PDB: AF-Q9NYV4 — CMGC CDK12_HUMAN

Total number of chains: 2
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-Q9NYV4-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN AF-Q9NYV4-K1A Q9NYV4 719 1028 1490.0 No_ligand No_ligand Active DFGin 6.7425 15.0213 BLAminus -135.31, 176.11 57.83, 65.7 -78.9, 19.02 283.91, 75.49 -59.53, -34.42 in-in in 8.8479 Saltbr-in 2.8717 HRD-in -74.38, -50.97 65.06, 11.96 in-in-in SNCiii in-in ActLoopNT-in 2.9537 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.35, 171.85 APE9-dihe-na 62.69, 132.06 APE8-dihe-in -56.47, 137.03 APE8-rot-in 300.21 APE67-dihe-in -68.24, -22.81 -49.07, -40.83 APE12-dist-in 13.0672 APE11-dist-in 11.1954 APE10-dist-in 6.6339 APE9-dist-in 3.3445 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 29 29 0 [[727, 1020]] 1.0 AF-Q9NYV4-K1 CMGC_CDK12_HUMAN CMGC 1.8e-84 289.4 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN AF-Q9NYV4-K3A Q9NYV4 719 1028 1490.0 No_ligand No_ligand Active DFGin 6.9432 15.648 BLAminus -131.2, -179.25 62.41, 52.03 -71.34, 9.91 284.98, 77.79 -61.92, -24.64 in-in in 8.4488 Saltbr-in 3.0263 HRD-in -78.33, -50.25 65.94, 8.6 in-in-in SNCiii in-in ActLoopNT-in 2.9006 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.81, 169.8 APE9-dihe-na 61.73, 134.8 APE8-dihe-in -58.63, 136.64 APE8-rot-in 295.26 APE67-dihe-in -64.98, -27.17 -49.82, -42.02 APE12-dist-in 13.4806 APE11-dist-in 11.6092 APE10-dist-in 7.1738 APE9-dist-in 3.2099 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 29 29 0 [[727, 1020]] 1.0 AF-Q9NYV4-K3 CMGC_CDK12_HUMAN CMGC 1.8e-84 289.4 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: AF-Q9NYV4 — CMGC CDK12_HUMAN

Total number of chains: 2
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-Q9NYV4-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN AF-Q9NYV4-K1A Q9NYV4 719 1028 1490.0 No_ligand No_ligand Active DFGin 6.7425 15.0213 BLAminus -135.31, 176.11 57.83, 65.7 -78.9, 19.02 283.91, 75.49 -59.53, -34.42 in-in in 8.8479 Saltbr-in 2.8717 HRD-in -74.38, -50.97 65.06, 11.96 in-in-in SNCiii in-in ActLoopNT-in 2.9537 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.35, 171.85 APE9-dihe-na 62.69, 132.06 APE8-dihe-in -56.47, 137.03 APE8-rot-in 300.21 APE67-dihe-in -68.24, -22.81 -49.07, -40.83 APE12-dist-in 13.0672 APE11-dist-in 11.1954 APE10-dist-in 6.6339 APE9-dist-in 3.3445 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 29 29 0 [[727, 1020]] 1.0 AF-Q9NYV4-K1 Homo sapiens CMGC_CDK12_HUMAN CMGC 1.8e-84 289.4 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN AF-Q9NYV4-K3A Q9NYV4 719 1028 1490.0 No_ligand No_ligand Active DFGin 6.9432 15.648 BLAminus -131.2, -179.25 62.41, 52.03 -71.34, 9.91 284.98, 77.79 -61.92, -24.64 in-in in 8.4488 Saltbr-in 3.0263 HRD-in -78.33, -50.25 65.94, 8.6 in-in-in SNCiii in-in ActLoopNT-in 2.9006 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.81, 169.8 APE9-dihe-na 61.73, 134.8 APE8-dihe-in -58.63, 136.64 APE8-rot-in 295.26 APE67-dihe-in -64.98, -27.17 -49.82, -42.02 APE12-dist-in 13.4806 APE11-dist-in 11.6092 APE10-dist-in 7.1738 APE9-dist-in 3.2099 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 29 29 0 [[727, 1020]] 1.0 AF-Q9NYV4-K3 Homo sapiens CMGC_CDK12_HUMAN CMGC 1.8e-84 289.4 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: AF-Q9NYV4 — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name