PDB: 8BUT — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 8BUTB
DFGin BLAminus 1 33.3% 8BUTE
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUTB Q9NYV4 715 1039 1490.0 RQ5:61101 Type1 Inactive DFGin 7.0564 15.3959 ABAminus -130.15, -50.58 -94.08, 102.79 -101.3, 34.01 287.2, 80.24 -71.28, -33.81 in-in in 8.1776 Saltbr-in 3.454 HRD-in -68.35, -50.74 72.26, 0.96 in-in-out SNCiio in-out ActLoopNT-in 2.8548 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.11, -52.89 APE9-dihe-na -83.71, 152.96 APE8-dihe-in -63.18, 146.03 APE8-rot-out 183.88 APE67-dihe-in -64.84, -30.01 -53.45, -39.74 APE12-dist-in 13.1524 APE11-dist-in 11.7525 APE10-dist-in 6.8757 APE9-dist-in 3.6644 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8but CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUTH Q9NYV4 715 1043 1490.0 RQ5:61101 Type1 Inactive DFGin 7.0927 15.4205 ABAminus -128.56, -49.4 -93.56, 100.15 -99.66, 30.54 282.78, 78.32 -73.44, -31.71 in-in in 8.0901 Saltbr-in 3.5145 HRD-in -72.59, -52.14 71.01, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.7456 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.31, -52.45 APE9-dihe-na -84.96, 155.97 APE8-dihe-in -63.11, 145.04 APE8-rot-in 301.85 APE67-dihe-in -65.27, -28.99 -54.91, -40.74 APE12-dist-in 13.688 APE11-dist-in 12.0303 APE10-dist-in 7.147 APE9-dist-in 3.4886 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8but CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUTE Q9NYV4 715 1039 1490.0 RQ5:61101 Type1 Inactive DFGin 7.2983 15.3231 BLAminus -139.51, -178.35 41.51, 85.24 -101.61, 29.69 285.9, 80.14 -70.78, -30.56 in-in in 8.259 Saltbr-in 3.086 HRD-in -67.79, -50.31 72.32, 0.48 in-in-out SNCiio in-out ActLoopNT-in 2.9303 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -100.83, -40.87 APE9-dihe-na -77.17, 152.92 APE8-dihe-in -63.05, 147.04 APE8-rot-out 167.97 APE67-dihe-in -65.55, -27.52 -54.27, -41.89 APE12-dist-in 12.9325 APE11-dist-in 12.5982 APE10-dist-in 6.8078 APE9-dist-in 3.452 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8but CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BUT — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 8BUTB
DFGin BLAminus 1 33.3% 8BUTE
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUTB Q9NYV4 715 1039 1490.0 RQ5:61101 Type1 Inactive DFGin 7.0564 15.3959 ABAminus -130.15, -50.58 -94.08, 102.79 -101.3, 34.01 287.2, 80.24 -71.28, -33.81 in-in in 8.1776 Saltbr-in 3.454 HRD-in -68.35, -50.74 72.26, 0.96 in-in-out SNCiio in-out ActLoopNT-in 2.8548 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.11, -52.89 APE9-dihe-na -83.71, 152.96 APE8-dihe-in -63.18, 146.03 APE8-rot-out 183.88 APE67-dihe-in -64.84, -30.01 -53.45, -39.74 APE12-dist-in 13.1524 APE11-dist-in 11.7525 APE10-dist-in 6.8757 APE9-dist-in 3.6644 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8but Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUTH Q9NYV4 715 1043 1490.0 RQ5:61101 Type1 Inactive DFGin 7.0927 15.4205 ABAminus -128.56, -49.4 -93.56, 100.15 -99.66, 30.54 282.78, 78.32 -73.44, -31.71 in-in in 8.0901 Saltbr-in 3.5145 HRD-in -72.59, -52.14 71.01, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.7456 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.31, -52.45 APE9-dihe-na -84.96, 155.97 APE8-dihe-in -63.11, 145.04 APE8-rot-in 301.85 APE67-dihe-in -65.27, -28.99 -54.91, -40.74 APE12-dist-in 13.688 APE11-dist-in 12.0303 APE10-dist-in 7.147 APE9-dist-in 3.4886 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8but Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUTE Q9NYV4 715 1039 1490.0 RQ5:61101 Type1 Inactive DFGin 7.2983 15.3231 BLAminus -139.51, -178.35 41.51, 85.24 -101.61, 29.69 285.9, 80.14 -70.78, -30.56 in-in in 8.259 Saltbr-in 3.086 HRD-in -67.79, -50.31 72.32, 0.48 in-in-out SNCiio in-out ActLoopNT-in 2.9303 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -100.83, -40.87 APE9-dihe-na -77.17, 152.92 APE8-dihe-in -63.05, 147.04 APE8-rot-out 167.97 APE67-dihe-in -65.55, -27.52 -54.27, -41.89 APE12-dist-in 12.9325 APE11-dist-in 12.5982 APE10-dist-in 6.8078 APE9-dist-in 3.452 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8but Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BUT — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name