TYR_EPHA7 (Ephrin type-A receptor 7)

Total number of chains: 7
Active chains: 2
Family: TYR
Uniprot: EPHA7_HUMAN
Kinase Domain Residues: 633 - 892
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 71.4% AF-Q15375-K1A
DFGin BLBminus 1 14.3% 7EEFA
DFGout BBAminus 1 14.3% 3DKOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q15375-K1A 625 900 998.0 No_ligand No_ligand Active DFGin 5.825 13.978 BLAminus -140.41, -179.58 58.44, 66.21 -82.47, 13.06 302.24, 93.86 -60.39, -33.71 in-in in 7.993 Saltbr-in 2.694 HRD-in -78.56, -43.49 67.64, -12.93 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.59, 138.1 APE9-dihe-in -118.55, 130.56 APE8-dihe-in -76.34, 77.15 APE8-rot-na 35.43 APE67-dihe-in -66.96, -15.03 -39.35, -53.29 APE12-dist-na 11.746 APE11-dist-na 9.227 APE10-dist-na 9.76 APE9-dist-in 6.191 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[633, 892]] 1.0 AF-Q15375-K1 TYR_EPHA7_HUMAN TYR 1.2e-109 371.6 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
AF-Q15375-K3A 625 900 998.0 No_ligand No_ligand Active DFGin 6.215 13.689 BLAminus -145.77, -179.5 60.66, 62.84 -79.61, 9.85 299.04, 101.75 -59.94, -30.84 in-in in 8.023 Saltbr-in 2.777 HRD-in -77.18, -45.91 70.57, -12.3 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.35, 129.31 APE9-dihe-in -100.55, 133.14 APE8-dihe-in -76.28, 78.05 APE8-rot-na 36.16 APE67-dihe-in -64.62, -21.42 -40.46, -47.0 APE12-dist-na 11.184 APE11-dist-na 8.996 APE10-dist-na 10.713 APE9-dist-in 6.462 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[633, 892]] 1.0 AF-Q15375-K3 TYR_EPHA7_HUMAN TYR 1.2e-109 371.6 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
7EEFA 606 899 998.0 No_ligand No_ligand Inactive DFGin 5.123 14.638 BLBminus -137.7, -172.22 60.44, 72.99 -90.88, 137.71 298.93, 94.94 -150.43, -28.25 in-in in 7.678 Saltbr-in 2.637 HRD-in -71.89, -51.22 74.79, -14.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -39.07, -28.59 APE9-dihe-in -49.72, 97.68 APE8-dihe-in -80.35, 154.08 APE8-rot-na 33.47 APE67-dihe-in -75.51, -3.16 -71.4, -33.64 APE12-dist-na 11.657 APE11-dist-na 11.917 APE10-dist-na 11.77 APE9-dist-in 4.819 G656E None None XRAY 2.6 0.246 0.28 A 304 280 14 0 0 14 [[633, 892]] 1.0 7eef TYR_EPHA7_HUMAN TYR 1.4e-109 371.3 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
3DKOA 607 899 998.0 IHZ:61001 Type2 Inactive DFGout 13.175 10.331 BBAminus -143.09, -173.33 -161.1, 120.52 -95.52, 1.37 288.12, 110.09 75.57, 999.0 in-in in 7.865 Saltbr-in 2.81 HRD-in -67.63, -53.71 83.87, -17.24 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.94 APE8-rot-na 17.98 APE67-dihe-in -71.86, -13.43 -49.8, -44.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.191 0.232 A 318 272 21 0 0 20 [[633, 892]] 1.0 3dko TYR_EPHA7_HUMAN TYR 2e-109 370.8 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
7EEDA 607 899 998.0 No_ligand No_ligand None DFGin 5.615 15.231 BLAminus -160.14, -166.28 43.23, 89.72 -111.48, -20.96 267.38, 102.35 -54.62, 166.76 in-in in 7.54 Saltbr-in 2.797 HRD-in -78.26, -42.61 76.57, -37.43 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -54.25 APE8-rot-na 338.3 APE67-dihe-in -74.18, -6.71 -44.02, -59.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D751H None None XRAY 3.05 0.201 0.247 A 304 275 18 0 0 18 [[633, 892]] 1.0 7eed TYR_EPHA7_HUMAN TYR 2.3e-109 370.6 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
2REIA 607 899 998.0 No_ligand No_ligand None DFGin 5.726 14.648 BLAminus -132.78, -176.46 70.06, 80.71 -109.81, 15.52 296.72, 101.1 -73.37, 178.43 in-in in 7.787 Saltbr-in 2.792 HRD-in -77.06, -49.41 79.73, -27.49 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -43.44 APE8-rot-na 327.54 APE67-dihe-in -71.85, -8.27 -50.21, -50.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.6 0.164 0.187 A 318 274 19 0 0 19 [[633, 892]] 1.0 2rei TYR_EPHA7_HUMAN TYR 2e-109 370.8 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
7EECA 607 899 998.0 No_ligand No_ligand None DFGin 4.921 14.381 BLAminus -139.59, -159.42 45.62, 100.81 -122.34, 29.16 288.48, 121.6 -110.62, -128.85 in-in in 7.604 Saltbr-in 3.2 HRD-in -65.62, -46.05 82.26, -52.23 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.96 APE8-rot-na 42.57 APE67-dihe-in -71.92, -1.3 -56.97, -50.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 G656R None None XRAY 3.1 0.183 0.21 A 305 274 19 0 0 19 [[633, 892]] 1.0 7eec TYR_EPHA7_HUMAN TYR 2e-109 370.8 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7

TYR_EPHA7 (Ephrin type-A receptor 7)

Total number of chains: 7
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 71.4% AF-Q15375-K1A
DFGin BLBminus 1 14.3% 7EEFA
DFGout BBAminus 1 14.3% 3DKOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EPHA7_HUMAN AF-Q15375-K1A Q15375 625 900 998.0 No_ligand No_ligand Active DFGin 5.825 13.978 BLAminus -140.41, -179.58 58.44, 66.21 -82.47, 13.06 302.24, 93.86 -60.39, -33.71 in-in in 7.993 Saltbr-in 2.694 HRD-in -78.56, -43.49 67.64, -12.93 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.59, 138.1 APE9-dihe-in -118.55, 130.56 APE8-dihe-in -76.34, 77.15 APE8-rot-na 35.43 APE67-dihe-in -66.96, -15.03 -39.35, -53.29 APE12-dist-na 11.746 APE11-dist-na 9.227 APE10-dist-na 9.76 APE9-dist-in 6.191 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[633, 892]] 1.0 AF-Q15375-K1 Homo sapiens TYR_EPHA7_HUMAN TYR 1.2e-109 371.6 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
EPHA7_HUMAN AF-Q15375-K3A Q15375 625 900 998.0 No_ligand No_ligand Active DFGin 6.215 13.689 BLAminus -145.77, -179.5 60.66, 62.84 -79.61, 9.85 299.04, 101.75 -59.94, -30.84 in-in in 8.023 Saltbr-in 2.777 HRD-in -77.18, -45.91 70.57, -12.3 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.35, 129.31 APE9-dihe-in -100.55, 133.14 APE8-dihe-in -76.28, 78.05 APE8-rot-na 36.16 APE67-dihe-in -64.62, -21.42 -40.46, -47.0 APE12-dist-na 11.184 APE11-dist-na 8.996 APE10-dist-na 10.713 APE9-dist-in 6.462 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[633, 892]] 1.0 AF-Q15375-K3 Homo sapiens TYR_EPHA7_HUMAN TYR 1.2e-109 371.6 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
EPHA7_HUMAN 7EEFA Q15375 606 899 998.0 No_ligand No_ligand Inactive DFGin 5.123 14.638 BLBminus -137.7, -172.22 60.44, 72.99 -90.88, 137.71 298.93, 94.94 -150.43, -28.25 in-in in 7.678 Saltbr-in 2.637 HRD-in -71.89, -51.22 74.79, -14.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -39.07, -28.59 APE9-dihe-in -49.72, 97.68 APE8-dihe-in -80.35, 154.08 APE8-rot-na 33.47 APE67-dihe-in -75.51, -3.16 -71.4, -33.64 APE12-dist-na 11.657 APE11-dist-na 11.917 APE10-dist-na 11.77 APE9-dist-in 4.819 G656E None None XRAY 2.6 0.246 0.28 A 304 280 14 0 0 14 [[633, 892]] 1.0 7eef Homo sapiens TYR_EPHA7_HUMAN TYR 1.4e-109 371.3 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
EPHA7_HUMAN 3DKOA Q15375 607 899 998.0 IHZ:61001 Type2 Inactive DFGout 13.175 10.331 BBAminus -143.09, -173.33 -161.1, 120.52 -95.52, 1.37 288.12, 110.09 75.57, 999.0 in-in in 7.865 Saltbr-in 2.81 HRD-in -67.63, -53.71 83.87, -17.24 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.94 APE8-rot-na 17.98 APE67-dihe-in -71.86, -13.43 -49.8, -44.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.191 0.232 A 318 272 21 0 0 20 [[633, 892]] 1.0 3dko Homo sapiens TYR_EPHA7_HUMAN TYR 2e-109 370.8 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
EPHA7_HUMAN 7EEDA Q15375 607 899 998.0 No_ligand No_ligand None DFGin 5.615 15.231 BLAminus -160.14, -166.28 43.23, 89.72 -111.48, -20.96 267.38, 102.35 -54.62, 166.76 in-in in 7.54 Saltbr-in 2.797 HRD-in -78.26, -42.61 76.57, -37.43 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -54.25 APE8-rot-na 338.3 APE67-dihe-in -74.18, -6.71 -44.02, -59.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D751H None None XRAY 3.05 0.201 0.247 A 304 275 18 0 0 18 [[633, 892]] 1.0 7eed Homo sapiens TYR_EPHA7_HUMAN TYR 2.3e-109 370.6 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
EPHA7_HUMAN 2REIA Q15375 607 899 998.0 No_ligand No_ligand None DFGin 5.726 14.648 BLAminus -132.78, -176.46 70.06, 80.71 -109.81, 15.52 296.72, 101.1 -73.37, 178.43 in-in in 7.787 Saltbr-in 2.792 HRD-in -77.06, -49.41 79.73, -27.49 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -43.44 APE8-rot-na 327.54 APE67-dihe-in -71.85, -8.27 -50.21, -50.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.6 0.164 0.187 A 318 274 19 0 0 19 [[633, 892]] 1.0 2rei Homo sapiens TYR_EPHA7_HUMAN TYR 2e-109 370.8 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
EPHA7_HUMAN 7EECA Q15375 607 899 998.0 No_ligand No_ligand None DFGin 4.921 14.381 BLAminus -139.59, -159.42 45.62, 100.81 -122.34, 29.16 288.48, 121.6 -110.62, -128.85 in-in in 7.604 Saltbr-in 3.2 HRD-in -65.62, -46.05 82.26, -52.23 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.96 APE8-rot-na 42.57 APE67-dihe-in -71.92, -1.3 -56.97, -50.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 G656R None None XRAY 3.1 0.183 0.21 A 305 274 19 0 0 19 [[633, 892]] 1.0 7eec Homo sapiens TYR_EPHA7_HUMAN TYR 2e-109 370.8 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7

TYR_EPHA7 (Ephrin type-A receptor 7)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name