AGC_GRK3 (G protein-coupled receptor kinase 3)

Total number of chains: 2
Active chains: 2
Family: AGC
Uniprot: ARBK2_HUMAN
Kinase Domain Residues: 191 - 453
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-P35626-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P35626-K1A 183 461 688.0 No_ligand No_ligand Active DFGin 5.389 12.979 BLAminus -119.85, -177.05 47.66, 71.7 -81.78, 19.84 282.66, 77.07 -60.27, -30.98 in-in in 8.444 Saltbr-in 2.574 HRD-in -79.78, -43.12 66.85, 1.96 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.85, 154.0 APE9-dihe-na 126.52, 172.74 APE8-dihe-in -77.57, 128.03 APE8-rot-in 302.33 APE67-dihe-inflip 86.21, -2.04 -52.74, 135.57 APE12-dist-in 9.228 APE11-dist-in 12.059 APE10-dist-in 6.147 APE9-dist-in 3.494 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[191, 453]] 1.0 AF-P35626-K1 AGC_GRK3_HUMAN AGC 1e-79 273.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 G protein-coupled receptor kinase 3
AF-P35626-K3A 183 461 688.0 No_ligand No_ligand Active DFGin 5.337 12.966 BLAminus -127.84, 178.42 53.44, 63.01 -72.34, 17.54 287.43, 91.74 -61.73, -26.86 in-in in 8.586 Saltbr-in 2.574 HRD-in -86.58, -43.9 68.67, 3.65 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.82, 153.69 APE9-dihe-na 128.92, -164.53 APE8-dihe-in -101.52, 124.31 APE8-rot-in 298.48 APE67-dihe-inflip 88.79, 1.53 -53.76, 131.32 APE12-dist-in 9.093 APE11-dist-in 11.84 APE10-dist-in 5.923 APE9-dist-in 3.195 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[191, 453]] 1.0 AF-P35626-K3 AGC_GRK3_HUMAN AGC 1e-79 273.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 G protein-coupled receptor kinase 3

AGC_GRK3 (G protein-coupled receptor kinase 3)

Total number of chains: 3
Active chains: 2
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-P35626-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ARBK2_HUMAN AF-P35626-K1A P35626 183 461 688.0 No_ligand No_ligand Active DFGin 5.389 12.979 BLAminus -119.85, -177.05 47.66, 71.7 -81.78, 19.84 282.66, 77.07 -60.27, -30.98 in-in in 8.444 Saltbr-in 2.574 HRD-in -79.78, -43.12 66.85, 1.96 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.85, 154.0 APE9-dihe-na 126.52, 172.74 APE8-dihe-in -77.57, 128.03 APE8-rot-in 302.33 APE67-dihe-inflip 86.21, -2.04 -52.74, 135.57 APE12-dist-in 9.228 APE11-dist-in 12.059 APE10-dist-in 6.147 APE9-dist-in 3.494 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[191, 453]] 1.0 AF-P35626-K1 Homo sapiens AGC_GRK3_HUMAN AGC 1e-79 273.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 G protein-coupled receptor kinase 3
ARBK2_HUMAN AF-P35626-K3A P35626 183 461 688.0 No_ligand No_ligand Active DFGin 5.337 12.966 BLAminus -127.84, 178.42 53.44, 63.01 -72.34, 17.54 287.43, 91.74 -61.73, -26.86 in-in in 8.586 Saltbr-in 2.574 HRD-in -86.58, -43.9 68.67, 3.65 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.82, 153.69 APE9-dihe-na 128.92, -164.53 APE8-dihe-in -101.52, 124.31 APE8-rot-in 298.48 APE67-dihe-inflip 88.79, 1.53 -53.76, 131.32 APE12-dist-in 9.093 APE11-dist-in 11.84 APE10-dist-in 5.923 APE9-dist-in 3.195 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[191, 453]] 1.0 AF-P35626-K3 Homo sapiens AGC_GRK3_HUMAN AGC 1e-79 273.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 G protein-coupled receptor kinase 3
ARBK2_MOUSE 9IJJ4Z Q3UYH7 31 666 688.0 No_ligand No_ligand Inactive DFGin 6.388 11.974 BLAminus -147.08, -178.98 81.63, 135.2 -137.71, 2.58 276.22, 69.73 -66.04, -21.86 out-out out 11.784 Saltbr-out 7.534 HRD-in -110.71, -6.72 64.74, -98.38 out-out-out SNCooo out-out ActLoopNT-out 4.22 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -142.98, 144.25 APE9-dihe-na 78.54, -74.64 APE8-dihe-in -81.79, 66.78 APE8-rot-in 312.47 APE67-dihe-inflip 83.51, -14.06 -67.0, 154.56 APE12-dist-out 6.112 APE11-dist-in 9.881 APE10-dist-out 9.268 APE9-dist-out 11.145 None None None EM 7.7 999.0 999.0 4Z 688 636 0 0 0 0 [[191, 453]] 1.0 9ijj Mus musculus AGC_GRK3_MOUSE AGC 2e-77 266.9 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 G protein-coupled receptor kinase 3

AGC_GRK3 (G protein-coupled receptor kinase 3)

Total number of chains: 1
Active chains: 0
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 9IJJ4Z
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ARBK2_MOUSE 9IJJ4Z Q3UYH7 31 666 688.0 No_ligand No_ligand Inactive DFGin 6.388 11.974 BLAminus -147.08, -178.98 81.63, 135.2 -137.71, 2.58 276.22, 69.73 -66.04, -21.86 out-out out 11.784 Saltbr-out 7.534 HRD-in -110.71, -6.72 64.74, -98.38 out-out-out SNCooo out-out ActLoopNT-out 4.22 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -142.98, 144.25 APE9-dihe-na 78.54, -74.64 APE8-dihe-in -81.79, 66.78 APE8-rot-in 312.47 APE67-dihe-inflip 83.51, -14.06 -67.0, 154.56 APE12-dist-out 6.112 APE11-dist-in 9.881 APE10-dist-out 9.268 APE9-dist-out 11.145 None None None EM 7.7 999.0 999.0 4Z 688 636 0 0 0 0 [[191, 453]] 1.0 9ijj Mus musculus AGC_GRK3_MOUSE AGC 2e-77 266.9 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 G protein-coupled receptor kinase 3