CAMK_AURKC (Aurora kinase C)

Total number of chains: 6
Active chains: 2
Uniprot: AURKC_HUMAN
Kinase Domain Residues: 43 - 293
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 66.7% 6GR8A
DFGin BLAminus 2 33.3% AF-Q9UQB9-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AURKC AF-Q9UQB9-K1A Q9UQB9 35 301 309.0 No_ligand No_ligand Active DFGin 5.635 15.0761 BLAminus -126.22, 175.58 57.82, 73.67 -81.22, 19.26 286.92, 74.37 -59.64, -33.26 in-in in 9.6155 Saltbr-in 2.6962 HRD-in -77.09, -49.16 67.41, 4.37 in-in-in SNCiii in-in ActLoopNT-in 2.9646 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.86, 162.45 APE9-dihe-na 106.12, -161.9 APE8-dihe-in -104.75, 137.86 APE8-rot-in 305.41 APE67-dihe-in -68.53, -15.21 -46.94, -52.61 APE12-dist-in 8.552 APE11-dist-in 11.2427 APE10-dist-in 5.523 APE9-dist-in 3.6637 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 26 26 0 [[43, 293]] 1.0 AF-Q9UQB9-K1 CAMK_AURKC_HUMAN CAMK 6.5e-81 277.3 1.0 256.0 256.0 183 184 185 187 189 72 91 95 163 165 164 166.0 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
AURKC AF-Q9UQB9-K3A Q9UQB9 35 301 309.0 No_ligand No_ligand Active DFGin 5.7469 15.1725 BLAminus -125.84, 175.88 53.66, 71.06 -74.66, 15.01 288.03, 83.94 -57.4, -36.96 out-in out 10.0967 Saltbr-in 2.7874 HRD-in -76.36, -51.95 70.98, 3.74 in-in-in SNCiii in-in ActLoopNT-in 2.9419 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.99, 160.92 APE9-dihe-na 96.02, -158.34 APE8-dihe-in -106.03, 137.86 APE8-rot-in 305.48 APE67-dihe-in -66.92, -15.31 -47.34, -55.42 APE12-dist-in 8.9265 APE11-dist-in 11.3904 APE10-dist-in 5.6515 APE9-dist-in 3.7693 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 26 26 0 [[43, 293]] 1.0 AF-Q9UQB9-K3 CAMK_AURKC_HUMAN CAMK 6.5e-81 277.3 1.0 256.0 256.0 183 184 185 187 189 72 91 95 163 165 164 166.0 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
AURKC 9ESAAAA Q9UQB9 32 306 309.0 No_ligand No_ligand Inactive DFGin 5.433 16.8828 ABAminus -62.04, -28.72 179.07, -174.45 -88.67, 25.64 294.85, 94.62 59.44, 60.75 out-out out 11.3792 Saltbr-out 8.8619 HRD-out -140.44, 154.82 -61.27, 119.4 out-out-out SNCooo out-out ActLoopNT-out 10.2764 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -58.98, -22.6 APE9-dihe-na 75.42, 33.12 APE8-dihe-out -119.6, 19.25 APE8-rot-out 46.66 APE67-dihe-in -59.85, -36.1 -64.53, -29.05 APE12-dist-out 23.1027 APE11-dist-out 21.9403 APE10-dist-out 18.0516 APE9-dist-out 17.1844 R195A,R196A,K197A None None XRAY 2.8 0.231 0.294 AAA 303.0 275.0 0 26 26 0 [[43, 293]] 1.0 9esa CAMK_AURKC_HUMAN CAMK 3.9e-80 274.8 1.0 256.0 256.0 183 184 185 187 189 72 91 95 163 165 164 166.0 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
AURKC 9ESABBB Q9UQB9 32 306 309.0 No_ligand No_ligand Inactive DFGin 5.4344 16.8397 ABAminus -61.93, -28.95 178.73, -174.57 -88.56, 24.83 295.03, 94.88 59.52, 60.63 out-out out 11.3511 Saltbr-out 8.4349 HRD-out -140.0, 154.34 -60.35, 118.62 out-out-out SNCooo out-out ActLoopNT-out 10.3227 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -60.23, -20.83 APE9-dihe-na 74.99, 33.76 APE8-dihe-out -117.9, 10.6 APE8-rot-in 259.04 APE67-dihe-in -59.49, -36.48 -65.18, -28.76 APE12-dist-out 23.1568 APE11-dist-out 21.9757 APE10-dist-out 18.0724 APE9-dist-out 17.2239 R195A,R196A,K197A None None XRAY 2.8 0.231 0.294 BBB 303.0 275.0 0 26 26 0 [[43, 293]] 1.0 9esa CAMK_AURKC_HUMAN CAMK 3.9e-80 274.8 1.0 256.0 256.0 183 184 185 187 189 72 91 95 163 165 164 166.0 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
AURKC 6GR9A Q9UQB9 37 305 309.0 VX6:401 Type1 Inactive DFGin 5.9382 15.1017 ABAminus -116.97, -17.33 -115.02, 131.77 -126.35, 27.77 291.73, 89.0 -57.7, -38.57 out-out out 10.9087 Saltbr-out 5.4158 HRD-in -77.17, -52.25 75.0, 6.87 out-in-in SNCoii in-in ActLoopNT-in 3.0211 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.06, 148.63 APE9-dihe-na 113.49, -141.6 APE8-dihe-in -139.5, 128.62 APE8-rot-in 303.24 APE67-dihe-in -70.15, -13.16 -34.43, -58.2 APE12-dist-in 8.5859 APE11-dist-in 10.6274 APE10-dist-in 5.1897 APE9-dist-in 3.7549 None TPO39,TPO198 TPO39,TPO198 XRAY 2.25 0.184 0.224 A 274.0 269.0 0 26 26 0 [[43, 293]] 1.0 6gr9 CAMK_AURKC_HUMAN CAMK 1e-80 276.7 1.0 256.0 256.0 183 184 185 187 189 72 91 95 163 165 164 166.0 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
AURKC 6GR8A Q9UQB9 36 303 309.0 F8Z:60401 Type1.5_Front Inactive DFGin 6.3882 16.3688 ABAminus -86.33, -37.22 -148.5, 121.35 -101.84, 15.84 276.95, 115.08 -62.41, -31.31 out-out out 10.6586 Saltbr-out 7.7558 HRD-in -76.6, -55.3 75.61, 5.87 out-in-out SNCoio in-out ActLoopNT-in 3.0175 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.48, 154.35 APE9-dihe-na 86.68, -167.53 APE8-dihe-in -103.19, 151.93 APE8-rot-out 71.83 APE67-dihe-in -66.94, -16.94 -38.52, -57.04 APE12-dist-in 8.1613 APE11-dist-in 10.454 APE10-dist-in 5.3796 APE9-dist-in 3.7534 None TPO39,TPO198 TPO39,TPO198 XRAY 1.75 0.178 0.216 A 274.0 268.0 0 26 26 0 [[43, 293]] 1.0 6gr8 CAMK_AURKC_HUMAN CAMK 1e-80 276.7 1.0 256.0 256.0 183 184 185 187 189 72 91 95 163 165 164 166.0 221 209 204 203 202 201 200 199 198 121 Aurora kinase C

CAMK_AURKC (Aurora kinase C)

Total number of chains: 6
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 66.7% 6GR8A
DFGin BLAminus 2 33.3% AF-Q9UQB9-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AURKC AURKC_HUMAN AF-Q9UQB9-K1A Q9UQB9 35 301 309.0 No_ligand No_ligand Active DFGin 5.635 15.0761 BLAminus -126.22, 175.58 57.82, 73.67 -81.22, 19.26 286.92, 74.37 -59.64, -33.26 in-in in 9.6155 Saltbr-in 2.6962 HRD-in -77.09, -49.16 67.41, 4.37 in-in-in SNCiii in-in ActLoopNT-in 2.9646 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.86, 162.45 APE9-dihe-na 106.12, -161.9 APE8-dihe-in -104.75, 137.86 APE8-rot-in 305.41 APE67-dihe-in -68.53, -15.21 -46.94, -52.61 APE12-dist-in 8.552 APE11-dist-in 11.2427 APE10-dist-in 5.523 APE9-dist-in 3.6637 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 26 26 0 [[43, 293]] 1.0 AF-Q9UQB9-K1 Homo sapiens CAMK_AURKC_HUMAN CAMK 6.5e-81 277.3 1.0 256.0 256.0 183 184 185 187 189 72 91 95 163 165 164 166.0 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
AURKC AURKC_HUMAN AF-Q9UQB9-K3A Q9UQB9 35 301 309.0 No_ligand No_ligand Active DFGin 5.7469 15.1725 BLAminus -125.84, 175.88 53.66, 71.06 -74.66, 15.01 288.03, 83.94 -57.4, -36.96 out-in out 10.0967 Saltbr-in 2.7874 HRD-in -76.36, -51.95 70.98, 3.74 in-in-in SNCiii in-in ActLoopNT-in 2.9419 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.99, 160.92 APE9-dihe-na 96.02, -158.34 APE8-dihe-in -106.03, 137.86 APE8-rot-in 305.48 APE67-dihe-in -66.92, -15.31 -47.34, -55.42 APE12-dist-in 8.9265 APE11-dist-in 11.3904 APE10-dist-in 5.6515 APE9-dist-in 3.7693 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 26 26 0 [[43, 293]] 1.0 AF-Q9UQB9-K3 Homo sapiens CAMK_AURKC_HUMAN CAMK 6.5e-81 277.3 1.0 256.0 256.0 183 184 185 187 189 72 91 95 163 165 164 166.0 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
AURKC AURKC_HUMAN 9ESAAAA Q9UQB9 32 306 309.0 No_ligand No_ligand Inactive DFGin 5.433 16.8828 ABAminus -62.04, -28.72 179.07, -174.45 -88.67, 25.64 294.85, 94.62 59.44, 60.75 out-out out 11.3792 Saltbr-out 8.8619 HRD-out -140.44, 154.82 -61.27, 119.4 out-out-out SNCooo out-out ActLoopNT-out 10.2764 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -58.98, -22.6 APE9-dihe-na 75.42, 33.12 APE8-dihe-out -119.6, 19.25 APE8-rot-out 46.66 APE67-dihe-in -59.85, -36.1 -64.53, -29.05 APE12-dist-out 23.1027 APE11-dist-out 21.9403 APE10-dist-out 18.0516 APE9-dist-out 17.1844 R195A,R196A,K197A None None XRAY 2.8 0.231 0.294 AAA 303.0 275.0 0 26 26 0 [[43, 293]] 1.0 9esa Homo sapiens CAMK_AURKC_HUMAN CAMK 3.9e-80 274.8 1.0 256.0 256.0 183 184 185 187 189 72 91 95 163 165 164 166.0 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
AURKC AURKC_HUMAN 9ESABBB Q9UQB9 32 306 309.0 No_ligand No_ligand Inactive DFGin 5.4344 16.8397 ABAminus -61.93, -28.95 178.73, -174.57 -88.56, 24.83 295.03, 94.88 59.52, 60.63 out-out out 11.3511 Saltbr-out 8.4349 HRD-out -140.0, 154.34 -60.35, 118.62 out-out-out SNCooo out-out ActLoopNT-out 10.3227 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -60.23, -20.83 APE9-dihe-na 74.99, 33.76 APE8-dihe-out -117.9, 10.6 APE8-rot-in 259.04 APE67-dihe-in -59.49, -36.48 -65.18, -28.76 APE12-dist-out 23.1568 APE11-dist-out 21.9757 APE10-dist-out 18.0724 APE9-dist-out 17.2239 R195A,R196A,K197A None None XRAY 2.8 0.231 0.294 BBB 303.0 275.0 0 26 26 0 [[43, 293]] 1.0 9esa Homo sapiens CAMK_AURKC_HUMAN CAMK 3.9e-80 274.8 1.0 256.0 256.0 183 184 185 187 189 72 91 95 163 165 164 166.0 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
AURKC AURKC_HUMAN 6GR9A Q9UQB9 37 305 309.0 VX6:401 Type1 Inactive DFGin 5.9382 15.1017 ABAminus -116.97, -17.33 -115.02, 131.77 -126.35, 27.77 291.73, 89.0 -57.7, -38.57 out-out out 10.9087 Saltbr-out 5.4158 HRD-in -77.17, -52.25 75.0, 6.87 out-in-in SNCoii in-in ActLoopNT-in 3.0211 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.06, 148.63 APE9-dihe-na 113.49, -141.6 APE8-dihe-in -139.5, 128.62 APE8-rot-in 303.24 APE67-dihe-in -70.15, -13.16 -34.43, -58.2 APE12-dist-in 8.5859 APE11-dist-in 10.6274 APE10-dist-in 5.1897 APE9-dist-in 3.7549 None TPO39,TPO198 TPO39,TPO198 XRAY 2.25 0.184 0.224 A 274.0 269.0 0 26 26 0 [[43, 293]] 1.0 6gr9 Homo sapiens CAMK_AURKC_HUMAN CAMK 1e-80 276.7 1.0 256.0 256.0 183 184 185 187 189 72 91 95 163 165 164 166.0 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
AURKC AURKC_HUMAN 6GR8A Q9UQB9 36 303 309.0 F8Z:60401 Type1.5_Front Inactive DFGin 6.3882 16.3688 ABAminus -86.33, -37.22 -148.5, 121.35 -101.84, 15.84 276.95, 115.08 -62.41, -31.31 out-out out 10.6586 Saltbr-out 7.7558 HRD-in -76.6, -55.3 75.61, 5.87 out-in-out SNCoio in-out ActLoopNT-in 3.0175 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.48, 154.35 APE9-dihe-na 86.68, -167.53 APE8-dihe-in -103.19, 151.93 APE8-rot-out 71.83 APE67-dihe-in -66.94, -16.94 -38.52, -57.04 APE12-dist-in 8.1613 APE11-dist-in 10.454 APE10-dist-in 5.3796 APE9-dist-in 3.7534 None TPO39,TPO198 TPO39,TPO198 XRAY 1.75 0.178 0.216 A 274.0 268.0 0 26 26 0 [[43, 293]] 1.0 6gr8 Homo sapiens CAMK_AURKC_HUMAN CAMK 1e-80 276.7 1.0 256.0 256.0 183 184 185 187 189 72 91 95 163 165 164 166.0 221 209 204 203 202 201 200 199 198 121 Aurora kinase C

CAMK_AURKC (Aurora kinase C)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name