| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AGC | RPS6KA2-1 | KS6A2_HUMAN | AF-Q15349-K1A | Q15349 | 51 | 326 | 733.0 | No_ligand | No_ligand | Active | DFGin | 6.5598 | 14.2976 | BLAminus | -128.83, -162.98 | 39.17, 62.6 | -73.7, 13.33 | 288.23, 79.39 | -63.05, -17.58 | in-in | in | 8.7464 | Saltbr-in | 2.6179 | HRD-in | -82.39, -49.82 | 64.45, 9.53 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8943 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -156.56, 163.19 | APE9-dihe-na | 114.31, 169.62 | APE8-dihe-in | -69.73, 130.78 | APE8-rot-in | 293.85 | APE67-dihe-in | -60.4, -27.19 | -59.3, -42.05 | APE12-dist-in | 8.3994 | APE11-dist-in | 11.4439 | APE10-dist-in | 5.6991 | APE9-dist-in | 3.5393 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 276.0 | 276.0 | 0 | 28 | 28 | 0 | [[59, 318], [415, 672]] | 2.0 | AF-Q15349-K1 | AGC_RPS6KA2-1_HUMAN | AGC | 6.1e-97 | 329.7 | 1.0 | 260.0 | 260.0 | 201 | 202 | 203 | 205 | 207 | 91 | 109 | 113 | 181 | 183 | 182 | 184.0 | 241 | 229 | 224 | 223 | 222 | 221 | 220 | 219 | 218 | 139 | Ribosomal protein S6 kinase alpha-2 |
| AGC | RPS6KA2-1 | KS6A2_HUMAN | AF-Q15349-K3A | Q15349 | 51 | 326 | 733.0 | No_ligand | No_ligand | Active | DFGin | 6.4336 | 14.1588 | BLAminus | -128.23, -175.81 | 52.4, 64.67 | -72.62, 10.99 | 294.75, 82.08 | -64.43, -12.72 | in-in | in | 8.6258 | Saltbr-in | 2.6429 | HRD-in | -85.46, -48.02 | 66.82, 11.67 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8436 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -154.59, 164.28 | APE9-dihe-na | 111.5, 172.79 | APE8-dihe-in | -74.02, 136.08 | APE8-rot-in | 294.1 | APE67-dihe-in | -63.58, -25.11 | -70.41, -35.48 | APE12-dist-in | 8.3739 | APE11-dist-in | 11.4208 | APE10-dist-in | 5.655 | APE9-dist-in | 3.3875 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 276.0 | 276.0 | 0 | 28 | 28 | 0 | [[59, 318], [415, 672]] | 2.0 | AF-Q15349-K3 | AGC_RPS6KA2-1_HUMAN | AGC | 6.1e-97 | 329.7 | 1.0 | 260.0 | 260.0 | 201 | 202 | 203 | 205 | 207 | 91 | 109 | 113 | 181 | 183 | 182 | 184.0 | 241 | 229 | 224 | 223 | 222 | 221 | 220 | 219 | 218 | 139 | Ribosomal protein S6 kinase alpha-2 |
| CAMK | RPS6KA2-2 | KS6A2_HUMAN | AF-Q15349-K2A | Q15349 | 407 | 680 | 733.0 | No_ligand | No_ligand | Active | DFGin | 6.6518 | 14.1101 | BLAminus | -125.4, -179.16 | 57.55, 70.32 | -78.41, 25.17 | 287.92, 78.56 | -56.51, -34.86 | in-in | in | 8.845 | Saltbr-in | 2.7449 | HRD-in | -75.04, -44.25 | 70.02, -1.4 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.9675 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -135.57, 128.45 | APE9-dihe-na | -171.02, 160.68 | APE8-dihe-in | -94.96, 132.21 | APE8-rot-in | 299.43 | APE67-dihe-in | -73.4, -9.74 | -51.26, -43.01 | APE12-dist-in | 8.7404 | APE11-dist-in | 10.7763 | APE10-dist-in | 4.9315 | APE9-dist-in | 4.1178 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 274.0 | 274.0 | 0 | 28 | 28 | 0 | [[59, 318], [415, 672]] | 2.0 | AF-Q15349-K2 | CAMK_RPS6KA2-2_HUMAN | CAMK | 1.2e-87 | 299.4 | 1.0 | 256.0 | 256.0 | 553 | 554 | 555 | 557 | 559 | 444 | 456 | 460 | 529 | 531 | 530 | 532.0 | 593 | 581 | 576 | 575 | 574 | 573 | 572 | 571 | 570 | 487 | Ribosomal protein S6 kinase alpha-2 |
| CAMK | RPS6KA2-2 | KS6A2_HUMAN | AF-Q15349-K4A | Q15349 | 407 | 680 | 733.0 | No_ligand | No_ligand | Active | DFGin | 6.3278 | 14.2282 | BLAminus | -135.27, -175.54 | 54.15, 64.63 | -71.12, 21.3 | 285.37, 81.71 | -73.26, -23.14 | in-in | in | 8.9583 | Saltbr-in | 2.6983 | HRD-in | -78.2, -43.66 | 65.94, -8.2 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8877 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -124.63, 122.14 | APE9-dihe-na | -169.16, 159.04 | APE8-dihe-in | -89.7, 129.99 | APE8-rot-in | 297.48 | APE67-dihe-in | -79.03, -7.61 | -53.86, -39.13 | APE12-dist-in | 9.026 | APE11-dist-in | 11.3332 | APE10-dist-in | 5.3242 | APE9-dist-in | 4.172 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 274.0 | 274.0 | 0 | 28 | 28 | 0 | [[59, 318], [415, 672]] | 2.0 | AF-Q15349-K4 | CAMK_RPS6KA2-2_HUMAN | CAMK | 1.2e-87 | 299.4 | 1.0 | 256.0 | 256.0 | 553 | 554 | 555 | 557 | 559 | 444 | 456 | 460 | 529 | 531 | 530 | 532.0 | 593 | 581 | 576 | 575 | 574 | 573 | 572 | 571 | 570 | 487 | Ribosomal protein S6 kinase alpha-2 |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AGC | RPS6KA2-1 | KS6A2_HUMAN | AF-Q15349-K1A | Q15349 | 51 | 326 | 733.0 | No_ligand | No_ligand | Active | DFGin | 6.5598 | 14.2976 | BLAminus | -128.83, -162.98 | 39.17, 62.6 | -73.7, 13.33 | 288.23, 79.39 | -63.05, -17.58 | in-in | in | 8.7464 | Saltbr-in | 2.6179 | HRD-in | -82.39, -49.82 | 64.45, 9.53 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8943 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -156.56, 163.19 | APE9-dihe-na | 114.31, 169.62 | APE8-dihe-in | -69.73, 130.78 | APE8-rot-in | 293.85 | APE67-dihe-in | -60.4, -27.19 | -59.3, -42.05 | APE12-dist-in | 8.3994 | APE11-dist-in | 11.4439 | APE10-dist-in | 5.6991 | APE9-dist-in | 3.5393 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 276.0 | 276.0 | 0 | 28 | 28 | 0 | [[59, 318], [415, 672]] | 2.0 | AF-Q15349-K1 | Homo sapiens | AGC_RPS6KA2-1_HUMAN | AGC | 6.1e-97 | 329.7 | 1.0 | 260.0 | 260.0 | 201 | 202 | 203 | 205 | 207 | 91 | 109 | 113 | 181 | 183 | 182 | 184.0 | 241 | 229 | 224 | 223 | 222 | 221 | 220 | 219 | 218 | 139 | Ribosomal protein S6 kinase alpha-2 |
| AGC | RPS6KA2-1 | KS6A2_HUMAN | AF-Q15349-K3A | Q15349 | 51 | 326 | 733.0 | No_ligand | No_ligand | Active | DFGin | 6.4336 | 14.1588 | BLAminus | -128.23, -175.81 | 52.4, 64.67 | -72.62, 10.99 | 294.75, 82.08 | -64.43, -12.72 | in-in | in | 8.6258 | Saltbr-in | 2.6429 | HRD-in | -85.46, -48.02 | 66.82, 11.67 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8436 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -154.59, 164.28 | APE9-dihe-na | 111.5, 172.79 | APE8-dihe-in | -74.02, 136.08 | APE8-rot-in | 294.1 | APE67-dihe-in | -63.58, -25.11 | -70.41, -35.48 | APE12-dist-in | 8.3739 | APE11-dist-in | 11.4208 | APE10-dist-in | 5.655 | APE9-dist-in | 3.3875 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 276.0 | 276.0 | 0 | 28 | 28 | 0 | [[59, 318], [415, 672]] | 2.0 | AF-Q15349-K3 | Homo sapiens | AGC_RPS6KA2-1_HUMAN | AGC | 6.1e-97 | 329.7 | 1.0 | 260.0 | 260.0 | 201 | 202 | 203 | 205 | 207 | 91 | 109 | 113 | 181 | 183 | 182 | 184.0 | 241 | 229 | 224 | 223 | 222 | 221 | 220 | 219 | 218 | 139 | Ribosomal protein S6 kinase alpha-2 |
| CAMK | RPS6KA2-2 | KS6A2_HUMAN | AF-Q15349-K2A | Q15349 | 407 | 680 | 733.0 | No_ligand | No_ligand | Active | DFGin | 6.6518 | 14.1101 | BLAminus | -125.4, -179.16 | 57.55, 70.32 | -78.41, 25.17 | 287.92, 78.56 | -56.51, -34.86 | in-in | in | 8.845 | Saltbr-in | 2.7449 | HRD-in | -75.04, -44.25 | 70.02, -1.4 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.9675 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -135.57, 128.45 | APE9-dihe-na | -171.02, 160.68 | APE8-dihe-in | -94.96, 132.21 | APE8-rot-in | 299.43 | APE67-dihe-in | -73.4, -9.74 | -51.26, -43.01 | APE12-dist-in | 8.7404 | APE11-dist-in | 10.7763 | APE10-dist-in | 4.9315 | APE9-dist-in | 4.1178 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 274.0 | 274.0 | 0 | 28 | 28 | 0 | [[59, 318], [415, 672]] | 2.0 | AF-Q15349-K2 | Homo sapiens | CAMK_RPS6KA2-2_HUMAN | CAMK | 1.2e-87 | 299.4 | 1.0 | 256.0 | 256.0 | 553 | 554 | 555 | 557 | 559 | 444 | 456 | 460 | 529 | 531 | 530 | 532.0 | 593 | 581 | 576 | 575 | 574 | 573 | 572 | 571 | 570 | 487 | Ribosomal protein S6 kinase alpha-2 |
| CAMK | RPS6KA2-2 | KS6A2_HUMAN | AF-Q15349-K4A | Q15349 | 407 | 680 | 733.0 | No_ligand | No_ligand | Active | DFGin | 6.3278 | 14.2282 | BLAminus | -135.27, -175.54 | 54.15, 64.63 | -71.12, 21.3 | 285.37, 81.71 | -73.26, -23.14 | in-in | in | 8.9583 | Saltbr-in | 2.6983 | HRD-in | -78.2, -43.66 | 65.94, -8.2 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8877 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -124.63, 122.14 | APE9-dihe-na | -169.16, 159.04 | APE8-dihe-in | -89.7, 129.99 | APE8-rot-in | 297.48 | APE67-dihe-in | -79.03, -7.61 | -53.86, -39.13 | APE12-dist-in | 9.026 | APE11-dist-in | 11.3332 | APE10-dist-in | 5.3242 | APE9-dist-in | 4.172 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 274.0 | 274.0 | 0 | 28 | 28 | 0 | [[59, 318], [415, 672]] | 2.0 | AF-Q15349-K4 | Homo sapiens | CAMK_RPS6KA2-2_HUMAN | CAMK | 1.2e-87 | 299.4 | 1.0 | 256.0 | 256.0 | 553 | 554 | 555 | 557 | 559 | 444 | 456 | 460 | 529 | 531 | 530 | 532.0 | 593 | 581 | 576 | 575 | 574 | 573 | 572 | 571 | 570 | 487 | Ribosomal protein S6 kinase alpha-2 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|