.41 out-out out 14.0072 Saltbr-out 14.3647 HRD-in -101.3, -38.37 77.41, -41.31 out-out-none SNCoon out-none ActLoopNT-out 6.7331 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 18.85 APE8-rot-na 30.48 APE67-dihe-in -65.84, -20.55 -144.01, -39.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.464 0.281 0.281 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 3vs1 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS2B P08631 81 526 526.0 VSB:60601 Type1 Inactive DFGin 4.1152 13.5671 None -172.86, 118.27 -95.57, 158.0 70.94, 64.18 175.32, 32.25 108.45, -126.49 out-out out 14.0308 Saltbr-out 15.5528 HRD-in -134.11, -48.57 73.0, -14.11 out-out-none SNCoon out-none ActLoopNT-out 7.3664 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.96 APE8-rot-na 32.11 APE67-dihe-in -73.24, -13.59 -122.47, 3.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.609 0.279 0.279 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 3vs2 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS7A P08631 81 526 526.0 KS1:60601 Type1 Inactive DFGin 6.7194 17.468 None -90.49, -125.14 -63.27, 78.08 -85.63, 139.18 138.5, 78.54 73.41, 14.52 out-out out 12.6896 Saltbr-out 12.695 HRD-in -99.39, -35.83 68.71, -16.04 out-out-none SNCoon out-none ActLoopNT-out 7.1153 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 27.21 APE8-rot-na 27.98 APE67-dihe-in -66.27, -13.07 -124.75, -5.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 3.001 0.29 0.29 A 454.0 432.0 14 29 15 14 [[262, 513]] 1.0 3vs7 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK 3VS1A P08631 81 526 526.0 VSA:60602 Type1.5_Back Inactive DFGin 6.3901 17.1455 None -69.87, 118.45 -52.39, 130.08 95.26, -49.41 153.54, 67.46 -76.6, -8.56 out-out out 13.1819 Saltbr-out 15.1558 HRD-in -89.48, -44.64 76.16, -14.14 out-out-none SNCoon out-none ActLoopNT-out 6.893 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.94 APE8-rot-na 32.7 APE67-dihe-in -65.2, -12.86 -62.99, -17.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.464 0.281 0.281 A 454.0 424.0 13 29 16 13 [[262, 513]] 1.0 3vs1 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK

TYR_HCK (Tyrosine-protein kinase HCK)

Total number of chains: 46
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 25 54.3% 5H0BA
DFGin BLBtrans 8 17.4% 3VRZB
DFGin BLAminus 7 15.2% AF-P08631-K1A
DFGin None 6 13.0% 3VS1B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
HCK HCK_HUMAN AF-P08631-K1A P08631 254 521 526.0 No_ligand No_ligand Active DFGin 6.3113 14.1319 BLAminus -122.14, -160.92 37.16, 68.25 -80.85, 14.5 295.64, 94.86 -58.22, -33.85 in-in in 7.9212 Saltbr-in 2.6368 HRD-in -85.47, -46.06 65.16, 2.97 in-in-in SNCiii in-in ActLoopNT-in 2.8724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.0, 134.26 APE9-dihe-in -122.88, 155.02 APE8-dihe-in -71.54, 86.49 APE8-rot-na 31.06 APE67-dihe-in -70.36, -19.34 -41.02, -38.85 APE12-dist-na 14.8879 APE11-dist-na 10.1199 APE10-dist-na 12.5311 APE9-dist-in 6.6015 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 29 29 0 [[262, 513]] 1.0 AF-P08631-K1 Homo sapiens TYR_HCK_HUMAN TYR 2.6e-96 327.8 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN AF-P08631-K3A P08631 254 521 526.0 No_ligand No_ligand Active DFGin 6.2128 13.9113 BLAminus -135.77, -176.37 61.31, 47.91 -67.27, 12.49 301.02, 98.33 -59.04, -30.46 in-in in 7.9067 Saltbr-in 2.7462 HRD-in -90.59, -44.18 68.72, -6.91 in-in-in SNCiii in-in ActLoopNT-in 2.8904 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.25, 132.34 APE9-dihe-in -123.62, 153.73 APE8-dihe-in -75.72, 83.5 APE8-rot-na 34.41 APE67-dihe-in -64.86, -17.62 -42.96, -41.09 APE12-dist-na 14.811 APE11-dist-na 10.0573 APE10-dist-na 11.8279 APE9-dist-in 6.5182 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 29 29 0 [[262, 513]] 1.0 AF-P08631-K3 Homo sapiens TYR_HCK_HUMAN TYR 2.6e-96 327.8 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 2HK5A P08631 247 514 526.0 1BM:60499 Type1.5_Back Active DFGin 6.0374 14.0118 BLAminus -125.02, -169.05 46.01, 87.48 -101.95, 25.89 305.09, 88.79 -63.71, -34.22 in-in in 8.5319 Saltbr-in 2.7821 HRD-in -102.54, -51.97 77.09, -2.67 in-in-in SNCiii in-in ActLoopNT-in 2.9506 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.11, 141.59 APE9-dihe-in -137.5, 148.55 APE8-dihe-in -58.4, 107.06 APE8-rot-na 16.93 APE67-dihe-in -69.15, -18.5 -57.53, -42.26 APE12-dist-na 15.0339 APE11-dist-na 10.4791 APE10-dist-na 13.177 APE9-dist-in 6.9159 None None None XRAY 2.0 0.201 0.25 A 270.0 268.0 0 29 29 0 [[262, 513]] 1.0 2hk5 Homo sapiens TYR_HCK_HUMAN TYR 2.6e-96 327.8 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 1AD5A P08631 79 526 526.0 ANP:60001 ATPlike Inactive DFGin 6.8776 13.5562 BLAminus -111.54, 157.75 55.86, 95.53 -99.86, -56.89 321.06, 144.41 -91.88, 132.97 out-out out 13.5916 Saltbr-out 14.4523 HRD-out -92.59, 96.14 -56.64, -30.38 out-out-out SNCooo out-out ActLoopNT-out 11.4135 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.24, 53.46 APE9-dihe-in -96.28, 143.43 APE8-dihe-out -62.47, 38.68 APE8-rot-na 35.25 APE67-dihe-in -59.4, -26.12 -40.35, -46.47 APE12-dist-na 11.6595 APE11-dist-na 16.6044 APE10-dist-na 16.1334 APE9-dist-out 10.4142 None PTR522 PTR522 XRAY 2.6 0.239 0.307 A 438.0 438.0 0 29 29 0 [[262, 513]] 1.0 1ad5 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-88 303.1 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 1AD5B P08631 79 526 526.0 ANP:60532 ATPlike Inactive DFGin 6.635 13.5293 BLAminus -108.53, 152.83 57.68, 95.37 -100.87, -57.78 321.85, 133.69 -88.86, 132.45 out-out out 13.5911 Saltbr-out 14.3339 HRD-out -97.62, 96.0 -55.31, -32.54 out-out-out SNCooo out-out ActLoopNT-out 11.4801 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.78, 54.95 APE9-dihe-in -97.18, 143.16 APE8-dihe-out -68.08, 36.88 APE8-rot-na 32.16 APE67-dihe-in -59.62, -27.02 -36.62, -45.49 APE12-dist-na 11.6841 APE11-dist-na 16.5851 APE10-dist-na 16.2062 APE9-dist-out 10.5337 None PTR522 PTR522 XRAY 2.6 0.239 0.307 B 438.0 438.0 0 29 29 0 [[262, 513]] 1.0 1ad5 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-88 303.1 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 2HCKA P08631 79 526 526.0 QUE:60001 Type1 Inactive DFGin 6.8835 12.5651 BLAminus -135.76, 164.51 54.3, 68.19 -77.81, -69.05 321.97, 16.74 -94.78, 122.42 out-out out 13.2106 Saltbr-out 14.3378 HRD-out -102.03, 93.6 -54.25, 0.34 out-out-out SNCooo out-out ActLoopNT-out 11.4885 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -143.26, 34.29 APE9-dihe-in -78.64, 135.24 APE8-dihe-out -35.07, 8.77 APE8-rot-na 20.27 APE67-dihe-in -59.37, -32.12 -13.52, -63.84 APE12-dist-na 12.2557 APE11-dist-na 16.8036 APE10-dist-na 16.1956 APE9-dist-out 9.9055 None PTR522 PTR522 XRAY 3.0 0.228 0.311 A 438.0 438.0 0 29 29 0 [[262, 513]] 1.0 2hck Homo sapiens TYR_HCK_HUMAN TYR 1.4e-88 303.1 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 2HCKB P08631 79 526 526.0 QUE:60532 Type1 Inactive DFGin 6.1601 13.0826 BLAminus -141.04, 165.96 51.23, 63.5 -82.56, -71.35 330.45, 4.54 -82.38, 116.43 out-out out 13.5095 Saltbr-out 14.9112 HRD-out -122.75, 94.61 -56.98, 8.3 out-out-out SNCooo out-out ActLoopNT-out 12.0275 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -128.02, 26.89 APE9-dihe-in -77.78, 149.77 APE8-dihe-out -49.68, 1.53 APE8-rot-na 15.16 APE67-dihe-out -63.87, -24.64 2.1, -68.98 APE12-dist-na 12.2521 APE11-dist-na 17.3047 APE10-dist-na 16.4343 APE9-dist-out 10.2218 None PTR522 PTR522 XRAY 3.0 0.228 0.311 B 438.0 438.0 0 29 29 0 [[262, 513]] 1.0 2hck Homo sapiens TYR_HCK_HUMAN TYR 1.4e-88 303.1 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 5ZJ6A P08631 248 518 526.0 VSE:60601 Type1 Inactive DFGin 5.3351 13.0525 BLBplus -114.95, 163.29 60.26, 24.97 -64.12, 121.71 39.09, 88.22 79.49, -5.11 out-out out 14.0956 Saltbr-out 14.1936 HRD-in -73.59, -54.91 86.39, -11.4 out-out-out SNCooo out-out ActLoopNT-out 7.3139 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -71.95, -51.49 APE9-dihe-in -118.55, 145.05 APE8-dihe-in -85.67, 130.57 APE8-rot-na 32.67 APE67-dihe-in -73.71, -13.22 -54.97, -44.28 APE12-dist-na 16.603 APE11-dist-na 15.4722 APE10-dist-na 10.7965 APE9-dist-in 6.3027 None None None XRAY 1.696 0.208 0.24 A 287.0 271.0 0 29 29 0 [[262, 513]] 1.0 5zj6 Homo sapiens TYR_HCK_HUMAN TYR 3.3e-96 327.5 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 1QCFA P08631 81 526 526.0 PP1:60532 Type1 Inactive DFGin 4.9808 13.2184 BLBplus -122.28, 162.63 66.05, 14.52 -58.73, 126.22 40.94, 93.39 78.61, -11.82 out-out out 13.8541 Saltbr-out 14.605 HRD-in -71.4, -55.63 83.68, -15.14 out-out-out SNCooo out-out ActLoopNT-out 7.337 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.4, -24.56 APE9-dihe-in -80.87, 135.02 APE8-dihe-in -72.72, 52.96 APE8-rot-na 38.75 APE67-dihe-in -60.55, -20.73 -46.63, -48.12 APE12-dist-na 17.7105 APE11-dist-na 18.8098 APE10-dist-na 13.6061 APE9-dist-out 8.6423 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.0 0.215 0.257 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 1qcf Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS2A P08631 81 526 526.0 VSB:60601 Type1 Inactive DFGin 5.5175 12.5421 BLBplus -126.13, 168.77 60.55, 22.01 -69.92, 133.32 46.99, 86.38 78.45, -37.41 out-out out 13.5267 Saltbr-out 15.5989 HRD-in -85.68, -45.22 76.56, -16.0 out-out-none SNCoon out-none ActLoopNT-out 6.9595 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.36 APE8-rot-na 338.28 APE67-dihe-in -69.46, -15.36 -72.31, -17.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.609 0.279 0.279 A 454.0 430.0 13 29 16 13 [[262, 513]] 1.0 3vs2 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS5A P08631 81 526 526.0 VSG:60601 Type1 Inactive DFGin 5.3025 12.7869 BLBplus -113.17, 163.39 44.9, 47.31 -70.54, 124.98 29.01, 97.87 91.21, -36.02 out-out out 13.8811 Saltbr-out 13.6733 HRD-in -80.1, -56.21 84.49, -32.57 out-out-none SNCoon out-none ActLoopNT-out 6.9642 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 38.63 APE8-rot-na 346.37 APE67-dihe-in -64.79, -16.3 -91.95, -10.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.851 0.309 0.309 A 454.0 429.0 13 29 16 13 [[262, 513]] 1.0 3vs5 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS5B P08631 81 526 526.0 VSG:60601 Type1 Inactive DFGin 5.4472 12.5823 BLBplus -103.49, 162.99 68.58, 22.76 -66.54, 121.33 37.51, 94.92 89.07, -18.65 out-out out 13.3899 Saltbr-out 15.2332 HRD-in -74.25, -62.25 87.12, -19.0 out-out-none SNCoon out-none ActLoopNT-out 7.0627 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 0.98 APE8-rot-na 18.82 APE67-dihe-in -69.89, 0.28 -92.91, -10.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.851 0.309 0.309 B 454.0 427.0 13 29 16 13 [[262, 513]] 1.0 3vs5 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS7B P08631 81 526 526.0 KS1:60601 Type1 Inactive DFGin 5.7675 11.4394 BLBplus -102.99, 166.51 26.69, 56.44 -48.57, 110.73 13.09, 67.36 46.85, 38.89 out-out out 13.8824 Saltbr-out 9.7121 HRD-in -118.73, -5.37 61.6, -75.75 out-out-none SNCoon out-none ActLoopNT-out 8.6935 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -27.55 APE8-rot-na 331.6 APE67-dihe-in -67.6, -20.33 -137.5, 6.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 3.001 0.29 0.29 B 454.0 426.0 15 29 14 15 [[262, 513]] 1.0 3vs7 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 4LUDA P08631 81 526 526.0 SK8:60603 Type1 Inactive DFGin 5.6892 15.9043 BLBplus -116.28, 150.35 49.81, 43.36 -87.12, 142.97 63.18, 99.69 99.14, -26.26 out-out out 13.412 Saltbr-out 13.2246 HRD-in -86.33, -45.0 75.85, -22.84 out-out-none SNCoon out-none ActLoopNT-out 7.3437 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 27.69 APE8-rot-na 31.21 APE67-dihe-in -65.55, -26.53 -70.89, -24.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.85 0.215 0.261 A 454.0 421.0 20 29 16 13 [[262, 513]] 1.0 4lud Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 4LUDB P08631 81 524 526.0 SK8:60601 Type1 Inactive DFGin 4.7253 13.6615 BLBplus -114.11, 155.75 54.4, 45.03 -86.4, 134.52 55.73, 98.16 92.31, -27.22 out-out out 13.8813 Saltbr-out 14.0633 HRD-in -87.61, -43.81 76.82, -22.41 out-out-none SNCoon out-none ActLoopNT-out 7.3226 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 28.06 APE8-rot-na 31.21 APE67-dihe-in -64.0, -26.01 -70.38, -21.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.85 0.215 0.261 B 454.0 409.0 15 29 16 13 [[262, 513]] 1.0 4lud Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 5H0GA P08631 81 526 526.0 OOU:60601 Type1 Inactive DFGin 5.2194 12.8655 BLBplus -114.86, 166.88 60.14, 23.7 -65.58, 123.61 41.31, 90.91 79.47, -5.9 out-out out 13.8355 Saltbr-out 14.4677 HRD-in -74.56, -54.56 85.66, -16.83 out-out-out SNCooo out-out ActLoopNT-out 7.3017 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -56.03, -58.81 APE9-dihe-in -120.65, 154.72 APE8-dihe-in -92.18, 119.14 APE8-rot-na 33.08 APE67-dihe-in -67.75, -14.83 -50.37, -44.57 APE12-dist-na 17.1599 APE11-dist-na 16.4386 APE10-dist-na 11.4684 APE9-dist-in 6.9005 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 1.8 0.183 0.224 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 5h0g Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 5ZJ6B P08631 249 518 526.0 VSE:60601 Type1.5_Back Inactive DFGin 5.2974 12.9925 BLBplus -118.41, 160.6 63.16, 25.41 -63.98, 121.7 38.72, 89.85 78.05, -3.85 out-out out 14.1267 Saltbr-out 14.3758 HRD-in -77.39, -53.67 86.07, -14.13 out-out-out SNCooo out-out ActLoopNT-out 7.3995 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.8, -50.61 APE9-dihe-in -118.54, 142.1 APE8-dihe-in -83.18, 129.22 APE8-rot-na 29.87 APE67-dihe-in -70.77, -17.72 -53.15, -41.64 APE12-dist-na 16.6098 APE11-dist-na 15.4604 APE10-dist-na 10.8036 APE9-dist-in 6.3182 None None None XRAY 1.696 0.208 0.24 B 287.0 270.0 0 29 29 0 [[262, 513]] 1.0 5zj6 Homo sapiens TYR_HCK_HUMAN TYR 3.3e-96 327.5 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 9BYJA P08631 81 526 526.0 VSE:60601 Type1.5_Back Inactive DFGin 5.4202 12.6438 BLBplus -125.53, 164.62 65.89, 20.8 -62.8, 120.35 41.87, 89.23 80.88, -7.85 out-out out 13.565 Saltbr-out 14.7462 HRD-in -74.56, -57.47 88.73, -16.79 out-out-out SNCooo out-out ActLoopNT-out 7.2394 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.18, -27.82 APE9-dihe-in -112.35, 133.23 APE8-dihe-in -75.16, 116.15 APE8-rot-na 30.36 APE67-dihe-in -68.49, -15.64 -50.64, -44.35 APE12-dist-na 16.2999 APE11-dist-na 15.1608 APE10-dist-na 9.7617 APE9-dist-in 6.1557 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 1.8 0.2 0.219 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 9byj Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VRYA P08631 81 526 526.0 B43:60601 Type1.5_Back Inactive DFGin 5.3033 12.6289 BLBplus -119.81, 168.31 60.84, 32.96 -79.15, 125.05 35.96, 87.52 75.63, 2.45 out-out out 13.4698 Saltbr-out 14.2418 HRD-in -83.86, -50.67 75.41, -10.82 out-out-out SNCooo out-out ActLoopNT-out 7.0493 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 44.99 APE8-dihe-in -86.53, 62.73 APE8-rot-na 37.21 APE67-dihe-in -73.89, -9.73 -67.84, -18.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.664 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.481 0.281 0.281 A 454.0 428.0 12 29 17 12 [[262, 513]] 1.0 3vry Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VRYB P08631 81 526 526.0 B43:60602 Type1.5_Back Inactive DFGin 5.5286 12.7355 BLBplus -124.73, 163.97 61.97, 27.82 -75.15, 120.98 41.12, 86.83 77.64, 7.73 out-out out 13.5709 Saltbr-out 14.2814 HRD-in -92.65, -52.42 79.61, -13.54 out-out-out SNCooo out-out ActLoopNT-out 7.1623 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.27 APE8-dihe-in -82.4, 85.69 APE8-rot-na 32.14 APE67-dihe-in -71.65, -3.94 -95.0, -13.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3431 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.481 0.281 0.281 B 454.0 434.0 12 29 17 12 [[262, 513]] 1.0 3vry Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS3A P08631 81 526 526.0 VSE:60601 Type1.5_Back Inactive DFGin 5.5067 12.703 BLBplus -113.89, 168.6 61.04, 21.1 -67.43, 128.3 47.77, 89.98 67.78, 34.56 out-out out 13.8346 Saltbr-out 15.043 HRD-in -96.96, -54.21 81.88, -16.05 out-out-out SNCooo out-out ActLoopNT-out 7.2454 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 144.12 APE8-dihe-in -128.46, 60.71 APE8-rot-na 31.05 APE67-dihe-in -71.07, -14.35 -69.43, -16.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.3677 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.17 0.279 0.279 A 454.0 434.0 12 29 17 12 [[262, 513]] 1.0 3vs3 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS3B P08631 81 526 526.0 VSE:60601 Type1.5_Back Inactive DFGin 5.3646 12.6117 BLBplus -119.71, 171.03 60.1, 22.2 -67.88, 124.89 43.05, 86.27 84.83, -11.09 out-out out 13.6909 Saltbr-out 14.613 HRD-in -90.51, -51.33 80.7, -19.73 out-out-out SNCooo out-out ActLoopNT-out 7.5216 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 176.56 APE9-dihe-in -71.84, 130.34 APE8-dihe-in -72.47, 67.45 APE8-rot-na 28.63 APE67-dihe-in -66.79, -16.88 -59.5, -36.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.2488 APE9-dist-out 9.4057 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.17 0.279 0.279 B 454.0 431.0 10 29 19 10 [[262, 513]] 1.0 3vs3 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS4A P08631 81 526 526.0 VSF:60603 Type1.5_Back Inactive DFGin 5.2959 12.6167 BLBplus -129.05, 156.5 78.18, 7.28 -55.31, 122.08 48.34, 94.72 91.65, -36.18 out-out out 13.5298 Saltbr-out 14.391 HRD-in -89.51, -57.9 84.08, -11.13 out-out-out SNCooo out-out ActLoopNT-out 6.8746 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 47.3 APE8-dihe-in -93.7, 67.91 APE8-rot-na 28.82 APE67-dihe-in -68.45, -16.47 -64.44, -22.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.6975 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.747 0.265 0.265 A 454.0 429.0 11 29 18 11 [[262, 513]] 1.0 3vs4 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS4B P08631 81 526 526.0 VSF:60603 Type1.5_Back Inactive DFGin 5.2845 12.6652 BLBplus -120.89, 167.83 61.49, 15.86 -62.02, 121.53 47.24, 95.4 75.03, 10.7 out-out out 13.7661 Saltbr-out 15.0419 HRD-in -94.45, -46.27 74.87, -7.2 out-out-out SNCooo out-out ActLoopNT-out 7.1349 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 48.23 APE8-dihe-in -84.31, 74.96 APE8-rot-na 34.0 APE67-dihe-in -71.24, -2.76 -88.69, -13.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.5953 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.747 0.265 0.265 B 454.0 434.0 12 29 17 12 [[262, 513]] 1.0 3vs4 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS6A P08631 81 526 526.0 VSH:60603 Type1.5_Back Inactive DFGin 5.5738 13.0065 BLBplus -118.63, 173.06 55.31, 21.4 -65.15, 123.93 39.6, 95.61 74.91, -1.15 out-out out 13.9136 Saltbr-out 14.5656 HRD-in -84.94, -50.54 80.12, -18.35 out-out-out SNCooo out-out ActLoopNT-out 7.1467 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -64.17 APE8-dihe-in -74.02, 58.62 APE8-rot-na 33.3 APE67-dihe-in -64.63, -21.22 -73.45, -22.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.9247 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.373 0.28 0.28 A 454.0 434.0 12 29 17 12 [[262, 513]] 1.0 3vs6 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS6B P08631 81 526 526.0 VSH:60603 Type1.5_Back Inactive DFGin 5.7234 13.1865 BLBplus -116.1, 166.06 60.58, 23.3 -65.66, 128.54 39.99, 90.02 65.39, 33.14 out-out out 13.738 Saltbr-out 14.163 HRD-in -89.01, -50.06 78.41, -20.06 out-out-out SNCooo out-out ActLoopNT-out 7.5082 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.18 APE8-dihe-in -84.44, 55.22 APE8-rot-na 34.46 APE67-dihe-in -66.08, -19.87 -67.04, -14.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.8679 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.373 0.28 0.28 B 454.0 434.0 12 29 17 12 [[262, 513]] 1.0 3vs6 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 4LUEA P08631 81 525 526.0 VSE:60602 Type1.5_Back Inactive DFGin 5.4708 12.767 BLBplus -122.72, 161.78 60.91, 25.36 -68.49, 129.05 43.25, 85.69 79.66, -15.83 out-out out 13.7253 Saltbr-out 15.2762 HRD-in -84.46, -56.17 83.88, -6.66 out-out-none SNCoon out-none ActLoopNT-out 7.1075 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.88 APE8-rot-na 30.04 APE67-dihe-in -72.15, -20.12 -64.45, -27.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 3.04 0.208 0.256 A 454.0 422.0 19 29 16 13 [[262, 513]] 1.0 4lue Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 4LUEB P08631 81 525 526.0 VSE:60603 Type1.5_Back Inactive DFGin 5.4871 12.7203 BLBplus -122.08, 162.6 61.61, 26.01 -68.05, 129.15 43.17, 85.26 79.37, -16.77 out-out out 13.8589 Saltbr-out 13.9045 HRD-in -86.09, -56.89 84.27, -5.71 out-out-none SNCoon out-none ActLoopNT-out 7.0522 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.26 APE8-rot-na 30.0 APE67-dihe-in -72.01, -19.64 -64.44, -29.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 3.04 0.208 0.256 B 454.0 417.0 24 29 16 13 [[262, 513]] 1.0 4lue Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 5H09A P08631 81 526 526.0 OOO:60601 Type1.5_Back Inactive DFGin 5.3227 12.8413 BLBplus -119.41, 164.45 62.61, 23.39 -67.49, 124.25 40.02, 90.79 79.63, -8.11 out-out out 13.8946 Saltbr-out 14.3235 HRD-in -72.48, -55.6 87.36, -12.88 out-out-out SNCooo out-out ActLoopNT-out 7.301 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.96, -40.82 APE9-dihe-in -128.15, 146.91 APE8-dihe-in -82.62, 123.41 APE8-rot-na 28.7 APE67-dihe-in -68.7, -17.07 -52.89, -42.17 APE12-dist-na 16.8064 APE11-dist-na 15.6245 APE10-dist-na 11.169 APE9-dist-in 6.4908 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 1.945 0.192 0.223 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 5h09 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 5H0BA P08631 81 526 526.0 OOQ:60601 Type1.5_Back Inactive DFGin 5.1947 12.968 BLBplus -120.19, 167.13 61.98, 21.03 -65.87, 121.12 41.37, 91.21 83.04, -7.66 out-out out 13.916 Saltbr-out 14.5003 HRD-in -74.41, -54.69 86.34, -12.23 out-out-out SNCooo out-out ActLoopNT-out 7.3031 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -81.72, -39.23 APE9-dihe-in -136.84, 153.35 APE8-dihe-in -86.74, 125.6 APE8-rot-na 30.3 APE67-dihe-in -69.37, -17.33 -50.9, -41.62 APE12-dist-na 16.9696 APE11-dist-na 15.8556 APE10-dist-na 11.3843 APE9-dist-in 6.7676 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 1.651 0.181 0.205 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 5h0b Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 5H0EA P08631 81 526 526.0 OOS:60601 Type1.5_Back Inactive DFGin 5.3327 12.9353 BLBplus -121.03, 169.99 58.79, 24.6 -66.39, 120.74 38.13, 94.8 84.92, -10.16 out-out out 13.845 Saltbr-out 14.2465 HRD-in -74.39, -53.63 84.89, -9.61 out-out-out SNCooo out-out ActLoopNT-out 7.1685 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -75.99, -39.62 APE9-dihe-in -133.04, 151.48 APE8-dihe-in -86.73, 118.64 APE8-rot-na 27.16 APE67-dihe-in -70.28, -17.08 -49.56, -42.7 APE12-dist-na 17.0207 APE11-dist-na 15.6757 APE10-dist-na 11.2666 APE9-dist-in 6.5657 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.1 0.188 0.226 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 5h0e Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 5H0HA P08631 81 526 526.0 OOV:60601 Type1.5_Back Inactive DFGin 5.1742 12.8501 BLBplus -121.84, 166.14 63.19, 20.31 -64.42, 123.79 41.33, 90.61 78.85, -6.45 out-out out 13.8276 Saltbr-out 14.3333 HRD-in -74.28, -54.85 86.89, -14.03 out-out-out SNCooo out-out ActLoopNT-out 7.3415 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -75.07, -42.41 APE9-dihe-in -128.28, 151.93 APE8-dihe-in -86.13, 127.03 APE8-rot-na 29.7 APE67-dihe-in -68.31, -17.39 -50.74, -43.04 APE12-dist-na 16.6688 APE11-dist-na 15.8323 APE10-dist-na 11.0795 APE9-dist-in 6.4987 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 1.72 0.186 0.224 A 454.0 446.0 0 29 29 0 [[262, 513]] 1.0 5h0h Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 2C0IB P08631 81 526 526.0 L1G:61506 Type1 Inactive DFGin 6.4691 17.7266 BLBtrans -118.5, 156.15 76.55, 12.4 -65.22, 111.07 174.33, 50.9 114.94, -35.19 out-out out 14.021 Saltbr-out 15.5699 HRD-out -104.67, 98.76 -75.08, 8.06 out-out-none SNCoon out-none ActLoopNT-out 6.8918 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 15.64 APE8-rot-na 330.95 APE67-dihe-in -62.78, -19.75 -60.97, -25.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.3 0.224 0.274 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 2c0i Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 2C0OB P08631 81 526 526.0 L2G:61506 Type1 Inactive DFGin 6.7063 17.7058 BLBtrans -110.11, 165.43 71.01, 15.69 -62.58, 118.15 183.74, 34.04 90.09, -15.98 out-out out 14.2265 Saltbr-out 13.9175 HRD-out -123.92, 88.64 -59.99, -10.92 out-out-none SNCoon out-none ActLoopNT-out 6.6926 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 85.76 APE8-rot-na 331.38 APE67-dihe-in -49.13, -29.59 -92.66, -35.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.85 0.204 0.273 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 2c0o Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 2C0IA P08631 81 526 526.0 L1G:61506 Type1.5_Front Inactive DFGin 6.7692 17.7438 BLBtrans -115.37, 154.0 70.82, 18.12 -65.91, 121.57 184.38, 41.99 105.96, -38.14 out-out out 13.4018 Saltbr-out 13.3108 HRD-in -75.63, -56.77 92.51, -29.31 out-out-none SNCoon out-none ActLoopNT-out 6.4934 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.77 APE8-rot-na 14.74 APE67-dihe-in -66.54, -21.29 -71.46, -21.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.3 0.224 0.274 A 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 2c0i Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 2C0OA P08631 81 526 526.0 L2G:61506 Type1.5_Front Inactive DFGin 6.6226 17.5579 BLBtrans -102.76, 170.81 68.33, 6.06 -62.19, 117.6 178.08, 53.25 105.15, -37.25 out-out out 13.4254 Saltbr-out 14.0408 HRD-in -86.82, -49.88 88.79, -24.67 out-out-none SNCoon out-none ActLoopNT-out 6.5433 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 93.2 APE8-rot-na 27.76 APE67-dihe-in -65.03, -25.33 -76.85, -18.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.85 0.204 0.273 A 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 2c0o Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 2C0TA P08631 81 526 526.0 L3G:61506 Type1.5_Front Inactive DFGin 6.5841 17.8458 BLBtrans -103.62, 161.87 63.4, 18.68 -68.73, 122.03 173.01, 50.25 109.42, -49.86 out-out out 13.2929 Saltbr-out 13.4528 HRD-in -82.0, -51.15 69.41, -3.28 out-out-none SNCoon out-none ActLoopNT-out 6.0662 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 73.05 APE8-rot-na 27.06 APE67-dihe-in -75.03, -15.66 -73.32, -16.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.15 0.197 0.253 A 454.0 427.0 13 29 16 13 [[262, 513]] 1.0 2c0t Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 2C0TB P08631 81 526 526.0 L3G:61506 Type1.5_Front Inactive DFGin 6.7091 17.8655 BLBtrans -104.05, 163.35 58.02, 34.32 -79.78, 115.19 166.03, 51.93 89.06, 7.58 out-out out 14.2057 Saltbr-out 14.127 HRD-in -92.96, -48.52 72.3, -13.86 out-out-none SNCoon out-none ActLoopNT-out 7.0744 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 168.21 APE8-rot-na 23.75 APE67-dihe-in -65.46, -15.21 -125.7, -33.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.15 0.197 0.253 B 454.0 429.0 13 29 16 13 [[262, 513]] 1.0 2c0t Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VRZA P08631 81 526 526.0 VRZ:60603 Type1.5_Front Inactive DFGin 6.6529 17.6049 BLBtrans -107.49, 162.36 65.41, 22.25 -66.55, 118.82 172.12, 49.89 104.47, -23.12 out-out out 13.7038 Saltbr-out 14.1613 HRD-in -91.87, -51.27 85.65, -25.59 out-out-none SNCoon out-none ActLoopNT-out 6.9471 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 57.56 APE8-rot-na 29.34 APE67-dihe-in -64.65, 2.38 -52.77, -22.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.218 0.267 0.267 A 454.0 429.0 13 29 16 13 [[262, 513]] 1.0 3vrz Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VRZB P08631 81 526 526.0 VRZ:60603 Type1.5_Front Inactive DFGin 6.4964 17.5037 BLBtrans -106.94, 168.11 63.9, 13.84 -60.21, 119.93 180.64, 41.8 108.28, -25.57 out-out out 13.2287 Saltbr-out 13.4672 HRD-in -97.14, -43.33 79.11, -20.29 out-out-out SNCooo out-out ActLoopNT-out 6.263 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.9 APE8-dihe-in -90.85, 64.85 APE8-rot-na 34.91 APE67-dihe-in -66.47, -19.82 -63.44, -23.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.4917 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.218 0.267 0.267 B 454.0 430.0 12 29 17 12 [[262, 513]] 1.0 3vrz Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS0A P08631 81 526 526.0 VS0:60602 Type1 Inactive DFGin 5.5705 16.6537 None -129.57, 162.1 -82.47, -42.29 67.42, 124.57 160.77, 70.48 69.5, 30.08 out-out out 14.2453 Saltbr-out 14.6605 HRD-in -88.57, -37.73 75.77, -11.97 out-out-none SNCoon out-none ActLoopNT-out 7.1153 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -2.1 APE8-rot-na 22.57 APE67-dihe-in -68.2, -25.74 -107.06, -1.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.934 0.295 0.295 A 454.0 428.0 13 29 16 13 [[262, 513]] 1.0 3vs0 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS0B P08631 81 526 526.0 VS0:60602 Type1 Inactive DFGin 6.0642 17.1807 None -111.8, 150.48 -110.07, -32.77 65.61, 113.92 163.11, 68.65 100.74, -23.61 out-out out 14.2153 Saltbr-out 14.3341 HRD-in -78.42, -39.25 73.05, -7.55 out-out-none SNCoon out-none ActLoopNT-out 6.5568 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 18.88 APE8-rot-na 26.41 APE67-dihe-in -67.85, -25.96 -92.49, -6.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.934 0.295 0.295 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 3vs0 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS1B P08631 81 526 526.0 VSA:60602 Type1 Inactive DFGin 6.7322 16.9114 None -77.82, 121.43 -54.05, 124.88 82.63, -74.78 150.57, 57.75 -49.96, -36.41 out-out out 14.0072 Saltbr-out 14.3647 HRD-in -101.3, -38.37 77.41, -41.31 out-out-none SNCoon out-none ActLoopNT-out 6.7331 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 18.85 APE8-rot-na 30.48 APE67-dihe-in -65.84, -20.55 -144.01, -39.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.464 0.281 0.281 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 3vs1 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS2B P08631 81 526 526.0 VSB:60601 Type1 Inactive DFGin 4.1152 13.5671 None -172.86, 118.27 -95.57, 158.0 70.94, 64.18 175.32, 32.25 108.45, -126.49 out-out out 14.0308 Saltbr-out 15.5528 HRD-in -134.11, -48.57 73.0, -14.11 out-out-none SNCoon out-none ActLoopNT-out 7.3664 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.96 APE8-rot-na 32.11 APE67-dihe-in -73.24, -13.59 -122.47, 3.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.609 0.279 0.279 B 454.0 433.0 13 29 16 13 [[262, 513]] 1.0 3vs2 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS7A P08631 81 526 526.0 KS1:60601 Type1 Inactive DFGin 6.7194 17.468 None -90.49, -125.14 -63.27, 78.08 -85.63, 139.18 138.5, 78.54 73.41, 14.52 out-out out 12.6896 Saltbr-out 12.695 HRD-in -99.39, -35.83 68.71, -16.04 out-out-none SNCoon out-none ActLoopNT-out 7.1153 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 27.21 APE8-rot-na 27.98 APE67-dihe-in -66.27, -13.07 -124.75, -5.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 3.001 0.29 0.29 A 454.0 432.0 14 29 15 14 [[262, 513]] 1.0 3vs7 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
HCK HCK_HUMAN 3VS1A P08631 81 526 526.0 VSA:60602 Type1.5_Back Inactive DFGin 6.3901 17.1455 None -69.87, 118.45 -52.39, 130.08 95.26, -49.41 153.54, 67.46 -76.6, -8.56 out-out out 13.1819 Saltbr-out 15.1558 HRD-in -89.48, -44.64 76.16, -14.14 out-out-none SNCoon out-none ActLoopNT-out 6.893 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.94 APE8-rot-na 32.7 APE67-dihe-in -65.2, -12.86 -62.99, -17.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.464 0.281 0.281 A 454.0 424.0 13 29 16 13 [[262, 513]] 1.0 3vs1 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK

TYR_HCK (Tyrosine-protein kinase HCK)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name