AGC_GRK3 (G protein-coupled receptor kinase 3)

Total number of chains: 2
Active chains: 2
Family: AGC
Uniprot: ARBK2_HUMAN
Kinase Domain Residues: 191 - 453
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-P35626-K1A

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PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P35626-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 183 - 461 0 None None G protein-coupled receptor kinase 3
AF-P35626-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 183 - 461 0 None None G protein-coupled receptor kinase 3

AGC_GRK3 (G protein-coupled receptor kinase 3)

Total number of chains: 3
Active chains: 2
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-P35626-K1A

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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ARBK2_HUMAN AF-P35626-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 183 - 461 0 None None G protein-coupled receptor kinase 3 Homo sapiens
ARBK2_HUMAN AF-P35626-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 183 - 461 0 None None G protein-coupled receptor kinase 3 Homo sapiens
ARBK2_MOUSE 9IJJ4Z 7.7 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oioo No_ligand No_ligand 31 - 666 0 None None G protein-coupled receptor kinase 3 Mus musculus

AGC_GRK3 (G protein-coupled receptor kinase 3)

Total number of chains: 1
Active chains: 0
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 9IJJ4Z

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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ARBK2_MOUSE 9IJJ4Z 7.7 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oioo No_ligand No_ligand 31 - 666 0 None None G protein-coupled receptor kinase 3 Mus musculus