PDB: 8HLT — CMGC DYRK2_HUMAN

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 8HLTA
DFGin None 1 50.0% 8HLTB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK2 DYRK2_HUMAN 8HLTA Q92630 151 535 601.0 XSE:60501 Type1 Active DFGin 7.1534 15.6614 BLAminus -128.03, -174.41 42.45, 74.99 -83.08, 17.4 279.93, 74.95 -62.5, -19.89 in-in in 9.1767 Saltbr-in 2.717 HRD-in -71.74, -44.48 73.83, 0.55 in-in-in SNCiii in-in ActLoopNT-in 2.7466 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.16, 170.0 APE9-dihe-na 71.16, 164.17 APE8-dihe-in -84.62, 135.53 APE8-rot-in 250.25 APE67-dihe-in -56.1, -31.76 -49.25, -50.28 APE12-dist-in 13.3151 APE11-dist-in 11.9661 APE10-dist-in 7.5704 APE9-dist-in 3.2103 None PTR382 PTR382 XRAY 2.8 0.213 0.267 A 393.0 385.0 0 25 25 0 [[222, 535]] 1.0 8hlt CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 8HLTB Q92630 151 537 601.0 XSE:60501 Type1 Inactive DFGin 6.6774 15.1725 None -123.1, -45.42 -92.76, 76.97 -82.13, 19.07 287.19, 77.16 -64.05, -27.16 in-in in 8.9659 Saltbr-in 2.9746 HRD-in -75.54, -44.65 72.51, -4.12 in-in-in SNCiii in-in ActLoopNT-in 2.7835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.69, 168.46 APE9-dihe-na 73.66, 156.43 APE8-dihe-in -77.8, 146.18 APE8-rot-in 309.51 APE67-dihe-in -59.07, -35.58 -50.16, -47.35 APE12-dist-in 12.9871 APE11-dist-in 11.6227 APE10-dist-in 7.106 APE9-dist-in 3.1243 None PTR382 PTR382 XRAY 2.8 0.213 0.267 B 393.0 387.0 0 25 25 0 [[222, 535]] 1.0 8hlt CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

PDB: 8HLT — CMGC DYRK2_HUMAN

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 8HLTA
DFGin None 1 50.0% 8HLTB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK2 DYRK2_HUMAN 8HLTA Q92630 151 535 601.0 XSE:60501 Type1 Active DFGin 7.1534 15.6614 BLAminus -128.03, -174.41 42.45, 74.99 -83.08, 17.4 279.93, 74.95 -62.5, -19.89 in-in in 9.1767 Saltbr-in 2.717 HRD-in -71.74, -44.48 73.83, 0.55 in-in-in SNCiii in-in ActLoopNT-in 2.7466 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.16, 170.0 APE9-dihe-na 71.16, 164.17 APE8-dihe-in -84.62, 135.53 APE8-rot-in 250.25 APE67-dihe-in -56.1, -31.76 -49.25, -50.28 APE12-dist-in 13.3151 APE11-dist-in 11.9661 APE10-dist-in 7.5704 APE9-dist-in 3.2103 None PTR382 PTR382 XRAY 2.8 0.213 0.267 A 393.0 385.0 0 25 25 0 [[222, 535]] 1.0 8hlt Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 8HLTB Q92630 151 537 601.0 XSE:60501 Type1 Inactive DFGin 6.6774 15.1725 None -123.1, -45.42 -92.76, 76.97 -82.13, 19.07 287.19, 77.16 -64.05, -27.16 in-in in 8.9659 Saltbr-in 2.9746 HRD-in -75.54, -44.65 72.51, -4.12 in-in-in SNCiii in-in ActLoopNT-in 2.7835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.69, 168.46 APE9-dihe-na 73.66, 156.43 APE8-dihe-in -77.8, 146.18 APE8-rot-in 309.51 APE67-dihe-in -59.07, -35.58 -50.16, -47.35 APE12-dist-in 12.9871 APE11-dist-in 11.6227 APE10-dist-in 7.106 APE9-dist-in 3.1243 None PTR382 PTR382 XRAY 2.8 0.213 0.267 B 393.0 387.0 0 25 25 0 [[222, 535]] 1.0 8hlt Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

PDB: 8HLT — CMGC DYRK2_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name